Navigation Links
Researchers identify new genetic marker for breast cancer
Date:3/3/2008

NEW YORK, March 3, 2008An international group of investigators led by scientists at Memorial Sloan-Kettering Cancer Center (MSKCC) and the National Cancer Institute has identified a new genetic marker of risk for breast cancer. Women with this DNA variation are at a 1.4 times greater risk of developing breast cancer compared to those without the variation. The findings are to be published online on March 3, 2008 in the journal Proceedings of the National Academy of Sciences.

These results are exciting because they point us to new molecular pathways that may be associated with breast cancer, said the head of the research team and the studys senior author, Kenneth Offit, MD, MPH, Chief of the Clinical Genetics Service at MSKCC.

The study used a methodology called genome-wide association mapping, which looks at genetic variations across the entire genome that alter the individual building blocks of DNA makeup. These alterations may occur more frequently in individuals who have certain types of disease than in carriers without such disease. In this study, a new gene locus, a specific place on a chromosome where a gene is located, was associated with breast cancer risk. That gene locus is on the long arm of chromosome 6.

These research findings are of great interest because of the method of genome- wide association used to discover this new locus as well as others in recent months, said Bert Gold, PhD, a Staff Scientist at the National Cancer Institute in Frederick, MD., and first author of the current study.

While the risk associated with this genetic marker is much lower than that of BRCA genetic mutations for example, this discovery will increase the understanding of the genetic variants that contribute to breast cancer.

Researchers used samples largely from MSKCC, but also from other sites in the US, Canada, and Israel. Participants were all of Ashkenazi (Eastern European Jewish) ancestry. The study used a three-pha
'/>"/>

Contact: Jeanne D'Agostino
dagostij@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
2. Researchers develop new tool to predict who will use microbicides
3. USC researchers discover novel way to develop tumor vaccines
4. St. Jude Researchers Find Key Step in Programmed Cell Death
5. St. Jude researchers find key step in programmed cell death
6. Mayo Researchers Look for Explanation Behind High Incidence of Diabetes Among Asian Indians
7. Mayo researchers look for explanation behind high incidence of diabetes among Asian Indians
8. UT Southwestern researchers investigate predictors for sickle-cell-anemia complications
9. Researchers find possible target to treat deadly bloodstream infections
10. Rutgers researchers unlock mysteries of vitamin A metabolism during embryonic development
11. U of Minn researchers discover genetic cancer link between humans and dogs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... study has found that India,s shocking rates of suicide ... who are clinging to tiny smallholdings less than ... such as cotton and coffee, that are highly susceptible ... range of previous case studies that point to a ... the ,liberalisation, of the nation,s economy during the 90s. ...
(Date:4/17/2014)... Researchers from LSTM have called for more research ... coinfection in children in sub-Saharan Africa. In a ... LSTM,s Professor Russell Stothard, working with colleagues in ... Western Reserve University, in Cleveland Ohio, University of ... previous research into the joint burden of HIV/AIDS ...
(Date:4/16/2014)... , DOWNERS GROVE, Ill. April 16, 2014 ... of surveillance colonoscopy in average-risk patients with one to ... about 90 percent of cases. This may be an ... multicenter endoscopic database study to quantify adherence to guidelines ...
(Date:4/15/2014)... by the RECIST Working Group published in the European ... more refined categorization of tumor response or various aspects of ... database. They found that modeling target lesion tumor growth ... beyond that of the other components of progression. The RECIST ...
(Date:4/14/2014)... USA The International and American Associations for Dental ... Diseases and Their Dental, Oral, and Craniofacial Manifestations." The ... Burke, Alison M. Boyce, Michael Collins, Brian L. Foster, ... Martha J. Somerman and J. Timothy Wright is published ...
Breaking Medicine News(10 mins):Health News:New evidence of suicide epidemic among India's 'marginalized' farmers 2Health News:New evidence of suicide epidemic among India's 'marginalized' farmers 3Health News:More research called for into HIV and schistosomiasis coinfection in African children 2Health News:Surveillance colonoscopy recommendations for average-risk patients with 1 to 2 small polyps consistent with guidelines 2Health News:Surveillance colonoscopy recommendations for average-risk patients with 1 to 2 small polyps consistent with guidelines 3Health News:Can refined categorization improve prediction of patient survival in RECIST 1.1? 2Health News:Rare bone diseases and their dental, oral and craniofacial manifestations 2
... from academic and business leaders, technologists, physicians, ... In response to President Obama,s call ... for Connected Health, a division of Partners ... in December, to explore the opportunities and ...
... patients, help rural broadband developmentWASHINGTON, Jan. 22 An ... protect patients from medical errors was adopted by unanimous ... & Commerce Committee,s markup of the Democrats, $825 billion ... secure electronic system to store our medical records, it ...
... 23 Rigel,Pharmaceuticals, Inc. (Nasdaq: RIGL ) today announced ... Sclerosis taking,place this week in Santa Fe, New Mexico. , ... Time: 2:30 - 4:30pm , ... MS , Presentation Title: The orally ...
... DEPTFORD, N.J., Jan. 23 In an effort to ... and Licensed Practical Nurses are set to participate in ... Innova Hammonton scheduled to begin at 6 a.m. on ... The National Union of Hospital and Health Care Employees ...
... open here in March, will provide clients with the opportunity in ... team of expert physicians at a state-of-the-art evaluation facility. , ... ... Health Evaluation Center (WHEC), set to open here in March, will ...
... Stethoscope.com announced today the implementation of customer product reviews for the ... ... Wayland, MA (PRWEB) January 23, 2009 -- Stethoscope.com ... full line of medical products offered on their website., , ,"We ...
Cached Medicine News:Health News:Healthcare Reform Should Include Connected Health and Participatory Medicine, Says Report Submitted to President Obama by Center for Connected Health 2Health News:Healthcare Reform Should Include Connected Health and Participatory Medicine, Says Report Submitted to President Obama by Center for Connected Health 3Health News:New Williamsburg Health Evaluation Center, The Ultimate Investment In Future Health And Well-Being, Set To Open In March 2
(Date:1/15/2014)... 2014 As health officials across the Midwest warn against ... in Michigan will offer free diagnostic ... Meijer pharmacists to administer tests and, in some cases, fill ... participating in the study. The Grand ...
(Date:1/15/2014)... Jan. 15, 2014 Massachusetts General Hospital (MGH), ... AMGN ) announced today that they have launched ... new therapeutic targets and develop novel therapies for ... affects millions worldwide. The MGH-Broad-Amgen collaboration brings together ...
(Date:1/15/2014)...  Manufacturers, suppliers and distributors of innovative medical-related products ... most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the Medical ... most litigious industry sectors of cases involving IP ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Intellectual Property Insurance for Medical-related Products and Services 2
... seats and large backrests with lumbar support ... and casters and glides. • Choose the ... variety of environments including: industry, education, laboratory, ... office. • With cast aluminum base • ...
... chairs with concave seats and large ... options like seats, backrests, armrests, and ... BE Series for top performance in ... education, laboratory, clean room, static control, ...
... ergonomic chairs with concave seats and ... Select options like seats, backrests, armrests, ... the BE Series for top performance ... industry, education, laboratory, clean room, static ...
... chairs with concave seats and large backrests ... seats, backrests, armrests, and casters and glides. ... performance in a variety of environments including: ... health care and office. • With cast ...
Medicine Products: