Navigation Links
Researchers identify how a gene linked to both Alzheimer's disease and type 2 diabetes works
Date:7/18/2011

Researchers at Mount Sinai School of Medicine have identified how a gene for a protein that can cause Type 2 diabetes, also possibly kills nerve cells in the brain, thereby contributing to Alzheimer's disease.

The gene, called SorCS1, controls the generation of amyloid-beta (Abeta) in the brain. Abeta plays a key role in the development of Alzheimer's disease. The researchers previously linked SorCS1 to Alzheimer's disease and identified where the molecules lived in the cell, but not how they control Abeta. The new data were presented today at the Alzheimer's Association's Annual International Conference in Paris.

Sam Gandy, MD, PhD, the Mount Sinai Professor in Alzheimer's Disease Research, Professor of Neurology and Psychiatry, and Associate Director of the Alzheimer's Disease Research Center at Mount Sinai School of Medicine, led the research team with Rachel Lane, PhD, a postdoctoral researcher in Dr. Gandy's lab.

The researchers determined various "traffic patterns" in the cell for the amyloid precursor protein (APP) that makes Abeta and uncovered how much APP is converted into the toxic, and ultimately nerve-killing, Abeta. In some experiments Drs. Lane and Gandy altered the dose of the diabetes gene, SorCS1, and evaluated how that changed the "traffic pattern" that APP used to move around the cell and generate Abeta. In other experiments, Dr. Lane made small changes in the SorCS1 gene's and again saw dramatic changes in the "traffic pattern" of APP around the cell.

These data suggest that SorCS1 controls the movement of APP within the cell between areas where Abeta is readily made to areas where Abeta is not so easily made. In turn, the "traffic pattern" of influences the amount of Abeta being made by cells. The implication is that people with deficiencies in SorCS1 are at higher risk of developing Alzheimer's disease because their APP spends too much time in the region of the cell where APP is broken down to make the toxic Abeta.

"The great thing about studying SorCS1," said Dr. Gandy, "is that we already have entirely new ideas about how to treat both Alzheimer's disease and type 2 diabetes. Our hunch is that SorCS1 also controls how the insulin receptor moves around the cell, but we have not yet proven that," he said. "With both diseases reaching epidemic proportions, this discovery is encouraging news that brings us one step closer to developing treatments."


'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. NYU researchers develop compound to block signaling of cancer-causing protein
2. Mayo researchers: Genetic mutation linked to Parkinsons disease
3. Researchers Closer to Developing Universal Meningitis B Vaccine
4. Novel Virus Jumped From Monkeys to Humans, Researchers Find
5. Dentists can identify people with undiagnosed diabetes, Columbia researchers show
6. UAB researchers present a study on the psychological adaptation of adopted children
7. Researchers identify key role of microRNAs in melanoma metastasis
8. A change of heart: Penn researchers reprogram brain cells to become heart cells
9. Researchers identify early biomarker for future atopy in asymptomatic children
10. Berkeley Lab researchers apply NMR/MRI to microfluidic chromatography
11. Leeds researchers test benefit of fish oil in bowel cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... McKinney, Texas (PRWEB) , ... February 24, 2017 , ... ... south to The Medical Center at Craig Ranch building at 8080 State Highway 121, ... Ranch Medical District with easy access to Highway 121. , As the practice has ...
(Date:2/24/2017)... , ... February 24, 2017 , ... The California ... conference convening academic faculty engaged in or interested in palliative care education and research. ... will be held in North County San Diego on Sept. 28 and 29, 2017, ...
(Date:2/24/2017)... ... February 24, 2017 , ... Indiana Fiber Network (IFN) President and CEO Kelly ... Dyer started as the Chairman of the Management Committee when IFN was originally ... including the recruitment of investor/owners and development of the business plan. He became ...
(Date:2/24/2017)... ... February 24, 2017 , ... Congratulations to Head Over Heels’ ... February 12th. Ms. Esparza qualified into this prestigious status after winning the ... Las Vegas, Nevada. Frida is one of approximately 25 gymnasts in the nation ...
(Date:2/23/2017)... ... February 23, 2017 , ... On February ... a letter to withdraw previous guidance issued by the Obama Administration ... guidance issued in May 2016 by the Obama Administration came in response to ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... , Feb. 23, 2017 The ... of the PhenoTest BC Kit, performed on the ... identify organisms that cause bloodstream infections and provide ... to respond to (antibiotic sensitivity). The test also ... provide this important information, which can guide antibiotic ...
(Date:2/24/2017)... 2017  Directors from Pharma To Market Pty Ltd and Ador ... resulting in the founding of Pharma To Market Pte Ltd, based ... are pleased to announce their expansion into Asia ... . The company are delighted to appoint Joelle Chia ... Singapore based entity. Joelle brings with her an ...
(Date:2/24/2017)... Medivir AB (Nasdaq Stockholm: MVIR) ... Board of Directors that will be submitted to the ... representatives of the company,s three largest shareholders at the ... accepted a seat on the Nomination Committee, and the ... Nomination Committee was as follows:  ...
Breaking Medicine Technology: