Navigation Links
Researchers identify enzyme that regulates degradation of damaged proteins
Date:9/27/2011

A study by scientists at the University of California, San Diego and UC Irvine has identified an enzyme called a proteasome phosphatase that appears to regulate removal of damaged proteins from a cell. The understanding of how this process works could have important implications for numerous diseases, including cancer and Parkinson's disease.

The study led by Jack E. Dixon, PhD, professor of Pharmacology, Cellular & Molecular Medicine, and Chemistry/Biochemistry at the University of California, San Diego and Vice President and chief scientific officer of the Howard Hughes Medical Institute appears this week in the online edition of Proceedings of the National Academy of Sciences (PNAS).

Proteasomes are very large protein complexes found in all eukaryote cells, in archaea (a group of single-celled microorganisms) and in some bacteria. These basket-like chambers are essential for removing damaged or misfolded proteins from the cell. The inability of a defective proteasome to destroy misfolded or damaged proteins can be cataclysmic.

Scientists have known for some time that the proteasome can be regulated by a process called phosphorylation a chemical process by which a phosphate is added to a protein in order to activate or deactivate it, and which plays a crucial role in biological functions, controlling nearly every cellular process, including metabolism, gene transcription and translation, cell movement, and cell death. However, researchers had a poor understanding of the kinases that put the phosphate residues on the proteasome and almost no understanding of the phosphatases that remove the phosphates.

Now researchers have described for the first time how a eukaryotic phosphatase known as ubiquitin-like domain-containing C-terminal phosphatase (UBLCP1) regulates nuclear proteasome activity, revealing that UBLCP1 decreases proteasome activity by selectively dephosphorylating the proteasome.

"So far, UBLCP1 is the only proteasome-specific phosphatase identified to exist in mammalian cells," said Dixon. "We are just beginning to understand how it alters proteasome activity, but one can anticipate that defects in the phosphatase activity are likely to result in major alterations in the ability of the cell to remove damaged protein."


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. UTHealth researchers train promotoras to combine mobile technology, cancer prevention messages
2. Researchers uncover gene associated with blood cancers
3. Boston researchers share in $10 million grant to study HIV and alcohol
4. Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
5. Decoding vaccination: Mayo researchers reveal genetic underpinnings of response to measles vaccine
6. Researchers discover how promiscuous parasites hijack host immune cells
7. Buyer beware: Advertising may seduce your brain, UCLA researchers say
8. Researchers Find Link Between Epilepsy, Schizophrenia Risk
9. Researchers identify components that keep immune system in check
10. Researchers identify potential molecular target to prevent growth of cancer cells
11. Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... Erlanger Agency has announced ... Columbus, OH area. The latest campaign focuses on the fight against breast cancer, fundraising ... now being accepted here . , Carmen is a loving single mother of ...
(Date:2/12/2016)... ... February 12, 2016 , ... For Coast Dental dentist Everet ... RDH, and dental assistant Terrell Moore shortly before 7 a.m. to volunteer at Friday’s ... professionals, donating their time and skills to help hundreds of uninsured and underinsured people ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... High-Cost Drug Categories: Strategies for Health Plans and PBMs,” an upcoming Feb. 24 ... maintain affordability and access in big-dollar therapeutic categories, such as the $1,000-per-pill hepatitis ...
(Date:2/12/2016)... ... ... Healthcare careers in the medical laboratory, nursing, and in the imaging field topped ... leader Aureus Medical Group during the month of January. Aureus Medical specializes in placing ... in travel and direct hire opportunities in other allied health fields. , The jobs ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Basketball is ... and integral part of the Peety PoppersTM series, sign language translation is featured in ... of health and wellness in Peety PoppersTM lessons has a sign language translator to ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... februari 2016 AAIPharma Services Corp./Cambridge ... van productie en ontwikkeling op maat voor ... een uitbreiding aan van steriele vul- en ... Charleston, SC . Substantiële ... recente investeringen. http://photos.prnewswire.com/prnh/20150806/256637LOGO ...
(Date:2/12/2016)... --> ... Global Clinical Trials Review, H2, 2015 provides an ... trials landscape along with top level data related ... & E7), Trial Status, Trial Phase, Sponsor Type ... involved and enlists all trials (Trial title, Phase, ...
(Date:2/11/2016)... -- Stem cells are primitive cells found in all ... capacity to differentiate into mature cell types Stem cells ... mouse embryonic stem cells were derived from embryos in ... first culturing of embryonic stem cells from non-human primates ... 2006 As a result of these discoveries, stem cells ...
Breaking Medicine Technology: