Navigation Links
Researchers identify new method to selectively kill metastatic melanoma cells
Date:8/3/2009

RICHMOND, Va. (August 3, 2009) An international team of researchers has identified a new method for selectively killing metastatic melanoma cells, which may lead to new areas for drug development in melanoma a cancer that is highly resistant to current treatment strategies.

Researchers from Virginia Commonwealth University, in collaboration with a team of researchers led by Maria S. Soengas, Ph.D., with the Spanish National Cancer Research Center in Madrid, Spain, found that activation of a specific molecular pathway triggers melanoma cells to begin a process of self-destruction through self-digestion and programmed cell death. The study is published in the August 4 print issue of the journal Cancer Cell.

"The present research provides a path that could lead with further studies and a phase I clinical trial for safety to the development of a strategy that reenergizes the immune system to destroy this highly aggressive cancer," said lead investigator at VCU, Paul B. Fisher, M.Ph., Ph.D., the first incumbent of the Thelma Newmeyer Corman Endowed Chair in Cancer Research with the VCU Massey Cancer Center.

According to Fisher, the pathway that is activated involves the melanoma differentiation associated gene-5, or mda-5, a gene initially cloned in Fisher's laboratory, that activates a protein called NOXA that is involved with programmed cell death. This series of chemical reactions results in induction of a cell-killing process involving self-digestion that leads to programmed cell death specifically in melanoma cells. Fisher said that mda-5 is a key regulator of innate immunity that induces interferon beta production limiting replication of specific pathogenic viruses.


'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers effectively treat tumors with use of nanotubes
2. Fox Chase researchers identify differences in treatments and outcomes of patients with second primary lung cancers versus those with one primary lung cancer
3. Researchers Discover the Tale Behind Short Dogs
4. Higher drug doses needed to defeat tuberculosis, UT Southwestern researchers report
5. Mayo researchers find anesthesia not harmful for babies during birth process
6. Mayo Researchers Find Anesthesia Not Harmful for Babies During Birth Process
7. Pinpointing cause of colic: UT Houston researchers identify organism
8. Zucker Hillside Researchers to Receive Large Federal Grant to Test for the Early Treatment of Schizophrenia
9. Researchers find that eating high levels of fructose impairs memory in rats
10. Ben-Gurion U. researchers identify how stressed fat tissue malfunctions
11. U of M researchers find childhood cancer risk rises with mothers age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2017)... FL (PRWEB) , ... May 19, 2017 , ... ... feature RawTrition’s BioEnergy in an upcoming episode of Innovations with Ed Begley, Jr., ... Jersey, RawTrition is the distributor of a clean, organic dietary supplement made from ...
(Date:5/19/2017)... (PRWEB) , ... May 19, 2017 , ... The Hill ... to families and entrepreneurs throughout the California Central Valley, is announcing a joint charity ... raising community support for a local kid’s camp event. , The Boys and Girls ...
(Date:5/19/2017)... ... May 19, 2017 , ... ... announced a sponsorship and speaking session at the 7th Annual ET6 Exchange ... hosted enterprise mobility and digital transformation conference whose expressed purpose is to connect ...
(Date:5/19/2017)... ... 2017 , ... CloSYS products which are marketed as the gentle giants of ... and gum health, which is linked to one’s overall health. Since 1991 when the ... powerful ways in which CloSYS products immediately helped eliminate bad breath as well as ...
(Date:5/18/2017)... ... ... Dr. Kim Ross supports Stroke Awareness Month by now accepting new patients ... condition and serious systemic health conditions including heart disease and stroke. Those with bleeding ... and seeking treatment with Dr. Ross immediately may prevent bacteria from spreading. , ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... SAN DIEGO , May 4, 2017 ... 2017 Annual Clinical and Scientific Meeting— OBP Medical , ... devices, today announced the launch of a new extra-small ... and ER-SPEC vaginal specula. Already available ... and extra-large sizes makes OBP Medical,s line of single-use ...
(Date:5/3/2017)... , May 3, 2017 A ... any hospital or healthcare facility. Commonly referred to ... is equipped with diagnostic imaging technology to give ... the heart. In these spaces, a team of ... balloon angioplasty, percutaneous coronary intervention, congenital heart defect ...
(Date:5/2/2017)... WASHINGTON and NEW YORK ... 2017 As the leading distributor of market ... with European Med Tech Reimbursement Consulting AB ... Med Tech Reimbursement Consulting AB,s proprietary market analyses through ... business professionals around the world easy access to complete ...
Breaking Medicine Technology: