Navigation Links
Researchers identify enzyme that regulates degradation of damaged proteins
Date:9/27/2011

A study by scientists at the University of California, San Diego and UC Irvine has identified an enzyme called a proteasome phosphatase that appears to regulate removal of damaged proteins from a cell. The understanding of how this process works could have important implications for numerous diseases, including cancer and Parkinson's disease.

The study led by Jack E. Dixon, PhD, professor of Pharmacology, Cellular & Molecular Medicine, and Chemistry/Biochemistry at the University of California, San Diego and Vice President and chief scientific officer of the Howard Hughes Medical Institute appears this week in the online edition of Proceedings of the National Academy of Sciences (PNAS).

Proteasomes are very large protein complexes found in all eukaryote cells, in archaea (a group of single-celled microorganisms) and in some bacteria. These basket-like chambers are essential for removing damaged or misfolded proteins from the cell. The inability of a defective proteasome to destroy misfolded or damaged proteins can be cataclysmic.

Scientists have known for some time that the proteasome can be regulated by a process called phosphorylation a chemical process by which a phosphate is added to a protein in order to activate or deactivate it, and which plays a crucial role in biological functions, controlling nearly every cellular process, including metabolism, gene transcription and translation, cell movement, and cell death. However, researchers had a poor understanding of the kinases that put the phosphate residues on the proteasome and almost no understanding of the phosphatases that remove the phosphates.

Now researchers have described for the first time how a eukaryotic phosphatase known as ubiquitin-like domain-containing C-terminal phosphatase (UBLCP1) regulates nuclear proteasome activity, revealing that UBLCP1 decreases proteasome activity by selectively dephosphorylating the proteasome.

"So far, UBLCP1 is the only proteasome-specific phosphatase identified to exist in mammalian cells," said Dixon. "We are just beginning to understand how it alters proteasome activity, but one can anticipate that defects in the phosphatase activity are likely to result in major alterations in the ability of the cell to remove damaged protein."


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. UTHealth researchers train promotoras to combine mobile technology, cancer prevention messages
2. Researchers uncover gene associated with blood cancers
3. Boston researchers share in $10 million grant to study HIV and alcohol
4. Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
5. Decoding vaccination: Mayo researchers reveal genetic underpinnings of response to measles vaccine
6. Researchers discover how promiscuous parasites hijack host immune cells
7. Buyer beware: Advertising may seduce your brain, UCLA researchers say
8. Researchers Find Link Between Epilepsy, Schizophrenia Risk
9. Researchers identify components that keep immune system in check
10. Researchers identify potential molecular target to prevent growth of cancer cells
11. Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... ... critical to ensuring high-quality results and maintaining GMP and USP compliance. In a ... in accordance with GMP requirements " these requirements are explained. The challenge ...
(Date:3/28/2017)... ... March 28, 2017 , ... With less than 10,000 dermatologists ... to quality care can be limited while the desire to conquer breakouts and eliminate ... acne care for every customer online, today released its inaugural survey on the State ...
(Date:3/28/2017)... Ohio (PRWEB) , ... March 28, 2017 , ... Columbus ... was selected as one of few medical professionals in the country to sit on ... Founder of Juvly Aesthetics, in just 2 years Dr. Harper helped propel the clinic ...
(Date:3/28/2017)... PA (PRWEB) , ... March 28, 2017 , ... Public ... and across a variety of business channels. , While many results are clear, ... any public relations program. , When it comes to measurement, firms should always ...
(Date:3/28/2017)... ... ... a common and unwelcomed occurrence in people of all ages, genders and ethnicities. Dermatologist Dr. ... of dealing with excess skin oil. “Oily skin is a challenge to many of my ... the oily shine while keeping the skin fresh and clean,” says Dr. Au. , What ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... , March 28, 2017  "US Cancer Generics ... the various indicators and trend analysis related to ... in mainstream pharmaceutical market in US. The report ... the growth on cancer generics drugs in recent ... saving of billions of dollars for various stake ...
(Date:3/28/2017)... -- Orexigen Therapeutics, Inc. (Nasdaq: OREX ) today ... and year ended December 31, 2016. ... Orexigen, beginning with the re-acquisition of the rights to ... team at Orexigen demonstrated remarkable focus, executing on a ... our Company while rewarding us full control of our ...
(Date:3/28/2017)... , March 28, 2017 ... consolidated vendor landscape, with the top three companies, namely ... accounting for a significant 49% of the overall market ... report. The vendor landscape is intensely competitive and has ... the overall market. These factors have restricted the entry ...
Breaking Medicine Technology: