Navigation Links
Researchers identify a 'life-and-death' molecule on chronic leukemia cells
Date:5/30/2012

  • SMIP-016 is a promising experimental drug that kills chronic leukemia cells.
  • The drug targets a protein called CD37, but it wasn't known how this kills leukemia cells.
  • This study showed unexpectedly that CD37 helps regulate both cell-death and cell-survival signals, explaining how the drug works and how it might be improved.

COLUMBUS, Ohio A new study has identified a life-and-death signaling role for a molecule on the surface of the immune cells involved in the most common form of chronic leukemia. The finding could lead to more effective therapy for chronic lymphocytic leukemia (CLL), an as yet incurable cancer that occurs in more than 16,000 Americans annually.

The study, led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James), examines how an experimental drug called SMIP-016 kills CLL cells.

Earlier work by the same researchers showed that the drug targets a molecule called CD37, which is found on the surface of CLL cells. In this new study, the researchers discovered that the CD37 molecule has two regions that can concurrently activate two separate pathways in CLL cells, one that leads to cell death and another that promotes cell survival.

The findings show SMIP-016 activates the "death" part of the molecule, and they suggest that blocking the "survival" part of the molecule could improve the drug's effectiveness, the researchers say.

The study is published in the May issue of journal Cancer Cell.

"These findings open new possibilities for the use of immune-based therapy for treating CLL," says principal investigator Dr. John Byrd, a CLL specialist and professor of Medicine, of Medicinal Chemistry and of Veterinary Biosciences.

"We are already targeting the cell-death pathway using SMIP-016, and we might be able to optimize the drug's effectiveness by
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. GW researchers discover biomarker for advanced bile duct fibrosis and bile duct cancer
2. Researchers restore neuron function to brains damaged by Huntingtons disease
3. UC San Diego researchers receive new CIRM funding
4. Ben-Gurion U. researchers successfully test solar desalination system for arid land agriculture
5. McMaster University researchers discover drug destroys human cancer stem cells but not healthy ones
6. Barrow researchers use magic for discoveries
7. Researchers present new findings for novel pancreatic cancer vaccine
8. Dartmouth researchers investigate the cognitive effects of athlete head impacts
9. Fish Pedicure a Recipe for Bacterial Infection, Researchers Warn
10. Fox Chase researchers find no disparities in imaging before breast cancer surgery
11. Researchers undertake radical new cancer survivorship study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... PHILADELPHIA The presence of chronic inflammation in ... aggressive, prostate cancer, and this association was found ... levels, according to a study published in ... of the American Association for Cancer Research. , ... some participants of the placebo arm of the ...
(Date:4/17/2014)... the most popular vaccine brands for children may not ... overlooking some cost factors when choosing vaccines, driving the ... according to a new study by University of Illinois ... be driven by numerous factors," says Sheldon H. Jacobson, ... computer science and of mathematics at the U. of ...
(Date:4/17/2014)... Two recent papers by a University of Colorado ... scientists develop treatments or vaccines for Dengue fever, ... other disease-causing flaviviruses. , Jeffrey S. Kieft, PhD, ... the School of Medicine and an early career ... colleagues recently published articles in the scholarly journals ...
(Date:4/17/2014)... personnel who served in Iraq and Afghanistan and ... (TBI) were compared to military personnel without TBI ... in measures of overall disability, cognitive function, post-traumatic ... reported in an article in Journal of ... Liebert, Inc., publishers. The article is available free ...
(Date:4/17/2014)... CHICAGO, IL, April 17, 2014-- Colic affects about one ... accounts for numerous pediatric visits during the first several ... of colic symptoms was showing promise; however, the April ... (BMJ2014;348:g2107; Sung, Valerie) reported on a study, "Probiotics ... probiotic L reuteri for infant colic ...
Breaking Medicine News(10 mins):Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3Health News:Study recalculates costs of combination vaccines 2Health News:CU researchers discover target for treating dengue fever 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2
... Losing weight can help reduce your risk of cancer if ... effective in lowering that risk, an expert says. Diets ... changes in eating habits and also provide a variety of ... clinical dietitian in the clinical nutrition department at the University ...
... Urinary tract infections are common in women, costing an ... in the United States alone. These infections frequently ... A depletion of vaginal lactobacilli, a type of ... suggests that replenishing these bacteria may be beneficial. Researchers ...
... , cancer scientists Ana Soto and Carlos Sonnenschein pit their ... cancer against the widely accepted Somatic Mutation Theory (SMT) in ... theories have formally opposed each other championed by authors ... forum for discussion. Soto and Sonnenschein, from Tufts University, ...
... , THURSDAY, April 14 (HealthDay News) -- ... target the new organ can develop accelerated narrowing of ... may lead to organ rejection. That,s the finding ... kidney biopsies from 99 kidney transplant patients -- 40 ...
... a statin before having major elective surgery reduces potentially ... an upcoming issue of the Journal of the ... than 230 million major elective surgeries are performed around ... develop kidney injury soon after surgery, often due to ...
... , Thursday, April 14 (HealthDay News) -- Just as the ... world,s languages also originated there and spread across the globe, ... analyzed the phonemes -- distinct units of sound that differentiate ... pattern mirrors that of human genetic diversity. As humans ...
Cached Medicine News:Health News:A Good Diet Includes Many Cancer-Fighting Foods: Expert 2Health News:Statins may protect against kidney complications following elective surgery 2Health News:Human Language Origins Traced to Africa, Study Finds 2
(Date:1/14/2014)... Jan. 14, 2014  Luminex Corporation (Nasdaq: LMNX ) ... fourth quarter of 2013 on Monday, February 3, 2014. A ... the close of trading. (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ... discuss the operating highlights and financial results for the fourth ...
(Date:1/14/2014)... , Jan. 14, 2014 /PRNewswire-iReach/ -- Acumed,s new ... targeting guide with accompanying instrumentation to place and insert ... to the soft tissue (e.g. ligament) repair or reconstruction ... repair heals. (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) ...
(Date:1/14/2014)... , Jan. 14, 2014   Oligomerix, Inc. , a ... therapeutics for Alzheimer,s disease (AD) and related neurodegenerative disorders, ... Valhalla, NY as of January ... space at New York Medical College. Oligomerix, ...
Breaking Medicine Technology:Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... Mich., Dec. 3 Stryker Corporation (NYSE: SYK ) ... to repurchase up to $750 million of its common stock. ... by the Company,s management based on their evaluation of market conditions, ... considerations. Purchases may be made from time to time in ...
... CAMBRIDGE, Mass., Dec. 3, 2009 Raytheon BBN Technologies, a ... has licensed its patented, award-winning stereo digital mammography (SDM) technology ... SDM technology with the Aspire HD FFDM system. Combined with ... stereo images for 3-D viewing. FUJIFILM will display the Raytheon ...
Cached Medicine Technology:Stryker Announces $750 Million Share Repurchase Program and Declares a $0.15 Per Share Quarterly Dividend 2Raytheon BBN Technologies Licenses Stereo Digital Mammography Technology to FUJIFILM Corporation 2Raytheon BBN Technologies Licenses Stereo Digital Mammography Technology to FUJIFILM Corporation 3
PDA formatted guide containing outlines and detailed information on the diagnosis and treatment of HIV infection and AIDS....
PDA version of the best-selling guide....
PDA application contains 15,000+ ICD-9-CM Diagnosis codes....
More than 200 key diagnostic and treatment tables culled from Tierney's Current Medical Diagnostics and Treatment 2003....
Medicine Products: