Navigation Links
Researchers identify 'master coordinator' for aortic rupture
Date:6/20/2013

Every year, more than 16,000 Americans die as a result of what's known as an "aortic dissection" a catastrophic rupture of the aorta, the body's largest artery. Once thought to be a simple structural failure, aortic dissection is now understood to be caused by an inflammatory process that weakens the artery's walls.

University of Texas Medical Branch at Galveston researchers have been at the forefront of understanding this process. In earlier studies they linked the blood-pressure-regulating molecule, angiotensin II, to the immune signaling protein IL6, which they determined played a major role in producing aortic dissections. Exactly how IL6 generated the inflammation leading to aortic dissection remained unknown, however.

Now the UTMB researchers have found what they believe is the missing piece of the puzzle in a group of cells called Th17 lymphocytes. Part of the body's adaptive immune system, these cells normally serve a protective function; they generate a protein called IL17 to bring other cells to support immune defenses. But in laboratory mouse experiments, the scientists found that locally produced vascular IL6 promotes Th17 formation and accumulation in the vessel wall. There, Th17 lymphocytes instigate a misguided immune attack on the aorta.

"In our study, we compared the effects of angiotensin II on normal mice and mice deficient in Th17 cells, either genetically or by blocking its action," said UTMB professor Allan Brasier, senior author of a paper on the discovery now online in the journal Arteriosclerosis, Thrombosis, and Vascular Biology. "The results showed us that interfering with the Th17 lymphocyte significantly reduces dissections. These data suggest that Th17 lymphocyte is the master coordinator of cellular inflammation in the vessel wall."

To establish the clinical relevance of their findings, the scientists examined tissue samples from patients with a genetic mutation that predisposed them to aortic dissections. The samples, which were derived from a bank maintained by University of Texas Health Science Center at Houston professor and paper author Dianna Milewicz, showed clear signs of Th17 cell accumulation.

"The idea here is that the immune system has evolved to protect us against viruses and bacteria, these sorts of things," Brasier said. "But under certain pathological conditions, the immune system can actually produce disease through chronic inflammation."


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2017)... ... July 25, 2017 , ... Facing medical needs with a newborn boy ... advantage of a new benefit for employees that is uncommon in American business: 12 ... company supports me and other employees as new parents. It keeps our family life ...
(Date:7/25/2017)... ... ... SignatureCare Emergency Center – South Austin is treating both adult and pediatric patients ... The Emergency Room opened early March, making it the first SignatureCare Emergency ... are running smoothly,” said Aaron Braun, SignatureCare Emergency Center’s Chief Medical Officer. “We’re glad ...
(Date:7/24/2017)... ... July 24, 2017 , ... Contact: ... Robins & Morton, Perkins Will, Newcomb & Boyd, Walter P Moore and ... new Destination Medical Building located at Mayo Clinic in Jacksonville, Florida. , ...
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... SignatureCare ... scholarship will be awarded for the fall semester to a deserving student. Get ... Centers Spring 2017 scholarship was awarded to Mariana Castillo who is a nursing student ...
(Date:7/24/2017)... ... July 24, 2017 , ... BayMark Health Services has been ... Administration’s (SAMHSA) State Targeted Response to the Opioid Crisis program. The funding, ... the development of a hub and spoke model for opioid treatment in California. ...
Breaking Medicine News(10 mins):
(Date:7/17/2017)... , July 17, 2017  MedX Holdings, Inc., the ... testing, strengthening and rehabilitation equipment, today announced the national ... MedX is considered the gold standard for the treatment ... specialized medical strengthening equipment. ... with the physician or practice who prescribe the MedX ...
(Date:7/13/2017)... 13, 2017 RK Logistics Group, Inc. was awarded ... for its Fremont, CA headquarters facility ... Tri-Valley and San Jose for hi-tech, ... Fremont , with its Fremont Innovation District, is excited ... a powerful resource to the hundreds of biotech, pharma and ...
(Date:7/11/2017)... , July 11, 2017  Bayer has awarded grants ... countries as part of its prestigious Bayer Hemophilia Awards Program ... of Philadelphia and Uniformed Services University ... are among the winners. Grant recipients were announced last night ... Hemostasis (ISTH) 2017 Congress, Berlin, Germany . ...
Breaking Medicine Technology: