Navigation Links
Researchers identify gene that spurs deadly brain cancer
Date:12/3/2009

Howard Hughes Medical Institute (HHMI) researchers have identified a new factor that is necessary for the development of many forms of medulloblastoma, the most common type of malignant childhood brain cancer.

HHMI investigator Huda Y. Zoghbi and colleagues at Baylor College of Medicine prevented medulloblastoma from developing in mice by shutting down production of the protein Atoh1 in susceptible brain cells. The team's findings, reported in the December 4, 2009, issue of Science, suggest Atoh1 may be a new target for medulloblastoma treatment.

"When we cloned the gene for Atoh1 in 1996, we had no clue that it had any medical relevance," said Zoghbi, a neuroscientist and neurologist. "Now we know that it's critical for many medical issues, the most recent one being this common childhood cancer."

Atoh1 (also known as Math1) is a transcription factor that works in the nuclei of cells to keep certain genes switched on. It is evolutionarily ancient, appearing in slightly varying forms in various species, from fruit flies to humans. In cells where Atoh1 is active, it seems to be switched on only during fetal development, when cells proliferate rapidly to fill out the various parts of the nervous system.

However, in the region of the brain known as the cerebellum, Atoh1 is active after birth in the fast-dividing granule neuron precursor (GNPs) cells that eventually stop dividing and become mature granule neurons. "The cerebellar granule neurons are unique in that most of their development happens after birth, both in mice and humans," Zoghbi said.

A few years ago, experiments done in several laboratories hinted that Atoh1 might be required to keep GNPs in their fast-dividing state and make them more susceptible to developing into medulloblastoma tumors.

"The question for us was whether we could really prove, not just in the cell culture dish or in microarrays but in animals, that Atoh1 plays this role in medulloblastoma," Zoghbi
'/>"/>

Contact: Jim Keeley
keeleyj@hhmi.org
240-688-6630
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. CWRU researchers report poor outcomes for CCI patients leaving hospitals on ventilators
2. VAI Researchers Find Long Awaited Key to Creating Drought Resistant Crops
3. Parent mentors can improve the asthmatic care of minority children, UT Southwestern researchers find
4. Researchers identify proteins in lung cancer cells that may provide potential drug targets
5. Researchers Identify Possible Causative Mutation for Crohn's Disease: Crohn's & Colitis Foundation Annual Conference to Present Emerging Research
6. Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps
7. Researchers identify role of gene in tumor development, growth and progression
8. On the trail of a vaccine for Lyme disease: Yale researchers target tick saliva
9. UCLA researchers create fly paper to capture circulating cancer cells
10. Researchers focus on helping dying patients take care of unfinished business
11. Mount Sinai researchers to test first gene therapy For Alzheimers patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide professional shopping tips ... the models at LunaDress.co.uk come with big discounts, up to 80 ... can turn out to be a most exciting memory and can ... bring surprise to a wedding. On the updated fashion blog, ladies ... for a big day . , Going out with friends to ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. ... on a "fountain of youth" drug that can delay the ... a new study suggests. Seniors received a significant boost ... a genetic signaling pathway linked to aging and immune function, ... The experimental medication, a version of the drug rapamycin, improved ...
(Date:12/25/2014)... North Carolina (PRWEB) December 25, 2014 ... North Carolina Retirement Community, recently showed their generous ... girls of the Catawba County Parenting Network- Grandparents ... the 10 children gathered around the largest Christmas ... to open presents purchased by residents of the ...
(Date:12/24/2014)... Epigenetics finds applications in a large number ... discovery, developmental biology, and research for metabolic and genetic ... most widely used techniques for the discovery and development ... cancer is rapidly growing worldwide. In 2012, there were ... and 32.6 million people living with cancer (within five ...
(Date:12/24/2014)... Dr. Vu Ho, a Dallas based facial plastic ... med-spa with the addition of new Silk Peel skin ... and services. , “Silk Peel is a procedure that ... “As a result it can address issues like acne ... or blemishes.” , Similar to microdermabrasion, Silk Peel ...
Breaking Medicine News(10 mins):Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:Global Epigenetics Market Was Valued at $413.24 Million in 2014 - New Research Report by MarketsandMarkets 2Health News:Global Epigenetics Market Was Valued at $413.24 Million in 2014 - New Research Report by MarketsandMarkets 3Health News:Dr. Vu Ho Expands Facial Plastic Surgery Practice to Include New Skin Care Treatment 2
... Inc. (NYSE: MYL ),today announced that its subsidiary, ... and Drug Administration (FDA) for its,Abbreviated New Drug Application ... Zaleplon Capsules are the generic version of King Pharmaceuticals,Sonata(R) ... for,the 12 months ending March 31, 2008, according to ...
... news that DuPont,s Teflon chemicals likely,contaminate area residential wells. ... level., - Private residential well contamination with PFOA ... private drinking water wells and warnings,issued to residents in ... DEEPWATER, N.J., June 9 A coalition of,environmental ...
... ALEXANDRIA, Va., June 9 The National,Community ... of,Compounding Pharmacists (IACP) are collaborating to increase ... engage in compounding.,IACP has established a satellite ... their Director of Public Affairs, Sarah R. ...
... and Good Health this Father,s Day, Nearly 40 Million ... ... 9 Families sick and tired of Dad,s raucous,snoring, incessant allergic ... Snoring Center: a unique medical practice dedicated,exclusively to the evaluation and ...
... A new study demonstrates that microRNAs can modulate the ... may play a significant role in some human cancers. ... issue of the journal Cancer Cell, is likely to ... and leukemias. , MicroRNAs (miRNAs) are small noncoding pieces ...
... way solid tumors adapt the body,s machinery to bring ... these tumors stronger. , "In a sense, these therapies ... D.V.M., Ph.D., professor of radiation oncology at Duke University ... killing many if not most tumor cells, you are ...
Cached Medicine News:Health News:New Jersey Coalition Calls for Investigation of Private Wells to Protect Families from PFOA in Drinking Water 2Health News:New Jersey Coalition Calls for Investigation of Private Wells to Protect Families from PFOA in Drinking Water 3Health News:Pharmacist Associations Partner to Increase the Voice of Pharmacy 2Health News:Stop Dad's Sleepless Nights - and the Sniffles - With the Snoring Center 2Health News:Stop Dad's Sleepless Nights - and the Sniffles - With the Snoring Center 3Health News:MicroRNA controls expression of oncogenes 2Health News:Solid tumor cells not killed by radiation and chemotherapy become stronger 2
(Date:12/24/2014)... CHAPEL HILL, N.C. , Dec. 23, 2014 /PRNewswire/ ... marketplace success. As the key link between the medical ... will grow even more in the coming years as ... relationships. According to research by benchmarking ... and MSLs can gain an important edge is by ...
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... "US Self-monitoring Blood Glucose Market" report to ... This market insight focuses on the developments ... the United States . Reimbursement analysis and the ... analyses for more than 73 SMBG meters have been ...
(Date:12/22/2014)... 2014 Cyberonics, Inc. (NASDAQ: CYBX ), ... management of epilepsy, today announced it will participate in the ... January 14, 2015, in San Francisco . ... Executive Officer, will speak at 11:00 AM Pacific Time.  A ... clicking on the Investor Relations link on the Cyberonics home ...
Breaking Medicine Technology:Role of Medical Science Liaisons Evolving in Medical Device Sector 2US Self-monitoring Blood Glucose Market 2
... (Nasdaq: NVAX ) a clinical-stage vaccine company, ... of Novavax will be presenting at the Stifel Nicolaus ... 17, 2010 at 10:20am local time at the Four ... company overview, outline its competitive position and characterize Novavax,s ...
... Halozyme Therapeutics, Inc. (Nasdaq: HALO ... million shares of its common stock pursuant to an effective ... Inc. is the sole book-running manager of the offering and ... to purchase up to 1,245,000 additional shares. Halozyme intends to ...
Cached Medicine Technology:Halozyme Therapeutics Announces Public Offering of Common Stock 2Halozyme Therapeutics Announces Public Offering of Common Stock 3
...
Angled 45 Degrees to Right, 9.5mm blade, gently curved .5x .25mm blunt tips; Lower blade is 0.5mm longer; 14mm from mid screw to tip; (Available in left and right;) overall length 120mm; Stainless ...
16mm Slightly Curved sharp Tips; overall length 120mm; Stainless Steel...
16mm from Mid-Screw to Blunt Tips, Gently Curved Blades; overall length 120mm; Stainless Steel...
Medicine Products: