Navigation Links
Researchers identify individuals at risk for developing colon cancer
Date:7/13/2009

A new study identifies a group of individuals at increased risk for developing colon cancer and holds the promise for developing new tailored cancer treatments. The study in this week's issue of the Proceedings of the National Academy of Sciences (PNAS) is by Sanford Markowitz, M.D., Ph.D., the Markowitz-Ingalls Professor of Cancer Genetics at Case Western Reserve University School of Medicine and oncologist at the Ireland Cancer Center of University Hospitals Case Medical Center, and colleagues.

"The bottom line is that we have found an uncommon but potentially important group of individuals who are born with certain genetic mutations and are at increased risk for developing colon cancer," says Dr. Markowitz, who is also an investigator in the Howard Hughes Medical Institute. "This is yet another step towards identifying who is at increased risk for this deadly form of cancer and it may potentially allow us a greater ability to detect and treat, as well as develop therapies, for cancer."

Dr. Kishore Guda, a postdoctoral fellow in Dr. Markowitz's laboratory, is lead author on the study. Dr. Markowitz's laboratory along with colleagues at Johns Hopkins Medical Center analyzed DNA from individuals who are born with mutations that cause defects in the pathways that put sugar groups on proteins. The normal process, called glycosylation, is used to synthesize mucus and is involved in many cellular activities. The individuals with this genetic defect appeared to develop colon cancer later in life. Data was from patients at UH Case Medical Center and Johns Hopkins.

A defect in glycosylation is a hallmark of many cancers, but the reason for this defect has been unknown. This study discovered the presence of mutations in a group of enzymes, called GALNTs, which are required for normal glycoslylation. These mutations contribute to alterations in the glycosylation process, and in turn, to the development of colon cancer.

"Our findings support the idea that defects in glycosylation, the process for making mucus, can contribute to tumor development," said Dr. Markowitz. "Knowing how these glycosylation enzymes malfunction and contribute to tumor formation may give us another target that can be potentially used to prevent the development of colon and other cancers. Certainly, individuals who have these mutations should be getting screening for colon cancer, so that the disease can be caught during the early stages when it is highly curable."

Colon cancer, the second leading cause of cancer deaths in the U.S., accounts for 50,000 deaths annually.


'/>"/>

Contact: Alicia Reale
Alicia.Reale@UHhospitals.org
216-844-5158
University Hospitals Case Medical Center
Source:Eurekalert

Related medicine news :

1. Arizona researchers to sequence West African rice strain
2. Six Researchers to Receive Prestigious Awards from the American Society of Hematology
3. Mount Sinai researchers find new Alzheimers disease treatment promising
4. Researchers consider herd movements to help eradicate bovine TB
5. Pre-cessation patch doubles quit success rate: Researchers call for labeling changes
6. Researchers identify potential patient safety risks among methadone maintenance treatment patients
7. Purdue researchers create prostate cancer homing device for drug delivery
8. Moles and melanoma -- researchers find genetic links to skin cancer
9. Australian researchers identify genes that cause melanoma
10. Researchers find possible environmental causes for Alzheimers, diabetes
11. IU researchers find vibrator use to be common, linked to sexual health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... April 24, 2017 , ... Salus ... announces the company’s VideoMedicine mobile platform has launched Quick Care, a new service ... day, Quick Care provides patients with the option to request and begin a ...
(Date:4/24/2017)... IL (PRWEB) , ... April 24, 2017 , ... Rod ... the Senior Housing News website. , Rod has been at the forefront of Gardant ... company’s culture. As CEO, Rod has overseen the opening of more than 40 new ...
(Date:4/24/2017)... ... , ... Donna Parker, L. Ac. reads all sorts of books on ... be very practical. She wanted to write a guide/workbook that would give readers step-by-step ... prompted her in writing “ A Clear Path to a Vibrant Life : 7 ...
(Date:4/24/2017)... ... April 24, 2017 , ... Miami ... attending the 2017 Oral Reconstruction Foundation’s 2017 Symposium on Tissue Regeneration and Implant ... will present its annual Global Symposium at the Fontainebleau Hotel located in Miami ...
(Date:4/23/2017)... ... April 23, 2017 , ... "An event Horizon is ... the process rendered in my Art and Music. These are created as Metaphysical Transformations ... the boundary of mystery culminate to the ultimate singularity.", -- Karen Salicath Jamali , ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... Companion animal vaccines ... pets such as canine, avian and feline. ... such as Attenuated Live Vaccines, Conjugate Vaccines, Inactivated ... Recombinant Vaccines. Attenuated live vaccines are derived from ... have been weakend under laboratory conditions. Conjugate vaccines ...
(Date:4/18/2017)... , April 18, 2017 Cogentix Medical, Inc. ... providing the Urology, Uro/Gyn and Gynecology markets with innovative ... first quarter ended March 31, 2017 after the market ... The Company will host a conference call and webcast ... Tuesday, May 2, 2017 at 4:30 p.m. Eastern Time ...
(Date:4/18/2017)... SUNNYVALE, Calif. , April 18, 2017 /PRNewswire/ ... results of collaboration started in 2016, in which ... "Artificial Brain SOINN". The companies achieved initial results ... ultrasound solution by Artificial Brain SOINN. The results ... Tokyo Big Sight, April 19-21, at booths 4505 ...
Breaking Medicine Technology: