Navigation Links
Researchers identify genetic root to early-onset prostate cancer
Date:2/11/2013

Prostate cancer is often considered an elderly man's disease, and little is known about the approximately 2% of cases that arise in men who are aged 50 years or younger. Research published in the February 11th issue of the Cell Press journal Cancer Cell uncovers the genetic origin of such early-onset prostate cancer. The findings could help in the development of new diagnostic, prognostic, therapeutic, and prevention strategies for the disease.

"It's been unclear whether prostate cancer in the young is explainable by a different mechanism than prostate cancer in the elderly. Our study implicates a different cause of disease in young patients," says co-senior author Dr. Jan Korbel of the European Molecular Biology Laboratory in Heidelberg, Germany.

Dr. Korbel and his colleagues sequenced the entire genetic code of cells in 11 tumors from early-onset prostate cancer patients, comparing it with the code in tumors from 7 patients with elderly-onset prostate cancer.

The researchers found that the receptor that binds testosteronecalled the androgen receptoris very active in tumors from young patients, causing a number of genes to rearrange and become cancer promoting. The genomes of elderly prostate cancer patients primarily showed abnormalities that were not caused by the androgen receptor's activity. Data from more than 10,000 additional patients showed that androgen receptor activity and corresponding gene rearrangements were indeed higher in younger patients.

"Interestingly, young men have generally higher testosterone levels than elderly men, which raises the question of whether high physiological levels of testosterone in young men may be linked with early-onset prostate cancer, a question that we are keen to address in the future," says Dr. Korbel.

Early-onset prostate cancer requires early diagnosis and definitive treatment due to the long life expectancy of younger patients and their higher risk of dying from the disease. "We hope that our findings on the disease's cause will promote the development of new strategies to diagnose, prevent, and even individually treat this cancer," says co-senior author Dr. Thorsten Schlomm of the University Medical Center Hamburg-Eppendorf in Hamburg, Germany.


'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. U of M researchers develop a molecular calcium sponge to tackle heart failure
2. UIC researchers to study how young adults use e-cigarettes, snus
3. Cancer Drug Doesnt Speed Up Tumor Growth, Researchers Say
4. UAB researchers cure type 1 diabetes in dogs
5. University of Minnesota researchers discover enzyme behind breast cancer mutations
6. Yale researchers spot attention deficits in babies who later develop autism
7. Researchers use new molecular inhibitors to successfully hit difficult cancer target
8. Researchers discover mutations linked to relapse of childhood leukemia
9. Moffitt Cancer Center researchers develop automated breast density test linked to cancer risk
10. Leading researchers warn of brain drain as scientists struggle to find funding
11. Researchers Identify Involuntary Tobacco Smoke Exposure in Boston Public Housing Authority Residents with Salivary Cotinine Testing from Salimetrics.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... For breast cancer clinicians and researchers who were ... desire a more intimate review and analysis of its highlights, a novel half-day, complimentary ... offered by Imedex on February 4, 2017 in Chicago. Chaired by Kathy S. Albain, ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... at the National Association of Music Merchants (NAMM) winter trade show, Booth #2876, ... , Etymotic’s ER•4® has long been the gold standard for high-definition, in-ear earphones. ...
(Date:1/17/2017)... ... January 17, 2017 , ... Peoples ... the Peoples Health network on Dec. 1, 2016. Peoples Health, a Metairie-based Medicare ... Center is an exciting addition to our provider network, and the addition will ...
(Date:1/17/2017)... ... January 17, 2017 , ... Wettstein Agencies, a ... and business professionals throughout central Colorado, is joining local nonprofit Aurora Warms The ... Warms The Night organization is committed to breaking the cycle of homelessness and ...
(Date:1/17/2017)... ... 2017 , ... The Sharie Withers Agency, a full-service insurance ... beneficiary of their thriving community involvement program. The current campaign fundraises to support ... of terminally ill patients. Donations to this worthy cause may now be made ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)...  Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) today ... a Phase 3 clinical trial comparing the efficacy and ... the prevention of hepatic veno-occlusive disease (VOD) in adult ... who are at high risk or at very high ... be conducted across approximately 100 medical centers in ...
(Date:1/17/2017)... 17, 2017  Edwards Lifesciences Corporation (NYSE: ... structural heart disease and critical care monitoring, plans to ... 31, 2016 after the market closes on Wednesday, February ... 5:00 p.m. ET that day to discuss those results. ... (877) 407-8037 or (201) 689-8037.  For 72 hours following ...
(Date:1/17/2017)... company that brought a full line of equine first aid kits ... of companion animal pet first aid kits.  EquiMedic USA ... developed two sizes of small pet first aid kits under the ... a small and a large companion pet first aid kit, this ... newcomer to working with small animals either. Corporate owners, mother and ...
Breaking Medicine Technology: