Navigation Links
Researchers identify a new breast and ovarian cancer susceptibility gene
Date:4/21/2010

The discovery 15 years ago that the genes BRCA1 and BRCA2 confer high risks for breast and ovarian cancer was a breakthrough for cancer prediction and therapy, especially for familial cases. Now the research group of Prof. Alfons Meindl (Klinikum rechts der Isar of the Technische Universitaet Muenchen), in collaboration with other groups from Germany, the U.K., and the U.S., can identify another gene that increases susceptibility to breast and ovarian cancer. Their results have been published online in Nature Genetics. The identification of such high risk-conferring genes is a prerequisite for offering women tailored early recognition programs and more individualized therapies.

The gene newly identified as causing breast and ovarian cancer in familial cases is designated RAD51C. It is, like BRCA1 and BRCA2, essential for DNA repair within cells. Mutations in the gene can therefore cause either breast or ovarian cancer. In six out of 480 pedigrees with occurrence of breast and/or ovarian cancer, mutations within the RAD51C gene were found. The risk for breast cancer in women with mutation of RAD51C is 60 to 80 percent, for ovarian cancer 20 to 40 percent. As the cancers in such families were diagnosed significantly earlier than in women who developed sporadic breast or ovarian cancer, experts might also call the newly identified gene BRCA3.

"These results reinforce our assumption that various rare gene mutations contribute to hereditary breast and ovarian cancer. The now known genes that predispose women to breast and/or ovarian cancer only explain 60 percent of the high-risk families," says TUM Professor Alfons Meindl, Klinikum rechts der Isar, but novel technologies allow the rapid identification of other such rarely mutated disease-causing genes.

"We are also optimistic that in the future the individual breast cancer risks for the majority of women can be determined. These risk predictions will allow the offering of tailored prevention and small meshed early recognition programs. Risk-aligned prevention will become a new clinical area," explains Prof. Dr. Rita Schmutzler of the University Hospital of Cologne, one of the other main authors of the article.


'/>"/>

Contact: Tanja Schmidhofer
schmidhofer@lrz.tum.de
49-894-140-2046
Technische Universitaet Muenchen
Source:Eurekalert

Related medicine news :

1. Researchers show that nitric oxide-donating naproxen can boost colorectal cancer prevention
2. Vitamin K may protect against developing non-Hodgkins lymphoma, say Mayo Clinic researchers
3. UAB researchers find 4 biomarkers important in colorectal cancer treatment prognosis
4. UAB researchers find 4 biomarkers important in colerectal cancer treatment prognosis
5. USC researchers discover new molecular subtype of brain cancer
6. Plant pathogen genetically tailors attacks to each part of host, say Stanford researchers
7. Researchers find compound effective in destroying antibiotic-resistant biofilms
8. Boston researchers lead $15 million federal research grant to support advancement of health IT
9. Researchers discover new approach for identifying smokers at highest risk for developing lung cancer
10. Researchers aim for consensus on measuring the impact of visual impairment
11. Researchers Boost Post-Heart Attack Survival in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... Macomb, Michigan (PRWEB) , ... ... ... report published by CBC News on April 4th, 2016 questioned the use ... organization referred to EOTTS-HyProCure as “a controversial procedure.” EOTTS-HyProCure is a minimally ...
(Date:4/29/2016)... ... 2016 , ... World Patent Marketing , a vertically ... automotive invention that improves the storage features of a pick up truck. , ... Cooper, CEO and Creative Director of World Patent Marketing. "Over the next five ...
(Date:4/29/2016)... MA (PRWEB) , ... April 29, 2016 , ... ... the Two Ten Footwear Foundation, the national charitable foundation serving the footwear industry, ... With 8,000 volunteers representing more than 130 companies across 23 states during the ...
(Date:4/29/2016)... ... 29, 2016 , ... Our bodies are bombarded daily by environmental and lifestyle ... these stressors is to adopt a more healthful diet, but too many people think ... certified Holistic Nutritionist and the creator of the Newport Beach Cleanse and 14-Day Eating ...
(Date:4/29/2016)... ... April 29, 2016 , ... Dr. ... of best seller "LOVE, MEDICINE and MIRACLES") addresses touchy topics related to Death ... podcasted thereafter . Dr. Bernie Siegel, author of a plethora of essential ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... PARIS , le 27 Avril 2016 /PRNewswire/ ... chiffre d,affaires a progressé de +5% sur le ... ventes récurrentes de consommables  Croissance de ... Mauna Kea Technologies (Euronext : ... multidisciplinaire d,endomicroscopie confocale laser, annonce aujourd,hui son chiffre ...
(Date:4/27/2016)... NEW DELHI , April 27, 2016 ... CSR initiative to save newborns ... ,s hospital for women & newborns in collaboration with Breast ... has launched the first Pasteurized Human Milk Bank, ,Amaara, in ... the best nutritional food source for infants and should be ...
(Date:4/27/2016)... 2016 Global  urinalysis market ... by 2022, according to a new report by ... http://photos.prnewswire.com/prnh/20150105/723757 ) , Automation ... and accuracy delivered by the new generation urinalysis ... urinalysis instruments and consumables. For instance, the automatic ...
Breaking Medicine Technology: