Navigation Links
Researchers identify a gene that predicts recurrence in squamous cell carcinoma of the head and neck
Date:4/2/2012

e gene had a longer time-to-recurrence than individuals carrying the more typical form of the gene. Moreover, only 16 percent of patients with the N453S variant had a recurrence, compared to 33 percent of patients with the normal version of the gene. By contrast, the other CYP1B1 gene variants known as R48G or L432V did not have any impact on time-to-recurrence.

In addition, the research team found that women with the normal form of CYP1B1 had a shorter time-to-recurrence than men with the same gene variant. This finding is consistent with CYP1B1's known ability to metabolize estrogens, the primary sex hormones in females, to carcinogenic derivatives.

"The genetic makeup of a person could have an impact on how detrimental exposure to tobacco smoke or estrogen might be, and on the time course of their cancer recurrence," says Clapper, who is co-leader of the Cancer Prevention and Control Program at Fox Chase. "This is really an exciting finding because it suggests that the CYP1B1 protein may be a target for intervention in head and neck cancer."

The researchers also tested, at the cellular level, how variants of CYP1B1 may affect time-to-recurrence and found that cells with high levels of the N453S variant proliferated five to eight times slower than did cells with the normal form of the protein.

The results could have important implications for the treatment of patients with squamous cell carcinoma of the head and neck. Clinicians could use information about variations in the CYP1B1 gene to identify individuals who are at risk for faster recurrence. That subset of patients could receive "a treatment regimen that is tailored to be more aggressive," Clapper says. "Using a personalized medicine approach, we could impact the duration of the disease-free interval for these individuals if we knew ahead of time which ones were more likely to experience recurrence at a faster rate."

Moving forward, Shatalova and her colleagues
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-815-7828
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers uncover new clues to the development of blood and other cancers
2. Researchers work to help soldiers break camouflage
3. Researchers identify mechanism that makes breast cancer invasive
4. Penn researchers call for a re-examination of transplant waitlist prioritization
5. Nemours researchers uncover new evidence of cancer-causing agent present in gaseous phase of cigarette smoke
6. NIH researchers highlight progress, path forward for developing TB vaccines
7. Penn researchers find mentoring provides health benefits for African American veterans with diabetes
8. Mayo Clinic researchers building melanoma vaccine to combat skin cancer
9. Evidence builds that meditation strengthens the brain, UCLA researchers say
10. Wilmot researchers create new way to study liver cancer
11. Researchers develop first theranostic treatment for acute lymphoblastic leukemia (ALL)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... (PRWEB) September 19, 2014 “Copay coupons,” ... sales of brand drugs among patients with prescription drug ... according to a new report from the Department ... General (OIG). Federal anti-kickback laws prohibit suppliers from offering ... by the federal government. , The report highlights that ...
(Date:9/19/2014)... 2014 BearCom, a nationwide provider ... the key role played by instant, one-to-one and ... healthcare industry. , “In healthcare, speed of ... and in emergency situations, can save precious seconds ... death,” said Hugh Johnston, Product & Purchasing Manager ...
(Date:9/19/2014)... More than half of human cancers have ... yet how these signals are controlled during tumor ... PhD, MD, and Svetlana Fayngerts, PhD, both researchers ... at the Perelman School of Medicine, University of ... described oncogenic protein, promotes cancer by targeting these ...
(Date:9/19/2014)... 19, 2014 Visiting Nurse Association (VNA) ... health care, hospice and palliative care and community-based care, ... Opening Bell yesterday at the New York Stock Exchange. ... and social entrepreneur to care for immigrant families suffering ... always worked to meet the urgent healthcare needs of ...
(Date:9/19/2014)... U.S. military troops deployed to sunny climates may have ... new study. Many returning troops reported getting ... military personnel developed blisters on their skin or noticed ... their moles since being deployed overseas. All of ... the study authors noted. "The past decade of ...
Breaking Medicine News(10 mins):Health News:PCMA: New OIG Report Cites Drug Manufacturer“Copay Coupon” Use in Medicare Part D 2Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 2Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 3Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 4Health News:New cancer drug target involving lipid chemical messengers 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 3Health News:Some U.S. Troops May Face Greater Skin Cancer Risk 2
... endoscopy is a well accepted tool for evaluation of ... some limitations due to restricted recording time and reduced ... preparation (e.g., prokinetic drugs, laxatives and defoaming agents) have ... However, to date no standardized protocol has been recommended ...
... with pancreatico-biliary carcinoma has been reported as a definite ... This study, performed by a team led by Professor ... in a research article to be published on April ... , The study evaluated 31 patients who underwent paraaortic ...
... SAN ANTONIO, May 20 Medco Health Solutions,Inc. ... benefit manager, and,Healthways (Nasdaq: HWAY ), the ... announced the opening of an innovative new,center that ... managing health risks and chronic conditions. The Medco ...
... Recognized Nationally-, WASHINGTON, May 20 Michelle Mays, ... Advocate of the Year,by the Campaign for Tobacco-Free Kids ... being honored at a gala in the nation,s,capital on ... winner,three other regional winners and a group winner., ...
... in the Water Just Like ... BioLab ... marketing communications agency, Fletcher Martin (, http://www.fletchermartin.com ) launched an interactive ... http://www.biolabuv.com ). The,banner-ad game is designed to entice consumers to ...
... available in Spanish . , , A research team from ... on the psychological process that triggers the craving or intense desire ... the brain mechanisms that activate this state and how to control ... Department of Personality, Evaluation and Psychological Treatment of the ...
Cached Medicine News:Health News:How does sodium phosphate combined with bisacodyl affect small intestine? 2Health News:Medco, Healthways Launch Center for Health Action to Deliver Optimal Health(TM) 2Health News:Medco, Healthways Launch Center for Health Action to Deliver Optimal Health(TM) 3Health News:Medco, Healthways Launch Center for Health Action to Deliver Optimal Health(TM) 4Health News:Medco, Healthways Launch Center for Health Action to Deliver Optimal Health(TM) 5Health News:Campaign for Tobacco-Free Kids Honors Michelle Mays of Rhinelander, WI As Youth Advocate of the Year 2Health News:Fletcher Martin Creates Interactive Game-Ad for BioLab(R) UV for BioGuard(R) 2Health News:A research on 'craving' for tobacco establishes the bases for addiction control 2
(Date:9/19/2014)... , Sept. 19, 2014 Kiromic, LLC, a ... addition of Kent Hance , the former chancellor of ... Hance retired as chancellor in July 2014, after raising $1.2 ... announce that Kent Hance , the most successful chancellor ... Kiromic team not only as an investor, but also as ...
(Date:9/19/2014)... , September 19, 2014 ... Market by Equipment (Cryotherapy, Heat, therapy, Hydrotherapy), Accessories (Posture ... Users (Hospitals), Advanced technologies - Global Forecast to ... is poised to reach $19,786.3 Million by 2019 ... of 6.8% from 2014 to 2019. ...
(Date:9/19/2014)... Sept. 19, 2014  4WEB Medical announces the formal ... and ankle osteotomy implants on the market today ... annual meeting in Chicago .  The ... a surgeon,s osteotomy needs with 74 size options included in ... offerings of only 15 to 18 implant sizes, which ...
Breaking Medicine Technology:Former Texas Tech Chancellor Named New Vice Chairman of the Board of Kiromic, LLC 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 44WEB Medical Unveils 3D-Printed Osteotomy Truss System 2
... Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced today ... Biosciences, will be presenting at the Deutsche Bank 36th Annual ... presentation takes place on Wednesday, May 4, 2011 at 10:40 ... will be webcast and may be accessed on the Company,s ...
... Inc. (Nasdaq: AMLN ) will be presenting at ... Wednesday, May 4, 2011 at 12:15 p.m. ET / 9:15 ... and chief financial officer at Amylin Pharmaceuticals, will provide a ... through the "Investors" section of Amylin,s corporate website at ...
Cached Medicine Technology:
ROB-NEL Catheters (100% Latex-Free)...
Red Rubber Robinson Catheters (Latex)...
Urethral Red Rubber Catheters (Latex)...
Foley Catheters (Latex) 3-Way...
Medicine Products: