Navigation Links
Researchers identify and shut down protein that fuels ovarian cancer
Date:2/26/2008

ents diagnosed and treated between 1988 and 2006 at M. D. Anderson and the University of Iowa. Of those, 43 had tumors with high levels of IL-8 and 59 had low levels. The median survival of those with high IL-8 tumors was 1.62 years, compared with 3.79 years for those with low expression of the protein.

All 43 tumors with high expression of IL-8 were of high grade and 42 of 43 were advanced, either stage III or IV tumors. By comparison, 10 of 59 tumors with low IL-8 expression were early stage tumors and six were of low grade.

Shrinking tumors

Genes transcribe single strands of RNA that in turn are "read" by ribosomes to produce proteins. siRNAs are short, double-stranded bits of RNA capable of halting that process. The team confirmed in a lab experiment that a specific siRNA silences IL-8 and then tested it against two lines of ovarian cancer in a mouse model.

Sood, Gabriel Lopez-Berestein, M.D., professor in M. D. Anderson's Department of Experimental Therapeutics, and colleagues are building an arsenal of siRNAs capable of silencing genes that produce cancer-promoting proteins. They packaged siRNA that stymies IL-8 into a small ball of fat known as a liposome, a combination they developed to overcome a problem - siRNA is hard to deliver to tumors.

Tumors shrank by a median of 32 percent and 52 percent in the two cancer lines among mice that received injections of the IL-8 siRNA liposome compared to those receiving control siRNA or empty liposomes.

Mice that got both the IL-8 siRNA plus the taxane-based chemotherapy drug docetaxel had median tumor weight reduction of 90 percent and 98 percent in the two cell lines. Mice with control siRNA plus docetaxel saw reductions of 67 and 84 percent.

Finally, they tested the approach in mice with an ovarian cancer cell line known to be resistant to taxane-based drugs such as docetaxel. IL-8 siRNA alone reduced the size of these tumors by 47 perc
'/>"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify and shut down protein that fuels ovarian cancer
(Date:8/30/2015)... , ... August 30, 2015 , ... ... platforms and devices, today announced it is a Silver Sponsor of the Digital ... Sky City Convention Centre in Auckland, NZ. Throughout the event, AvePoint will showcase ...
(Date:8/30/2015)... ... August 30, 2015 , ... InHealth Media ( ... new Global Communications Director for InHealth Media. Mr. Spector comes with a ... 16 years doing on-air television, producing shows, on air-radio and media relations. ...
(Date:8/30/2015)... ... August 30, 2015 , ... Nutritional Products ... lead the expansion of global cosmeceutical and skin care brands. Mr. Fernandez ... the last 25 years working in operations, purchasing and management for some of ...
(Date:8/29/2015)... ... ... Rio Salado College President Chris Bustamante announced on Aug. 19 ... Initiatives and Information Services. O’Shea, who has served Rio Salado for the last two ... through innovative technologies and strategies. , “I am very proud to be able to ...
(Date:8/29/2015)... PA (PRWEB) , ... August 29, 2015 , ... On ... the Mesothelioma Applied Research Foundation (Meso Foundation) will present an educational program ... at 7:00 PM and lasts through 9:30 PM (doors open at 6:45pm) at Calvary ...
Breaking Medicine News(10 mins):Health News:AvePoint Showcases the Future of Enterprise Collaboration as Silver Sponsor of the Digital Workplace Conference in New Zealand 2Health News:AvePoint Showcases the Future of Enterprise Collaboration as Silver Sponsor of the Digital Workplace Conference in New Zealand 3Health News:AvePoint Showcases the Future of Enterprise Collaboration as Silver Sponsor of the Digital Workplace Conference in New Zealand 4Health News:InHealth Media Appoints New Global Communications Director 2Health News:NPI Executive Vice President Leads Cosmeceutical Expansion 2Health News:Rio Salado College Appoints New Vice President of Strategic Initiatives and Information Services 2Health News:Mesothelioma Applied Research Foundation to Hold Educational Class About Asbestos and Mesothelioma Prevention 2
... Snowblowers are a great tool for those who get lots ... your driveway clear, they can also leave your fingers in ... surgeon from Loyola University Health System in Chicago says that ... amputations and extensive rehabilitation. "Every winter, we get three or ...
... Dotinga HealthDay Reporter , FRIDAY, Dec. 31 (HealthDay ... at an increasingly young age, with about one-third of them ... old, researchers have found. There are some caveats about ... were born about a decade ago. And it,s not clear ...
... Gordon HealthDay Reporter , THURSDAY, Dec. 30 (HealthDay ... holiday parties, hangovers are not uncommon. And while folk remedies ... the misery of a hangover the morning after are time ... of a hangover -- drinking too much alcohol -- is ...
... , , , , , , , ... , , , ... can be. Now a study led by researchers... , Click here for more information. ... , , , , , , ...
... Reporter , THURSDAY, Dec. 29 (HealthDay News) -- Following mothers, ... major health crisis. Fears of the H1N1 flu virus ... fearing a widespread outbreak caused by short supplies of the ... experts believe that,s because more people than ever before regularly ...
... By Ellin Holohan HealthDay Reporter , WEDNESDAY, Dec. ... may lead to less satisfying marriages because couples can fail ... new research suggests. The study, done at Brigham Young ... sex while they were dating were more likely to communicate, ...
Cached Medicine News:Health News:In U.S., Obesity Afflicts Even Some of the Tiniest Tots 2Health News:In U.S., Obesity Afflicts Even Some of the Tiniest Tots 3Health News:'Hair Of The Dog' No Hangover Cure, Say Experts 2Health News:'Hair Of The Dog' No Hangover Cure, Say Experts 3Health News:Consistent exercise associated with lower risk of colon cancer death 2Health News:Consistent exercise associated with lower risk of colon cancer death 3Health News:Hand-Washing May Have Kept Flu at Bay 2Health News:Hand-Washing May Have Kept Flu at Bay 3Health News:Delaying Sex Might Strengthen Marriage 2Health News:Delaying Sex Might Strengthen Marriage 3
(Date:8/28/2015)... 28, 2015 According to a ... (Breast, Lung, Prostate) Type (Protein & Genetic Biomarkers) Profiling ... Prognostic) & Geography - Global Forecast to 2020", published ... reach around 17,689.0 Million USD by 2020 at a ... to 2020. Browse 191 Tables and ...
(Date:8/28/2015)... Aug. 28, 2015 Research ... of the "Investigation Report on China,s Tobramycin Market, ... is a traditional antibiotic whose eye drop and ointment ... of potential infection or inflammation caused by eye infection. ... are able to produce tobramycin, among which the ...
(Date:8/28/2015)... , Aug. 28, 2015 ... the addition of the "Investigation Report on ... their offering. Developed by Novo Nordisk, ... is an important drug for the treatment of ... a fast- acting insulin analog, starts working fast ...
Breaking Medicine Technology:Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 2Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 3Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 4Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 5Investigation Report on China's Tobramycin Market, 2015-2019 2China Insulin Aspart Market Report 2010-2019 - Developed by Novo Nordisk 2
... ISPE announced today that it has brought ... pharmaceutical industry leaders to be plenary speakers at the ... Baltimore, Maryland, USA on 4 – 5 June 2012. ... the key CGMP issues affecting the pharmaceutical industry today.  ...
... Pharmaceuticals, Inc. (PINKSHEETS: GMPM.PK) a marketing and product ... everyday health and wellness, announced this afternoon, the ... for the Company,s 17-gram Gamma Energy GEL.  The ... Gamma will support sales with point of purchase ...
Cached Medicine Technology:Global Regulatory and Pharmaceutical Industry Leaders to Appear as Plenary Speakers at Joint FDA-ISPE CGMP Conference 2Gamma Pharmaceuticals, Inc. Announces Distribution Agreement for New York Tri-state Area and Purchase Order for Gamma Energy GEL™ 2Gamma Pharmaceuticals, Inc. Announces Distribution Agreement for New York Tri-state Area and Purchase Order for Gamma Energy GEL™ 3
... System is an automated multiplexing platform that ... detection, pathogen sequence detection and pharmacogenetics applications. ... applied to an open and flexible electronic ... reused until all tests sites have been ...
Cable connections for 5 different adapters: Storz, ACMI, Pentax, Wolf and Olympus....
... Mark The X & Y Coordinates At The ... Alignment. 11mm Inner Diameter & 13mm Outer Diameter ... Guess Work Associated With Hand-Held Markers By Mounting ... Housing To Ensure A More Perfect Mark. , ...
... • V-shaped bottom allows easy withdrawal ... facilitate pour-out ,• Nesting ring allows ... Basin designed for 4, 8, and 12 ... bottom permits withdrawal of practically all of ...
Medicine Products: