Navigation Links
Researchers identify new drug target for treating jet lag and shift work disorders
Date:8/30/2013

ck. They identified one gene and its corresponding protein product, called SIK1, that limits the body clock's ability to adjust to changes in the daily patterns of light and dark. In one particular experiment, when the researchers blocked the activity of SIK1 in laboratory mice, the mice adjusted faster to changes in the light-dark cycle that mimic a time zone change. The study proposes that the light-stimulated production of SIK1 in turn switches off the molecular pathway that feeds into the clock mechanism, thereby halting the shifting response of the biological clock.

"Our key contribution to the project was to manipulate the SIK1 protein pharmacologically, and we revealed that such blockage of the protein's activity in combination with exposure to a natural clock resetting agent, such as light, enhanced the clock shifting response," Duffield said. "For example, a one hour shift of the clock became two hours. We also showed this effect in both peripheral tissues as well as in the clock in the brain.

"It would appear that SIK1 plays a common role in our circadian clocks found throughout our body, and working as a hand-brake on our ability to shift our biorhythms and adjust to new time zones, whether these are real or artificial, such as those produced during shift work schedules."

In addition to the inconvenience of jet lag, disruptions in the circadian system, such as produced during shift work, have been linked to many diseases including diabetes, heart disease and cancer. Disturbances of the circadian clock have even been linked to mental disorders, such as schizophrenia, bipolar disease and seasonal affective disorder, also known as winter depression. It is important to note that approximately 16 percent of the U.S. and European workforces undertake some form of shift work.

"Having such a hand-break on the circadian clock systems makes sense so as to prevent excessive responses to environmental change, and that it is only in our modern 24-h
'/>"/>

Contact: Giles Duffield
Giles.E.Dufield.2@nd.edu
574-631-1834
University of Notre Dame
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... review website Top10BestSEOHosting.com compares many popular hosting suppliers and ... suppliers for webmasters for webmasters who want to buy ... at affordable prices. , GoDaddy offers three Linux ... plans depends on the length of a contract. This ... flexible hosting packages, decent uptime record and beneficial support ...
(Date:8/29/2014)... Cosmetic Town has devised a system ... its doctors. Cosmetic Town utilizes a validated referral ... in their field are chosen to present their procedure. ... direct link to potentially hundreds of recommended doctors in ... to communicate through the site’s community features and multimedia ...
(Date:8/29/2014)... a famous online supplier of trendy clothes, has unveiled its ... moment, all these mini outfits are offered at discounted rates, ... is September 14. , The company’s senior spokesman states, ... hot designs, we have listed some of the best-selling items ... ladies to get high quality, fashionable clothes. Many of our ...
(Date:8/29/2014)... Panic attacks are extremely difficult to ... intense stress and fear, which appears with no particular ... insecurity and affecting relationships. , A panic attack can ... symptoms that patients can deal with. Anxiety, shortness of ... panic attacks is extremely important for sufferers, who need ...
(Date:8/29/2014)... DailyGossip.org publishes a review to the Natural Multiple ... curing multiple sclerosis in a fast and natural way. ... M. Levin, who has become well known as a ... alternative remedies for a series of health problems when ... all cases for the cure of some disorders. ...
Breaking Medicine News(10 mins):Health News:Cosmetic Town Now Advocates for the Rights of Cosmetic Patients Using Novel Approach 2Health News:Cheap Sexy Mini Dresses Added To The Product Line Of Skmen.com 2Health News:60 Second Panic Solution Review Exposes Simple Panic Attacks Remedy 2Health News:New Natural Multiple Sclerosis Treatment Review Reveals Gary M. Levin’s Unique Cure 2
... blood test for early detection of ovarian cancer//. ,Ovarian ... is very difficult to diagnose during its early stages. It ... ovaries, like the surface epithelial cells, germ cells, and the ... ranked 4th in terms of causing deaths due to cancer. ...
... its said that it is better// to go for surgery ... and see if the disease progresses. ,Surgery for treating ... The researchers had conducted he study to see if prostatectomy ... more than watching and waiting the cancer in the prostate ...
... kidney failure in men.// ,The researchers had taken 473 ... a glass a day) and compared their elevated creatinine levels ... than a glass a day of alcohol. The research had ... through a period of 14 years. ,The results of ...
... the May issue of the journal Neurology states that patients// ... to take decisions about their treatments, but those with moderate ... to do so. ,The study also points out that ... in the mare more likely to take competent decisions about ...
... of cholesterol in the blood can increase the risk of ... the recent issue of British Journal of Cancer says that ... of testicular cancer by almost as much as 4.5 % ... ,The Swedish researchers from Karolinska University Hospital had looked into ...
... diet taken during pregnancy not only decides the health// of ... children as well. ,In a study to understand fetal ... about long-term influence on the genetic code of the fetus ... Their research had provided evidence that adverse effects of intrauterine ...
Cached Medicine News:
(Date:8/29/2014)... 2014 Medina Medical announced today that Mr. ... the Board of Directors on August 18, 2014. Mr. ... commercialization experience, including over a decade of direct experience ... a Partner of the medical device incubator The Foundry, ... Foundry start-ups. Mr. Engelson previously served as the Chief ...
(Date:8/29/2014)... , Aug. 29, 2014 Research and ... "China Orthopedic Instrument Industry Report, 2014-2017" report to ... population and rising proportion of reimbursement for medical expenses, ... released, with its scale presenting a CAGR of 19.2% ... are three product segments of orthopedic instruments in ...
(Date:8/29/2014)... 29, 2014 According to ... by Extraction type (SFE, Cold Pressed, Organic Solvent, & ... Pharmaceutical, Food Supplements, Fragrance, & Others) - Global Trends ... and segments the Amaranth Seed Oil Market with ... in terms of value. The Amaranth Seed Oil ...
Breaking Medicine Technology:Medina Medical Announces Erik T. Engelson Joins as Chief Executive Officer 2China Orthopedic Instrument Industry Report, 2014-2017 2Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4
... Calif., July 26, 2011 Epitomics, Inc., a ... based on its groundbreaking Rabbit Monoclonal (RabMAb®) technology, ... novel cancer-related antibodies that were developed through a ... Cancer Research. The goal of this partnership is ...
... 26, 2011 Bacterin International Holdings, Inc. ... the development of revolutionary bone graft material and anti-infective coatings ... August 11, at 4:30 p.m. Eastern time to discuss results ... will be issued in a press release after the close ...
Cached Medicine Technology:Epitomics Releases New Antibodies Developed With the National Cancer Institute's Center for Cancer Research 2Bacterin Sets Second Quarter 2011 Conference Call for Thursday, August 11, 2011 at 4:30 p.m. ET 2
SkinStation, powered by LHE, is Radiancys flagship product. A powerhouse by design, it incorporates todays most sought after applications all on one user-friendly system ....
Inquire...
Sebia's Hb AFSC Control provides excellent resolution of normal hemoglobins A & F and abnormal hemoglobins S & C. The control is designed for use with Sebia's Hydragel Hemoglobin and Hydragel Acid He...
... Normal and Hypergamma Controls are ... either agarose gels or Sebia's ... Our unique control manufacturing process ... the other serum components, presenting ...
Medicine Products: