Navigation Links
Researchers identify key enzyme in DNA repair pathway
Date:7/29/2010

d DNA but leaves the normal, separate double-stranded DNA alone. Mutant versions of FAN1 were unable to slice branched DNA.

Like a lock and key

The researchers also demonstrated that FAN1 cannot get at DNA damage without being taken there by the FANCI-FANCD2 protein complex, which detects and moves to the damaged site. The complex recruits the FAN1 enzyme by acquiring a single ubiquitin molecule. FAN1 connects with the complex by binding to the ubiquitin site.

"It's like a lock and key system, once they fit, FAN1 is recruited," Chen said.

Analyzing the activity of this repair pathway could guide treatment for cancer patients, Chen said, with the platinum-based therapies used when the cross-linking repair mechanism is less active.

Scientists had shown previously that DNA repair was much less efficient when FANCI and FANCD2 lack the single ubiquitin. DNA response and damage-repair proteins can be recruited to damage sites by the proteins' ubiquitin-binding domains. The team first identified a protein that had both a ubiquitin-binding domain and a known nuclease domain. When they treated cells with mitomycin C, which promotes DNA cross-linking, that protein, then known as KIAA1018, gathered at damage sites. This led them to the functional experiments that established its role in DNA repair.

They renamed the protein FAN1, short for Fanconi anemia-associated nuclease 1. The FANCI-FANCD2 complex is ubiquitinated by an FA core complex containing eight FA proteins. These genes and proteins were discovered during research of Fanconi anemia, a rare disease caused by mutations in 13 fanc genes that is characterized by congenital malformations, bone marrow failure, cancer and hypersensitivity to DNA cross-linking agents.

Chen said the FANCI-FANCD2 pathway also is associated with the BRCA1 and BRCA2 pathways, which are involved in homologous recombination repair. Scientists know that homologous recombination repair
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Researchers study benefits of white button mushrooms
2. Use of decision-aid program increases safety for women experiencing abuse, researchers find
3. Researchers uncover biological rationale for why intensive lupus treatment works
4. OHSU Knight Cancer Institute researchers isolate importance of gene in breast cancer prognosis
5. Researchers pinpoint key stem cells for eating and sex
6. BUSPH researchers link widely used chemicals to ADHD in children
7. Researchers Use Ecstasy to Treat PTSD
8. UC San Diego researchers find cause of metabolic disease -- and possible cure
9. Researchers cut years from drug development with nanoscopic bead technology
10. Researchers study relationship of oral cancers and periodontal disease
11. HIV care providers and researchers applaud release of national HIV/AIDS strategy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify key enzyme in DNA repair pathway
(Date:11/23/2014)... 23, 2014 The report, “Market ... to 2020 - Asia-Pacific” provides quantitative analysis of ... segments: minimally invasive body contouring devices, non-invasive body ... includes market size data by revenue and volume ... countries: China, Japan, South Korea, Australia and India. ...
(Date:11/23/2014)... Pro Ace Care, a renowned Vancouver hot ... be providing an 8 year warranty on its selected hot ... went up due to the impending winter season, it was ... the premium service that the company provides. As a result, ... John Wood and Bradford hot water tanks. , “Every ...
(Date:11/23/2014)... -- Close friends have more influence on teens, alcohol ... study says. "We,ve known for a long ... individual alcohol use, but there are no common studies ... friend group,s influence on those decisions," Jonathon Beckmeyer, an ... said in a university news release. Beckmeyer analyzed ...
(Date:11/23/2014)... Locks-Magnetic.com, a notable magnetic locks maker, ... the new products are available at low rates up ... proud of the new emergency doors. The emergency door ... can choose from several colors. All of the products ... door release is not as easy as many people ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 To show thanks ... its new collection of white evening dresses for ... online workers 24/7. , iFitDress.com is a distinguished dress manufacturer, ... and supported by worldwide customers for a very long time. ... place where a customer will be able to buy not ...
Breaking Medicine News(10 mins):Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 4Health News:Pro Ace Care Now Gives 8 Year Guarantee on Selected Vancouver Hot Water Tanks 2Health News:Close Friends May Be Key to Teens' Drinking 2Health News:iFitDress.com: Wonderful White Evening Dresses Now Available 2
... 5; as a teenager, she,says she was "cursed" by psoriasis ... her cause, and she is a spokesperson for the National,Psoriasis ... English, Cycle 7 winner of America,s Next Top Model, for ... Sept.,29, at Mission Bay Park. The event features 5K and ...
... Integrated, Inc., a,pioneer in health and condition (disease) ... ground-breaking Synergy Personal Health,Management program at DMAA,s Disease ... 16th at Caesar,s Palace in Las,Vegas. With ... need to stay,informed of the best practices, latest ...
... RIDGE, N.J., Sept. 12 Hooper Holmes,Inc. (Amex: ... Behling as,President of the Company,s new Health & Wellness ... 2006 as Senior Vice President,and Business Development Officer, charged ... opportunities, including the wellness,market. The division has made rapid ...
... is a prevailing issue in the United States, with ... study reveals that Pycnogenol, (pic-noj-en-all), an antioxidant plant extract ... reduces ADHD in children. The study shows Pycnogenol balances ... a decrease of ADHD. , The findings, to ...
... grant and an Ontario Early Researcher Award, Prof. Yu ... http://amnl.mie.utoronto.ca ) at the University of Toronto (U of ... of zebrafish embryos. , Based on computer vision ... of immobilizing a large number of zebrafish embryos into ...
... Arlington, Virginia (Sept. 12, 2007) For the first ... Species includes ocean corals in its annual report of ... life sponsored by Conservation International (CI) and implemented jointly ... the Galapagos-based Charles Darwin Research Station and other regional ...
Cached Medicine News:Health News:America's Next Top Model Steps up for Psoriasis Awareness 2Health News:Health Integrated to Showcase Synergy Personal Health Management(R) at DMAA Conference 2Health News:Hooper Holmes Names Chris Behling President of Health & Wellness Division 2Health News:Hooper Holmes Names Chris Behling President of Health & Wellness Division 3Health News:New study: Pine bark extract reduces ADHD symptoms in children 2Health News:Corals added to IUCN Red List of Threatened Species for first time 2Health News:Corals added to IUCN Red List of Threatened Species for first time 3
(Date:11/24/2014)... 2014  Marta Rendon, MD, founder of the Rendon Center ... , FL and international key opinion leader in dermatology, was one ... United States to attend the international Aesthetic Experts ... . Here, at this gathering of over 600 physicians from ... plastic surgery experts from Asia and ...
(Date:11/24/2014)... Nov. 24, 2014  AiCure, an artificial intelligence ... to monitor medication ingestion, has announced the start ... intervene with patients receiving medication as maintenance therapy ... from prescription opiates have quadrupled in the last ... year than heroin, cocaine and benzodiazepines combined. Overall, ...
(Date:11/24/2014)... , Nov. 24, 2014  Rigel Pharmaceuticals, Inc. (Nasdaq: ... is retiring from the board of directors and from his ... Rodriguez , most recently serving as the company,s president and ... officer and join the board of directors.  Gary Lyons ... will become chairman. Mr. Gower is expected to remain an ...
Breaking Medicine Technology:Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 2Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 3Can artificial intelligence solve the $55 billion problem of opioid abuse? 2Rigel Announces Executive Management Changes 2Rigel Announces Executive Management Changes 3
... Company (Nasdaq: PRGO;TASE) today announced that its Board ... per share, payable on March 20, 2012 to ... Perrigo Company is a leading global healthcare ... generic prescription (Rx) pharmaceuticals, infant formulas, nutritional products, ...
... Corporation (NASDAQ: LIFE ) today announced ... Leader, GE Molecular Diagnostics, has joined the company as ... of experience in the diagnostics industry, including leadership positions ... As President, Medical Sciences at Life Technologies, ...
Cached Medicine Technology:Ronnie Andrews Joins Life Technologies as President, Medical Sciences 2Ronnie Andrews Joins Life Technologies as President, Medical Sciences 3Ronnie Andrews Joins Life Technologies as President, Medical Sciences 4
... The Featured Products ... at Mediflex and are ... modular in regular or ... come equipped with insulation, ...
... incorporate a layered design unique in the ... to prevent stray electrosurgical burns along the ... failure or capacitive coupling; a well-documented patient ... all AEM Instruments provides a neutral return ...
... The 5mm AEM Laparoscopic Instruments incorporate a ... Instruments are shielded and monitored to prevent ... the instrument caused by insulation failure or ... The protective shield built into all AEM ...
... AEM Laparoscopic Instruments incorporate a layered design ... shielded and monitored to prevent stray electrosurgical ... caused by insulation failure or capacitive coupling; ... shield built into all AEM Instruments provides ...
Medicine Products: