Navigation Links
Researchers identify how binge drinking may drive heart disease
Date:11/26/2008

mately 250 percent for 0.1 M acetaldehyde, and 700 percent for 25M acetaldehyde, when compared to controls.

When endothelial cells were subjected to a technique that shut down the genes that code for both P-selectin and TNFα prior to the addition of acetaldehyde, the ability of acetaldehyde to cause increased monocyte adhesion was reduced by 90 percent. These results argue strongly that acetaldehyde has its effects on monocytes primarily through these proteins.

Along with Cullen, the work was led in Rochester by Eileen Redmond, David Morrow, Sreenath Kundimi and Carol Miller-Graziano within in the Department of Surgery at the Medical Center. The work was supported in part by grants from the American Heart Association and the National Institutes of Health.

"Our study demonstrates for the first time that physiologically relevant concentrations of acetaldehyde can initiate several key steps involved in the monocyte recruitment cascade, specifically through P-selectin, CCR2 and TNFα," Cullen said. "We hypothesize that, following alcohol consumption, there is a delicate equilibrium between the effects of alcohol and its metabolite, acetaldehyde, on blood vessel walls. Further studies are underway to confirm that these actions of acetaldehyde underlie, in part, the detrimental effects of binge drinking on cardiovascular disease. "


'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-275-3676
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. UCSD researchers identify potential new drug target for chronic leukemia
2. USC researchers identify novel approach for suppressing prostate cancer development
3. Researchers identify new leprosy bacterium
4. UT Southwestern researchers develop new strategy for broad spectrum anti-viral drugs
5. Researchers discover strategy for predicting the immunity of vaccines
6. Ability to quit smoking may depend on ADHD symptoms, Columbia researchers find
7. Researchers ID Suite of Genes in Aging Process
8. Researchers: Ban on fast food TV advertising would reverse childhood obesity trends
9. Brigham and Womens Researchers Partner with Vocantas to use CallAssure in Clinical Research Study
10. Leeds researchers reshape the future of drug discovery
11. UNC researchers find clue to stopping breast-cancer metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... scientists are working out how to safely increase the ... offering improved local control and survival. , Standard treatment ... combination of radiotherapy and chemotherapy. Traditionally this is planned ... not always be enough to stop tumour growth. , ... cancerous tissue varies between patients and depends on the ...
(Date:8/28/2014)... August 28, 2014 Vaccine market - ... great interest among other healthcare industry sectors and sub-circles ... demand in vaccine with respect to evolving and spreading ... due to an improved understanding for a well-balanced life ... States. It has led to new opportunities for manufacturing ...
(Date:8/28/2014)... 2014 AmeriPride Services, a leading textile ... the launch of its new Customer Portal, an online ... and more convenient for customers. The industry-leading digital tool ... communicate with the company. , Features of the new ... Access, download and pay bills online , ...
(Date:8/28/2014)... After more than two years of designing ... to announce the opening of Houston’s Mirror Mirror Beauty ... Mirror Mirror Beauty Boutique offers premium aesthetic services in ... of Richmond and Drexel near Highland Village, Mirror Mirror ... technology in a private, easy to access location. Patients ...
(Date:8/28/2014)... Hastings and Hastings is a Phoenix ... accident attorney services and other legal services in Arizona ... announce that it has saved a client more than ... at over half of a million dollars. This is ... attorney's fees that result in real savings for clients. ...
Breaking Medicine News(10 mins):Health News:Research demonstrates potential method to better control lung cancer using radiotherapy 2Health News:U.S. Vaccine Market: Opportunities and Threats by Transparency Market Research 2Health News:U.S. Vaccine Market: Opportunities and Threats by Transparency Market Research 3Health News:AmeriPride Services Launches New Customer Portal 2Health News:AmeriPride Services Launches New Customer Portal 3Health News:Mirror Mirror Beauty Boutique to Welcome Its First Patients 2Health News:Hastings and Hastings Is Pleased To Report Having Saved A Client $23,400 On Settlement Of $540,000 2Health News:Hastings and Hastings Is Pleased To Report Having Saved A Client $23,400 On Settlement Of $540,000 3
... Geffen School of Medicine and the Henry Samueli School of ... have successfully// transformed adult stem cells taken from human adipose, ... normal function of a large number of organs like the ... their study might help lead to the use of fat ...
... A new approach to detecting cancer has recently been ... detect cancer cells of many malignancies before// they turn ... that they have applied this technique to detect leukemia ... approach to diagnosing cancer at the molecular level." This ...
... to a study conducted by the researchers at the ... diet in pregnancy influences the child's susceptibility to atherosclerosis. ... children and correlated that the lower the mother's calorific ... The researchers used ultrasound scans to measure the thickness ...
... time high in the United Kingdom, and space sensors have ... levels. //According to the Met office reports, during the period ... high in UK along with nitrogen dioxide pollution, which is ... ,These facts are dramatically demonstrated by the latest images ...
... cases of malaria are reported each year. However, a ... Leeds, //with funding from the Bill & Melinda Gates ... from the disease. ,Design lecturer Dr Stephen ... at the Roslin Biocentre will develop a precisely engineered ...
... which environmental stimulation decelerates Alzheimer's disease, further affirming ... decline. ,A paper to this effect ... amyloid angiopathy and A? plaque burden after enriched ... appears in the2006 August issue of The American ...
Cached Medicine News:Health News:UCLA Researchers Transform Stem cells From Fat tissues Into Smooth Muscle 2Health News:UCLA Researchers Transform Stem cells From Fat tissues Into Smooth Muscle 3Health News:New Technique To Diagnose Cancer At Molecular Level 2Health News:Sensor Images Show Soaring Temperature and Pollution Levels in UK 2Health News:Revolutionary Net To Control Malaria 2Health News:Active Life Decelerates Alzheimer's 2
(Date:8/28/2014)... Pa. , Aug. 28, 2014 Today ... of medical, mental health, higher education, student and pharmaceutical ... abuse and diversion of ADHD prescription stimulant medication. The ... Although reported rates of nonmedical use ... indicated that 9.3 percent 1 of college students ...
(Date:8/27/2014)... 27, 2014 /PRNewswire-iReach/ -- In a new, interactive ... gap between the electronic medical record (EMR) and ... can experience, first-hand, how seamless integration makes diagnostic ... Photo - http://photos.prnewswire.com/prnh/20140827/140443 ... imaging from within the patient record was near ...
(Date:8/27/2014)... Varian Medical Systems (NYSE: VAR) today broke ground on ... Lake City manufacturing facility and allow for the ... to ultimately create 1,000 new full time jobs ... " Utah is home to hardworking ... can be credited with Varian,s success in the manufacturing of ...
Breaking Medicine Technology:New Coalition Aims to Help Prevent Misuse, Abuse and Diversion of ADHD Medications 2New Coalition Aims to Help Prevent Misuse, Abuse and Diversion of ADHD Medications 3New Coalition Aims to Help Prevent Misuse, Abuse and Diversion of ADHD Medications 4New Coalition Aims to Help Prevent Misuse, Abuse and Diversion of ADHD Medications 5New Coalition Aims to Help Prevent Misuse, Abuse and Diversion of ADHD Medications 6DICOM Grid Launches Interactive Guide to Demonstrate Image-Enabling the EMR 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 4
... Therapeutics (Nasdaq: NKTR ) will announce its financial ... Wednesday, April 27, 2011, after the close of U.S.-based financial ... a conference call to review the results beginning at 5:00 ... The press release and a live audio-only Webcast of ...
... processes happen in the blink of an eye – ... events virtually impossible. The advent of magnetoencephalography (MEG) changed ... measured in milliseconds, and offering the potential to reveal ... University of Technology is set to join the global ...
Cached Medicine Technology:Nektar to Announce Financial Results for the First Quarter of 2011 on Wednesday, April 27, 2011, After Close of U.S.-Based Financial Markets 2Australian Center Readies Brain Research Program for Addition of Elekta MEG System 2Australian Center Readies Brain Research Program for Addition of Elekta MEG System 3Australian Center Readies Brain Research Program for Addition of Elekta MEG System 4
For Atrial Mapping. Biosense Webster offers a complete line of specialty 20-pole catheters. The CRISTA CATH 20-pole deflectable catheter is designed for positioning along the crista terminals....
... Inquiry H Steerable Catheter. Steerable ... variety of designs and a ... stability. 10 to 24 electrodes, ... inactive and active tip electrodes, ...
Sophisticated DecaPolar Catheters provide enhanced recording and mapping quality....
... Torqr Quadripolar Braided Shaft ... The Medtronic CardioRhythm Torqr ... use in diagnostic electrophysiologic ... designed for recording intracardiac ...
Medicine Products: