Navigation Links
Researchers identify new method to selectively kill metastatic melanoma cells
Date:8/3/2009

RICHMOND, Va. (August 3, 2009) An international team of researchers has identified a new method for selectively killing metastatic melanoma cells, which may lead to new areas for drug development in melanoma a cancer that is highly resistant to current treatment strategies.

Researchers from Virginia Commonwealth University, in collaboration with a team of researchers led by Maria S. Soengas, Ph.D., with the Spanish National Cancer Research Center in Madrid, Spain, found that activation of a specific molecular pathway triggers melanoma cells to begin a process of self-destruction through self-digestion and programmed cell death. The study is published in the August 4 print issue of the journal Cancer Cell.

"The present research provides a path that could lead with further studies and a phase I clinical trial for safety to the development of a strategy that reenergizes the immune system to destroy this highly aggressive cancer," said lead investigator at VCU, Paul B. Fisher, M.Ph., Ph.D., the first incumbent of the Thelma Newmeyer Corman Endowed Chair in Cancer Research with the VCU Massey Cancer Center.

According to Fisher, the pathway that is activated involves the melanoma differentiation associated gene-5, or mda-5, a gene initially cloned in Fisher's laboratory, that activates a protein called NOXA that is involved with programmed cell death. This series of chemical reactions results in induction of a cell-killing process involving self-digestion that leads to programmed cell death specifically in melanoma cells. Fisher said that mda-5 is a key regulator of innate immunity that induces interferon beta production limiting replication of specific pathogenic viruses.


'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers effectively treat tumors with use of nanotubes
2. Fox Chase researchers identify differences in treatments and outcomes of patients with second primary lung cancers versus those with one primary lung cancer
3. Researchers Discover the Tale Behind Short Dogs
4. Higher drug doses needed to defeat tuberculosis, UT Southwestern researchers report
5. Mayo researchers find anesthesia not harmful for babies during birth process
6. Mayo Researchers Find Anesthesia Not Harmful for Babies During Birth Process
7. Pinpointing cause of colic: UT Houston researchers identify organism
8. Zucker Hillside Researchers to Receive Large Federal Grant to Test for the Early Treatment of Schizophrenia
9. Researchers find that eating high levels of fructose impairs memory in rats
10. Ben-Gurion U. researchers identify how stressed fat tissue malfunctions
11. U of M researchers find childhood cancer risk rises with mothers age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... July 03, 2015 , ... On ... for a new SEO training system called "Page One Engine" . The ... generation has received glowing reviews from several well-known marketers. HonestyFirstReviews.com's Tiffany Hendricks has ...
(Date:7/3/2015)... , ... July 03, 2015 , ... ... to healthcare providers, has been retained to lead a national president recruitment ... search firms in the healthcare industry, B. E. Smith has recently placed more ...
(Date:7/3/2015)... Louis, MO (PRWEB) , ... July 03, 2015 , ... ... responsive website to replace their existing Talcum Powder Cancer Lawsuit Center website. Just as ... talcum powder lawsuit news , offering timely lawsuit updates and ovarian cancer warning ...
(Date:7/3/2015)... ... July 03, 2015 , ... Yisrayl Hawkins, Pastor and Overseer at The ... he says will reveal biblical truth and expose popular lies regarding proper relationships according ... Don’t Have Sex”, immediately goes into the core of the subject by explaining why ...
(Date:7/2/2015)... ... ... Enterprises, LLC. is pleased to announce the opening of its newest location in Dallas, Texas. ... premium frozen yogurt chain was listed as #22 on the Inc. 500 list of fastest ... Bachman Lake, is located at:, 3701 W. Northwest Highway, STE 430, Dallas, TX 75220 , ...
Breaking Medicine News(10 mins):Health News:Page One Engine - Review Of Dori Friend's SEO Training Course Released 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 3Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 2Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 3Health News:Yisrayl Hawkins Explains What the Bible Really Says about Sex in New Publication This Week 2Health News:sweetFrog Opens 18th Location in the Lone Star State 2
... benefit in study of those with spinal afflictions, ... osteoporosis patients with spinal fractures, vertebroplasty provides significant ... a new study. , Vertebroplasty involves injection ... to shore up the fracture and provide pain ...
... ACM, one of the country,s leading,healthcare ... Plans, Inc. today announced a new agreement ... pricing precision to medical,pharmacy infusion services provided ... a decade, ACM,s e-Precision Claims(SM) technology has ...
... the SCIAMACHY instrument aboard ESA,s Envisat environmental satellite, scientists ... carbon dioxide the most important greenhouse gas that ... , More than 30 billion tonnes of extra carbon ... annually by human activities, mainly through the burning of ...
... St. John Hospital and Medical Center are recognized ... hospitals by one of the country,s leading,sources of ... from Thomson (formally Solucient), recognizes hospitals,that achieve or ... and SJH&MC were two of only 15 hospitals ...
... scientists from North Carolina State University have shown that ... reduces harmful carcinogens in cured tobacco leaves. , The ... products with reduced amounts of cancer-causing agents. , ... and Dr. Ramsey Lewis, assistant professor of crop science, ...
... may improve the health of patients with rheumatoid ... medical universit Karolinska Institutet. The diet has a ... disease. , Rheumatoid arthritis is associated with an ... and cardiovascular diseases. The underlying causes are unknown, ...
Cached Medicine News:Health News:Pain Relief for Osteoporosis Patients With Fractures 2Health News:ACM Partners With Tufts Associated Health Plans to Improve the Cost-effective Delivery of Home Infusion Services 2Health News:Envisat makes first ever observation of regionally elevated CO2 from manmade emissions 2Health News:Envisat makes first ever observation of regionally elevated CO2 from manmade emissions 3Health News:St. John Health Hospitals Honored as Nation's Top 15 Major Teaching Hospitals 2Health News:Gene 'knockout' floors tobacco carcinogen 2
(Date:7/2/2015)... -- BGI a annoncé aujourd,hui que son laboratoire ... à Hong Kong avait ...  (Collège des pathologistes américains, ou CAP). Les installations ... constituent le premier laboratoire clinique de séquençage ... CAP en Chine, car il satisfait les normes ...
(Date:7/2/2015)... 2, 2015  New product launches are critical events ... in educating thought leaders about new products, Medical Affairs ... how well a new therapy performs at launch. ... and consulting leader Best Practices, LLC, critical aspects of ... on are early stage thought leader (TL) interaction, successful ...
(Date:7/2/2015)... 2, 2015 Roche,s Bloodhound technology is ... segment in hematology testing, according to Kalorama Information.  ... unveiling of its Bloodhound digital cell imaging technology ... 511 hematology analyzer – is notable as ... by current leader CellaVision, but also compete more ...
Breaking Medicine Technology:BGI obtient la certification du Collège des pathologistes américains (CAP) 2Medical Affairs Role in Thought Leader Education is Key Success Factor for New Product Launches in the Pharmaceutical Industry 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 3
... today visited the future site of Endo Pharmaceutical,s corporate headquarters ... continued commitment to the region and its plans to create ... Pennsylvania we are employing the kind of creative cooperation that ... ribbon on a new headquarters," said Corbett. "This investment in ...
... FISHKILL, N.Y., Jan. 17, 2012  Nano Mask, Inc. (NMI) (Pink ... company focused on emergency and critical care as well as ... sales, marketing and distribution office in Riyadh, Saudi Arabia to ... into the strong demand for its products in the region. ...
Cached Medicine Technology:Nano Mask Opens Office in Riyadh, Saudi Arabia Due to Strong Demand for Company's Products 2
... System combines the flexibility of polyaxial screws ... a single system. The result is ... loading to the vertebral anatomy, thus reducing ... polyaxial screws and lateral connectors reduces the ...
... The Equation System incorporates a semi-rigid design ... System is a reduced-volume and top-tightening spinal ... of fixation that mimics the load distribution ... designed to share, not bear, the load). ...
... System is a comprehensive and versatile hook, ... used for both deformity and degenerative cases. ... spine in 3-dimensions, the ISOLA/VSP Spine System ... correctly align and stabilize the spine. In ...
Multiwindow transcranial and peripheral Doppler system....
Medicine Products: