Navigation Links
Researchers identify individuals at risk for developing colon cancer
Date:7/13/2009

A new study identifies a group of individuals at increased risk for developing colon cancer and holds the promise for developing new tailored cancer treatments. The study in this week's issue of the Proceedings of the National Academy of Sciences (PNAS) is by Sanford Markowitz, M.D., Ph.D., the Markowitz-Ingalls Professor of Cancer Genetics at Case Western Reserve University School of Medicine and oncologist at the Ireland Cancer Center of University Hospitals Case Medical Center, and colleagues.

"The bottom line is that we have found an uncommon but potentially important group of individuals who are born with certain genetic mutations and are at increased risk for developing colon cancer," says Dr. Markowitz, who is also an investigator in the Howard Hughes Medical Institute. "This is yet another step towards identifying who is at increased risk for this deadly form of cancer and it may potentially allow us a greater ability to detect and treat, as well as develop therapies, for cancer."

Dr. Kishore Guda, a postdoctoral fellow in Dr. Markowitz's laboratory, is lead author on the study. Dr. Markowitz's laboratory along with colleagues at Johns Hopkins Medical Center analyzed DNA from individuals who are born with mutations that cause defects in the pathways that put sugar groups on proteins. The normal process, called glycosylation, is used to synthesize mucus and is involved in many cellular activities. The individuals with this genetic defect appeared to develop colon cancer later in life. Data was from patients at UH Case Medical Center and Johns Hopkins.

A defect in glycosylation is a hallmark of many cancers, but the reason for this defect has been unknown. This study discovered the presence of mutations in a group of enzymes, called GALNTs, which are required for normal glycoslylation. These mutations contribute to alterations in the glycosylation process, and in turn, to the development of colon cancer.

"
'/>"/>

Contact: Alicia Reale
Alicia.Reale@UHhospitals.org
216-844-5158
University Hospitals Case Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Arizona researchers to sequence West African rice strain
2. Six Researchers to Receive Prestigious Awards from the American Society of Hematology
3. Mount Sinai researchers find new Alzheimers disease treatment promising
4. Researchers consider herd movements to help eradicate bovine TB
5. Pre-cessation patch doubles quit success rate: Researchers call for labeling changes
6. Researchers identify potential patient safety risks among methadone maintenance treatment patients
7. Purdue researchers create prostate cancer homing device for drug delivery
8. Moles and melanoma -- researchers find genetic links to skin cancer
9. Australian researchers identify genes that cause melanoma
10. Researchers find possible environmental causes for Alzheimers, diabetes
11. IU researchers find vibrator use to be common, linked to sexual health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... August 31, 2015 , ... “My mother and husband use oxygen therapy ... Ky. “I thought there could be a comfortable way to prevent the irritation, so ... Ear Protector offers a more secure way to anchor the cannula tubing used in ...
(Date:8/31/2015)... ... August 31, 2015 , ... For 12 years, since 2004, the Mesothelioma ... Mesothelioma Awareness Day . On this day, and in the weeks leading up ... involved and helping the cause. , “One of the ways a person can be ...
(Date:8/31/2015)... TX (PRWEB) , ... August 31, 2015 , ... ... serving communities in and around Grand Prairie, is teaming up with the Tarrant ... throughout the area. , Meals on Wheels is the oldest and largest national ...
(Date:8/31/2015)... ... August 31, 2015 , ... The Workgroup for ... of health IT to create efficiencies in healthcare information exchange, announces the agenda ... place at the Hyatt Regency Reston in Reston, Va. from October 26-29, WEDI-Con ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... Juvent Sports ... growing list of major sports figures who are finding joint pain relief after using ... former #1 men’s tennis player in the world said, “For the first time in ...
Breaking Medicine News(10 mins):Health News:InventHelp® Inventor Designs Nasal Cannula Ear Protector (AVZ-1217) 2Health News:Cancer Research Organization Paints the World in Mesothelioma Awareness 2Health News:Cancer Research Organization Paints the World in Mesothelioma Awareness 3Health News:Westchester Insurance and the Meals on Wheels Association Announce Joint Charity Effort to Provide Nutritious Meals for Senior Citizens 2Health News:Westchester Insurance and the Meals on Wheels Association Announce Joint Charity Effort to Provide Nutritious Meals for Senior Citizens 3Health News:WEDI Announces Program for Annual Fall Conference: WEDI-Con 2015 2Health News:WEDI Announces Program for Annual Fall Conference: WEDI-Con 2015 3Health News:Mats Wilander, 7 Grand Slam Title Winner and Tennis Legend, Now Plays Without Joint Pain 2Health News:Mats Wilander, 7 Grand Slam Title Winner and Tennis Legend, Now Plays Without Joint Pain 3
... right, exercised lowered chances of cardiovascular trouble , TUESDAY, July ... the right foods, exercising and losing weight pay off in ... show. , The reports, both originating at Brigham and Women,s ... of the Journal of the American Medical Association , ...
... Clarian/IUSM ... ... 2009 -- Nine clinical programs at Clarian Health / Indiana University School of ... World Report,s "2009-10 America,s Best Hospitals" guide. Clarian,s Methodist Hospital and Indiana University Hospital ...
... of the disease , TUESDAY, July 21 (HealthDay News) -- ... figured what genes turn on and off in a person,s ... infection. , The work, done on children with severe ... lead to better treatments for these diseases, including the methicillin-resistant ...
... , OWINGS MILLS, Md., July 21 ... program, today announced the launch of Honey Mustard Pretzel Sticks and ... Puffs. The new pretzel sticks and cheese puffs add to the ... while also maintaining the nutritional value of Medifast Meals. The pretzel ...
... OAKLAND, Calif., July 21 Stress is a natural part of ... crises, and other seemingly endless things, individuals are experiencing heightened anxiety. ... lessen their intense emotions. However, a number of eating patterns that ... , , Here are some common ...
... NEW YORK (July 21, 2009) Columbia University Medical ... the field of schizophrenia, has been selected by the ... Institutes of Health as principal investigator of a nationwide ... treating people experiencing a first episode of the psychotic ...
Cached Medicine News:Health News:Studies Affirm Value of Healthy Lifestyle 2Health News:Studies Affirm Value of Healthy Lifestyle 3Health News:Clarian Health/Indiana University School of Medicine Specialty Programs Ranked Among Best in Nation 2Health News:Clarian Health/Indiana University School of Medicine Specialty Programs Ranked Among Best in Nation 3Health News:Immune System Gene Discovery Sheds Light on Staph Infections 2Health News:Medifast Adds Pretzel and Puffs to Meal Replacement Line 2Health News:Medifast Adds Pretzel and Puffs to Meal Replacement Line 3Health News:Five Eating Patterns That Worsen Stress 2Health News:Five Eating Patterns That Worsen Stress 3Health News:Columbia leads national effort to develop early intervention for schizophrenia 2Health News:Columbia leads national effort to develop early intervention for schizophrenia 3
(Date:8/28/2015)... 28, 2015 Research and ... the "Investigation Report on China,s Tobramycin Market, 2010-2019" ... a traditional antibiotic whose eye drop and ointment are ... potential infection or inflammation caused by eye infection. Currently, ... are able to produce tobramycin, among which the Top ...
(Date:8/28/2015)... Research and Markets ... the "Investigation Report on China,s Latanoprost Market, ... Developed by Pharmacia & Upjohn in 1995, latanoprost ... reduces intraocular pressure. As the first pressure- lowering ... name of Xalatan) entered China ...
(Date:8/28/2015)... 2015  Perrigo Company plc ("Perrigo") (NYSE: PRGO ... acquisition of leading OTC brands from GSK in an ... is a clear demonstration of Perrigo,s unique ability to ... network spanning 36 countries.  Perrigo Chairman, ... "We are excited to complete this transaction, which clearly ...
Breaking Medicine Technology:Investigation Report on China's Tobramycin Market, 2015-2019 2China Latanoprost Market Investigation Report 2015-2019 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 3Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 4
... Inc. (OTC Bulletin Board: HSPO ), a ... oral thin film products that deliver pharmaceutical and OTC ... has signed a Letter of Intent (LOI) to acquire ... LLC.  HealthSport,s acquisition includes the lease of the 50,000 ...
... March 30, 2011 Regado Biosciences, a privately held ... control agents, announced that David J. Mazzo, PhD, President ... Company,s 10th Annual Healthcare Conference at the New York ... 6, 2011 at 11:20 a.m. EDT.  The presentation will ...
Cached Medicine Technology:HealthSport Signs Letter of Intent to Acquire "Excellent" Rated cGMP Certified Nutraceutical Manufacturing Plant 2HealthSport Signs Letter of Intent to Acquire "Excellent" Rated cGMP Certified Nutraceutical Manufacturing Plant 3Regado Biosciences to Present at the Needham & Company's 10th Annual Healthcare Conference in New York City 2Regado Biosciences to Present at the Needham & Company's 10th Annual Healthcare Conference in New York City 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: