Navigation Links
Researchers identify 'master coordinator' for aortic rupture
Date:6/20/2013

Every year, more than 16,000 Americans die as a result of what's known as an "aortic dissection" a catastrophic rupture of the aorta, the body's largest artery. Once thought to be a simple structural failure, aortic dissection is now understood to be caused by an inflammatory process that weakens the artery's walls.

University of Texas Medical Branch at Galveston researchers have been at the forefront of understanding this process. In earlier studies they linked the blood-pressure-regulating molecule, angiotensin II, to the immune signaling protein IL6, which they determined played a major role in producing aortic dissections. Exactly how IL6 generated the inflammation leading to aortic dissection remained unknown, however.

Now the UTMB researchers have found what they believe is the missing piece of the puzzle in a group of cells called Th17 lymphocytes. Part of the body's adaptive immune system, these cells normally serve a protective function; they generate a protein called IL17 to bring other cells to support immune defenses. But in laboratory mouse experiments, the scientists found that locally produced vascular IL6 promotes Th17 formation and accumulation in the vessel wall. There, Th17 lymphocytes instigate a misguided immune attack on the aorta.

"In our study, we compared the effects of angiotensin II on normal mice and mice deficient in Th17 cells, either genetically or by blocking its action," said UTMB professor Allan Brasier, senior author of a paper on the discovery now online in the journal Arteriosclerosis, Thrombosis, and Vascular Biology. "The results showed us that interfering with the Th17 lymphocyte significantly reduces dissections. These data suggest that Th17 lymphocyte is the master coordinator of cellular inflammation in the vessel wall."

To establish the clinical relevance of their findings, the scientists examined tissue samples from patients with a genetic mutation that predisposed them to aortic dissections. The samples, which were derived from a bank maintained by University of Texas Health Science Center at Houston professor and paper author Dianna Milewicz, showed clear signs of Th17 cell accumulation.

"The idea here is that the immune system has evolved to protect us against viruses and bacteria, these sorts of things," Brasier said. "But under certain pathological conditions, the immune system can actually produce disease through chronic inflammation."


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... 2016 , ... Sourced from the Isbre Springs beneath the 5,000 year old ... purity of just 6 ppm TDS (Total Dissolved Solids) in addition to its excellent ... in several ShopRite and FoodTown stores in NJ and received rave comments from consumers. ...
(Date:12/2/2016)... ... December 02, 2016 , ... Yisrayl Hawkins, at The House of Yahweh in ... fits into Bible Prophecy. Yisrayl says this generation, known as the Last Generation, started ... how the details line up exactly with Bible Prophecy – a protected way for ...
(Date:12/2/2016)... ... December 02, 2016 , ... Clarify Health Solutions, Inc., ... $6.0 million in an initial round of funding. The round was led by ... caregivers can receive far better care through the application of the best technologies ...
(Date:12/2/2016)... ... 2016 , ... Today CloudMine, a secure, cloud-based platform that ... best Sales Team of 2016 as part of the 2016 SIIA Company CODiE ... & Information Industry Association (SIIA), the principal trade association for the software and ...
(Date:12/2/2016)... ... 02, 2016 , ... ‘Tis the season for giving! Today, 20 creative teams ... Family Partnership and the Drug Enforcement Administration as part of the National Red Ribbon ... winning schools who decorated their campuses with this year’s Red Ribbon Week theme: “YOLO. ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... On Thursday, the NASDAQ Composite and the S&P ... Jones Industrial Average managed to stay in green. Losses were ... Stock-callers this morning to look at the performances of the ... Smith & Nephew PLC (NYSE: SNN ), Nxstage ... Inc. (NASDAQ: KOOL ). You can access our ...
(Date:12/2/2016)... 1, 2016 Around the corners of world, ... each habitable land present over earth. Cancer has become ... in a life time this is because of the ... now. Given the steady increase in global cancer incidence ... spiraling healthcare costs of treatment, there is increasing interest ...
(Date:11/30/2016)... , Nov 30, 2016 Research and Markets ... Pressure Monitoring Devices 2017 - MedCore" report to their offering. ... , , ... and the skull. In healthy individuals, it is circulated though the brain ... cases where the amount of CSF surrounding the brain changes significantly. ...
Breaking Medicine Technology: