Navigation Links
Researchers identify gene set that shows which patients benefit from chemo after surgery
Date:9/7/2010

Lung cancer researchers have identified a genetic signature that can help doctors determine which patients with early-stage non-small cell lung cancer are at high risk for developing disease recurrence and therefore may benefit from chemotherapy after surgery ("adjuvant chemotherapy").

"The findings give patients and their doctors a clearer map of the appropriate post-operative treatment route to follow. Not all patients benefit from chemotherapy after surgery and those with less aggressive cancer may be spared from the potentially debilitating side effects of this treatment," says principal investigator Dr. Ming Tsao, pathologist at the Princess Margaret Hospital (PMH) Cancer Program, University Health Network (UHN), and Professor of Laboratory Medicine and Pathobiology at the University of Toronto. He also holds the M. Qasim Choksi Chair in Lung Cancer Translational Research at UHN.

"Our study was rigorously validated by multiple testing across data from different patient populations and so we believe these findings can be applied generally to other patients with early-stage non-small cell lung cancer," says Dr. Tsao.

"The ability to tell whether a particular patient is a good candidate for adjuvant chemotherapy will bring us closer to our goals of improving patient care through personalized medicine," adds study collaborator Dr. Frances Shepherd, PMH medical oncologist and holder of the Scott Taylor Chair in Lung Cancer Research at UHN.

The study, published online today in the Journal of Clinical Oncology (JCO 64325), advances the 2005 findings of the NCIC Clinical Trials Group study JBR.10, conducted in collaboration with the U.S. National Cancer Institute. The JBR.10 findings showed significant survival benefit from the anti-cancer drugs vinorelbine and cisplatin in patients with early-stage (stage I and II) non-small cell lung cancer whose tumors had been surgically removed. Dr. Tsao's research tea
'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.on.ca
416-946-2846
University Health Network
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers will test suicide prevention program in high schools
2. Mount Sinai researchers find new target to improve pain management
3. Non-invasive therapy significantly improves depression, UCLA researchers say
4. For the first time, researchers identify and isolate adult mammary stem cells in mice
5. UNH researchers develop improved tool for cycling fitness
6. Sodium MRI gives new insights into detecting osteoarthritis, NYU researchers find
7. Researchers urge reclassification of traumatic brain injury as chronic disease
8. Researchers closer to development of drug to prevent deadly immune response
9. Mayo researchers develop new laboratory cell lines to study treatment for ATC
10. Researchers zero in on protein that destroys HIV
11. 15 new US patents awarded this past year to NJIT researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... PLOS Pathogens , children who live in regions ... an immune response to infection with malaria parasites that ... fever and illness and partially control the growth of ... researchers develop future interventions that prevent or mitigate the ... approximately 200 million cases of malaria occur worldwide, resulting ...
(Date:4/17/2014)... MANHASSET, NY In a review published in the ... MD, president of The Feinstein Institute for Medical Research, ... the medical community,s approach to treating sepsis, ... 200,000 Americans. , Sepsis occurs when molecules released into ... inflammation throughout the body. Inflammation is necessary for maintaining ...
(Date:4/17/2014)... Doctors who treat patients with a severe and ... an agonizing treatment decision. , The drug sirolimus ... relieve shortness of breath. But some patients eventually ... potentially fatal complications following transplantation. , "It,s a ... director of Loyola University Medical Center,s LAM Clinic ...
(Date:4/17/2014)... Irvine, Calif., April 17, 2014 By discovering a ... immediately after a stroke, researchers at UC Irvine and ... therapies that may limit or prevent stroke-induced brain damage. ... the fourth-leading cause of death and primary reason for ... damaged in a stroke and lets blood-borne material into ...
(Date:4/17/2014)... the potential to ward off depression among retirees, particularly ... online in The Journals of Gerontology, Series ... the article " Internet Use and Depression Among Retired ... ," the authors report that Internet use reduced the ... their study sample. , Late-life depression affects between ...
Breaking Medicine News(10 mins):Health News:Study sheds light on how the immune system protects children from malaria 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:Internet use may cut retirees' depression 2
... in heart rate patterns provide information on how the ... long considered heart rate patterns to be important indicators ... as in labor and delivery. Now a new study ... predict the rate at which children develop through their ...
... November 15, 2007, Washington, DCEnsuring that everyone in the ... is not enough to drive the kind of reform ... released today by the Commonwealth Fund Commission on a ... for all, changing the way doctors and other health ...
... doctors for some prescriptions , , WEDNESDAY, Nov. 14 (HealthDay ... whether to allow certain drugs to be sold by ... officials listened to arguments for and against the proposal ... , But at the day,s end, the FDA officials ...
... a favourable clinical outcome in women with ovarian carcinoma, ... research published this week in the online open access ... family of peptide hormones, and the receptor GPR54 have ... tumours. In this study, researchers have shown that kisspeptin ...
... Nov. 14 The following is a,statement from ... Health,(TFAH):, "Trust for America,s Health (TFAH) urges ... Health and Human Services, Education and,Related Agencies Appropriations ... vital programs that:, -- Assist states, territories, ...
... Escalon Medical Corp.,(Nasdaq: ESMC ) today announced ... For the first quarter of fiscal 2008, the ... the $7,168,160, reported in the prior,year period. This decrease ... and Vascular business units, which decreased 3% and 2%,respectively, ...
Cached Medicine News:Health News:Fetal heart rate yields clues to children's later development 2Health News:Commonwealth Fund Commission issues reform recommendations for next president 2Health News:Commonwealth Fund Commission issues reform recommendations for next president 3Health News:FDA Hears Pros, Cons of Pharmacist-to-Patient Drug Sales 2Health News:FDA Hears Pros, Cons of Pharmacist-to-Patient Drug Sales 3Health News:FDA Hears Pros, Cons of Pharmacist-to-Patient Drug Sales 4Health News:Predicting the future in ovarian cancer 2Health News:Escalon(R) Reports First Quarter Fiscal 2008 Results 2Health News:Escalon(R) Reports First Quarter Fiscal 2008 Results 3Health News:Escalon(R) Reports First Quarter Fiscal 2008 Results 4Health News:Escalon(R) Reports First Quarter Fiscal 2008 Results 5Health News:Escalon(R) Reports First Quarter Fiscal 2008 Results 6Health News:Escalon(R) Reports First Quarter Fiscal 2008 Results 7
(Date:1/15/2014)... Most osteoporosis patients want a choice in the ... sponsored by Mission Pharmacal Company. The survey, conducted by ... support community, revealed that 74 percent of osteoporosis patients ... form other than a pill or a tablet. ...
(Date:1/15/2014)... N.J. , Jan. 15, 2014  Celsion Corporation (the "Company") ... has received commitments from institutional investors to purchase an ... stock in an at-the-market registered direct offering, led by ... entered into definitive purchase agreements with these investors pursuant ...
(Date:1/15/2014)... 15, 2014  Manufacturers, suppliers and distributors of innovative ... protect their most important business assets, intellectual property ... Because of the highly-competitive nature of ... of the most litigious industry sectors of cases ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Intellectual Property Insurance for Medical-related Products and Services 2
... Conn., March 16, 2011 Amarin Corporation plc (Nasdaq: ... on cardiovascular disease, today reported financial results for the ... The Company also provided an update on its progress ... product candidate, AMR101 for the treatment of elevated triglyceride ...
... announces that a new market research report is available ... Industry http://www.reportlinker.com/p098391/Global-Breast-Pumps-Industry.html ... in Thousands of Units by the following Product Segments: ... provides separate comprehensive analytics for the US, Canada, Europe, ...
Cached Medicine Technology:Amarin Reports Year-End and Q4 2010 Results 2Amarin Reports Year-End and Q4 2010 Results 3Amarin Reports Year-End and Q4 2010 Results 4Amarin Reports Year-End and Q4 2010 Results 5Amarin Reports Year-End and Q4 2010 Results 6Amarin Reports Year-End and Q4 2010 Results 7Amarin Reports Year-End and Q4 2010 Results 8Amarin Reports Year-End and Q4 2010 Results 9Global Breast Pumps Industry 2Global Breast Pumps Industry 3Global Breast Pumps Industry 4Global Breast Pumps Industry 5Global Breast Pumps Industry 6Global Breast Pumps Industry 7Global Breast Pumps Industry 8Global Breast Pumps Industry 9Global Breast Pumps Industry 10
... Roche Diagnostics Task Targeted Automation ... state-of-the-art automation of pre- and ... decapping, sorting / archiving of ... bar code labeled secondary tubes. ...
... an open platform for clinical diagnostic applications. The ... of 75, 100, 150 and 200 cm ... laboratory space and throughput requirements. Tecan will focus ... new applications and to evolve the quality, safety ...
... For maximum productivity, and proven reliability, ... compact, fully automatic cell washing and ... fast 80-second wash cycle for stat ... controls, and standardized, reproducible procedures. High ...
Excellent all-around performance in digital format - MIC-D offers an exciting new way to observe the natural world. Multiple performance features provide new ways to enjoy microscope observation....
Medicine Products: