Navigation Links
Researchers identify enzyme that regulates degradation of damaged proteins
Date:9/27/2011

A study by scientists at the University of California, San Diego and UC Irvine has identified an enzyme called a proteasome phosphatase that appears to regulate removal of damaged proteins from a cell. The understanding of how this process works could have important implications for numerous diseases, including cancer and Parkinson's disease.

The study led by Jack E. Dixon, PhD, professor of Pharmacology, Cellular & Molecular Medicine, and Chemistry/Biochemistry at the University of California, San Diego and Vice President and chief scientific officer of the Howard Hughes Medical Institute appears this week in the online edition of Proceedings of the National Academy of Sciences (PNAS).

Proteasomes are very large protein complexes found in all eukaryote cells, in archaea (a group of single-celled microorganisms) and in some bacteria. These basket-like chambers are essential for removing damaged or misfolded proteins from the cell. The inability of a defective proteasome to destroy misfolded or damaged proteins can be cataclysmic.

Scientists have known for some time that the proteasome can be regulated by a process called phosphorylation a chemical process by which a phosphate is added to a protein in order to activate or deactivate it, and which plays a crucial role in biological functions, controlling nearly every cellular process, including metabolism, gene transcription and translation, cell movement, and cell death. However, researchers had a poor understanding of the kinases that put the phosphate residues on the proteasome and almost no understanding of the phosphatases that remove the phosphates.

Now researchers have described for the first time how a eukaryotic phosphatase known as ubiquitin-like domain-containing C-terminal phosphatase (UBLCP1) regulates nuclear proteasome activity, revealing that UBLCP1 decreases proteasome activity by selectively dephosphorylating the proteasome.

"So far, UBLCP1 is the only proteasome-specific phosphatase identified to exist in mammalian cells," said Dixon. "We are just beginning to understand how it alters proteasome activity, but one can anticipate that defects in the phosphatase activity are likely to result in major alterations in the ability of the cell to remove damaged protein."


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. UTHealth researchers train promotoras to combine mobile technology, cancer prevention messages
2. Researchers uncover gene associated with blood cancers
3. Boston researchers share in $10 million grant to study HIV and alcohol
4. Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
5. Decoding vaccination: Mayo researchers reveal genetic underpinnings of response to measles vaccine
6. Researchers discover how promiscuous parasites hijack host immune cells
7. Buyer beware: Advertising may seduce your brain, UCLA researchers say
8. Researchers Find Link Between Epilepsy, Schizophrenia Risk
9. Researchers identify components that keep immune system in check
10. Researchers identify potential molecular target to prevent growth of cancer cells
11. Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Pixel Film ... Pro X. , "Film editors can give their videos a whole new perspective by ... Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Global Market - Forecast to 2022" report to their ... treatment method for the patients with kidney failure, it replaces ... fluid from the patient,s blood and thus the treatment helps ... and chloride in balance. Increasing number of ...
Breaking Medicine Technology: