Navigation Links
Researchers identify components that keep immune system in check
Date:9/19/2011

CHAPEL HILL, N.C. Within the immune system, a subtle balance exists between the cells that destroy alien pathogens and those that preserve the body's own tissues. When the balance gets out of whack, the cells that normally target viruses or bacteria can go astray, attacking innocent cells and causing autoimmune and inflammatory disease.

Now, researchers at the University of North Carolina at Chapel Hill have revealed the genetic underpinnings of the cells called Foxp3-expressing regulatory T cells or Tregs that can prevent the immune response from turning cannibalistic. Their finding lends insight into these key cells, which are currently being tested as treatments for diseases such as type I diabetes, arthritis and lupus.

"Understanding how the immune system is controlled can give people a better, bigger picture of how these diseases can emerge and could help us find more effective therapies in the future," said senior study author Yisong Y. Wan, PhD, assistant professor of microbiology and immunology at the UNC School of Medicine.

The study, published online Sept. 15, 2011, in the journal Immunity, is the first to implicate a regulatory switch known as GATA-3 in Treg function and immune tolerance. The factor was known to regulate another type of immune cell, called a type-2 helper T cell, but its role in Tregs was unknown.

So Wan and his colleagues looked to see what would happen if they deleted the GATA-3 gene specifically in Tregs of mice. They found that the mutant mice developed a spontaneous inflammatory disorder, with abnormal immune cell invasion into tissues (Images). When they delved deeper, the scientists discovered that the Tregs were no longer able to suppress the immune system like they should. The researchers then traced this defect through the chain of command, from the Foxp3 that regulates Treg function (hence the name Foxp3-expressing regulatory T cells), up to the GATA-3 that regulates Foxp3.

Having uncovered this previously unknown function of GATA-3, Wan would now like to see what else this important master regulator may be controlling in immune cells. In particular, he is looking for components of the immune system that could be potential targets for correcting the underlying defects that lead to inflammatory and autoimmune diseases.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Related medicine news :

1. Researchers identify potential molecular target to prevent growth of cancer cells
2. Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test
3. Moffitt researchers find possible key to preventing chemotherapy resistance in ovarian cancer
4. $1.1 million grant targets disparities among medical researchers
5. Yale researchers use uterine stem cells to treat diabetes
6. Clemson researchers using interactive vision tool for driving studies
7. Researchers utilize neuroimaging to show how brain uses objects to recognize scenes
8. Researchers focus on secondary stroke prevention after study reveals room for improvement
9. Moffitt Cancer Center researchers use new tool to counter multiple myeloma drug resistance
10. Researchers find process that clears cholesterol and could reverse major cause of heart attack
11. Aerobic exercise may reduce the risk of dementia, Mayo Clinic researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify components that keep immune system in check
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension ... that it will receive two significant new grants to support its work to ... its 25th anniversary by recognizing patients, medical professionals and scientists for their work ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
Breaking Medicine Technology: