Navigation Links
Researchers identify early biomarker for future atopy in asymptomatic children
Date:7/6/2011

The signs of atopy may be present long before symptoms begin, even in month-old babies, according to a new research study from Denmark. The study found that the level of urinary eosinophil protein-X (u-EPX), a marker of inflammatory cells, in newborn babies was linked to higher risk of allergic sensitization, nasal eosinophilia and eczema at six years.

The study appeared online in advance of the print publication of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

"We asked whether the allergic disease process may be active prior to the development of symptoms, and if so, whether there are biomarkers that could be clinically useful in predicting the development of disease," said principle investigator Hans Bisgaard, MD, DMSci, professor of pediatrics at the University of Copenhagen. "We found that in babies born to asthmatic mothers, urine levels of eosinophil protein-X may predict the development of allergic symptoms."

The researchers measured the levels of u-EPX and several other markers of inflammation in 369 healthy month-old infants who were enrolled in the Copenhagen Prospective Study on Asthma in Childhood (COPSAC), a birth cohort study of symptom-free month-old children born to asthmatic mothers.

The children were evaluated for allergic sensitization to 16 common inhalant and food allergens at 6 months, 18 months, 4 years and 6 years. Their blood eosinophil count was also taken at these intervals. Nasal eosinophilia was investigated by nasal scraping in the child's sixth year of life, and allergic rhinitis was diagnosed by age six based on interviews of parents and the child's history of symptoms. Asthma-like symptoms, and diagnoses of asthma and eczema were also noted.

In the first year of life, four percent of the children developed asthma-like symptoms and more than one-quarter (27 percent) were diagnosed with eczema. Another 17 percent went on to develop asthma-like symptoms and 15 percent developed eczema by age six.

When the researchers analyzed the data for associations between infant levels of u-EPX and future symptoms and diagnoses, they found that elevated u-EPX at one month was associated with 49 percent increase in risk of allergic sensitization, an association that was statistically significant for both food and aeroallergens. High u-EPX was also associated with a three-fold risk of developing nasal eosinophilia, indicating allergic inflammation of the upper airways. Finally, infants whose u-EPX was in the top quartile had a 40 percent greater risk for developing eczema by the age of six than those in the lower three quartiles.

"These data suggest that there is early life eosinophilic activation prior to symptom debut in children developing atopy-related conditions," said Dr. Bisgaard. "The mechanism behind the apparent pre-symptom eosinophilic activation in very young children is still unknown, but this study suggests that there is an ongoing pathogenesis in these children that begins well before symptom onset and includes the activation of eosinophil granulocytes."

Dr. Bisgaard noted that the current findings support similar findings of previous studies done in the same cohort. "These findings are in line with our previous studies, one where we saw increased concentration of exhaled nitric oxide in the breath of these healthy babies preceding later development of lung symptoms, and one that showed an association between bacterial colonization in the airways and later risk of asthma. Together, these three studies support the concept that a disease process is present long before symptoms become present'a patient is a patient before he is diagnosed as a patient' and that the disease originates very early in life," he said.

"This knowledge may help us identify the highest risk groups of children from a very early age for targeted prevention as well as individualized intervention and treatment," he continued. "This has redirected our research into what causes asthma, eczema and allergy, and we are now focusing on events in the first months of life or before birth."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/25/2017)... ... 2017 , ... Norland at Swissray is pleased to announce the release of the ... ELITE DXA has an active scan window, which is more than double that of existing ... scan area could not undergo an accurate total body bone density or body composition study. ...
(Date:3/24/2017)... New York, NY (PRWEB) , ... March 24, ... ... a global scale; from third world countries to hospitals in the United States, ... sparks a conversation on the current obstacles facing infection prevention and offers strategies ...
(Date:3/24/2017)... ... March 24, 2017 , ... Texas Physical Therapy Specialists (TexPTS) is pleased ... Huebner Road. The clinic is the group’s 7th location in San Antonio and 23rd ... PT, will provide care from the clinic, which opened March 22, 2017. ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... its innovative EcoQube Frame vertical micro-veggies garden on Kickstarter . Surpassing the ... product – with nearly 2,000 consumers (and counting) already backing the campaign. ...
(Date:3/24/2017)... Westchester County, NY (PRWEB) , ... March 24, 2017 , ... ... in Somers and White Plains, N.Y., is pleased to announce Westchester resident Lauren C. ... as a law clerk for the firm, will concentrate her practice in elder law, ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... in St. Joseph, Missouri , has selected AccuReg to help standardize ... 22 cities, and its flagship St. Joseph Medical Center. Mosaic Life Care ... to its patients, including the insurance, billing and collections processes. ... ... Joseph Medical Center ...
(Date:3/23/2017)... , March 23, 2017  Transportation Insight, a multi-modal ... end-to-end supply chain management firm with expertise serving clients ... Solutions Rick Zaffarano was named a 2017 ... Supply Chain by the only publication exclusively dedicated to ... supply chain. "Rick has brought to Transportation ...
(Date:3/23/2017)... -- As a result of diagnostic technology increasing ... allergic diseases, cutting edge developments in targeted drugs ... in which pharmaceutical and biotech companies are addressing ... both a high quality meeting and a platform ... research scholars and doctors. The event will also ...
Breaking Medicine Technology: