Navigation Links
Researchers identify genetic mutation linked to congenital heart disease
Date:7/29/2013

at Nationwide Children'sone of the largest in the nationrevealed two additional patients with a similar complex heart defect who had a rare mutation in the same gene. On further analysis, Dr. Garg's team found that this mutation affected the gene's ability to express a transcription factor called Nkx2.5, which has been implicated in congenital heart disease.

"If you have three unrelated people with an abnormality in the same gene, and they also have an extremely rare type of congenital heart disease, there's a high likelihood that the gene is contributing to the condition," says Dr. Garg, who also is an associate professor of pediatrics at The Ohio State University College of Medicine. "Understanding how either deletion or loss of FOXP1 affects normal heart development could help contribute to our understanding of congenital heart disease."

The next step in the research is to see if they can find the FOXP1 mutation in patients with different types of congenital heart disease. From there, they will begin to look at how the gene interacts with others involved in the formation of a normal heart. Given that congenital heart disease is probably the result of mutations in many genes, Dr. Garg says, it's quite possible that by studying this gene and its potential partners, we can uncover other potential candidate genes for heart malformations.


'/>"/>

Contact: Gina Bericchia
Gina.Bericchia@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 2014 After a 13-year absence from ... returning to the stage to entertain his many worldwide ... performances, and the successful tour has been steadily expanding ... , Visit Ticketability.com for a large inventory ... at fair prices. , Music fans have had a ...
(Date:12/19/2014)... The Hermitage Club at Haystack ... Vermont’s Deerfield Valley, announced today that it has unveiled ... songs. , Three time Grammy Award Winner Kenny ... followed by a trail naming ceremony. Hermitage Club Founder, ... “I’m Alright” the theme song for the movie soundtrack ...
(Date:12/19/2014)... News) -- The tragic death from "rat-bite fever" of a ... pet rodents, according to a report from the U.S. Centers ... rare but potentially fatal illness that should be considered in ... history of rodent exposure is reported," said a team led ... The case outlined in the report occurred in August ...
(Date:12/19/2014)... (HealthDay News) -- Traveling through the same U.S. airport ... three others within a four-hour time span, illustrating just ... shows. "The exposures in this report were not ... international terminal, highlighting the fact that measles is highly ... infectious disease specialist at the U.S. Centers for Disease ...
(Date:12/17/2014)... While countless companies tempt patients to buy hCG ... of their purchase. Not only is the sale of hCG ... patients who buy hCG online are typically receiving products that ... real hCG present. Illegal internet hCG is typically manufactured outside ... and may contain unknown fillers that can pose very serious ...
Breaking Medicine News(10 mins):Health News:Garth Brooks Tickets for Joe Louis Arena: Ticketability.com Becomes a Popular Destination for Discount Tickets for Garth Brooks’ Detroit Concerts Set for February 27-28 2Health News:The Hermitage Club Officially Names Four Ski Trails after Iconic Rock Songs by Grammy Award Winner Kenny Loggins 2Health News:Scratch From Pet Rat Kills Child; CDC Warns of Risk 2Health News:Arriving Now at Gate 42: Measles 2Health News:Arriving Now at Gate 42: Measles 3Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 2Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 3
... CardioGenics Holdings Inc. (OTC Bulletin Board: JAGH) has received ... for the Company on the OTCBB will take place at ... The new ticker symbol for "CardioGenics Holdings Inc." on the ... name and ticker symbol change that is scheduled to take ...
... (Nasdaq: AKRX ) will release third quarter 2009 earnings Tuesday, November 10, before the market ... results followed by a Q&A session: , , Subject: ... Date/Time: ... ...
... waists in men spell trouble, study finds , MONDAY, Oct. ... appears to affect the risk of dangerous blood clots in ... new Danish study indicates. , The 10-year study found that ... thromboembolism (VTE) in women but not men, while a wider ...
... Some simple precautions will safeguard young trick-or-treaters, experts say ... trick to keeping children and the rest of the ... that the night is a treat for everyone. , ... tips: , Choose costumes that are bright and ...
... BOSTON, Oct. 26 Uno Chicago Grill®, America,s Healthiest Chain ... limited-time-only fall menu. , This exciting fall menu ... cranberries are a well-known and popular accent to many dishes, ... once the territory of a select few health food aficionados. ...
... , CENTENNIAL, Colo., Oct. 26 LABS Inc., one ... the country, announced today that it will begin offering ... transfusion medicine and blood services industry. LABS Inc.,s acquisition ... expertise to blood collection programs nationwide. , LABS Inc. ...
Cached Medicine News:Health News:Where You Put on Pounds May Influence Clot Risk 2Health News:Treat Kids to a Safe Halloween 2Health News:Go, Go, Goji! UNO(R) Fall Menu Is 'Berry' Delicious 2Health News:Go, Go, Goji! UNO(R) Fall Menu Is 'Berry' Delicious 3Health News:LABS Inc. to Offer Donor Testing Services for Transfusion Medicine and Blood Services Industry 2
(Date:12/19/2014)... WASHINGTON , Dec. 18, 2014 Since ... Road, the site now known as the leading online ... has seen explosive growth in its offering of drugs ... Citizens Alliance show the takedowns did succeed in lowering ... our last review of the markets in August. But ...
(Date:12/19/2014)... China separating membrane market has witnessed robust development ... years, albeit as a later starter. In 2012, the size ... approximated RMB12 billion, with the proportion worldwide soaring to 16.3%. ... membrane market will continue its growth rate by around 20% ... will jump to roughly RMB25 billion. An integrated ...
(Date:12/17/2014)... , December 17, 2014 Revenue and ... expenditure on research and development In the past ... revenue by two percent to EUR 4.287 billion (last year: ... by 14 percent to EUR 360 million. "Overall, 2013/14 was ... Michael Kaschke , President and CEO of Carl Zeiss ...
Breaking Medicine Technology:Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 3Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3ZEISS Asserts its Position in Difficult Environment 2
... used in matured cataract surgery, which stains ... the surgeon to see capsule clearly. ... blue combined with sodium chloride and buffer ... injection into the anterior chamber of the ...
... LCD color monitor ... of the icons for ... your desired choices for ... measure much smaller pupils ...
... objective automatic refractor designed for those that ... are performed with an electronic joystick. It ... 1 degree of axis). The AR-600 fogs ... and maintains it throughout the measurement process. ...
... ophthalmic laser system provides two lasers in ... a photodisruptor for posterior capsulotomy and iridotomy. ... producing pulsed 532 nm light. The photodisruptor ... The appropriate laser can be easily selected ...
Medicine Products: