Navigation Links
Researchers identify a histone demethylase associated with non-small cell lung cancer
Date:11/8/2013

Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer deaths worldwide. Current therapies that target cellular kinases have been effective for some patients: however, many individuals with NSCLS do not respond. Recent studies of other cancers indicate that the global changes in DNA methylation patterns may drive tumor formation.

In this issue of the Journal of Clinical Investigation, MinGyu Lee and colleagues at MD Anderson Cancer Center evaluated histone methylation modifications in NSCLS cell lines and determined that the histone demethylase KDM2A was upregulated in NSCLC cell lines. Furthermore, induced KDM2A expression increased cell proliferation and invasiveness through activation of the ERK1/2 signaling pathway. Evaluation of tumors from NSCLS patients uncovered a correlation between increased levels of KDM2A and poor prognosis.

This study suggests that therapies targeting KDM2A may benefit a subset of NSCLS patients.


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers at Pace University Explore the Lived Experiences of Families Members That Have the Possible Risk of Genetic Mutations That Cause Sudden Cardiac Death
2. UT Southwestern researchers discover a new driver of breast cancer
3. Sanders-Brown researchers produce new research on little-understood brain disease
4. UCSF researchers offer solutions to looming health-care provider shortage
5. Hot-air balloon rides -- researchers advise, proceed with caution
6. Researchers gain new insights into brain neuronal networks
7. Researchers warn of the myths of global medical tourism
8. Canadian researchers discover how to measure quality of life for rare blood condition
9. Kessler researchers find aerobic exercise benefits memory in persons with multiple sclerosis
10. Voices Against Brain Cancer Commends Researchers for the Identification of an Important Protein that May Give Insight to More Effective Glioblastoma Treatments
11. Increasing rate of knee replacements linked to obesity among young, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... ... , ... Ray Insurance Agencies, a Dallas area firm providing asset protection services ... a six month charity event aimed at raising local support and donations that will ... the deadliest diseases in America; more than 7.5 million people die from cancer related ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... clinical trial solutions, today announced the further expansion of its eHealth App ... can leverage as part of Bioclinica’s extensive and growing eHealth platform. Applications ...
(Date:2/21/2017)... Francisco, California (PRWEB) , ... February 21, 2017 ... ... the world with over 50,000 participants. The connected care demonstration spanned multiple ... of the National Coordinator, roughly 30% of providers have no Health Information Exchange ...
(Date:2/21/2017)... ... February 21, 2017 , ... CLICKco LLC, ... announced its products are now available for purchase on RonnieColemanNutrition.com, a popular website ... become popular among health-conscious consumers who love coffee but are looking to add ...
(Date:2/20/2017)... ... 20, 2017 , ... MRI screening improves early diagnosis of breast cancer in ... online in the journal Radiology . , MRI has long been known ... ultrasound. Currently, guidelines reserve breast MRI screening for women who have a strong family ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... , Feb. 21, 2017  International Isotopes Inc. ... a private placement with certain investors for approximately $3.4 ... the Company, Series C Convertible Redeemable Preferred Stock (the ... at an annual rate of 6% and is convertible ... plans to use the proceeds for operating capital, to ...
(Date:2/21/2017)... , February 21, 2017 According to a new ... Systems (Surgical Robots, Rehabilitation Robots, Hospital Robots, Non-invasive Surgery Robots)), Application (Orthopedic, Laparoscopy, ... Continue Reading ... MarketsandMarkets Logo ... This report studies the global ...
(Date:2/21/2017)... Feb. 21, 2017 Research and Markets has announced ... Global Strategic Business Report" report to their offering. ... The report provides separate comprehensive analytics for ... Europe , Asia-Pacific , ... are provided for the period 2015 through 2022. Also, a six-year historic ...
Breaking Medicine Technology: