Navigation Links
Researchers identify new biomarker for Creutzfeldt-Jakob disease, the human form of mad cow disease
Date:3/9/2011

Neena Singh, MD, PhD and colleagues at Case Western Reserve University School of Medicine have identified the first disease-specific biomarker for sporadic Creutzfeldt-Jakob disease (sCJD), a universally fatal, degenerative brain disease for which there is no cure. sCJD is one of the causes of dementia and typically leads to death within a year of disease onset.

The finding, published in the March 9th issue of PLoS ONE, a scientific journal produced by the Public Library of Science, provides a basis for developing a test to diagnosis sCJD while patients are still alive. Presently, the only definitive diagnostic test for the disease requires brain tissue be obtained by biopsy or after death.

In their study, Dr. Singh, associate professor of pathology at the School of Medicine, and her team found that levels of the iron-transport protein transferrin (Tf) are significantly decreased in the cerebrospinal fluid (CSF) of patients with sCJD well before the end stage of the disease, potentially allowing for earlier diagnosis.

"The decrease in Tf is significant enough to distinguish sCJD from dementia of non-CJD origin with an accuracy of 80 percent," Dr. Singh says. "When combined with the currently used non-disease-specific biomarker T-tau, the diagnostic accuracy increases to 86 percent. This suggests that the two biomarkers represent separate disease processes, and complement each other as diagnostic biomarkers."

A decrease in the levels of CSF Tf reflects the imbalance of brain's iron metabolism that is associated with sCJD. Being a part of the sCJD disease process, CSF Tf is likely to be a more precise indicator of sCJD than the current tests, Dr. Singh explains.

"CSF Tf is the first biomarker that is related to the underlying pathology in sCJD brains," Dr. Singh explains.

Presently, sCJD is diagnosed by testing for elevated levels of the proteins 14-3-3 and T-tau in the CSF of cases suspected of the disease. Sin
'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers selectively control anxiety pathways in the brain
2. Researchers develop synthetic compound that may lead to drugs to fight pancreatic, lung cancer
3. Report: International collaboration between researchers results in greater recognition
4. U of M researchers using salmonella to fight cancer
5. University of South Florida researchers find blood-brain barrier damaged by disease
6. Boston researchers create SMArt platform architecture, launch $5,000 health app competition
7. UCLA researchers use nano-Velcro technology to improve capture of circulating cancer cells
8. Aging in place preserves seniors independence, reduces care costs, MU researchers find
9. Elderly see pedestrians half as often as younger drivers, according to Ben-Gurion U. researchers
10. Researchers use human cues to improve computer user-friendliness
11. Researchers find new mechanism behind the formation and maintenance of long-term memories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... Dealing with a drug or alcohol substance abuse is never ... child. Adolescent addiction has been an important issue among young ... helpline is now providing a valuable resource for teenage ... addiction recovery center. , The Troubled Teens Atlanta helpline was ... By calling (404) 975-2762, parents and their teens can speak ...
(Date:8/23/2014)... 23, 2014 Teen drug and alcohol ... no different in Wilmington, NC. Substance abuse can happen ... victim to drug and alcohol dependency in higher numbers ... to overcome substance abuse, but don’t know where to ... facility can be a challenge because most treatment options ...
(Date:8/23/2014)... Summer vacation is almost over and before we know it ... for school supplies and a new wardrobe might take precedence ... to also spend some time brushing up on bed bug ... in heavily populated places,” said Randy Rupert, Bed Bug Team ... settings for bed bugs to take up residence.” , An ...
(Date:8/22/2014)... 23, 2014 The IT manager of ... hosting for several years. He has recently announced that ... hosting suppliers in 2014. , GoDaddy is a popular ... features and great hosting solutions at affordable rates. It ... for shared hosting plans depend on the length of ...
(Date:8/22/2014)... On Friday, Aug. 22, Liberty University unveiled its ... hosting a ceremony in its courtyard attended by some ... welfare. , The 162-member inaugural class of the ... Liberty staff, faculty, and community leaders in celebrating the ... school. Classes began on Monday, Aug. 4. , The ...
Breaking Medicine News(10 mins):Health News:Atlanta’s New Troubled Teen Helpline Is Making a Difference in the Community 2Health News:Troubled Teens Wilmington Helpline Guides Adolescents to the Path of Recovery 2Health News:Expert Advice for a Bed Bug-Free School Year 2Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 2Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 3Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 4
... for the ongoing World Championships seem to be too keen ... //of rupturing their womb muscles that could prevent them from ... others, mostly foreign boxers, marriage is not on their radar ... Mary Kom, 24, who is seeking a third successive gold ...
... eggs with red yolk are considered to be more nutritious ... eggs are natural – says a recent investigations. ... investigation that found that the red color found in many ... as Sudan Red I, a toxic industrial colorant, being used ...
... The Pediatric Dengue Vaccine Initiative (PDVI), a program of ... , announced today their partnership to help develop and ... prevention of Dengue fever, the second most widespread tropical ... disease to which over 2 billion people are exposed ...
... Those in their 50s and 60s who want to ... room instead of counting calories, suggests new research out ... and those who exercised lost a significant amount of ... whether a calorie-restriction diet can extend lifespan. However, while ...
... the immune systems in colorectal cancer patients to attack ... of 67 patients, researchers at the University of Nottingham ... post surgery of the cancerous growth, it activated the ... The November 15 issue of Clinical Cancer Research has ...
... works as well as some sports drinks like Gatorade. The ... conducted by Indiana University // suggested found that those ... longer than those drinking a carbohydrate drink, an effect similar ... ,The story was picked up as mainstream news in many ...
Cached Medicine News:Health News:As these women box on, do they risk becoming mothers? 2Health News:As these women box on, do they risk becoming mothers? 3Health News:Fear Of Cancer Due To Duck Egg Contamination In China 2Health News:Pediatric Dengue Vaccine Initiative and Hawaii Biotech Partner Against Dengue Fever 2Health News:New Study Weighs Benefits of Exercise, Diets 2Health News:A novel vaccine proves a shot in the arm for colorectal cancer patients 2
(Date:8/21/2014)... , Aug. 21, 2014  Vermillion, Inc. (NASDAQ: ... gynecologic cancers and women,s health, has appointed Holly ... Managed Markets. Ms. Bauzon has a proven ... payer coverage for laboratory services companies. She has more ... PerkinElmer, Inc., where she held the position of Director, ...
(Date:8/21/2014)... YORK , Aug. 21, 2014  Publicis Groupe ... Shannon Hartley , Managing Partner and Healthcare Industry Group ... PharmaVoice 100, which recognizes the most inspiring people in ... are leaders in research and development, marketing, technology, creativity, ... agency in 2006 as a partner in its leading ...
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- ... Equipment, Inc. for the third straight year, No. ... 500|5000, an exclusive ranking of the nation,s fastest-growing ... look at the most important segment of the ... Timberland, Dell, Domino,s Pizza, LinkedIn, Zillow, and many ...
Breaking Medicine Technology:Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2Shannon Hartley Shines in PharmaVOICE 100 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3
... Nov. 10, 2011 ADVENTRX Pharmaceuticals, Inc. (NYSE Amex: ... market and other conditions, to offer and sell shares of ... in an underwritten public offering.  The Company also intends to ... an additional 15% of the shares and warrants sold in ...
... Throughout the healthcare industry, compliance guidelines for pharma,s interactions ... tightening as increased regulations intensify scrutiny and budget constraints ... cycles are slowing and more pressure is being placed ... of pharma PTR groups feel compliance concerns will lead ...
Cached Medicine Technology:ADVENTRX Announces Public Offering of Stock 2ADVENTRX Announces Public Offering of Stock 3Restrictive Compliance Environment Weakens Professional and Trade Relations Group Impact 2
Injection Cannula, Angled; 20g (0.90) x 1" (25mm); Tip Extension: 5mm, 30g (0.30); Angled at 45°, 2.5mm from Tip....
...
Lacrimal Cannula, Curved - Open End, 21gSize: 21g x 1-1/2"....
Interchangeable design allows you to select a single handpiece and change tips during the procedure. Universal connector. Disassembles for easy cleaning. Tips can rotate 360 degrees to re-orient port...
Medicine Products: