Navigation Links
Researchers identify a novel therapeutic approach for liver cancer
Date:12/9/2011

BOSTON Cancer of the liver rare in the United States but the third-leading cause of cancer death worldwide can result from environmental exposures or infections like chronic hepatitis, but the link is poorly understood.

Now, researchers at Dana-Farber Cancer Institute have identified a mechanism in mice that triggers inflammation in the liver and transforms normal cells into cancerous ones. In addition, they demonstrated in a mouse model that a particular micro-RNA (miR-124) - a member of a recently discovered class of molecular regulators could be harnessed to treat or even prevent liver cancer.

"In this study we are describing for the first time a micro-RNA that is able to prevent and treat liver cancer," said Dimitrios Iliopoulos, of Dana-Farber's Department of Cancer Immunology and AIDS. The findings are being published today in the journal Cell.

The authors said they plan to start a phase I clinical trial using miR-124 in liver cancer patients in 2012.

Iliopoulos and his colleagues found that in mice given a carcinogenic chemical, DEN, liver cancer is initiated by the activation of a molecular circuit that sets up an inflammatory state in the cells, leading to cancer. Once this inflammatory circuit is turned on even for a few days, it becomes permanent, sustaining its activity through a never-ending feedback loop a "snowball effect," as Iliopoulos termed it.

Iliopoulos previously identified a similar feedback circuit implicated in the development of breast cancer.

One element of the circuit is a micro-RNA called miR-124, the Dana-Farber team reported.

Micro-RNAs are extremely short lengths of RNA a messenger molecule that helps the cell build proteins according to DNA instructions - which are not translated into proteins. MiRNAs have been recently implicated in the pathogenesis of human diseases including different types of cancer. The Dana-Farber team found that miR-124 and another key controller of the feedback circuit, HNF4α, showed reduced activity in the cancer cells.

HFN4α is an essential factor in formation of liver cells and their proper function. When HNF4α is suppressed, said Iliopoulos, it creates a temporary state of inflammation in the cell a forerunner of cancer. "After only a few days, this transient inflammatory response is converted into a chronic inflammatory response by this feedback circuit that is continuously amplified," he said.

Because HNF4α and miR-124 interact with each other, the scientists hypothesized that boosting activity of miR-124 might restore normal activity in HNF4α, halting the runaway inflammatory cycle and causing tumors to stop growing.

To test this notion they administered systemically miR-124 once a week for four weeks to mice that had developed liver cancer by exposure to DEN. "We found that miR-124 suppressed more than 80 per cent of tumor growth and size" by causing the cancer cells to self-destruct, the scientists wrote. They observed no toxic effects in other essential organs, such as the kidneys, spleen, heart and lungs.

Further, they showed that giving miR-124 to mice exposed to DEN actually prevented the development of liver tumors.

"Our hope is that miR-124 potentially could be used as a preventive in patients at high risk of liver cancer because they have chronic hepatitis C or as a therapeutic agent in patients with liver cancer" said Iliopoulos.


'/>"/>
Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-5665
Dana-Farber Cancer Institute
Source:Eurekalert  

Related medicine news :

1. Researchers design Alzheimers antibodies
2. Toronto researchers obtain detailed molecular signature for Tankyrase
3. Danish mushroom inspires cancer researchers
4. Bone Drugs May Also Battle Breast Cancer, Researchers Say
5. Researchers discover that changes in bioelectric signals cause tadpoles to grow eyes in back, tail
6. UCLA researchers suggest unconventional approach to control HIV epidemics
7. Mayo Clinic researchers find drug duo kills chemotherapy-resistant ovarian cancer cells
8. Researchers discover patterns of genes associated with timing of breast cancer recurrences
9. University of Kentucky researchers awarded CDC grant to study cancer survival in Appalachia
10. Moffitt researchers will be strong participants in American Society of Hematology meeting
11. Moffitt Cancer Center researchers find MK1775 active against sarcomas
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify a novel therapeutic approach for liver cancer
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now ... of Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Final Cut Pro X users can now reveal the media of their split ...
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: