Navigation Links
Researchers identify genetic root to early-onset prostate cancer
Date:2/11/2013

Prostate cancer is often considered an elderly man's disease, and little is known about the approximately 2% of cases that arise in men who are aged 50 years or younger. Research published in the February 11th issue of the Cell Press journal Cancer Cell uncovers the genetic origin of such early-onset prostate cancer. The findings could help in the development of new diagnostic, prognostic, therapeutic, and prevention strategies for the disease.

"It's been unclear whether prostate cancer in the young is explainable by a different mechanism than prostate cancer in the elderly. Our study implicates a different cause of disease in young patients," says co-senior author Dr. Jan Korbel of the European Molecular Biology Laboratory in Heidelberg, Germany.

Dr. Korbel and his colleagues sequenced the entire genetic code of cells in 11 tumors from early-onset prostate cancer patients, comparing it with the code in tumors from 7 patients with elderly-onset prostate cancer.

The researchers found that the receptor that binds testosteronecalled the androgen receptoris very active in tumors from young patients, causing a number of genes to rearrange and become cancer promoting. The genomes of elderly prostate cancer patients primarily showed abnormalities that were not caused by the androgen receptor's activity. Data from more than 10,000 additional patients showed that androgen receptor activity and corresponding gene rearrangements were indeed higher in younger patients.

"Interestingly, young men have generally higher testosterone levels than elderly men, which raises the question of whether high physiological levels of testosterone in young men may be linked with early-onset prostate cancer, a question that we are keen to address in the future," says Dr. Korbel.

Early-onset prostate cancer requires early diagnosis and definitive treatment due to the long life expectancy of younger patients and their higher risk of dying fr
'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. U of M researchers develop a molecular calcium sponge to tackle heart failure
2. UIC researchers to study how young adults use e-cigarettes, snus
3. Cancer Drug Doesnt Speed Up Tumor Growth, Researchers Say
4. UAB researchers cure type 1 diabetes in dogs
5. University of Minnesota researchers discover enzyme behind breast cancer mutations
6. Yale researchers spot attention deficits in babies who later develop autism
7. Researchers use new molecular inhibitors to successfully hit difficult cancer target
8. Researchers discover mutations linked to relapse of childhood leukemia
9. Moffitt Cancer Center researchers develop automated breast density test linked to cancer risk
10. Leading researchers warn of brain drain as scientists struggle to find funding
11. Researchers Identify Involuntary Tobacco Smoke Exposure in Boston Public Housing Authority Residents with Salivary Cotinine Testing from Salimetrics.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... 2014 "As a nurse I see ... of urinary incontinence," said an inventor from Whiting, N.J. ... specialized accessory to prevent leakage and keep them dry ... urine leakage. This prevents stains on pants, skirts and ... pad ensures that the individual has time to get ...
(Date:11/27/2014)... THURSDAY, Nov. 27, 2014 (HealthDay News) -- Thanksgiving meals ... eat a gluten-free diet, an expert says. Many ... potatoes and cranberry sauce -- are gluten-free, but "when ... may need to be considered," Dr. Anca Safta, director ... Wake Forest Baptist Medical Center in North Carolina, said ...
(Date:11/27/2014)... (PRWEB) November 27, 2014 Tylenol lawsuits ... were allegedly injured by the medication are continuing to ... litigation is looking ahead to a status conference in ... a Scheduling Order issued earlier this year, a conference ... 16th at 10:00 a.m. Items likely to be discussed ...
(Date:11/27/2014)... (PRWEB) November 27, 2014 Developers and plugin ... new plugin entitled ProPip, taking FCPX to the next level. ... effect with a few clicks of a mouse,” said Christina ... saver that our users will appreciate.” , With ProPip users ... leaving the possibilities truly endless. ProPip is great for commentaries, ...
(Date:11/27/2014)... to help with chores while they are home from school, ... self-esteem, and above all, helps parents maintain a somewhat tidy ... do you encourage your children to want to help? Is ... Development Journal, there is. The study found that adults’ language ... lend a hand. , The study found that using ...
Breaking Medicine News(10 mins):Health News:Expert Shares Gluten-Free Thanksgiving Tips 2Health News:Federal Litigation Presiding over Tylenol Lawsuits Looks Ahead to Status Conference in December, Bernstein Liebhard LLP Reports 2Health News:Federal Litigation Presiding over Tylenol Lawsuits Looks Ahead to Status Conference in December, Bernstein Liebhard LLP Reports 3Health News:Pixel Film Studios released ProPip plugin Exclusively for Final Cut Pro X 2Health News:Pixel Film Studios released ProPip plugin Exclusively for Final Cut Pro X 3
... providers also report a positive financial return on,investment, ... health,information electronically between physicians, hospitals, health plans, and,patients ... outcomes, according,to a new survey released by the ... of Health Information Exchange at the State and,Local ...
... are happy to discuss subject with eye docs, says researcher ... might expect the eye doctor,s office to be the last ... suggests that most people would appreciate such a conversation. ... weekly religious services, and 82 percent felt that prayer was ...
... newly-developed technology at the Delft University of Technology in the ... be a thing of the past. This is the message ... Institute Delft (RID) in an article in university journal ... hospitals are facing a shortage of radio isotopes which means ...
... taking place, experts say , , THURSDAY, Sept. 11 (HealthDay News) -- ... as it is possible to heal at all -- from the ... 2001, experts now say. , "There is a thing called natural ... it takes a long time. What,s happened over the past seven ...
... Secretary of,State George P. Shultz and John B. Shoven, one ... in a free Webinar on,September 29th, 2008 at 1:00 pm ... book "Putting Our House In Order: A Citizen,s Guide,to Social ... entitlement crisis and a unique approach to solving it., ...
... ScentToSleep.com,which specializes in the production and distribution ... the magazine cover "Aromatherapy,secrets that end insomnia!", ... baby?" was researched by Nancy,Minikes. The feature highlights ... tired and wishing they could sleep through the ...
Cached Medicine News:Health News:eHealth Initiative Survey Links Health IT to Lower Costs and Improved Outcomes 2Health News:eHealth Initiative Survey Links Health IT to Lower Costs and Improved Outcomes 3Health News:eHealth Initiative Survey Links Health IT to Lower Costs and Improved Outcomes 4Health News:Spiritual Beliefs Part of Health Care for Some 2Health News:Spiritual Beliefs Part of Health Care for Some 3Health News:Delft University of Technology patent for manufacturing radio isotopes 2Health News:9/11's Psychological Scars Slowly Healing 2Health News:9/11's Psychological Scars Slowly Healing 3Health News:9/11's Psychological Scars Slowly Healing 4Health News:George P. Schultz and John B. Shoven to Speak in Free Webinar on Social Security and Health Care Reform 2Health News:ScentToSleep.com Is Pleased to Announce That the Company Was Featured in the September 15th Issue of Woman's World Magazine 2
(Date:11/26/2014)... 2014 Zynerba Pharmaceuticals , Inc., a ... transdermal synthetic cannabinoid treatments, today announced that the company ... Conference 2014. The conference will be held December 2 ... New York . Zynerba,s Chairman and CEO, ... on Tuesday, December 2. To listen to ...
(Date:11/26/2014)... Nov. 26, 2014  Aridis Pharmaceuticals, Inc., a ... therapies for infectious diseases, announced today the addition ... recognized key opinion leader in the areas of ... board. Founder and Chief Executive Officer, ... Dr. Opal,s extensive experience investigating bacterial toxins and ...
(Date:11/26/2014)... NEW YORK and ... the leading distributor of market intelligence, MarketResearch.com is pleased ... by IQ4I Research and Consultancy focusing on the active ... about IQ4I Research visit: http://www.marketresearch.com/land/publisher.asp?vendorid=4023&progid=86891 . ... Ingredients Global Market – Forecast to 2020 ...
Breaking Medicine Technology:Zynerba Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2014 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 2MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 3
... Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) ... numerous advanced programs from Isis, cardiovascular franchise. The ... Biology,s (ATVB) Annual Conference. The presentations included data ... study of mipomersen in which treatment with mipomersen resulted ...
... CONSHOHOCKEN, Pa., April 30 ePharmaSolutions, a leading provider ... biopharmaceutical industry announced that it has been selected along ... the Bio-IT World Best Practice Award for it,s Clinical ... submissions in 7 categories by a peer reviewed panel ...
Cached Medicine Technology:Isis and Collaborators Present New Research at the ATVB Annual Conference 2Isis and Collaborators Present New Research at the ATVB Annual Conference 3Isis and Collaborators Present New Research at the ATVB Annual Conference 4Isis and Collaborators Present New Research at the ATVB Annual Conference 5ePharmaSolutions' Clinical Trial Investigator Portal Wins Bio-IT World 2009 Best Practice Award 2
McPherson titanium tying forceps which is 5 mm long, smooth jaws and straight. Used for 8-0 to 11-0 sutures....
Straight shafts with 5 mm tying platform. Wide handle with dull finish. Overall length 4.3 inches....
Delicate curved tying forcep with round handle is excellent for all fine suturing techniques. Useful for corneal transplants where delicate control is required....
Angled Castroviejo handle. Manufactured in titanium. Overall length 4.2 inches....
Medicine Products: