Navigation Links
Researchers identify and block protein that interferes with appetite-suppressing hormone
Date:4/17/2013

Ever since the appetite-regulation hormone called leptin was discovered in 1994, scientists have sought to understand the mechanisms that control its action. It was known that leptin was made by fat cells, reduced appetite and interacted with insulin , but the precise molecular details of its function details that might enable the creation of a new treatment for obesity remained elusive.

Now, University of Texas Medical Branch at Galveston researchers have revealed a significant part of one of those mechanisms, identifying a protein that can interfere with the brain's response to leptin. They've also created a compound that blocks the protein's action a potential forerunner to an anti-obesity drug.

In experiments with mice fed a high-fat diet, scientists from UTMB and the University of California, San Diego explored the role of the protein, known as Epac1, in blocking leptin's activity in the brain. They found that mice genetically engineered to be unable to produce Epac1 had lower body weights, lower body fat percentages, lower blood-plasma leptin levels and better glucose tolerance than normal mice.

When the researchers used a specially developed "Epac inhibitor" to treat brain-slice cultures taken from normal laboratory mice, they found elevated levels of proteins associated with greater leptin sensitivity. Similar results were seen in the genetically engineered mice that lacked the Epac1 gene. In addition, normal mice treated with the inhibitor had significantly lower levels of leptin in their blood plasma an indication that Epac1 also affected their leptin levels.

"We found that we can increase leptin sensitivity by creating mice that lack the genes for Epac1 or through a pharmacological intervention with our Epac inhibitor," said UTMB professor Xiaodong Cheng, lead author of a paper on the study that recently appeared on the cover of Molecular and Cellular Biology, available on the journal's Web site at '/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... Mediaplanet has joined forces with Raw ... the importance of proper sun protection. The print component ... a circulation of approximately 250,000 copies and an estimated ... nationally, through a vast social media strategy, and across ... To explore the digital version of the campaign, ...
(Date:5/29/2015)... La Mirada, Ca (PRWEB) May 29, 2015 ... services, including pain consultations with specialists, physical therapy, ... who are experiencing mid back and/or lower back ... offering lumbar epidural injections for herniated discs, disc ... spine pain . , Healthpointe’s team of ...
(Date:5/29/2015)... The Croatia Cosmetic Dentistry Center - ... on what modern dentistry options are available today. The ... to revolutionize the perception of a dental practice — ... Spa. , The top dental provider is partnered ... tourism agencies and led by world-renowned experts, Dr. ...
(Date:5/29/2015)... Cokato, MN (PRWEB) May 29, 2015 ... Patio and Metro series outdoor saunas have increased ... backyard landscaping projects, and work at summer cottages. ... has piqued interest in summer projects a few weeks ... and suburban communities with smaller lot sizes tend to ...
(Date:5/29/2015)... Michigan (PRWEB) May 29, 2015 Vulvodynia ... and can cause significant physical, sexual, and psychological distress. ... altering disorder of Vulvodynia. The actual diagnosis is often ... in Endometriosis, they realize that this problem can be ... experiencing any of these symptoms, they need to schedule ...
Breaking Medicine News(10 mins):Health News:Healthpointe’s Pain Management Specialists Now Providing Lumbar Epidural Injections in Los Angeles County 2Health News:Healthpointe’s Pain Management Specialists Now Providing Lumbar Epidural Injections in Los Angeles County 3Health News:Croatian Cosmetic Dentistry Providers New Approach to Revolutionize Cosmetic Dentistry 2Health News:Croatian Cosmetic Dentistry Providers New Approach to Revolutionize Cosmetic Dentistry 3Health News:As Summer Approaches, Finnleo Notes Increased Interest in Patio and Metro Outdoor Saunas 2
... , , , , , ... , , AUDIO: ... risk... , Click here for more information. , ... , , , , , ...
... -- A new Swedish study shows that severe asthma seems ... that those afflicted by it have a higher prevalence of ... pay more attention to nasal congestion and similar issues. ... west of Sweden and asked about their health, including whether ...
... HealthDay Reporter , THURSDAY, Dec. 29 (HealthDay News) ... in averting a major health crisis. Fears of the ... public health officials fearing a widespread outbreak caused by short ... and some health experts believe that,s because more people than ...
... (HealthDay News) -- Researchers report that they,ve gained insight into ... a role in how the body stores fat to protect ... seems to be linked to both insulin sensitivity and the ... connection between all these different phenomena," Dr. Philipp Scherer, a ...
... all unhealthy life habits that are already being detected in ... young people between the ages of 19 and 26. The ... at risk and even take into account those less than ... be drawn from the PhD thesis presented at the University ...
... News) -- The number of emergency department visits that involved ... Year,s Day two years ago, compared with other days of ... the U.S. Substance Abuse and Mental Health Services Administration found ... had something to do with underage drinking. The national average ...
Cached Medicine News:Health News:Risk for alcoholism linked to risk for obesity 2Health News:Risk for alcoholism linked to risk for obesity 3Health News:Risk for alcoholism linked to risk for obesity 4Health News:Chronic Nasal Congestion May Be Linked to Severe Asthma 2Health News:Hand-Washing May Have Kept Flu at Bay 2Health News:Hand-Washing May Have Kept Flu at Bay 3Health News:Research Sheds Light on 'Starvation Hormone' 2Health News:Prevention of bad lifestyle habits should be tackled even before 13 years 2Health News:Prevention of bad lifestyle habits should be tackled even before 13 years 3Health News:ER Visits by Underage Drinkers Spike on New Year's 2
(Date:5/28/2015)... May 28, 2015  Eli Lilly and Company (NYSE: ... announced cash tender offer for up to $1.6 billion aggregate ... Holders of notes who tendered, and did not validly ... New York City time, on May 27, 2015 ... by Lilly, are eligible to receive the total consideration. The ...
(Date:5/28/2015)... NEW YORK , May 28, 2015 ... billions developing new drugs and tests, and ... for the instruments that can assist them. This ... research publisher. Kalorama Information said instruments such as ... can assist in the identification of drug ...
(Date:5/28/2015)... , May 28, 2015 Henry ... largest provider of health care products and services ... today reminded its customers that the Henry Schein ... and veterinarians who experience operational, logistical or financial ... in the South Central region of the U.S. ...
Breaking Medicine Technology:Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 2Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 3Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 4Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 5Report: Proteomics Research Market Reaches $1.6 Billion 2Report: Proteomics Research Market Reaches $1.6 Billion 3Henry Schein Disaster Relief Hotline Is Open To Support Customers Affected By Storms In South Central, U.S. 2Henry Schein Disaster Relief Hotline Is Open To Support Customers Affected By Storms In South Central, U.S. 3
... unit provides a convenient reservoir of cooling water for ... an extended period of time or in a location ... cool the hot side of the thermoelectric heat pump. ... which is adequate to run the 900R for up ...
Punch set for Advanced Tissue Arrayer, 0.6 mm...
Inquire...
Inquire...
Medicine Products: