Navigation Links
Researchers identify a promising target for multiple sclerosis treatments
Date:3/19/2013

A team of basic and clinical scientists led by the University of Montreal Hospital* Research Centre's (CRCHUM) Dr. Nathalie Arbour has opened the door to significantly improved treatments for the symptoms of Multiple Sclerosis (MS). In a study selected as among the top 10% most interesting articles published in the Journal of Immunology, the team identifies the elevated presence in MS patients of a type of white blood cell (CD4 T cell) that expresses NKG2C, a highly-toxic molecule harmful to brain tissues.

In close collaboration with clinicians at the University of Montreal Hospital and the Montreal Neurological Institute, McGill University, Dr. Arbour's team studied tissues from healthy subjects and MS patients. This approach enabled the team to uncover a novel mechanism by which CD4 T cells expressing NKG2C can directly target brain cells having a specific corresponding ligand found only in MS patients. "These results are very encouraging," says Arbour, "since they provide us with a much more refined picture of how the brain cells of MS patients are targeted by the immune system and provide us with a clearer understanding of how to go about blocking their action."

There is no known cure for this auto-immune disease of the central nervous system. While there are a number of approved MS therapies targeting molecules expressed by immune cells, they are sometimes too broad in their application. They can suppress the efficiency of the immune system but also open the way for serious infections in some MS patients such as progressive multifocal leukoencephalopathy, a serious viral disease that can cause death in people with severe immune deficiency, such as MS patients on immunosuppressive medication.

"Our research has made an important step in getting around this problem. Because NKG2C is specifically expressed by a subset of CD4 T cells only found in MS patients, targeting this receptor would not affect large populations of immune
'/>"/>

Contact: Sylvie Robitaille
sylvie.robitaille.chum@ssss.gouv.qc.ca
514-890-8000 x15262
McGill University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Spanish researchers link cancer to failures in chromosome protection for the first time
2. Researchers devise hidden dune filters to treat coastal stormwater runoff
3. Leading Canadian health researchers honored
4. Researchers propose a novel prognostic model for disease-specific survival in BCa patients
5. More parents say they wont vaccinate daughters against HPV, researchers find
6. Kessler Foundation researchers share findings in rehabilitation research at AAN meeting in San Diego
7. Mayo Clinic and Illinois researchers develop new sensor for methylated DNA
8. Researchers advance fight against biggest hidden virus
9. Brain researcher James Poulet receives the 2013 Paul Ehrlich Prize for Young Researchers
10. Bradley Hospital researchers find age-related changes in how autism affects the brain
11. LA BioMed physician-researchers honored as top doctors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... August 29, 2014 When subjected to ... been found to be one of the most consistent ... DISC, MBTI, the Hartman Personality Profile, and the “Big ... testing personality. Each of these testing tools uses a ... type. Once personality type has been identified, the test ...
(Date:8/29/2014)... Hope For The Warriors® is pleased ... Scholarships are awarded two times each year to spouses ... of fallen service members. Hope For The Warriors® is ... self, restoring the family unit, and restoring hope for ... The Spouse/Caregiver Scholarship Program identifies, recognizes, and rewards spouses ...
(Date:8/29/2014)... Boca Raton, Florida (PRWEB) August 29, 2014 ... in which surgeons, like Dr. Scott Katzman of ... endoscopic instruments to view and perform repairs. Problems ... around the vertebrae cause a number of treatment needs ... This type spine surgery involves an advantageously small incision ...
(Date:8/29/2014)... The Berkowitz Law Firm LLC is proud ... included in the Personal Injury Litigation section of the ... is the longest-standing and most highly-respected peer-reviewed legal publication ... in Best Lawyers® is considered a significant honor in ... have earned the respect of their peers. To be ...
(Date:8/29/2014)... Asheville, NC (PRWEB) August 29, 2014 ... District in the North Carolina General Assembly, spent the ... Aeroflow Healthcare and touring our facilities. , Representative Moffitt’s ... Asheville based durable medical equipment (DME) company and to ... could impact DME providers such as Aeroflow. , ...
Breaking Medicine News(10 mins):Health News:DISC Personality Tests Demonstrate High Rates of “Test-Retest Reliability” 2Health News:DISC Personality Tests Demonstrate High Rates of “Test-Retest Reliability” 3Health News:Hope For The Warriors Announces Fall 2014 Spouse/Caregiver Scholarship Recipients 2Health News:Hope For The Warriors Announces Fall 2014 Spouse/Caregiver Scholarship Recipients 3Health News:Advancements in Spine Surgery Offered by this Modern Florida Surgery Group are Cutting Out Historically Demanding Recovery Times 2Health News:Russell J. Berkowitz, Esq. of The Berkowitz Law Firm LLC Selected by Best Lawyers® for Personal Injury Litigation 2Health News:North Carolina Representative Tim Moffitt Visits Aeroflow Healthcare 2
... first link between colorings, preservatives and behavioral woes , , ... colorings and preservatives appear to increase the risk of ... link between food additives and hyperactivity has long been ... a direct connection. , The findings have already caused ...
... issue briefs from,HealthFitness (OTC Bulletin Board: HFIT) underscore ... to create a culture of health. (Logo: ... New Culture of Health" features,HealthFitness CEO Gregg O. ... for corporations to address the high cost of ...
... Another timely move by,Florida-based medical manufacturer, Ultroid ... a former vice president for two,important medical distributors ... joins Ultroid after more than 20 years in ... product/name recognition" is,the reason behind acquiring the former ...
... Marijuana Use by Teen Boys,More Youths Starting Drug Use with Painkillers Than ... Drug ... use,among teens ages 12-17 is at a five year low, according to ... released today.,But when it comes to youth, nonmedical use of painkillers continues ...
... Two-month public awareness campaign with New Haven County Cutters scores, more than ... ... families, NORTH HAVEN, Conn., ... Blue Cross and Blue Shield in,Connecticut, today announced the completion of its ...
... UT Southwestern Medical Centers obesity research team has ... of Health to enhance its groundbreaking efforts to attack ... developing medicines. , The award, formally announced today, is ... NIH Roadmap for Medical Research. These groups seek to ...
Cached Medicine News:Health News:Food Additives Could Fuel Hyperactivity in Kids 2Health News:Food Additives Could Fuel Hyperactivity in Kids 3Health News:HealthFitness CEO Supports Move Toward Cultural Shift, and Science-Based Health Management Programming 2Health News:HealthFitness CEO Supports Move Toward Cultural Shift, and Science-Based Health Management Programming 3Health News:Painless Hemorrhoid Treatment Adds Management Punch 2Health News:Youth Drug Use at a Five Year Low, New Survey Shows 2Health News:Youth Drug Use at a Five Year Low, New Survey Shows 3Health News:BlueCare(R) Family Plan, a HUSKY Health Plan from Anthem Blue Cross and Blue Shield in Connecticut, Raises Awareness, Funds and Diapers for New Haven Diaper Bank 2Health News:BlueCare(R) Family Plan, a HUSKY Health Plan from Anthem Blue Cross and Blue Shield in Connecticut, Raises Awareness, Funds and Diapers for New Haven Diaper Bank 3Health News:UT Southwestern's obesity research receives $22 million NIH Roadmap grant 2Health News:UT Southwestern's obesity research receives $22 million NIH Roadmap grant 3Health News:UT Southwestern's obesity research receives $22 million NIH Roadmap grant 4
(Date:8/29/2014)... ANDOVER, Mass. , Aug. ...  (NYSE: PHG ... at the  European Society of ... company is highlighting the full range of its cardiology solutions ... the care continuum from prevention and ...
(Date:8/28/2014)... -- Reportlinker.com announces that a new market research ... North America Aesthetic Lasers and Energy Devices Market ... North America Aesthetic Lasers and ... GlobalData,s new report, "North America Aesthetic Lasers ... key market data on the North America Aesthetic ...
(Date:8/28/2014)... -- Rigrodsky & Long, P.A.: , Do you, or ... )? , Did you purchase your shares before September ... inclusive? , Did you lose money in your investment ... discuss your rights? Rigrodsky & Long, ... J. MacFall , announces that a complaint has been filed in ...
Breaking Medicine Technology:Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 2Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 3Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 4Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 5North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 2North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 3North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 4North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 5North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 6North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 7North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 8North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 9North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 10North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 11North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 12North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 13North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 14North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 15North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 16Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 3
... of its commitment to supporting efforts to improve the ... has awarded $1,000 grants to ten health care organizations ... issues. (Logo: http://photos.prnewswire.com/prnh/20100412/DA84842LOGO ) ... the 2010 Beryl Institute Patient Experience grants are: ...
... PITTSBURGH, Oct. 19 Mylan Inc. (Nasdaq: MYL ... preferred stock issuance, the company has declared its quarterly dividend ... of 6.5% and a liquidation preference of $1,000.00 per share) ... of record as of Nov. 1, 2010.  Nov. 15, is ...
Cached Medicine Technology:Patient Experience Research Grants Awarded 2Patient Experience Research Grants Awarded 3
Jaws with fine teeth. Serrated handle with polished finish. Jaws: Wide, 4.5 mm. With thumb catch lock....
Straight shafts with curved 1 x 2 teeth. Serrated handle with polished finish....
Straight shafts, 1 x 2 teeth. Wide serrated handle with polished finish. Teeth: 0.3 mm. Most popular size or model....
Straight shafts with delicate 0.7 mm, 1 x 2 teeth. Serrated handle with polished finish....
Medicine Products: