Navigation Links
Researchers identify mechanism that could help old muscle grow
Date:6/17/2014

[Boston, MA June 17, 2014]─ Sarcopenia the significant loss of muscle mass and function that can occur as we age is associated with many chronic conditions such as diabetes, high cholesterol and obesity. In findings published online ahead of publication in the September 2014 issue of the FASEB Journal, researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University identify a muscle-building mechanism that could be important in addressing sarcopenia.

When people strength train the body responds by making muscle. The researchers recruited 16 healthy but sedentary men to perform a single bout of resistance exercise to trigger muscle growth and examined tissue samples taken before and six hours after the exercise. Half of the men were in their twenties and the other half in their seventies.

"In order for the body to make proteins that build muscle, certain genes need to be turned on," said lead author Donato A. Rivas, Ph.D., a scientist in the Nutrition, Exercise Physiology and Sarcopenia Laboratory at the USDA HNRCA at Tufts University. "We noticed the older people had a lot fewer genes turned on compared to the younger people, showing us their muscles weren't responding as well to the exercise."

Rivas and colleagues observed that the level of microRNAs, small RNA molecules that have a prominent role in regulating genes, was lower in the muscle tissue of the older men, compared to younger men. "One of the steps in building muscle seems to be missing in the older men, preventing them from responding to the exercise as strongly as the younger men did," Rivas said. "It is possible that the suppression of these microRNAs is setting off a chain of events that is causing older people to be less efficient in developing muscle."

With the population of older adults in the United States projected to increase significantly in the coming decades, more effective sarcopenia treatment and prevention could help control healthcare costs. "Age-related muscle loss has been associated with a myriad of other health problems," said senior author Roger A. Fielding, Ph.D., director of the Nutrition, Exercise Physiology and Sarcopenia Laboratory at the USDA HNRCA at Tufts University. "Muscle mass is closely tied to our metabolism and losing it increases the risk of developing metabolic diseases like type 2 diabetes and cardiovascular disease. We also know that a program of moderate physical activity, including resistance exercises, can strongly influence a person's chances of maintaining their ability to walk after age 70."

In addition to resistance exercises, scientists are exploring different approaches to preserving and building muscle mass in older adults. "A few studies suggest gene therapy, nutrient supplementation or hormone replacement therapy can assist with building muscle," said Fielding, who is also a professor at the Friedman School of Nutrition Science and Policy at Tufts University and the Tufts University School of Medicine. "Our identification of a possible microRNA target could help advance the study of these largely untested, but promising approaches to promoting muscle growth in older people."

The authors note the small size of the study necessitates future research in clinical models and in men and women, particularly those who have sarcopenia.


'/>"/>

Contact: Andrea Grossman
617-636-3728
Tufts University, Health Sciences Campus
Source:Eurekalert

Related medicine news :

1. Researchers identify new compound to treat depression
2. Researchers create better methods to detect E. coli
3. UGA researchers discover new method to reduce disease-causing inflammation
4. Ottawa researchers key to new neuromuscular disease care and research network
5. Researchers uncover new insights into developing rapid-acting antidepressant for treatment-resistant depression
6. Broad Institute, MGH researchers chart cellular complexity of brain tumors
7. Researchers uncover common heart drugs link to diabetes
8. Mayo Clinic researchers discover new form of cancer
9. Researchers recast addiction as a manageable disease
10. Mount Sinai researchers identify protein that keeps blood stem cells healthy as they age
11. Berkeley Lab researchers create nanoparticle thin films that self-assemble in 1 minute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... ... create “Ebola: In Praise of Prevention,” an animated video designed to ... and French translations of the video are being distributed throughout Togo, Liberia, Sierra ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... Shark Finds and Kevin Harrington, ... DRTV campaign with GRIP-DRY. , GRIP-DRY is a newly patented product that has solved some ... play in the wet and early morning dew or right after a rain shower, might ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Federal Laboratory ... federallabs.org . The site houses a wealth of federal resources that businesses can ... process called technology transfer (T2). As a network of over 300 federal laboratories, ...
(Date:2/8/2016)... Houma, LA (PRWEB) , ... February 08, 2016 ... ... Louisiana from offices in Houma, LA, celebrates the beginning of a new charity ... raised to assist Court Appointed Special Advocates (CASA). In the belief that children ...
(Date:2/8/2016)... Alexandria, Minn. (PRWEB) , ... February 08, 2016 ... ... introduces the BantamPro L top-load case packer for pouches, bags, and flow wrapped ... designed to help co-packers and specialty product manufacturers step up to semi-automatic or ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... 2016 The leader in accelerated orthodontics, OrthoAccel ... is the recipient of the 2015 Townie Choice Award ... II medical device that speeds up orthodontic tooth movement ... often associated with treatment, AcceleDent was selected by orthodontists ... Orthotown survey of the most reliable and ...
(Date:2/9/2016)... NEW BRUNSWICK, N.J. , Feb. 9, 2016 /PRNewswire/ ... in the RBC Capital Markets Global Healthcare Conference on ... New York City.  Dominic Caruso , Vice President, ... , Worldwide Chairman, Consumer will represent the Company in ... www.investor.jnj.com . --> www.investor.jnj.com . ...
(Date:2/9/2016)...  The Parenteral Drug Association, Inc. (PDA), the ... sterile drug products, today announced the publication of ... With link to Comparison Spreadsheet. The document ... FDA, the EU, the Pharmaceutical Inspection Convention/Scheme and ... --> PDA,s Global Sterile Task ...
Breaking Medicine Technology: