Navigation Links
Researchers identify mechanism, possible drug treatment for tumors in neurofibromatosis
Date:10/30/2008

Researchers studying neurofibromatosis type 1 a rare disease in which tumors grow within nerves have found that the tumors are triggered by crosstalk between cells in the nerves and cells in the blood. The researchers, who were funded by the National Institutes of Health (NIH) and the Department of Defense (DOD), also found that a drug on the market for treating certain kinds of blood cancer curbs tumor growth in a mouse model of neurofibromatosis type 1. A clinical trial of the drug is underway in people with the disease.

The results of the study on mice are published in the October 31, 2008 issue of Cell.

The study's senior investigators were Luis F. Parada, Ph.D., a neuroscientist at the University of Texas Southwestern Medical Center in Dallas, and D. Wade Clapp, M.D., a hematologist at the Indiana University School of Medicine in Indianapolis. Their research was supported by NIH's National Institute of Neurological Disorders and Stroke (NINDS), NIH's National Cancer Institute (NCI), and the Neurofibromatosis Research Program of the U.S. Army Medical Research and Material Command.

"By taking a team approach and combining their unique areas of expertise, Drs. Parada and Clapp were able to shed light on a complicated disease mechanism and to develop a potential treatment," says Jane Fountain, Ph.D., a program director with NINDS.

Neurofibromatosis type 1 is a genetic disease that affects about 1 in 3500 Americans. The nerve-associated tumors, or neurofibromas, that occur in the disease tend to grow just under the skin or at the nerve root. The latter type of tumor, called a plexiform neurofibroma, can cause disabling symptoms by compressing the nerve, the spinal cord, bones, muscles and internal organs.

The tumor forming cells within a neurofibroma may become malignant and spread to other parts of the body. There is currently no treatment to prevent neurofibroma growth.

In 1990, NIH-funded i
'/>"/>

Contact: Daniel Stimson
stimsond@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... December 25, 2014 AlignLife of Wauwatosa ... to afford certain items. During the holiday season, AlignLife looks ... over 70 toys," says Dr. Sara Mahalko-Leonhardt, owner of AlignLife. ... such joy, knowing that we are able to give kids ... it not been for the generosity of our patients." , ...
(Date:12/24/2014)... 2014 Recently, iFitDress.com, a famous dress manufacturer ... dresses under $150 . All these items are brand new; ... has already been updated with the new range of high ... so far. All iFitDress.com’s designs are made according to the ... great materials. Every outfit from the company is handpicked by ...
(Date:12/24/2014)... York (PRWEB) December 24, 2014 ... ) that allege the blood thinner caused life-threatening ... outlined a leadership structure for the proceeding, Bernstein ... December 17th, the Court plans to select lawyers ... and also plans on appointing a Plaintiffs’ Steering ...
(Date:12/24/2014)... Oregon (PRWEB) December 24, 2014 ... Rehab sat down with Derek Fenwick, PT, MBA, ... changes that will stem from the passing of the ... (IMPACT Act). In this taping of the Infinicast, ... title XVIII of the Social Security Act to standardize ...
(Date:12/24/2014)... Dec. 24, 2014 (HealthDay News) -- Hepatitis C infection does ... to a new study. Treatment advances have made it ... many develop memory and thinking problems, mood swings and other ... said. It,s believed that long-term infections with other viruses ... affect the brain. One of the prime suspects has been ...
Breaking Medicine News(10 mins):Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Many Prom Dresses under 150 from Well-known Dress Manufacturer iFitDress.com 2Health News:Court Overseeing Federal Xarelto Lawsuits Issues Coordination Order, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal Xarelto Lawsuits Issues Coordination Order, Bernstein Liebhard LLP Reports 3Health News:Latest Episode of Infinicast Features Infinity Rehab President Discussing IMPACT Act of 2014 and Changes for Post-Acute Therapy Providers in 2015 2Health News:Hepatitis C Infection Isn't Related to HIV Brain Woes: Study 2
... -- A fetus is sensitive to, and can be affected ... University of California, Irvine, researchers recruited pregnant women and ... The women,s babies were tested after birth to assess how ... state appeared to be important to a baby,s well-being. Development ...
... , THURSDAY, Nov. 17 (HealthDay News) -- ... severe mood dysregulation spend less time looking at the ... children without the psychiatric disorders, researchers say. This ... bipolar disorder and severe mood dysregulation have difficulty determining ...
... who identify themselves as such in the workplace are ... their job than transsexuals who do not, according to ... University. "Trans-parency in the Workplace: How the ... in an upcoming issue of the Journal of ...
... that has set standards for teaching women and clinicians ... around the country to detect lumps earlier and save ... of early detection of cancer. The Center for Disease ... cancer is the most common cancer among American females. ...
... 2011 InDevR, a Boulder-based biotechnology company that ... analysis of viruses and other microorganisms, announced today ... ampliPHOX, a colorimetric detection system that incorporates core ... Transfer Office, will enhance laboratories around the world ...
... 17 (HealthDay News) -- Young athletes who routinely take hits ... they do not suffer a concussion, according to the results ... of Rochester Medical Center (URMC) said their findings could be ... mild head injuries among young people whose brains are still ...
Cached Medicine News:Health News:Mom-to-Be's Mental State May Affect Child's Development 2Health News:Bipolar Kids May Focus on Different Facial Features 2Health News:'Trans-parency' in the workplace 2Health News:Indevr launches breakthrough colorimetric detection for microarrays using core technology from CU 2Health News:Routine Head Hits in Sports May Injure Brain, Experts Warn 2
(Date:12/24/2014)... 23, 2014  Medical Science Liaisons play a large ... between the medical device industry and key stakeholders, the ... coming years as the device industry relies on them ... research by benchmarking firm, Best Practices, LLC, one area ... edge is by harnessing new technology to enable education. ...
(Date:12/22/2014)... NxStage Medical, Inc. (NASDAQ: NXTM ... announced today that the U.S. Food and Drug ... perform hemodialysis overnight while the patient is at ... System One is the first and only hemodialysis ... Home nocturnal hemodialysis is an ...
(Date:12/22/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) has ... Glucose Market" report to their offering. ... insight focuses on the developments in the self-monitoring blood ... . Reimbursement analysis and the effects of competitive bidding ... 73 SMBG meters have been performed, based on the ...
Breaking Medicine Technology:Role of Medical Science Liaisons Evolving in Medical Device Sector 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3US Self-monitoring Blood Glucose Market 2
... innovative & portable FireFly LED light offers ... With the new FireFly LED you'll get ... go whereever your practice demands. High center-beam ... on your procedures, while the rechargeable battery ...
... LED headlight provides superior Illumination in an ... you'll get bright center-beam light with a ... direct it all totally hands free. ... quality materials to fit any manufacturers loupe ...
Easy pull-on garment's feature Rainey's exclusive Non-Slip Dome™design and adjustable Velcro© closure at neck for optimal comfort and support. Choose covered or non covered ear design....
For face-lifts and submental liposuction...
Medicine Products: