Navigation Links
Researchers identify mechanism that makes breast cancer invasive
Date:3/29/2012

A new study has identified a key mechanism that causes breast cancer to spread. The research, published by Cell Press on March 30th in the journal Molecular Cell, enhances our knowledge about the signals that drive cancer metastasis and identifies new therapeutic targets for a lethal form of invasive breast cancer that is notoriously resistant to treatment.

Amplification of the gene for ErbB2 has been linked with aggressive forms of breast cancer and is associated with a poor outcome. Although ErbB2-positive breast cancers are routinely treated with chemotherapy and the ErbB2-targeted drug trastuzumab (Herceptin), this treatment often fails. "Nearly half of breast cancers with high ErbB2 expression are either initially non-responsive or eventually develop resistance to trastuzumab," explains senior study author, Dr. Tuula Kallunki, from the Danish Cancer Society Research Center. "Therefore, a better understanding of the molecular basis of ErbB2-induced malignancy is critical for further development of targeted treatments."

In the current study, Dr. Kallunki and colleagues discovered that ErbB2 induces expression of proteins called cathepsins. Previous work has linked cathepsins with metastasis of pancreatic cancer, specifically with tumor cell invasion of surrounding tissues and with the establishment of tumor blood supply. Using a three-dimensional model system to study ErbB2-induced cellular invasion, the researchers demonstrated that inhibition of cathepsins prevented ErbB2-driven breast cancer invasion. They went on to identify components of the complex signaling network linking ErbB2 and cathepsin expression with cancer invasiveness.

Taken together, the results demonstrate that the invasive behavior of ErbB2-positive cancer cells is dependent on cathepsin activity and uncover a molecular link between ErbB2 and breast cancer invasion. "Our work has introduced a cellular model system to study ErbB2-induced invasion and identified an invasion-promoting signaling network," concludes Dr. Kallunki. "In addition, our findings provide several potential therapeutic targets against ErbB2-driven invasive cancers."


'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. Penn researchers call for a re-examination of transplant waitlist prioritization
2. Nemours researchers uncover new evidence of cancer-causing agent present in gaseous phase of cigarette smoke
3. NIH researchers highlight progress, path forward for developing TB vaccines
4. Penn researchers find mentoring provides health benefits for African American veterans with diabetes
5. Mayo Clinic researchers building melanoma vaccine to combat skin cancer
6. Evidence builds that meditation strengthens the brain, UCLA researchers say
7. Wilmot researchers create new way to study liver cancer
8. Researchers develop first theranostic treatment for acute lymphoblastic leukemia (ALL)
9. Researchers find possible genetic keys to surviving epithelial ovarian cancer
10. Researchers discover possible approach to the treatment of aggressive breast cancer
11. Researchers ID gene behind primary cervical dystonia, a neck-twisting disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... 26, 2016 , ... The MIAMI Institute for Age Management and Intervention celebrates ... MD, ABAARM. Dr. Adonis , Wellness Physician of the MIAMI Institute is certified ... Institute for Functional Medicine. , He also heads up FITTLab, the comprehensive medical testing ...
(Date:5/26/2016)... Paso Robles, CA (PRWEB) , ... May 26, 2016 , ... ... tailor’s bunion (also knowns as a bunionette) treatment was more than humbled by customer ... out of one of their SKU's mid sale. Now that Bunion Bootie has completely ...
(Date:5/26/2016)... CA (PRWEB) , ... May 26, 2016 , ... A ... Valley-based startup, The Dough Bar, has ignited an undeniable buzz in the ... a doughnut. But not just any doughnut.  These doughnuts are packed with 11 grams ...
(Date:5/26/2016)... ... 26, 2016 , ... Metcalf & Associates’ Maureen Metcalf ... experience in leading technology and human resources operations for health care, education, banking, ... be featured on Metcalf’s VoiceAmerica radio show , Innovative Leaders Driving Thriving ...
(Date:5/26/2016)... ... 2016 , ... Dr. LeRoy Perry’s recently authored whitepaper, “Tech Neck and ROI ... billions of users, hundreds of millions of whom are coming into the workplace with ... and common action of looking down at hand-held technology devices (tablets, smartphones) for extended ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... HILDEN , Deutschland und GERMANTOWN, ... Zusammenarbeit mit Therawis bedient ... Entscheidungen bei Brustkrebs   QIAGEN N.V. ... QIA) gab heute bekannt, eine Lizenz- und Entwicklungsvereinbarung ... prädiktiver Assays für die Onkologie eingegangen zu sein. ...
(Date:5/25/2016)... 2016 As illustrated by the ... month, the numbers and momentum of cannabis in the ... the billions, more research and development push the sector ... of Legal Marijuana Markets Report  from from ArcView Market ... of the increase in sector is attributed to adult ...
(Date:5/25/2016)... , May 25, 2016 ... 2016"market research report that provides an overview on ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
Breaking Medicine Technology: