Navigation Links
Researchers identify breast cancer culprits
Date:8/17/2010

Scientists have discovered an accomplice in breast cancer a master control switch with the power to set off a cascade of reactions orchestrated by a cancer-causing gene (or oncogene) named Wnt1. This executive molecule and its modus operandi are reported in back-to-back papers featured on the cover of the August 15 issue of Cancer Research.

"These papers are about the regulation of a Wnt oncogene," explains lead author Rakesh Kumar, Ph.D., professor and the Catharine Birch & William McCormick Chair of the department of biochemistry and molecular biology at The George Washington University School of Medicine and Health Sciences. Now, Kumar and his team describe how a master switch sparks a type of Wnt signaling in breast cancer. Moreover, this master control switch may help explain why increased levels of a protein called MTA1 (metastasis-associated protein 1) are oncogenic in certain types of breast cancer.

Like many molecular pathways underlying cancer, Wnt pathways govern normal processes like embryonic development and the communication between cells in healthy people. For reasons little understood, however, certain types of Wnt proteins sometimes go awry, sending off cascades of signals that turn normal cells into cancerous ones. Researchers often find evidence of Wnt pathway activation when they analyze what genes are turned on in tumors. Although Wnt has been connected with breast cancer for nearly 30 years, however, the signals (other than mutations) that trigger it remain largely unknown.

Kumar and his team have implicated MTA1 and a shorter variation of the protein, MTA1s, in Wnt1 (a type of Wnt) pathway activation. MTA1 belongs to the MTA family of genes, which help a range of cancers progress in a variety of ways. Before this study, researchers knew that MTA1 levels were higher than normal in breast, ovarian, prostate, colorectal, gastric, liver tumors, and more. But they still didn't know everything about what MTA's
'/>"/>

Contact: Anne Banner
mcmacb@gwumc.edu
202-994-2261
George Washington University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gulf Oil Spill Still a Health Threat to Many, Researchers Report
2. Researchers identify potential new target for ovarian cancer
3. Amphetamine use increases risk of aortic tears in young adults, UT Southwestern researchers report
4. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
5. In NIH-funded study, researchers uncover step in brain events leading up to addiction
6. Researchers develop magnetic molecular machines to deliver drugs to unhealthy cells
7. UCLA researchers discover protein that shuttles RNA into cell mitochondria
8. Help wanted: Highly cited researchers needed for high-ranking positions at research institutions
9. NIST researchers measure high infrared power levels from some green lasers
10. Mayo Clinic researchers share latest findings in CT radiation dose reduction efforts
11. Researchers develop advanced search tool to help physicians sort and retrieve vital EMR data
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... New York (PRWEB) July 26, 2014 ... filed in state and federal litigations since the 2012 ... has surpassed 3,700 filings, Bernstein Liebhard LLP reports. According ... at least 2,064 cases have been filed in the ... Rejuvenate Hip Stem and the ABG II Modular Hip ...
(Date:7/26/2014)... York, NY (PRWEB) July 26, 2014 ... Infosecurity magazine on July 23rd, new research by Palo ... starting to rewrite their playbook, now focusing more on ... en masse who have become increasingly wise to their ... founder and CEO/CTO, Joe Caruso, talks about the ...
(Date:7/26/2014)... ON (PRWEB) July 26, 2014 Studio B ... type of implant, often called Teeth in a Day, gives ... with a full set of bright, pearly whites with very ... teeth are permanent, look and feel just like natural teeth, ... and regular checkups. Studio B Dental is one of ...
(Date:7/26/2014)... 2014 According to the Banish My ... a comprehensive guide that covers detailed instructions on how ... the need of any medication. , Vkool reveals ... and safe remedies for relieving symptoms of keratosis pilaris ...     How to treat children's keratosis pilaris ...
(Date:7/25/2014)... 26, 2014 PersonalInjurySolicitorsIreland, a legal ... to people who have suffered from a variety ... both their new company, and a website, ... new website explained, http://www.personalinjurysolicitorsireland.com/personal-injury-claims , the law ... of the company is always on the client, ...
Breaking Medicine News(10 mins):Health News:Stryker Hip Lawsuit Filings in State and Federal Litigations Continue to Rise, Bernstein Liebhard LLP Reports 2Health News:Stryker Hip Lawsuit Filings in State and Federal Litigations Continue to Rise, Bernstein Liebhard LLP Reports 3Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 2Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 3Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 4Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 5Health News:Businesses the New Target for Nigeria’s 419 Cyber-Scammers 6Health News:Studio B Dental Improves Patient Smiles with All-on-Four Dental Implants 2Health News:Banish My Bumps Pdf Review Exposes Angela Steinberg's Keratosis Pilaris Treatment Plan – Vkool.com 2Health News:Banish My Bumps Pdf Review Exposes Angela Steinberg's Keratosis Pilaris Treatment Plan – Vkool.com 3Health News:PersonalInjurySolicitorsIreland.com Announces the Launch of their New Company and Website 2
... in diagnosing the condition, study says , , FRIDAY, Sept. 28 ... before, during or after pregnancy, a new study finds. , ... her baby and her entire family, according to the report ... of Psychiatry . , "The prevalence of women diagnosed with ...
... with important information on the use, of aspirin in the prevention ... ... strokes -, SILVER SPRING, Md., Sept. 28 Discovery Health ... and,secondary prevention of cardiovascular and cerebral-vascular events.,Premiering Sunday, September 30, at 9 ...
... Simcere,s Leading Position in China,s Stroke ... ... -- Simcere Pharmaceutical,Group (NYSE: SCR; "Simcere"), the manufacturer of the ... generic pharmaceuticals in China, today announced that it has,entered into ...
... for Medical Equipment/Healthcare IT, Facility Design Consulting, Building ... and NEW YORK, Sept. 28 ,Susquehanna Health has ... range,of technology and service solutions for a master ... Valley Hospital, Divine,Providence Hospital, Hepburn Plaza and The ...
... GOLDEN, Colo., Sept. 28 ABR-Affinity,BioReagents, a ... an expanded 100% Quality Guarantee. Launched ... was,established to bolster confidence in research antibodies. ... building blocks of early-stage life science,research and ...
... With audience members cheering and,famous Chicago chefs watching their ... the finalists at Consorta,s Battle of the Hospital,Chefs. ... organic cucumbers he,serves the patients at Saint Mary,s Health ... Gold Chef Award, becoming the reigning champion of,chefs among ...
Cached Medicine News:Health News:15% of Women Struggle With Pregnancy-Related Depression 2Health News:15% of Women Struggle With Pregnancy-Related Depression 3Health News:Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits 2Health News:Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits 3Health News:Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits 4Health News:Simcere Pharmaceutical Group Acquires a 51% Stake in Boda Pharmaceutical Co., Ltd. 2Health News:Simcere Pharmaceutical Group Acquires a 51% Stake in Boda Pharmaceutical Co., Ltd. 3Health News:Simcere Pharmaceutical Group Acquires a 51% Stake in Boda Pharmaceutical Co., Ltd. 4Health News:Susquehanna Health and Siemens Announce Plans to Improve Hospital Facilities Through Technology Investment 2Health News:Susquehanna Health and Siemens Announce Plans to Improve Hospital Facilities Through Technology Investment 3Health News:ABR-Affinity BioReagents Expands 100% Quality Guarantee 2Health News:National Battle of the Hospital Chefs Cooks Up a Winner 2
(Date:7/25/2014)... , July 25, 2014  Corporate libraries are constantly ... new advancements in technology and how to cope with ... in the pharmaceutical and medical device industries are increasingly ... information and services they provide. According ... there are many forces of change that leading corporate ...
(Date:7/25/2014)... , July 25, 2014  In today,s marketplace, ... costly and challenging - as is managing a portfolio ... Is it possible - or even preferable - ... so, where can you combine resources and activities, and ... These are just a few of the ...
(Date:7/25/2014)... -- "Australia Capsule Endoscopy Systems Market Outlook to 2020″, ... Systems market. The report provides value, in millions of ... US dollars) within market segments: Photo - ... , Capsule Endoscopy Data Recorders , Capsule ... company shares and distribution shares data for each of ...
Breaking Medicine Technology:Forces of Change Reshaping Corporate Libraries & Information Services 2Using Promotional Efficiency to Support Multiple Products and Indications in the Pharmaceutical Marketplace 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 3Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 4Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 5
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: