Navigation Links
Researchers identify mechanism of cancer caused by loss of BRCA1 and BRCA2 gene function
Date:4/28/2014

y, when we studied cells lacking BRCA1 or BRCA2, we found that the frequency of aberrant HR events triggered at Tus/Ter-stalled replication forks had actually increased compared to normal cells. We knew at this point that we had discovered a new and important process by which BRCA gene loss promotes cancer."

The discovery provides a promising bridge between basic science and the clinic, says Scully. "Sometimes a genetic sequencing test reveals a mutation in BRCA1 or BRCA2 that has not been definitively associated with cancer," he explains. Often described as "Variants of Uncertain Significance" (VUS), these mutations are not found in high enough frequency in healthy women or in women with breast or ovarian cancers to allow the specific BRCA1 or BRCA2 mutations to be reliably classified as high risk or low risk. This is an important issue since a woman with a known high-risk BRCA gene mutation may elect to undergo potentially lifesaving prophylactic mastectomy or oophorectomy, as Scully further explains.

"There is a growing appreciation that careful measurement of the HR functions of BRCA1 and BRCA2 VUS mutants might help to classify them into high risk or low risk groups," he notes. "It would be gratifying if our system could contribute new information to help ongoing efforts to classify these VUS mutants."

Furthermore, he adds, understanding the mechanisms that regulate HR at stalled replication forks might hold additional promise for the development of novel cancer therapeutics. "If we could use this tool to help develop new cancer therapies, it would be a grand slam," says Scully. "This new system might also be useful in genome editing, which is considered groundbreaking technology used for the development of new gene therapies."


'/>"/>

Contact: Bonnie Prescott
bprescot@bidcm.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Indiana University researchers gauge the toll of trampoline fractures on children
2. AGA showcases its commitment to improving the pipeline of minority researchers
3. Researchers identify potential new strategy to treat ovarian cancer
4. NYU Steinhardt researchers to study why male millennials risk HIV transmission
5. Researchers generate immunity against tumor vessel protein
6. Researchers at LSTM part of the international team to sequence the tsetse genome
7. Oxygen diminishes the hearts ability to regenerate, researchers discover
8. Finnish team of researchers finds a mutation in a tumor of the jaw
9. Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches
10. Life stressors trigger neurological disorders, researchers find
11. Penn researchers find link between sleep and immune function in fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2015)... Wixom, Michigan: Proof. Pest Control, a family-owned company focusing ... twist to its robust line of services-a 100% organic ... general pest management. , “We like killing bugs. ... Manager. “The average person cringes when they see a spider. ... that most people don’t even want to think about. ...
(Date:5/30/2015)... Key Housing, a top-rated corporate housing ... their June 2015 featured apartment community: 388 Beale Street. ... Key Housing is helping those people looking for corporate ... of the tightest apartment markets in the United States. ... anyone who requires temporary San Francisco corporate housing is ...
(Date:5/30/2015)... May 30, 2015 This year the ... with Pulmonary Horizons to offer one of the most ... and discuss successful practices to diagnose, treat and manage ... Pulmonary Horizons Conference is Interaction with Multidisciplinary ... the Overall Needs of Patients with COPD," said Brian ...
(Date:5/30/2015)... A live auction will be held to ... surgery centers and other medical facilities around the United ... radiology, surgery, endoscopy, lab, anesthesia, exam and much more. ... June 2nd starting at 10:00am EDT. The equipment is ... Hiatus Rd., Sunrise, FL 33351. Anyone can participate ...
(Date:5/30/2015)... York, NY (PRWEB) May 30, 2015 ... Wednesday, May 26th 2015, announcing that, “criminals used taxpayer-specific ... to information on approximately 100,000 tax accounts through IRS’ ... date of birth and street address.” , “You ... industry to have to think it was only a ...
Breaking Medicine News(10 mins):Health News:Proof. Pest Control-Now Offering 100% Organic Pest Control in Southeast Michigan 2Health News:San Francisco Corporate Housing Leader Key Housing Designates 388 Beale Street as Featured Community for June 2Health News:San Francisco Corporate Housing Leader Key Housing Designates 388 Beale Street as Featured Community for June 3Health News:Pulmonary Horizons 2nd Annual COPD Conference Miami Hilton Downtown, July 17-19, 2015 Patient Centered Cross-Continuum Education to Improve the Care of Patients with COPD 2Health News:Pulmonary Horizons 2nd Annual COPD Conference Miami Hilton Downtown, July 17-19, 2015 Patient Centered Cross-Continuum Education to Improve the Care of Patients with COPD 3Health News:Centurion to Sell Surplus Medical Equipment in Online and On-site Auction 2Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 2Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 3Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 4Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 5
... information about outbreak of Avian Influenza in Pakistan. ... in Pakistan, the North-Western States bordering Pakistan were ... areas especially to check informal/illegal trade of restricted ... especially of poultry and in areas visited by ...
... on a young woman, an Australian man gouged out both her ... to be the 28-year-old woman's partner, a man of around 30 ... the incident. ,The horrific string of events began ... of a Victorian country town- Malmsbury, 100 km northwest of Melbourne. ...
... is in trouble again. The Federal Drug Administration of U.S (FDA) ... pulled out of the market due to safety reasons. ... class of drugs as Vioxx ,was voted out 20-1 by ... from the market in September 2004 after research showed that it ...
... ‘chemo brain’ that chemotherapy patients complain about, is finally ... especially women have for years informed their doctors about ... to concentrate, difficulty retrieving words, trouble with multitasking and ... edge. Once brushing such complaints aside, these very people, ...
... is causing confusion among scientists, //is the mystery of ... decipher the reason for this. Normal healthy adult bees abandon the ... ago it was seen that a mass exodus would leave the ... in the new phenomenon it is seen that new bees ...
... of 95 infants were evaluated for urinary tract infection. ... as well as the diagnosis and treatment. This study ... the most common causes of unexplained fevers in infants ... ,All the patients in this study underwent renal ultrasonography, ...
Cached Medicine News:Health News:Steps To Prevent Out-Break Of Bird Flu 2Health News:Steps To Prevent Out-Break Of Bird Flu 3Health News:Arcoxia Slammed –Nothing Better Than Vioxx Says FD 2Health News:Chemo Brain- Nothing Forgettable About It 2Health News:Chemo Brain- Nothing Forgettable About It 3Health News:Vanishing Honey Bees 2
(Date:5/29/2015)... May 29, 2015  Fair Rate Funding, a leader ... jury in Delaware found Thursday ... to treat pelvic organ prolapse (POP) and Stress Urinary ... company executives hid the design flaws from the plaintiff, ... http://photos.prnewswire.com/prnh/20150529/219354LOGO Transvaginal mesh, also known ...
(Date:5/29/2015)... Eli Lilly and Company (NYSE: LLY ... Healthcare Conference on Tuesday, June 9, 2015. Jeffrey ... Health, will participate in a fireside chat at 2:20 ... audio webcast will be available on the "Webcasts & ... . A replay of the fireside chat will be ...
(Date:5/29/2015)... DIEGO and BOSTON , ... leader in instrument development, custom automation, and contract manufacturing, ... of the Nanopatch™ needle-free drug delivery technology, have been ... development of the Nanopatch Jet Coating Instrument , ... delivery research and product development.  The award was announced ...
Breaking Medicine Technology:TV Mesh Lawsuit Funding Firm, Fair Rate Funding, Reports Delaware Woman Awarded $100 Million Against Boston Scientific in Pelvic Mesh Verdict. 2TV Mesh Lawsuit Funding Firm, Fair Rate Funding, Reports Delaware Woman Awarded $100 Million Against Boston Scientific in Pelvic Mesh Verdict. 3Lilly to Participate in Goldman Sachs Global Healthcare Conference 2Invetech And Vaxxas Named Recipients Of The 2015 Good Design Award For Development Of Nanopatch Jet Coating Instrument For Needle-Free Drug Delivery 2Invetech And Vaxxas Named Recipients Of The 2015 Good Design Award For Development Of Nanopatch Jet Coating Instrument For Needle-Free Drug Delivery 3
... Ill., Sept. 29 Earlier this year, the National Association ... introduced to the AWARxE campaign, which was created and implemented ... power of the campaign, NABP obtained the AWARxE program so ... The Foundation was inspired to create the ...
... Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution -- ABBOTT PARK, Ill., Sept. 29 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we ...
Cached Medicine Technology:NABP Purchases AWARxE Consumer Protection Program 2Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 2Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 3Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 4Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 5Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 6Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 7
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: