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Researchers identify how binge drinking may drive heart disease
Date:11/26/2008

lls lining blood vessels (e.g. human umbilical venous endothelial cells (HUVEC)), and of two types of monocytes that stick to those vessel-lining cells when activated (e.g. primary blood monocytes (PBM) and THP-1 monocytes). The team then treated all cell cultures with acetaldehyde at varying doses (0.1󈞅 M) known to correlate with binge drinking for six hours.

Specifically, the current study found that acetaldehyde stimulated monocyte adhesion through its effect on three important proteins, CCR2, P-selectin, and tumor necrosis factor alpha (TNFα).

Several studies provide compelling evidence for a direct role of the monocyte chemoattractant protein-1 (MCP-1) receptor called chemokine (C-C motif) receptor 2 (CCR2) in the rush of monocytes to blood vessel walls as part of atherosclerosis. CCR2 is a receptor, a protein that occurs on the surfaces of monocytes that links up with MCP-1 as part of the signal that brings monocytes homing in on diseased blood vessel walls. The current study found that the addition of acetaldehyde to monocytes increased by more that twofold the number of cells with CCR2 expressed on their surfaces.

P-selectin is a cell adhesion molecule (CAM) that, upon receiving the right signal, quickly rises to the surface of the cells lining blood vessels (endothelial cells) to help monocytes grab them. The team found a 40 percent increase in endothelial cells showing P-selectin on their surfaces when exposed to acetaldehyde, and a 50 percent increase in the density of P-selectins expressed on the surface of each cell.

The study also found that the genetic expression of TNFα, an important driver of several aspects of inflammation in blood vessels, in endothelial cells increased by about 2.5 fold in the presence of acetaldehyde (10M). Given the above results, it is not surprising that the addition of acetaldehyde increased the overall adhesion of primary blood monocyte to endothelial cells by approxi
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Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-275-3676
University of Rochester Medical Center
Source:Eurekalert

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