Navigation Links
Researchers identify genetic marker of resistance to key malaria drug
Date:12/18/2013

WHAT:

An international team of researchers has discovered a way to identify, at a molecular level, malaria-causing Plasmodium falciparum parasites that are resistant to artemisinin, the key drug for treating this disease. The research team, which included scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, published their findings today in the journal Nature.

According to the World Health Organization, an estimated 627,000 people died of malaria in 2012. Artemisinin, in combination with other drugs, is the first-line treatment for malaria. In recent years, however, artemisinin-resistant malaria has appeared in patients in Southeast Asia, and researchers have begun exploring ways to maintain the drug's effectiveness. To monitor the spread of artemisinin resistance, scientists need a way to identify drug-resistant, malaria-causing parasites, the study authors write. They sought to fill this need by sequencing the complete genetic information of a laboratory-generated strain of artemisinin-resistant P. falciparum, and of both resistant and susceptible parasites found in nature in Cambodia, and then searching for links between the parasites' genes and resistance to the drug.

The researchers found that P. falciparum parasites with a mutant version of a gene called K13-propeller were more likely to survive exposure to artemisinin in the laboratory setting. Similarly, in malaria patients treated with the drug, parasites with the genetic mutation were eliminated more slowly. Further, they found that the geographical distribution of the genetic mutation in parasites in western Cambodia tracked with the spread of resistance among malaria patients in that region in recent years. Taken together, these results suggest that the mutant version of K13-propeller is associated with artemisinin resistance, according to the researchers. Future research will examine how the mutation causes resistance and explore whether this association extends to other regions of the world.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... , ... December 05, 2016 , ... The new knee ... individual looking to buy neoprene knee sleeves for lifting and any sport ... focuses heavily on two main aspects to provide a higher quality knee sleeve performance. ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... Rejuvenation" at the 2016 Anti-Aging & Beauty Awards at The Aesthetic & ... & Anti-aging Medicine European Congress (AMEC) brings together the industry’s leading scientific ...
(Date:12/4/2016)... ... December 02, 2016 , ... Metabolic Code (MC) and Power2Practice ... help doctors more efficiently manage their practice. Power2Practice is adding MC’s nutraceutical ... Integrative and Functional Medicine. , The Metabolic Code platform provides a leading-edge ...
(Date:12/4/2016)... ... ... While James Earl Jones is known for myriad roles on stage and screen, he ... of the forthcoming episodes examines mammogram techniques; a very important part of preventative medicine. ... early detection. Like any other disease, treatments have a much higher chance of success ...
(Date:12/4/2016)... ... December 04, 2016 , ... ... new attractive animation styles with unique displacement design elements," said Christina Austin - ... third designs. Choose from a variety of design styles that include both left ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... 2016  Zimmer Biomet Holdings, Inc. (NYSE and ... to its previously-announced cash tender offers (the "Offers") ... below (collectively, the "Notes"), approximately $2.6 billion in aggregate ... not validly withdrawn on or prior to 5:00 p.m., ... today, December 5, 2016 (the "Early Tender Deadline"). ...
(Date:12/5/2016)... , Dec. 5, 2016 France Glaucoma Surgery ... new report, "France Glaucoma Surgery Devices Market Outlook to ... Surgery Devices market. The report provides value, in millions ... (USD) within market segements - Canaloplasty Micro Catheters and ... shares and distribution shares data for each of these ...
(Date:12/5/2016)... , Dec. 5, 2016   Mallinckrodt Pharmaceuticals ... specialty pharmaceutical company, today announced that it received a ... Equality Index (CEI), a national benchmarking survey and report ... bisexual and transgender (LGBT) workplace equality, administered by the ... of 517 major U.S. businesses which also earned top ...
Breaking Medicine Technology: