Navigation Links
Researchers identify new protein that triggers breast cancer
Date:1/14/2009

This press release is available in French.

Montreal, January 14, 2009 Canadian researchers have identified a new protein in the progression of breast cancer. According to a recent study from the Universit de Montral and the University of Alberta, published in the Journal of Biological Chemistry, the protein ARF1 plays a critical role in cancer cell growth and the spread of tumours. Targeting this protein with drug therapy may provide hope to women with breast cancer.

"Until now, ARF1 has been associated with harmless albeit important housekeeping duties of cells," says senior author Audrey Claing, a professor of pharmacology at the Universit de Montral. "The Universit de Montral and the University of Alberta team is the first to characterize the role of ARF1 in breast cancer."

Dr. Claing and her colleagues used invasive breast cancer cell lines to study ARF1's role. These cells are sensitive to a particular growth factor, called epidermal growth factor or EGF, which has previously been shown to stimulate tumour growth and invasion. Their findings suggest that EGF works through ARF1 in these cells. In addition, when ARF1 activity was chemically blocked, breast cancer cell migration and growth was reduced. Conversely, when ARF1 was overproduced in these cells, their movement was enhanced.

"Taken together our findings reveal an unsuspected role for ARF1 and indicate that this small protein may be a potential therapeutic target for the treatment of invasive breast cancers," says Dr. Claing, who is a member of the Groupe d'tude des protines membranaires as well a the Groupe de Recherche Universitaire sur le Mdicament, two multidisciplinary research teams dedicated to the study of membrane protein functions and the identification of new therapeutic targets for drug discovery.


'/>"/>

Contact: Sylvain-Jacques Desjardins
sylvain-jacques.desjardins@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Page: 1

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... April 21, 2015 Displays & Exhibits, ... in the trade show exhibit building industry, announced a ... sales offices of Absolute Exhibits in Tustin, California.“It is ... shoppers to observe the variation in quality as offered ... Exhibits,” explained Zenos Adduru. Mr. Adduru is the new ...
(Date:4/21/2015)... 21, 2015 Henry Mayo Newhall Hospital, ... Care Exchange to automatically send continuation of care ... to further improve communication with clinics and other ambulatory ... Alert solution. , “Provider Alert will enable ... patient information they need to provide continuing care in ...
(Date:4/21/2015)... Texas (PRWEB) April 22, 2015 ... Review, H1 2015” provides comparative analysis on ... report strengthens R&D pipelines by identifying new ... best-in-class products. Complete report with TOC is ... The report also reviews key players involved ...
(Date:4/21/2015)... The report “Sinusitis – ... on the therapeutic development for Sinusitis. The ... targets and MOAs to produce first-in-class and ... available @ http://www.rnrmarketresearch.com/sinusitis-pipeline-review-h1-2015-market-report.html . , ... in the therapeutic development for Sinusitis and ...
(Date:4/21/2015)... Calif. (PRWEB) April 21, 2015 Information is ... , Kevin Ryan, MD, FACP, empowers patients and their families ... Tumor is the Rumor and Cancer is the Answer" and ... authoritative and informative language to guide patients from diagnosis through ... make patients active participants in their treatment, at home and ...
Breaking Medicine News(10 mins):Health News:Displays & Exhibits Reveals Tustin, California Showroom Under New Management 2Health News:Henry Mayo Newhall Hospital to Improve Ambulatory Information Sharing with Summit Healthcare's Summit Provider Alert 2Health News:Pulmonary Embolism Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 2Health News:Pulmonary Embolism Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 3Health News:Pulmonary Embolism Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 4Health News:Sinusitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 2Health News:Sinusitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 3Health News:Authoritative guide and new accompanying therapeutic web portal bridge information gaps in cancer treatment 2
... Pharmaceuticals,a developer and manufacturer of medical products that ... division of Smith & Nephew,plc announced today that ... dressing for wounds that require up to seven ... new addition to,the Acticoat(TM) family of barrier dressings ...
... medical home, personal health records and emergency,department coverage will ... conference presented by the Michigan State Medical Society (MSMS),on ... at The Inn at St. John,s,in Plymouth., State ... of the emerging health care model that ensures coordinated,patient ...
... EBITDA Increases 9.5% to $21.2 Million , Front-End Same-Store ... 3.7% , Gross Margin Improves to 31.3% , ... the Third,Quarter of 2007 , NEW YORK, Nov. 7 ... ended September 27, 2008., Third Quarter Key Highlights, ...
... Tips on Expressing Gratitude,and Staying Active, SALT ... of the most trusted and respected brands in ... has declared the,month of November to be "Give ... widespread appreciation for America,s mature adults, who,are changing ...
... Birdstep Technologies expansion in the worldwide embedded database market Birdstep has ... Israeli distributor of Birdstep,s Raima Database Manager Product Family. , ... ... (OSE: BIRD) today announced they have completed an agreement with the ...
... actually enjoy inflicting pain on others, research using brain scans ... aggressive youth,s brains showed that an area that is associated ... clip of someone inflicting pain on another person. Youth ... the study showed. , "This is the first time that ...
Cached Medicine News:Health News:New Acticoat(TM) Silver Coated Anti-microbial Barrier Dressing Receives Regulatory Approval from Health Canada 2Health News:New Acticoat(TM) Silver Coated Anti-microbial Barrier Dressing Receives Regulatory Approval from Health Canada 3Health News:New Acticoat(TM) Silver Coated Anti-microbial Barrier Dressing Receives Regulatory Approval from Health Canada 4Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 2Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 3Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 4Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 5Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 6Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 7Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 8Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 9Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 10Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 11Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 12Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 13Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 14Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 15Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 16Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 17Health News:Duane Reade Holdings, Inc. Reports Third Quarter Results 18Health News:Schiff(R) Nutrition International Declares November 'Give Thanks for Grandparents Month' 2Health News:Birdstep Technology Announced the Addition of the TACT Group to its Family of Distributors 2Health News:Birdstep Technology Announced the Addition of the TACT Group to its Family of Distributors 3Health News:Bullies may enjoy seeing others in pain 2
(Date:4/21/2015)... YORK , April 21, 2015 ... in 2019 World demand for caps and closures will ... is expected to exceed two trillion annually. Beverages will continue ... units. However, pharmaceuticals and a number of smaller markets are ... register faster advances Although the most developed markets -- ...
(Date:4/21/2015)... LONDON , April 21, 2015 The ... at a CAGR of 8.2% from 2014 to 2019. ... Europe hold larger shares in the global ... dermatology diagnostic devices market is mainly attributed to a ... skin disorders, growing demand of dermatologists, and technological advancements ...
(Date:4/21/2015)... 2015  Lincoln Computer Services has taken a proactive ... keep coming! LCS donated 10 laptops and carts to ... by Hebrew Home at Riverdale ... and Dad is a creative, non-pharmacological approach to Alzheimer,s ... sometimes agitated in the morning, start their day off ...
Breaking Medicine Technology:World Caps & Closures Market 2World Caps & Closures Market 3Dermatology Diagnostic Devices Market by Product, by End-User - Global Forecast to 2019 2Dermatology Diagnostic Devices Market by Product, by End-User - Global Forecast to 2019 3Lincoln Continues Support of the Community: Donates 10 Laptops for Alzheimer's Program 2
... NEW CENTERS AND TO ... INCREASE AWARENESS AMONG CARDIOLOGISTS, PLEASANTON, Calif., April 21 ... mechanical,circulatory support therapies to save, support and restore failing hearts,said ... (PreMarket,Approval) application, allowing the use of its HeartMate II LVAS ...
... April 21 A new study funded by,Health ... correlation,between dietary consumption of the omega-3 DHA* and ... Universite Laval,researchers and published in the Journal of ... pregnancy boosts an infant,s sensory,cognitive, and motor development., ...
Cached Medicine Technology:Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 2Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 3Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 4Thoratec Announces FDA Approval of HeartMate II(R) for Bridge-To-Transplantation 5Pregnant Women Need Omega-3 to Boost Infant Development 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: