Navigation Links
Researchers identify factors behind blood-making stem cells
Date:7/6/2010

This release is available in French.

Montreal, July 6, 2010 - A team of researchers from the Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal have made significant progress in the understanding of blood-producing (hematopoietic) stem cells. The study led by IRIC Chief Executive Officer and Scientific Director, Dr. Guy Sauvageau, identifies factors that control the production of hematopoietic stem cells. Published in the journal Cell Stem Cell, the research offers interesting insight critical to the development of novel regenerative therapies and treatments for leukemia.

Hematopoietic stem cells (HSCs) are located within the bone marrow and serve as a reservoir for the production of all blood cells. A disruption in this process can have dire consequences leading either to a depleted blood cell population which can cause severe immune deficiencies, or excessive proliferation of blood cells which can trigger the development of leukemia. At the moment, relatively little is known about what controls this production.

The current study aims to understand the roles of various proteins that are present in HSCs and their impact on blood production. Researchers found that three proteins (Msi2, Pard6a and Prkcz) help blood cells to regenerate. That is, when HSCs lack these proteins, blood cells have a reduced capacity to regenerate themselves. Results from a fourth protein, Prox1, showed the reverse effect: their presence hinders the reproduction of blood cells.

"Understanding which proteins control the production of blood-making stem cells is crucial knowledge for designing therapies for diseases caused by unruly HSCs" explains Dr. Sauvageau, "Now that we recognize the key roles that these proteins play, we can evaluate their potential as therapeutic targets to treat a variety of diseases such as leukemia."


'/>"/>

Contact: Carolyne Lord
carolyne.lord@umontreal.ca
514-343-7282
University of Montreal
Source:Eurekalert

Related medicine news :

1. Parkinsons Transplant Mystery Solved, Researchers Say
2. Researchers suggest new paradigm for breast cancer screening
3. Of lice and man: Researchers sequence human body louse genome
4. AcademyHealth honors leading health services researchers
5. UCLA researchers, US military collaborate to open center for traumatic brain injury
6. UCSD researchers receive $2.5 million in new stem cell grants
7. Researchers find key to getting estrogens benefits without cancer risk
8. Mount Sinai researchers find structural basis for incidence of skin cancers in a genetic disorder
9. WSU researchers find mothers of children with autism pay price in workplace
10. Free Resources from EBSCO Publishing Providing Useful Information to Researchers
11. University of Utah researchers fight genetic killer of infants and toddlers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... The Florida Hospital Tampa ... Hyperbaric Medical Society (UHMS), the leading authority in hyperbaric medicine. This accreditation identifies ... few hospitals and facilities have earned this distinction. This is the second time ...
(Date:12/8/2016)... ... December 08, 2016 , ... Mirixa ... (MTM), adherence, and other pharmacist-delivered patient care services, has announced the promotions of ... Hoessel to vice president of sales. , Litsinger joined Mirixa in 2008 ...
(Date:12/8/2016)... ... December 08, 2016 , ... SunView Software aims to ... that are both engaging and easy to use. Coming off the heels of ... revealed today its plans to roll out new AI-powered self-service enhancements to help ...
(Date:12/8/2016)... ... December 08, 2016 , ... California Senate Bill (SB) 863, signed into ... claim in 2013 and 2014, according to CompScope™ Medical Benchmarks for California, 17th ... According to the study, medical payments per claim in California decreased 4 percent in ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... services from offices headquartered in Hamilton County, is embarking on a charity drive ... specializes in finding new homes for orphaned or neglected senior dogs in the ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... , Dec. 9, 2016  RxWiki Inc., a digital ... digital marketing strategies of thousands of pharmacies through its ... Austin Inno,s "50 on Fire" Award in ... "We,re pleased to accept the award as one of ... Chief Executive Officer at RxWiki. "Our platform gives independent ...
(Date:12/8/2016)... , Dec. 8, 2016 IRIDEX Corporation (NASDAQ: ... newly issued shares of common stock, $0.01 par value (the ... underwritten public offering.  The final terms of the Offering will ... pricing, and there can be no assurance as to whether ... expects to use the net proceeds it will receive from ...
(Date:12/8/2016)... , Dec. 8, 2016 Global Interventional ... on the global interventional radiology market analyzes the ... report comprises an elaborate executive summary, including a ... segments and sub-segments. The research is a ... formed the bulk of our research efforts along ...
Breaking Medicine Technology: