Navigation Links
Researchers identify components that keep immune system in check
Date:9/19/2011

CHAPEL HILL, N.C. Within the immune system, a subtle balance exists between the cells that destroy alien pathogens and those that preserve the body's own tissues. When the balance gets out of whack, the cells that normally target viruses or bacteria can go astray, attacking innocent cells and causing autoimmune and inflammatory disease.

Now, researchers at the University of North Carolina at Chapel Hill have revealed the genetic underpinnings of the cells called Foxp3-expressing regulatory T cells or Tregs that can prevent the immune response from turning cannibalistic. Their finding lends insight into these key cells, which are currently being tested as treatments for diseases such as type I diabetes, arthritis and lupus.

"Understanding how the immune system is controlled can give people a better, bigger picture of how these diseases can emerge and could help us find more effective therapies in the future," said senior study author Yisong Y. Wan, PhD, assistant professor of microbiology and immunology at the UNC School of Medicine.

The study, published online Sept. 15, 2011, in the journal Immunity, is the first to implicate a regulatory switch known as GATA-3 in Treg function and immune tolerance. The factor was known to regulate another type of immune cell, called a type-2 helper T cell, but its role in Tregs was unknown.

So Wan and his colleagues looked to see what would happen if they deleted the GATA-3 gene specifically in Tregs of mice. They found that the mutant mice developed a spontaneous inflammatory disorder, with abnormal immune cell invasion into tissues (Images). When they delved deeper, the scientists discovered that the Tregs were no longer able to suppress the immune system like they should. The researchers then traced this defect through the chain of command, from the Foxp3 that regulates Treg function (hence the name Foxp3-expressing regulatory T cells), up to the GATA-3 that regulates Foxp3.

Having uncovered this previously unknown function of GATA-3, Wan would now like to see what else this important master regulator may be controlling in immune cells. In particular, he is looking for components of the immune system that could be potential targets for correcting the underlying defects that lead to inflammatory and autoimmune diseases.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Related medicine news :

1. Researchers identify potential molecular target to prevent growth of cancer cells
2. Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test
3. Moffitt researchers find possible key to preventing chemotherapy resistance in ovarian cancer
4. $1.1 million grant targets disparities among medical researchers
5. Yale researchers use uterine stem cells to treat diabetes
6. Clemson researchers using interactive vision tool for driving studies
7. Researchers utilize neuroimaging to show how brain uses objects to recognize scenes
8. Researchers focus on secondary stroke prevention after study reveals room for improvement
9. Moffitt Cancer Center researchers use new tool to counter multiple myeloma drug resistance
10. Researchers find process that clears cholesterol and could reverse major cause of heart attack
11. Aerobic exercise may reduce the risk of dementia, Mayo Clinic researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify components that keep immune system in check
(Date:9/21/2017)... ... September 21, 2017 , ... Promotional Communication:, Keeping Up with ... In the competitive world of drug and device marketing and promotion, drug and ... rules. , The FDA has issued two draft guidances that are the closest ...
(Date:9/21/2017)... ... , ... Bill Howe Plumbing’s mission is to create an employee friendly company, ... For over 37 years, they have operated with their mission at the foundation and ... Diego. They were chosen as the Best San Diego plumber in 2016, named a ...
(Date:9/21/2017)... , ... September 21, 2017 , ... The New England ... autism, announced today the election of Yie-Hsin Hung to the Board of Directors. ... our Board of Directors. Ms. Hung is an invaluable addition to our team,” said ...
(Date:9/21/2017)... ... 21, 2017 , ... A new addiction treatment service has ... when Virginia faces an opioid epidemic. , Last year, Virginia saw ... percent from 2015, underscoring the need for additional addiction treatment options. , Calyx ...
(Date:9/21/2017)... Payne, AL (PRWEB) , ... September 21, 2017 ... ... preparation provider with offices serving communities in northern Alabama and Georgia, is embarking ... breast cancer prevention by utilizing modern early detection methods. , US Breast ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... -- Consumer reviews on the independent review site Consumer Affairs ... for hearing aids, ranking it higher than Miracle Ear ™, ... ... Hearing Aids ... store that provides high performance, state-of-the-art, German-engineered hearing aids directly to ...
(Date:9/7/2017)... 7, 2017  Eli Lilly and Company (NYSE: ... streamline operations to more efficiently focus resources on ... structure. Global workforce reductions, including those from a ... impact approximately 3,500 positions. With ... savings of approximately $500 million that will begin ...
(Date:9/7/2017)... 7, 2017   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade cell and tissue hypothermic storage ... Mike Rice , President and CEO, will be presenting at ... Rodman & Renshaw 19 th Annual Global Investment Conference ... p.m. Pacific time). The conference is being held at the ...
Breaking Medicine Technology: