Navigation Links
Researchers identify a gene responsible for Lou Gehrig's disease
Date:3/31/2008

This release is available in French.

Montreal, March 31, 2008 A team of Canadian and French researchers has identified a novel gene responsible for a significant fraction of ALS (sporadic amyotrophic lateral sclerosis) cases. ALS is commonly referred to as Lou Gehrigs disease, an incurable neuromuscular disorder that affects motor neurons and leads to paralysis and death within one to five years.

Published in the current online edition of Nature Genetics, the study on 200 human subjects with ALS was led by Doctors Guy Rouleau, Edor Kabashi, Paul Valdmanis of the Research Centre of the Centre hospitalier de l'Universit de Montral (CRCHUM). The team identified several genetic mutations in the TDP-43 gene by studying ALS patients from France and Quebec. They established TDP-43 as the gene responsible for up to five percent of the ALS patients.

The breakthrough is the result of teamwork with peers from the Waterloo and Laval universities in Canada and the Fdration des maladies du systme nerveux and the Institute of Biology (Unit de Neurologie Comportementale et Dgnrative) in France.

Building on past studies

In 1993, Dr. Rouleau and his team also helped identify superoxide dismutase as the gene that causes the disease in 10 to 20 percent of all familial cases of ALS. This cornerstone study led to development of several mouse and rat models of ALS that closely resemble the motor neuron disorder observed in ALS patients. These models have been very useful to study molecular and cellular mechanisms of disease and to test treatments for ALS.

TDP-43s normal function is to bind and splice RNA. Two years ago, a team from the University of Pennsylvania discovered TDP-43 in abnormal protein clumps, referred to as aggregates, in motor neurons of ALS patients. However, it was not certain whether TDP-43 causes motor neuron disease
'/>"/>

Contact: Nathalie Forgue
nathalie.forgue.chum@ssss.gouv.qc.ca
51-489-080-001-4342
University of Montreal
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UCLA researchers examine human embryonic stem cell genome
2. Researchers Create Protective Sac for Growing Stem Cells
3. UC Irvine researchers present latest findings at emergency medicine forum
4. Researchers urge ethics guidelines for human-genome research
5. OHSU Cancer Institute researchers identify new approach to help control drug resistance in leukemia
6. NYU dental researchers find evidence of periodontal disease leading to gestational diabetes
7. Researchers Gain Insights Into On-Off Switch for Cells
8. Molecular science could further improve leukemia survival, say St. Jude researchers
9. Stanford researchers unmask proteins in telomerase, a substance that enables cancer
10. Recognizing outstanding young researchers
11. Researchers sharpen search for new marine medicines with novel techniques
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... Alliance Healthcare Foundation (AHF), a nonprofit organization which ... and underserved in San Diego and Imperial County, recently ... award, the Innovation Initiative (i2). , “Alliance Healthcare ... our Innovation Initiative Award,” AHF Executive Director Nancy Sasaki ... ambitious projects in the past with this award, and ...
(Date:3/26/2015)... 26, 2015 The American College of Traditional ... the topics of the DAOM Program as well as Marketing ... Webinar will be hosted by Dr. Carla Wilson, who will ... steps on how to prepare for the spring quarter. The ... March 27, April 1 and April 3. Attendees can log ...
(Date:3/26/2015)... (PRWEB) March 26, 2015 Xarelto ... forward nationwide, with the issuance of new court ... and Louisiana. According to an Order dated March ... established for Xarelto injury claims in the U.S. ... allow plaintiffs to file cases directly in the ...
(Date:3/26/2015)... 26, 2015 Behavioral Research Group, ... announced the release of BathroomMap® , a new ... access to public restrooms for travelers, especially those with ... BathroomMap does not facilitate a paid, social or crowdsourced ... and rate local establishments that have clean, available restrooms ...
(Date:3/26/2015)... Saving Moses is a global humanitarian ... needed but least available. As one of their staple ... in the Benguela province of Angola to treat babies ... visit to their clinics, staff employed the art of ... babies in a nation the The New York Times ...
Breaking Medicine News(10 mins):Health News:Applications Open for $1M Innovation Initiative Award from Alliance Healthcare Foundation 2Health News:ACTCM Announces Upcoming Webinars 2Health News:Xarelto Lawsuits Move Forward Nationwide, With Issuance of New Court Docs in State, Federal Litigations 2Health News:Xarelto Lawsuits Move Forward Nationwide, With Issuance of New Court Docs in State, Federal Litigations 3Health News:New Bathroom Finder App, BathroomMap®, Helps People with Medical Needs Who Urgently Need a Bathroom When Traveling 2Health News:New Bathroom Finder App, BathroomMap®, Helps People with Medical Needs Who Urgently Need a Bathroom When Traveling 3Health News:Saving Moses Utilized Photography in an Effort to Engage Mothers and Their Babies on a Recent Visit to Angola 2
... 22 /PRNewswire-FirstCall/ - Hard To Treat Diseases (HTDS) ... Sanja Pekovic provided updates from a recent medical ... Gesellschaft - Nederlandse Anatomen Vereniging, Antwerpen, 27-30 March ... of recent positive testing being conducted related to ...
... CITY, Calif., April 22 AcelRx Pharmaceuticals, Inc. ... 2 clinical trial of ARX-02, a proprietary sublingual ... control. The primary objective of this multicenter, randomized, ... and efficacy of ARX-02 relative to placebo in ...
... oil given to professional football players has proven to ... study published in the January/February 2009 issue of ... oil supplement was administered to 36 professional football players ... volunteered to be randomly assigned to either the treatment ...
... http://www.AmberCourtAL.com ) reaffirms its commitment to seniors on Medicaid. New ... Living Concepts, revealed a history of evictions when residents depleted ... ... NY (PRWEB) April 22, 2009 -- Raphael Weiss, Managing Director ...
... of Driver Technology to Power Artificial Heart Presented at ISHLT ... ... (Vocus) April 22, 2009 -- On April 22-25, SynCardia Systems, ... introduced the new 12-lb Freedom™ discharge driver at the International ...
... a new online training program designed to help medical transcriptionists ... ... Springville, Utah (PRWEB) April 22, 2009--Career ... transcription industry, has released a new online training program designed ...
Cached Medicine News:Health News:Hard To Treat Diseases (HTDS) Slavica BioChem Update on Research Activities 2Health News:Hard To Treat Diseases (HTDS) Slavica BioChem Update on Research Activities 3Health News:AcelRx Announces Initiation of Phase 2 Cancer Breakthrough Pain Program 2Health News:New Study Shows Fish Oil Improves Cholesterol Levels in Professional Football Players 2Health News:Amber Court Assisted Living Communities Reaffirms Its Commitment To Seniors On Medicaid 2Health News:SynCardia Introduces New 12-lb Freedom Discharge Driver ,Designed to Provide Quality 'Lifestyle' for Total Artificial Heart Patients 2Health News:Career Step Launches New Credential Exam Training Program for Medical Transcription Industry 2
(Date:3/26/2015)... March 26, 2015 Huntington Memorial Hospital is ... perform transcatheter aortic valve replacement (TAVR), a minimally invasive ... revolutionary new way to replace an aortic valve without ... lung machine. The procedure is performed by ... Azhil ( Alex) Durairaj , MD, interventional cardiologist and ...
(Date:3/26/2015)... 2015 Cardiologists at Beaumont Hospital, ... commercial implant of a device recently approved by the ... fibrillation. The Watchman Left Atrial Appendage Closure implant is ... to reduce the risk of stroke. Atrial ... more than 5 million Americans. Twenty percent of all ...
(Date:3/26/2015)... , March 26, 2015 Over-the-counter ... average American consumer. However, a new survey of ... ailments from the common cold to diabetes, can ... The research, conducted by the Private Label Manufacturers ... over-the-counter healthcare products, including those essential for treatment ...
Breaking Medicine Technology:Huntington Memorial Hospital Performs Groundbreaking Minimally Invasive Replacement of Heart Valves 2Beaumont Hospital, Royal Oak among first to offer alternative to blood-thinning medications for atrial fibrillation 2Beaumont Hospital, Royal Oak among first to offer alternative to blood-thinning medications for atrial fibrillation 3Consumers can keep over-the-counter medicine affordable by using store brands 2
... aureus and, Methicillin-Resistant Staphylococcus aureus from Positive ... BD Diagnostics, a segment,of BD (Becton, Dickinson and ... it,received clearance from the U.S. Food and Drug ... new assay is the first test available to,rapidly ...
... Dec. 27 Allos,Therapeutics, Inc. (Nasdaq: ALTH ... (DMC) has completed the pre-specified 65-patient,safety review of ... trial of,PDX (pralatrexate) in patients with relapsed or ... the trial continue per the,protocol. This interim assessment ...
Cached Medicine Technology:BD Announces FDA 510(k) Clearance of Two-Hour Test to Identify Superbug in Patients with Positive Blood Cultures 2BD Announces FDA 510(k) Clearance of Two-Hour Test to Identify Superbug in Patients with Positive Blood Cultures 3Interim Safety Analysis Supports Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma 2Interim Safety Analysis Supports Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma 3Interim Safety Analysis Supports Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma 4Interim Safety Analysis Supports Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma 5
... Portable Slit-Lamp. Rechargeable, cordless ... for any purpose , Easy selection ... blue filter , Extra-bright halogen lamp ... main and extra ,power pack , ...
The PillCam™ ESO video capsule is specifically designed to view the inner lining of the Esophagus. The capsule is equipped with miniature cameras on both ends and is about the size of a multi-v...
World's first commercially available vacuum assisted biopsy device for MRI....
... Now you can perform stereotactic, ultrasound ... the convenience of your office. Use the ... safer, easier and more clinically advanced method ... its best for the women who trust ...
Medicine Products: