Navigation Links
Researchers identify new compound to treat depression
Date:6/17/2014

There is new hope for people suffering from depression. Researchers have identified a compound, hydroxynorketamine (HNK), that may treat symptoms of depression just as effectively and rapidly as ketamine, without the unwanted side effects associated with the psychoactive drug, according to a study in the July issue of Anesthesiology, the official medical journal of the American Society of Anesthesiologists (ASA). Interestingly, use of HNK may also serve as a future therapeutic approach for treating neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, the authors note.

"The clinical use of ketamine therapy for depression is limited because the drug is administered intravenously and may produce adverse effects such as hallucinations and sedation to the point of anesthesia," said Irving Wainer, Ph.D., senior investigator with the Intramural Research Program at the National Institute on Aging, Baltimore. "We found that the HNK compound significantly contributes to the anti-depressive effects of ketamine in animals, but doesn't produce the sedation or anesthesia, which makes HNK an attractive alternative as an antidepressant in humans."

HNK is one of several different compounds produced when ketamine, an anesthesia medicine-turned-antidepressant, is broken down (metabolized) in the body. Using a rat model, researchers tested HNK to see if the compound alone could produce the same beneficial effects attributed to ketamine without ketamine's unwanted side effects.

In the study, rats were given intravenous doses of ketamine, HNK and another compound produced by ketamine metabolism known as norketamine. The effect each had on stimulating certain cellular pathways of the rats' brains was examined after 20, 30 and 60 minutes. Brain tissue from drug-free rats was used as a control.

Researchers found the compound HNK, like ketamine, not only produced potent and rapid antidepressant effects, but also stimulated neuro-regenerative pathways and initiated the regrowth of neurons in rats' brains. HNK also appears to have several advantages over ketamine in that it is 1,000 times more potent, does not act as an anesthetic agent, and can be taken by mouth, the authors report.

Surprisingly, HNK was also found to reduce the production of D-serine, a chemical found in the body, overproduction of which is associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. HNK's ability to reduce the production of D-serine, while stimulating the regeneration of neuron connections in the brain, may present a potential new therapeutic approach to the treatment of these disorders.


'/>"/>
Contact: Theresa Hill
t.hill@asahq.org
847-268-9246
American Society of Anesthesiologists
Source:Eurekalert  

Related medicine news :

1. Researchers create better methods to detect E. coli
2. UGA researchers discover new method to reduce disease-causing inflammation
3. Ottawa researchers key to new neuromuscular disease care and research network
4. Researchers uncover new insights into developing rapid-acting antidepressant for treatment-resistant depression
5. Broad Institute, MGH researchers chart cellular complexity of brain tumors
6. Researchers uncover common heart drugs link to diabetes
7. Mayo Clinic researchers discover new form of cancer
8. Researchers recast addiction as a manageable disease
9. Mount Sinai researchers identify protein that keeps blood stem cells healthy as they age
10. Berkeley Lab researchers create nanoparticle thin films that self-assemble in 1 minute
11. Study shows health policy researchers lack confidence in social media for communication
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify new compound to treat depression
(Date:2/5/2016)... , ... February 05, 2016 , ... Today, the Whole-Food ... announced that the much-anticipated feature with author Jahnavi Foster, specialist in healthy vegetarian cuisine, ... Network. , Each week, on his weekly Whole-Food Warrior TV show, Frank Davis highlights ...
(Date:2/5/2016)... , ... February 05, 2016 , ... ... the addition of micro-needling services in their Napa Valley office. The technique utilizes ... Plastic Surgery Associates, Dr. Canales and Dr. Furnas, are part of only a ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... ... organization devoted exclusively to funding innovative lymphoma research and serving the lymphoma community ... is poised to once again host, Swirl, A Wine Tasting Event at the ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know the routine: each January, ... to access the treadmills. It’s a predictable trend. After the excesses of November and ... in shape by joining gyms, starting new walking or running routines, or signing up ...
(Date:2/5/2016)... ... February 05, 2016 , ... At its annual meeting held last week, the ... the National Board of Directors. Mr. McDermott succeeds former APDA Chairman, Fred Greene. , ... A. Chambers , APDA President and CEO. “Pat has tirelessly served APDA since 2001 ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... ALBANY, New York , February 5, 2016 /PRNewswire/ ... A new Transparency Market Research report states that the ... bn in 2014 and is predicted to reach US$185.9 ... a CAGR of 6.50% from 2014 to 2020. The ... Market: (Branded/Generic/Over-the-counter, Chemical/Biological, Captive/Contract Manufactured, by Geography, and by ...
(Date:2/5/2016)... --> --> ... (Labor & Delivery) and Neonatal Care Equipment Market Ultrasound, ... Phototherapy/Jaundice Management Devices, CPAP, Capnograph, & Resuscitator) - Global ... the global market over the forecast period of 2015 ... Billion in 2015 and is poised to grow at ...
(Date:2/5/2016)... , February 4, 2016 France ... Spain , UK, and Israel ). It ... 1, 2, and 3 GD, segmented by age and sex in these ... epidemiologists. The EpiCast Report is in-depth, high quality, transparent and market-driven, providing ... France , Germany , Italy ...
Breaking Medicine Technology: