Navigation Links
Researchers identify mechanism of cancer caused by loss of BRCA1 and BRCA2 gene function
Date:4/28/2014

y, when we studied cells lacking BRCA1 or BRCA2, we found that the frequency of aberrant HR events triggered at Tus/Ter-stalled replication forks had actually increased compared to normal cells. We knew at this point that we had discovered a new and important process by which BRCA gene loss promotes cancer."

The discovery provides a promising bridge between basic science and the clinic, says Scully. "Sometimes a genetic sequencing test reveals a mutation in BRCA1 or BRCA2 that has not been definitively associated with cancer," he explains. Often described as "Variants of Uncertain Significance" (VUS), these mutations are not found in high enough frequency in healthy women or in women with breast or ovarian cancers to allow the specific BRCA1 or BRCA2 mutations to be reliably classified as high risk or low risk. This is an important issue since a woman with a known high-risk BRCA gene mutation may elect to undergo potentially lifesaving prophylactic mastectomy or oophorectomy, as Scully further explains.

"There is a growing appreciation that careful measurement of the HR functions of BRCA1 and BRCA2 VUS mutants might help to classify them into high risk or low risk groups," he notes. "It would be gratifying if our system could contribute new information to help ongoing efforts to classify these VUS mutants."

Furthermore, he adds, understanding the mechanisms that regulate HR at stalled replication forks might hold additional promise for the development of novel cancer therapeutics. "If we could use this tool to help develop new cancer therapies, it would be a grand slam," says Scully. "This new system might also be useful in genome editing, which is considered groundbreaking technology used for the development of new gene therapies."


'/>"/>

Contact: Bonnie Prescott
bprescot@bidcm.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Indiana University researchers gauge the toll of trampoline fractures on children
2. AGA showcases its commitment to improving the pipeline of minority researchers
3. Researchers identify potential new strategy to treat ovarian cancer
4. NYU Steinhardt researchers to study why male millennials risk HIV transmission
5. Researchers generate immunity against tumor vessel protein
6. Researchers at LSTM part of the international team to sequence the tsetse genome
7. Oxygen diminishes the hearts ability to regenerate, researchers discover
8. Finnish team of researchers finds a mutation in a tumor of the jaw
9. Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches
10. Life stressors trigger neurological disorders, researchers find
11. Penn researchers find link between sleep and immune function in fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... 2014 QueenBeeTickets.com is ready to offer ... performances. She will visit many cities in North America ... 16th of April. , Click Here to ... at QueenBeeTickets.com. , The star’s fans are not going ... favorite young singer in a live performance. Ariana Grande ...
(Date:9/20/2014)... The Arizona Advanced Manufacturing Institute (AzAMI) ... Day by opening its doors to the community. Guided ... labs will be offered between 10 a.m. and 2 ... Dobson campus (1833 W. Southern Ave, Mesa, AZ 85202). ... AzAMI at MCC was established in the fall of ...
(Date:9/20/2014)... Las Vegas, Nevada (PRWEB) September 20, 2014 ... from its extremely successful showing at the PAIN ... and wonderful Cosmopolitan Hotel and Casino in Las ... , While MarijuanaDoctors.com primarily attended PAIN Week in ... medical marijuana as a viable and legitimate tool ...
(Date:9/19/2014)... 20, 2014 Consistent premium price ... the Vision Insurance industry in recent years; however, ... of industry margins. From 2009 to 2014, industry ... provide coverage for routine eye exams and other ... contact lens and refractive surgery. According to IBISWorld ...
(Date:9/19/2014)... Unbound , an international humanitarian organization based in ... Philippines being affected by both a tropical storm and an ... the nearest public schools while others moved to higher ground ... to portions of the northern Philippines. , The storm ... more than 10 feet of water. , “It is ...
Breaking Medicine News(10 mins):Health News:Discount Ariana Grande Tickets: QueenBeeTickets.com Delights Fans with Discount Concert Tickets for Ariana Grande’s 2015 Honeymoon Tour 2Health News:National Manufacturing Day Open House at Mesa Community College Oct. 3 2Health News:MarijuanaDoctors.com Experiences Unprecedented Support and Growth at Pain Week 2014 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 4Health News:Double Threat in Philippines Displaces Thousands of Unbound Families 2
... ,Appetite Controller, Hits U.S. Market, WAYNE, N.J., ... of their appetite and eat up to 30 ... U.S. dietary supplement that offers the,breakthrough European weight ... seven clinical trials demonstrating its,effectiveness, SlimShots is poised ...
... Alzheimer,s Care, WASHINGTON, May 14 The nation,s ... Special,Committee on Aging to look to assisted living providers ... Richard Grimes, the CEO and President of the ... committee as it launched,hearings on the impact on Americans ...
... William V. Corr, Executive Director, Campaign for,Tobacco-Free Kids, ... Columbia,Council has taken a critical step to protect ... use by doubling the District,s cigarette tax to,$2 ... this life-saving measure,and urge members to also increase ...
... Woodenboat Publications first small business to receive wellness ... Anthem Blue Cross and,Blue Shield, in partnership with ... announce that Woodenboat Publications of Brooklin is the ... wellness discount through Chamber,BlueOptions. Woodenboat Publications will receive ...
... isn,t meant to encourage patients to throw out their ... researchers have some advice for those with high blood ... And watch your high blood pressure take a little ... small new study. But they aren,t suggesting anyone turn ...
... The genetic profile of two large Georgia families with ... gene that may cause the disease, researchers say. , ... common in DNA, but this pattern of SNPs shows ... says Dr. Shirley E. Poduslo, neuroscientist in the Medical ...
Cached Medicine News:Health News:New Supplement Helps Americans Eat Less Every Day 2Health News:Assisted Living Industry Looks at Future of Alzheimer's 2Health News:DC Council Delivers Victory for Kids and Taxpayers by Doubling the Cigarette Tax to $2 per Pack 2Health News:Anthem Rewards Employers for Healthy Behaviors 2Health News:Music Hath Charms to Calm Hypertension 2Health News:Families shed light on likely causative gene for Alzheimer's 2
(Date:9/19/2014)... Sept. 19, 2014 /PRNewswire-iReach/ -- "United ... 2020″, provides key market data on ... market. The report provides value, in ... (in units) within market categories – ... Esophagoscopes & Gastroscopes, Duodenoscopes, Laparoscopes, Hysteroscopes, ...
(Date:9/19/2014)... 19, 2014  The board of directors of AbbVie ... cash dividend of $0.42 per share.  ... stockholders of record at the close of business on ... a global, research-based biopharmaceutical company formed in 2013 following ... its expertise, dedicated people and unique approach to innovation ...
(Date:9/19/2014)... Medical announces the formal launch of the largest ... on the market today at this weekend,s American Orthopaedic ... Chicago .  The Osteotomy Truss System is a comprehensive ... size options included in one versatile set. Previously available ... 18 implant sizes, which limited a surgeon,s ability to ...
Breaking Medicine Technology:United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 3United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 4United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 54WEB Medical Unveils 3D-Printed Osteotomy Truss System 2
... Oct. 20 A number of costs ... over the past two and a half years. Certain ... risen by double digits during this time, increasing packaging ... largest cost components, although the majority of marketers reduced ...
... Generic Pirfenidone in India, Giving Hope to... -- MUMBAI, India, October 20, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we ...
Cached Medicine Technology:Nonprescription Drugs Cost Structures Fluctuate with Increased Cost of Goods, According to Kline 2Nonprescription Drugs Cost Structures Fluctuate with Increased Cost of Goods, According to Kline 3Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 2Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 3Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 4Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 5Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 6Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 7Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 8
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: