Navigation Links
Researchers identify a new breast and ovarian cancer susceptibility gene

The discovery 15 years ago that the genes BRCA1 and BRCA2 confer high risks for breast and ovarian cancer was a breakthrough for cancer prediction and therapy, especially for familial cases. Now the research group of Prof. Alfons Meindl (Klinikum rechts der Isar of the Technische Universitaet Muenchen), in collaboration with other groups from Germany, the U.K., and the U.S., can identify another gene that increases susceptibility to breast and ovarian cancer. Their results have been published online in Nature Genetics. The identification of such high risk-conferring genes is a prerequisite for offering women tailored early recognition programs and more individualized therapies.

The gene newly identified as causing breast and ovarian cancer in familial cases is designated RAD51C. It is, like BRCA1 and BRCA2, essential for DNA repair within cells. Mutations in the gene can therefore cause either breast or ovarian cancer. In six out of 480 pedigrees with occurrence of breast and/or ovarian cancer, mutations within the RAD51C gene were found. The risk for breast cancer in women with mutation of RAD51C is 60 to 80 percent, for ovarian cancer 20 to 40 percent. As the cancers in such families were diagnosed significantly earlier than in women who developed sporadic breast or ovarian cancer, experts might also call the newly identified gene BRCA3.

"These results reinforce our assumption that various rare gene mutations contribute to hereditary breast and ovarian cancer. The now known genes that predispose women to breast and/or ovarian cancer only explain 60 percent of the high-risk families," says TUM Professor Alfons Meindl, Klinikum rechts der Isar, but novel technologies allow the rapid identification of other such rarely mutated disease-causing genes.

"We are also optimistic that in the future the individual breast cancer risks for the majority of women can be determined. These risk predictions will allow the offering of tailored prevention and small meshed early recognition programs. Risk-aligned prevention will become a new clinical area," explains Prof. Dr. Rita Schmutzler of the University Hospital of Cologne, one of the other main authors of the article.


Contact: Tanja Schmidhofer
Technische Universitaet Muenchen

Related medicine news :

1. Researchers show that nitric oxide-donating naproxen can boost colorectal cancer prevention
2. Vitamin K may protect against developing non-Hodgkins lymphoma, say Mayo Clinic researchers
3. UAB researchers find 4 biomarkers important in colorectal cancer treatment prognosis
4. UAB researchers find 4 biomarkers important in colerectal cancer treatment prognosis
5. USC researchers discover new molecular subtype of brain cancer
6. Plant pathogen genetically tailors attacks to each part of host, say Stanford researchers
7. Researchers find compound effective in destroying antibiotic-resistant biofilms
8. Boston researchers lead $15 million federal research grant to support advancement of health IT
9. Researchers discover new approach for identifying smokers at highest risk for developing lung cancer
10. Researchers aim for consensus on measuring the impact of visual impairment
11. Researchers Boost Post-Heart Attack Survival in Mice
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Purdue University ... the Life Sciences Initiative aimed at enhancing Purdue’s life sciences research and graduate ... True” capital campaign. , The investment will result in cohesive efforts across several ...
(Date:10/13/2015)... , ... October 13, 2015 , ... Sir Grout of ... to the local Boston chapter of Ronald McDonald House Charities® (RMHC®). This donation was ... supported Sir Grout of Greater Boston since its inception. , “We believe strongly in ...
(Date:10/13/2015)... ... October 13, 2015 , ... Califia Farms , one ... the release of its limited edition holiday seasonal flavors: Almondmilk Holiday Nog, new ... the unique flavor combinations and delicious taste Califia Farms’ beverages are known for, ...
(Date:10/13/2015)... ... October 13, 2015 , ... According to an article published October ... women who successfully lose weight with a bariatric procedure are much less likely to ... article notes that anywhere from 40 to 50 percent of all endometrial cancer cases ...
(Date:10/13/2015)... ... October 13, 2015 , ... Symposium Chairman, Dr. Rod J. ... Dallas Cosmetic Symposium to be held March 2nd and 3rd, 2016. The annual meeting, ... plastic surgeons and cosmetic physicians from around the world. , Key topics at this ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 13, 2015  Kay Elledge, M.D., an established ... College of Obstetrics and Gynecology (FACOG) for the ... the Genuine Self Medical Laser Center where she ... recognition of Breast Cancer Awareness Month , ... MonaLisa Touch treatments initiated in the ...
(Date:10/13/2015)... N.J. , Oct. 13, 2015  ContraVir ... the "Company"), a biopharmaceutical company focused on the ... announced the closing of its previously announced underwritten ... stock and warrants to purchase up to 3,000,000 ... fixed combined price to the public of $3.00. ...
(Date:10/13/2015)... Science Automation (DSA), a system integration and automation engineering firm, ... the United Kingdom (UK) as the ... . The decision to open the new office comes in ... in the medical device industry throughout the UK. ... had tremendous success over the last several years in product ...
Breaking Medicine Technology: