Navigation Links
Researchers identify genetic marker of resistance to key malaria drug
Date:12/18/2013

WHAT:

An international team of researchers has discovered a way to identify, at a molecular level, malaria-causing Plasmodium falciparum parasites that are resistant to artemisinin, the key drug for treating this disease. The research team, which included scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, published their findings today in the journal Nature.

According to the World Health Organization, an estimated 627,000 people died of malaria in 2012. Artemisinin, in combination with other drugs, is the first-line treatment for malaria. In recent years, however, artemisinin-resistant malaria has appeared in patients in Southeast Asia, and researchers have begun exploring ways to maintain the drug's effectiveness. To monitor the spread of artemisinin resistance, scientists need a way to identify drug-resistant, malaria-causing parasites, the study authors write. They sought to fill this need by sequencing the complete genetic information of a laboratory-generated strain of artemisinin-resistant P. falciparum, and of both resistant and susceptible parasites found in nature in Cambodia, and then searching for links between the parasites' genes and resistance to the drug.

The researchers found that P. falciparum parasites with a mutant version of a gene called K13-propeller were more likely to survive exposure to artemisinin in the laboratory setting. Similarly, in malaria patients treated with the drug, parasites with the genetic mutation were eliminated more slowly. Further, they found that the geographical distribution of the genetic mutation in parasites in western Cambodia tracked with the spread of resistance among malaria patients in that region in recent years. Taken together, these results suggest that the mutant version of K13-propeller is associated with artemisinin resistance, according to the researchers. Future research will examine how the mutation causes resistance and explore whether this association extends to other regions of the world.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... ... The Global Wellness Summit (GWS), an annual conference for international ... travel, spa and beauty in Europe. The organization asked its partner experts in Europe ... researchers - to forecast where wellness is headed in Europe. Predictions range from European ...
(Date:5/31/2016)... Rosemont, IL (PRWEB) , ... May 31, 2016 , ... ... trustees and executive committee members: , David G. Lewallen, MD, began his term ... as past president. Michael L. Parks, MD, is OREF’s new president-elect. Richard F. Kyle, ...
(Date:5/31/2016)... ... , ... In a recent interview on The Greenburgh Report radio show hosted ... WVOX (1460 AM), leading medical insurance advocate Adria Goldman Gross discussed several eye-opening ... maelstrom.” , During the interview with Mr. Feiner that aired on May 7, ...
(Date:5/31/2016)... ... May 31, 2016 , ... To meet a ... the healthcare industry, The University of Scranton is adding a Certificate in Health ... a career in rapidly growing field of healthcare information. , Healthcare organizations ...
(Date:5/30/2016)... ... May 30, 2016 , ... "This ... FCPX," said Christina Austin - CEO of Pixel Film Studios. , TransPack ... Cut Pro X. Choose from abstract transitions to more simple wipes with blur ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... 27, 2016 Hutchison China ... focused on the highly lucrative global oncology and ... of potential first-in-class or best-in-class tyrosine kinase inhibitor ... with strategic partners. HCM,s profitable Chinese healthcare business ... We expect progress of the mid-to-late-stage pipeline during ...
(Date:5/27/2016)... The healthcare sector is large ... all falling under its umbrella.  A rather overlooked sector ... talked about, these healthcare companies are still trying to ... is by far the largest consumer of the healthcare ... ADMD), Nutranomics Inc. (OTC: NNRX), KollagenX Corp. (OTCQB: KGNX), ...
(Date:5/26/2016)... -- TARE (Transarterial Radio-embolization) Using Yttrium-90 ... Overall Decreased Use of Hospital Resource ... healthcare company, has today announced the publication of ... ISPOR (International Society for Pharmacoeconomics and Outcomes Research), ... yttrium-90 glass microspheres is associated with cost savings ...
Breaking Medicine Technology: