Navigation Links
Researchers identify 'carbohydrates in a coal mine' for cancer detection
Date:3/3/2014

Researchers at New York University and the University of Texas at Austin have discovered that carbohydrates serve as identifiers for cancer cells. Their findings, which appear in the journal Proceedings of the National Academy of Sciences, show how these molecules may serve as signals for cancer and explain what's going on inside these cells, pointing to new ways in which sugars function as a looking glass into the workings of their underlying structures.

"Carbohydrates can tell us a lot about what's going on inside of a cell, so they are potentially good markers for disease," said Lara Mahal, an associate professor in NYU's Department of Chemistry and the study's corresponding author. "Our study reveals how cancer cells produce certain 'carbohydrate signatures' that we can now identify."

Carbohydrates, or glycans, are complex cell-surface molecules that control multiple aspects of cell biology, including cancer metastasis. But less understood is the link between categories of cells and corresponding carbohydrate structures. That is, what do certain carbohydrates on a cell's surfaces tell us about its characteristics and inner workings or, more succinctly, how do you read a code backwards?

In the PNAS study, the researchers examined the role of microRNA, non-coding RNA that are regulators of the genome. Specific miRNAssuch as miR-200play a role in controlling tumor growth. Using microarray technology developed by NYU's Mahal, the team examined cancer cells in an effort to see how they generated a carbohydrate signature. Specifically, they mapped how miRNA controls carbohydrate signatures.

In their analysis, the researchers could see that miRNA molecules serve as major regulators of the cell's surface-level carbohydratesa discovery that showed, for the first time, that miRNA play a significant regulatory role in this part of the cell, also known as the glycome. Moreover, they could see which regulatory process was linked to specific carbohydrates.

"Carbohydrates aren't just telling you the type of cell they came from, but also by which process they were created," explains Mahal. "Our results showed that there are regulatory networks of miRNAs and that they are associated with specific carbohydrate codes."


'/>"/>
Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... ... June 24, 2017 , ... ... Located at 217 Portion Road in Lake Ronkonkoma, Dental365 offers patients high-quality and ... so that visits to the dentist fit into their patients’ busy lifestyles. Dental365 ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... the launch of Care Management Alerts and Dashboards, an innovative new service enabling ... Island. , RIQI’s Care Management Alerts and Dashboards provide near real-time data about ...
(Date:6/23/2017)... ... 2017 , ... Yesterday, U.S. Senate Republicans revealed details of ... replace the Affordable Care Act (ACA). Like the bill narrowly passed by the ... public health insurance program for low-income children, pregnant women, parents of dependent children, ...
(Date:6/23/2017)... ... 2017 , ... Dr. Ran Y. Rubinstein , a ... offering three new minimally invasive procedures to patients who want a younger and ... Rubinstein is excited to bring microneedling, microneedling facials, and platelet rich plasma (PRP) ...
(Date:6/23/2017)... ... ... Goodcents Deli Fresh Subs today announced the opening of a new restaurant in ... Kan. 66604 (near 21st and Gage). It is owned and operated by long-time Goodcents ... the Topeka and Bonner Springs, Kan. area. , “Goodcents has such a loyal ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)... Fla. , June 8, 2017  Less than ... that hit more than 200,000 companies, including hospital networks, ... being heralded as one of the largest online extortion ... in the healthcare market, it is imperative that providers ... protect their data from this — and many other ...
(Date:6/7/2017)... 2017  Diplomat Specialty Infusion Group, a brand of Diplomat Pharmacy, ... Iowa location. The ... features an ISO 7 cleanroom—the standard needed to compound intravenous (IV) ... level of pollutants. "Our new ... better serve our Iowa patients," said ...
(Date:6/1/2017)... BLUE BELL, Pa. , June 1, 2017 /PRNewswire/ ... Nutriceuticals (PRN) and Veterinarian Recommended Solutions (VRS), and KD ... direct investment in Nutriceutical Holdings by KD Pharma Group. ... Nutriceutical Holdings with the option to acquire the entire ... ideal partner in KD. They are committed to growing ...
Breaking Medicine Technology: