Navigation Links
Researchers identify early biomarker for future atopy in asymptomatic children

The signs of atopy may be present long before symptoms begin, even in month-old babies, according to a new research study from Denmark. The study found that the level of urinary eosinophil protein-X (u-EPX), a marker of inflammatory cells, in newborn babies was linked to higher risk of allergic sensitization, nasal eosinophilia and eczema at six years.

The study appeared online in advance of the print publication of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

"We asked whether the allergic disease process may be active prior to the development of symptoms, and if so, whether there are biomarkers that could be clinically useful in predicting the development of disease," said principle investigator Hans Bisgaard, MD, DMSci, professor of pediatrics at the University of Copenhagen. "We found that in babies born to asthmatic mothers, urine levels of eosinophil protein-X may predict the development of allergic symptoms."

The researchers measured the levels of u-EPX and several other markers of inflammation in 369 healthy month-old infants who were enrolled in the Copenhagen Prospective Study on Asthma in Childhood (COPSAC), a birth cohort study of symptom-free month-old children born to asthmatic mothers.

The children were evaluated for allergic sensitization to 16 common inhalant and food allergens at 6 months, 18 months, 4 years and 6 years. Their blood eosinophil count was also taken at these intervals. Nasal eosinophilia was investigated by nasal scraping in the child's sixth year of life, and allergic rhinitis was diagnosed by age six based on interviews of parents and the child's history of symptoms. Asthma-like symptoms, and diagnoses of asthma and eczema were also noted.

In the first year of life, four percent of the children developed asthma-like symptoms and more than one-quarter (27 percent) were diagnosed with eczema. Another 17 percent went on to develop asthma-like symptoms and 15 percent developed eczema by age six.

When the researchers analyzed the data for associations between infant levels of u-EPX and future symptoms and diagnoses, they found that elevated u-EPX at one month was associated with 49 percent increase in risk of allergic sensitization, an association that was statistically significant for both food and aeroallergens. High u-EPX was also associated with a three-fold risk of developing nasal eosinophilia, indicating allergic inflammation of the upper airways. Finally, infants whose u-EPX was in the top quartile had a 40 percent greater risk for developing eczema by the age of six than those in the lower three quartiles.

"These data suggest that there is early life eosinophilic activation prior to symptom debut in children developing atopy-related conditions," said Dr. Bisgaard. "The mechanism behind the apparent pre-symptom eosinophilic activation in very young children is still unknown, but this study suggests that there is an ongoing pathogenesis in these children that begins well before symptom onset and includes the activation of eosinophil granulocytes."

Dr. Bisgaard noted that the current findings support similar findings of previous studies done in the same cohort. "These findings are in line with our previous studies, one where we saw increased concentration of exhaled nitric oxide in the breath of these healthy babies preceding later development of lung symptoms, and one that showed an association between bacterial colonization in the airways and later risk of asthma. Together, these three studies support the concept that a disease process is present long before symptoms become present'a patient is a patient before he is diagnosed as a patient' and that the disease originates very early in life," he said.

"This knowledge may help us identify the highest risk groups of children from a very early age for targeted prevention as well as individualized intervention and treatment," he continued. "This has redirected our research into what causes asthma, eczema and allergy, and we are now focusing on events in the first months of life or before birth."


Contact: Keely Savoie
American Thoracic Society

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
(Date:12/1/2015)... Wilmington, Delaware (PRWEB) , ... December 01, 2015 ... ... award winner at the 7th Annual 2015 Golden Bridge Business Awards under the ... is a zero capex web based sample management software that ...
(Date:12/1/2015)... ... 01, 2015 , ... The importance of volumetric breast density ... of numerous abstracts accepted for presentation here, at the 101st Annual Radiology Society ... the use of Volpara Solutions’ quantitative breast imaging software tools for providing breast ...
(Date:12/1/2015)... CA (PRWEB) , ... December 01, 2015 , ... ... Health Center of Excellence (BHCOE) today announced that the organization has awarded Education ... San Francisco, with a Distinguished Award. The award celebrates exceptional special needs providers ...
(Date:12/1/2015)... ... December 01, 2015 , ... TCS ... care management and population health arenas, is pleased to announce that VIP Care ... services, has successfully implemented the ACUITY Complete Care™ Management to back their collaborative ...
(Date:12/1/2015)... ... December 01, 2015 , ... With FCPX Overlay: Grit , users can ... customization, the possibilities are truly endless, all with a click of a mouse. Each ... flip, horizontal flip, depth of field and more, all within Final Cut Pro X. ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , December 1, 2015 ... market research report "Nucleic Acid Labeling Market by Product ... Translation, Random Primer, In Vitro Transcription, Reverse Transcription, End ... by MarketsandMarkets, The global market is expected to reach ... in 2015, growing at a CAGR of 8.65%. ...
(Date:12/1/2015)... 01, 2015 ... "Veterinary Equipment and Disposables Market by product, by ... to their offering. --> ) ... Equipment and Disposables Market by product, by Animal ... their offering. --> Research and Markets ...
(Date:12/1/2015)... 1, 2015  Today, AmerisourceBergen, a ... CareFront, a first-of-its-kind population health management program focused ... Designed to be built into existing employer benefit ... resources for their care and explains how to ... tools to help patients understand their treatment options ...
Breaking Medicine Technology: