Navigation Links
Researchers identify mechanism that makes breast cancer invasive
Date:3/29/2012

A new study has identified a key mechanism that causes breast cancer to spread. The research, published by Cell Press on March 30th in the journal Molecular Cell, enhances our knowledge about the signals that drive cancer metastasis and identifies new therapeutic targets for a lethal form of invasive breast cancer that is notoriously resistant to treatment.

Amplification of the gene for ErbB2 has been linked with aggressive forms of breast cancer and is associated with a poor outcome. Although ErbB2-positive breast cancers are routinely treated with chemotherapy and the ErbB2-targeted drug trastuzumab (Herceptin), this treatment often fails. "Nearly half of breast cancers with high ErbB2 expression are either initially non-responsive or eventually develop resistance to trastuzumab," explains senior study author, Dr. Tuula Kallunki, from the Danish Cancer Society Research Center. "Therefore, a better understanding of the molecular basis of ErbB2-induced malignancy is critical for further development of targeted treatments."

In the current study, Dr. Kallunki and colleagues discovered that ErbB2 induces expression of proteins called cathepsins. Previous work has linked cathepsins with metastasis of pancreatic cancer, specifically with tumor cell invasion of surrounding tissues and with the establishment of tumor blood supply. Using a three-dimensional model system to study ErbB2-induced cellular invasion, the researchers demonstrated that inhibition of cathepsins prevented ErbB2-driven breast cancer invasion. They went on to identify components of the complex signaling network linking ErbB2 and cathepsin expression with cancer invasiveness.

Taken together, the results demonstrate that the invasive behavior of ErbB2-positive cancer cells is dependent on cathepsin activity and uncover a molecular link between ErbB2 and breast cancer invasion. "Our work has introduced a cellular model system to study ErbB2-induced invasion and iden
'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn researchers call for a re-examination of transplant waitlist prioritization
2. Nemours researchers uncover new evidence of cancer-causing agent present in gaseous phase of cigarette smoke
3. NIH researchers highlight progress, path forward for developing TB vaccines
4. Penn researchers find mentoring provides health benefits for African American veterans with diabetes
5. Mayo Clinic researchers building melanoma vaccine to combat skin cancer
6. Evidence builds that meditation strengthens the brain, UCLA researchers say
7. Wilmot researchers create new way to study liver cancer
8. Researchers develop first theranostic treatment for acute lymphoblastic leukemia (ALL)
9. Researchers find possible genetic keys to surviving epithelial ovarian cancer
10. Researchers discover possible approach to the treatment of aggressive breast cancer
11. Researchers ID gene behind primary cervical dystonia, a neck-twisting disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... ... June 30, 2015 , ... Micro Com Systems ... high quality record management services for patient records. Medical imaging includes services such ... physicians and clinics. , With the increase in the acceptance level of ...
(Date:6/30/2015)... ... 2015 , ... Harbor Village Detox is a drug and ... on June 12th. Holly Vasquez-Cortella was recently quoted as an expert in the addiction ... on trending addiction news and treatment innovations. The article highlights Florida governor Rick Scott’s ...
(Date:6/30/2015)... , ... June 30, 2015 , ... Due to today’s housing market, many people cannot ... difficult as they have to make adjustments as to how to carry laundry or groceries ... have laundry facilities in the basement or first floor of the home, and the bedrooms ...
(Date:6/30/2015)... ... June 30, 2015 , ... Experts estimate that up to 80% of ... can range from a dull, constant ache (chronic) to a sudden sharp pain (acute). ... injections, selective nerve root blocks and rhizotomy treatment, OPTIMAL Pain & Regenerative Medicine ...
(Date:6/30/2015)... ... June 30, 2015 , ... New Xarelto lawsuit claims proposed ... of new forms, according to attorneys handling Xarelto lawsuits included in ... Complaint, “provide guidance” for plaintiffs’ attorneys in filing new claims, according to court ...
Breaking Medicine News(10 mins):Health News:Micro Com Systems Ltd Now Specializes in Medical Imaging 2Health News:Harbor Village Detox’s Clinical Director Is Quoted as an Addiction Expert by The Fix 2Health News:Harbor Village Detox’s Clinical Director Is Quoted as an Addiction Expert by The Fix 3Health News:Butler Mobility Products announce a Solution to Carry Items from One Floor to the Next with a Dumbwaiter 2Health News:OPTIMAL Pain & Regenerative Medicine Brings Innovative Back Pain Management Options Including PRP Injections and Stem Cell-like Therapies to Dallas/Ft. Worth Metroplex 2Health News:OPTIMAL Pain & Regenerative Medicine Brings Innovative Back Pain Management Options Including PRP Injections and Stem Cell-like Therapies to Dallas/Ft. Worth Metroplex 3Health News:Xarelto Lawsuit News: New Xarelto Lawsuit Filings to Be Expedited 2Health News:Xarelto Lawsuit News: New Xarelto Lawsuit Filings to Be Expedited 3
... women between the ages of 18 and 24 are smokers, and ... But researchers at Temple University have found that when it ... be more effective than an exercise plan in helping women not ... lot of college--age women report smoking to keep their weight down ...
... a national organization, will recognize World Meningitis Day (WMD) by ... was founded in memory of Ryan Milley, the only child ... include over 600 families in the U.S. and some 30+ ... also works very hard as a children,s health and immunization ...
... and elephantjournal columnist Brigitte Mars weighs in on ... measure doing more harm than good? Should we ... Waylon Lewis, editor-in-chief at eco, spiritual, irreverent ... Huffington Post ( http://www.huffingtonpost.com/waylon-lewis/what-do-newmans-own-endan_b_188001.html ...
... inflammatory demyelinating polyneuropathy (CIDP) depend on plasma donationANNAPOLIS, ... inflammatory demyelinating polyneuropathy (CIDP) is a debilitating, ... and fatigue and can severely impair motor skills. ... two to seven individuals per 100,000 worldwide. The ...
... Corporation of America (Nasdaq: DCAI ) announced today ... on Tuesday, May 5, 2009, after the close of the ... conjunction with its first quarter 2009 earnings release the following ... interested in participating in the May 6, 2009 conference call ...
... patients, financial responsibility for their diabetes therapy, positively ... in real time at point of dispensing ACCU-CHEK(R) ... the launch of its new eVoucherRx(TM) pilot program ... patients with diabetes to receive their co-pay savings ...
Cached Medicine News:Health News:Mind over muscle 2Health News:World Meningitis Day in Texas 2Health News:elephantjournal.com: Is Fluoridating Waters Giving Kids Cavities? 2Health News:CIDP Treated With Plasma-Derived Therapy 2Health News:CIDP Treated With Plasma-Derived Therapy 3Health News:Dialysis Corporation of America Announces First Quarter 2009 Earnings Release Date 2Health News:Roche Announces New Co-Pay Program in California That Makes it Easier for Patients With Diabetes to Receive Savings on ACCU-CHEK(R) Blood Glucose Test Strips 2Health News:Roche Announces New Co-Pay Program in California That Makes it Easier for Patients With Diabetes to Receive Savings on ACCU-CHEK(R) Blood Glucose Test Strips 3
(Date:6/30/2015)... , June 30, 2015  Marken, the leading clinical ... life sciences industry, has been granted permission by the ... of clinical drug product in Korea.  This precedent-setting shipment ... to continue receiving their clinical trial drugs ... The emergency was caused by recent partial ...
(Date:6/30/2015)... , June 30, 2015  Isis Pharmaceuticals, Inc. (NASDAQ: ... its 2015 Annual Meeting of StockholdersWhen:Tuesday, June 30 at ... on the Internet.  Simply log onto our website listed ... participate during the live event, a replay of the ... www.isispharm.com . ABOUT ISIS PHARMACEUTICALS, ...
(Date:6/29/2015)... Mordor Intelligence presents their Global Pharmaceutical Packaging ... Paper, Metal) - ByType of Packaging (Ampules, Blister Packs, Bottles, ... - By Geographical Region ( North America , ... , Latin America , Middle ... discussing Industry Value Chain Analysis, Porter,s 5 Force Analysis, Drivers, ...
Breaking Medicine Technology:Marken Delivers Direct To Patients During MERS Outbreak 2Marken Delivers Direct To Patients During MERS Outbreak 3Webcast Alert: Corporate Presentation at the 2015 Isis Pharmaceuticals Annual Stockholder Meeting 2Webcast Alert: Corporate Presentation at the 2015 Isis Pharmaceuticals Annual Stockholder Meeting 3Global Pharmaceutical Packaging Market - North America and Europe Expected to Lead Followed by the Asia Pacific Market 2Global Pharmaceutical Packaging Market - North America and Europe Expected to Lead Followed by the Asia Pacific Market 3
Taper with blunt tip. Stainless steel. Round knurled handle with polished finish. Taper : Medium 23 mm. Overall length: 3.9 inches....
Taper with blunt tip. Stainless steel. Round knurled handle with polished finish. Taper : Short 19 mm. Overall length: 3.9 inches....
Size 2 dilator. Stainless steel. Round knurled handle with polished finish. Overall length: 4 inches....
Double ended dilator probes with gentle curve. Stainless steel. Round knurled handle with polished finish. Overall length: 5.3 inches....
Medicine Products: