Navigation Links
Researchers identify mechanism, possible drug treatment for tumors in neurofibromatosis
Date:10/30/2008

Researchers studying neurofibromatosis type 1 a rare disease in which tumors grow within nerves have found that the tumors are triggered by crosstalk between cells in the nerves and cells in the blood. The researchers, who were funded by the National Institutes of Health (NIH) and the Department of Defense (DOD), also found that a drug on the market for treating certain kinds of blood cancer curbs tumor growth in a mouse model of neurofibromatosis type 1. A clinical trial of the drug is underway in people with the disease.

The results of the study on mice are published in the October 31, 2008 issue of Cell.

The study's senior investigators were Luis F. Parada, Ph.D., a neuroscientist at the University of Texas Southwestern Medical Center in Dallas, and D. Wade Clapp, M.D., a hematologist at the Indiana University School of Medicine in Indianapolis. Their research was supported by NIH's National Institute of Neurological Disorders and Stroke (NINDS), NIH's National Cancer Institute (NCI), and the Neurofibromatosis Research Program of the U.S. Army Medical Research and Material Command.

"By taking a team approach and combining their unique areas of expertise, Drs. Parada and Clapp were able to shed light on a complicated disease mechanism and to develop a potential treatment," says Jane Fountain, Ph.D., a program director with NINDS.

Neurofibromatosis type 1 is a genetic disease that affects about 1 in 3500 Americans. The nerve-associated tumors, or neurofibromas, that occur in the disease tend to grow just under the skin or at the nerve root. The latter type of tumor, called a plexiform neurofibroma, can cause disabling symptoms by compressing the nerve, the spinal cord, bones, muscles and internal organs.

The tumor forming cells within a neurofibroma may become malignant and spread to other parts of the body. There is currently no treatment to prevent neurofibroma growth.

In 1990, NIH-funded i
'/>"/>

Contact: Daniel Stimson
stimsond@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... FL (PRWEB) , ... July 31, 2015 , ... Like ... enlargement techniques have also been advanced, upgraded, made more effective and less intrusive and ... of Loria Medical Penile Enlargement Center. Dr. Loria currently stands as the only ...
(Date:7/31/2015)... ... July 31, 2015 , ... Florida Hospital ... catheter that was developed for targeted delivery of fluids to selected sites in ... at Florida Hospital Tampa with the device that provides direct, local delivery of ...
(Date:7/31/2015)... N.Y. (PRWEB) , ... July 31, 2015 , ... ... is proud to announce that their latest designer handbag line will be named ... become an Internet sensation as the first globally recognized model with Down syndrome, ...
(Date:7/31/2015)... ... July 31, 2015 , ... According to WFLA on July ... heroin use and eventual overdoses. Thricefold deaths have held steady over the last “couple ... the Sarasota heroin epidemic, which was spurred by the crackdown of prescription painkillers. Many ...
(Date:7/31/2015)... ... 31, 2015 , ... New Energy Works Timberframers invites the public to join ... 15th, 2015 from 9am – 12pm. Timber frame raisings are special, celebrating ... community as the culmination of months of effort, planning, fundraising, and dreaming takes shape. ...
Breaking Medicine News(10 mins):Health News:Loria Medical Penile Enlargement Center to Expand, Offering Practice Partnership to Doctors 2Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 2Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 3Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 4Health News:everMaya to Launch Madeline Stuart Handbag Line 2Health News:everMaya to Launch Madeline Stuart Handbag Line 3Health News:Sarasota Sufferers Increased Heroin Overdoses and Deaths 2Health News:Sarasota Sufferers Increased Heroin Overdoses and Deaths 3Health News:Timber Frame Raising: Granary District Stage Amphitheater Timber Frame Hand-Raising by New Energy Works Timberframers 2Health News:Timber Frame Raising: Granary District Stage Amphitheater Timber Frame Hand-Raising by New Energy Works Timberframers 3
... levels raised risk of disease , , MONDAY, July 28 (HealthDay ... shed light on her risk for breast cancer. , ... (BMD) predicts a greater likelihood of developing breast cancer, independent ... model. , The two measurements together might be used in ...
... Healthcare,s annual compensation issue reports healthy pay raises ... for top ... "recession,proof" reputation remains intact as its top executives continue to ... published today., "One sign that any industry is in ...
... , The European Union has launched the ... ) a project with the aim to measure and ... Trials (2001/20/EC) in all areas or clinical research. Apart ... of the different stakeholders: Commercial Sponsors, Non-Commercial Sponsors, Ethics ...
... Talking to them like children brings out more resistance, ... Alzheimer,s patients may often become upset and even act ... to converse with them, a new,study shows. , Researchers ... people with moderate Alzheimer,s found that the residents often ...
... the radio address by President Bush to the Nation:, ... a,vital program that is saving lives across the developing world ... I thank members of,Congress from both sides of the aisle ... I will be honored to sign it into law next,week., ...
... Anthony Shih,M.D., M.P.H., has rejoined IPRO as ... Planning, after a two-year stint at The ... U.S. health system performance,where he directed the ... Efficiency., (Logo: http://www.newscom.com/cgi-bin/prnh/20080725/DC28791LOGO ), ...
Cached Medicine News:Health News:Bone Density Predicts Chances of Breast Cancer 2Health News:Healthcare Executives Well-Rewarded for Their Work 2Health News:Alzheimer's Patients React Poorly to 'Elderspeak' 2Health News:Alzheimer's Patients React Poorly to 'Elderspeak' 3Health News:Radio Address by President Bush to the Nation 2Health News:Radio Address by President Bush to the Nation 3Health News:IPRO Welcomes Back Anthony Shih as Chief Quality Officer, Strategic Planning Lead 2
(Date:7/30/2015)... 2015  Growth of the U.S. nonprescription market is ... prescription users to the OTC market. Due to an ... Rx-to-OTC switch activity over the next five years with ... new brands entering the market into existing categories. ... years (even those with low to moderate likelihood), the ...
(Date:7/30/2015)... OSAKA, Japan , July 30, 2015 /PRNewswire/ ... completion of the study to fulfill the post-marketing ... from the Pan European Multi-Database Bladder Cancer ... multi-database retrospective matched cohort study, conducted in four ... (pioglitazone HCI) with up to 10 years of ...
(Date:7/30/2015)... , July 30, 2015   Sentrian , ... all preventable hospitalization, recently received confirmation from the ... Patient Intelligence (RPI) solution meets the definition of ... to exercise "Enforcement Discretion." The ... to further FDA regulatory requirements at this time" ...
Breaking Medicine Technology:Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 2Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 3Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 4Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 5Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 6FDA Clears Way for Commercial Marketing of Sentrian Remote Patient Intelligence Solution 2FDA Clears Way for Commercial Marketing of Sentrian Remote Patient Intelligence Solution 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: