Navigation Links
Researchers identify a gene responsible for Lou Gehrig's disease
Date:3/31/2008

This release is available in French.

Montreal, March 31, 2008 A team of Canadian and French researchers has identified a novel gene responsible for a significant fraction of ALS (sporadic amyotrophic lateral sclerosis) cases. ALS is commonly referred to as Lou Gehrigs disease, an incurable neuromuscular disorder that affects motor neurons and leads to paralysis and death within one to five years.

Published in the current online edition of Nature Genetics, the study on 200 human subjects with ALS was led by Doctors Guy Rouleau, Edor Kabashi, Paul Valdmanis of the Research Centre of the Centre hospitalier de l'Universit de Montral (CRCHUM). The team identified several genetic mutations in the TDP-43 gene by studying ALS patients from France and Quebec. They established TDP-43 as the gene responsible for up to five percent of the ALS patients.

The breakthrough is the result of teamwork with peers from the Waterloo and Laval universities in Canada and the Fdration des maladies du systme nerveux and the Institute of Biology (Unit de Neurologie Comportementale et Dgnrative) in France.

Building on past studies

In 1993, Dr. Rouleau and his team also helped identify superoxide dismutase as the gene that causes the disease in 10 to 20 percent of all familial cases of ALS. This cornerstone study led to development of several mouse and rat models of ALS that closely resemble the motor neuron disorder observed in ALS patients. These models have been very useful to study molecular and cellular mechanisms of disease and to test treatments for ALS.

TDP-43s normal function is to bind and splice RNA. Two years ago, a team from the University of Pennsylvania discovered TDP-43 in abnormal protein clumps, referred to as aggregates, in motor neurons of ALS patients. However, it was not certain whether TDP-43 causes motor neuron disease
'/>"/>

Contact: Nathalie Forgue
nathalie.forgue.chum@ssss.gouv.qc.ca
51-489-080-001-4342
University of Montreal
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UCLA researchers examine human embryonic stem cell genome
2. Researchers Create Protective Sac for Growing Stem Cells
3. UC Irvine researchers present latest findings at emergency medicine forum
4. Researchers urge ethics guidelines for human-genome research
5. OHSU Cancer Institute researchers identify new approach to help control drug resistance in leukemia
6. NYU dental researchers find evidence of periodontal disease leading to gestational diabetes
7. Researchers Gain Insights Into On-Off Switch for Cells
8. Molecular science could further improve leukemia survival, say St. Jude researchers
9. Stanford researchers unmask proteins in telomerase, a substance that enables cancer
10. Recognizing outstanding young researchers
11. Researchers sharpen search for new marine medicines with novel techniques
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... October 30, 2014 Don Allred Insurance, ... health insurance plans for North Carolina residents, is excited ... in Burlington’s Holly Hill Mall. The new branch has ... already helping customers through all facets of the insurance ... Allred Insurance spokesman Scott Allred couldn’t be happier with ...
(Date:10/30/2014)... OR (PRWEB) October 30, 2014 Five ... firm Hodgkinson Street LLC announces new branding and ... Hodgkinson Street Mepham . After David Mepham’s promotion to ... their brand and website to include Mepham’s name and ... medical malpractice and mediation firm, the decision to implement ...
(Date:10/30/2014)... N.C. (PRWEB) October 30, 2014 Paramount ... health care, is increasing efforts to help people save ... expenses continue to increase for prescription drugs in the ... valuable savings and resources to bridge the relationship between ... One of the biggest challenges people face today with ...
(Date:10/30/2014)... Steven Reinberg HealthDay Reporter ... hormone therapy to men with prostate cancer who also have ... a heart-related cause, a new study suggests. , , The therapy ... in prostate cancer to reduce levels of male hormones to ... And, in the current research, this hormone therapy was linked ...
(Date:10/30/2014)... By Dennis Thompson ... -- The Ebola outbreak in Liberia -- one of three ... slowing, World Health Organization officials said Wednesday. Dr. Bruce ... in the number of burials in Liberia and no increase ... the global push to tame the epidemic may be making ...
Breaking Medicine News(10 mins):Health News:Allred Insurance Satellite Office Grand Opening 2Health News:Hodgkinson Street Mepham Rebrands 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 3Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 3Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 2Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 3
... study conducted by the University of Erfurt in Erfurt, ... inflict financial pain to achieve// collective gain. The study ... ,Researchers have found that groups in which individual ... popular than groups without this option. Though two thirds ...
... theme park people have come together to set up an ... from the Himalayan expedition to China and Nepal. They ... previously unknown to science. This was brought about by the ... a giant hornet which the local address as the Yak ...
... The drug Macugen was approved by the Food and ... as macular degeneration was reported// to show serious allergic ... use of their eye drug Macugen along with other ... companies have already notified the doctors about the reactions, ...
... a reassuring announcement that will bring hope to those people ... to be instituted, the government will realize its target of ... next two months. This will indeed provide a renewed thrust ... ,In the words of Anbumani Ramadoss “In another two ...
... Association (IMA),secretary of Ranchi, speaking for World Health ... all segments including doctors//, nurses, paramedics, laboratory technicians, ... society. ,The IMA secretary, Ajay Kumar ... healthcare, rather the cooperation of all healthcare segments ...
... with a new neupro skin patch which is offered the ... offer relief to patients// in the early stages of Parkinson's ... a naturally occurring brain chemical, which is in short supply ... said that the patch would aid the patients to manage ...
Cached Medicine News:Health News:Competitive Advantage Are Attained In Which Freeloaders Are Punished 2Health News:Competitive Advantage Are Attained In Which Freeloaders Are Punished 3Health News:Competitive Advantage Are Attained In Which Freeloaders Are Punished 4Health News:Disney’s New Attraction Showcases the Discoveries of the Himalayas Expeditio 2Health News:Disney’s New Attraction Showcases the Discoveries of the Himalayas Expeditio 3Health News:Disney’s New Attraction Showcases the Discoveries of the Himalayas Expeditio 4
(Date:10/30/2014)... --  BioLife Solutions , Inc. (NASDAQ: BLFS ... clinical grade hypothermic storage and cryopreservation ... for cells and tissues, today announced today that ... released on Thursday, November 6, 2014, and that the ... at 1:30 p.m. PST that afternoon. Management will provide ...
(Date:10/30/2014)... 30, 2014 , Extensively hydrolyzed ... milk   Cow milk protein allergy (CMPA) is the leading ... Until now, it has been managed by eliminating milk ... shown that it is possible to help build of ... of children during the first year of life by ...
(Date:10/30/2014)... LONDON , Oct. 29, 2014 ... electrical potential which can be amplified to diagnose ... The electrodes used in medical devices facilitate the ... obtained from muscle cells and neurons of the ... electrodes utilize the radiofrequency alternating current to perform ...
Breaking Medicine Technology:BioLife Solutions to Report Financial Results for Third Quarter 2014 and Provide Business Update on November 6, 2014 2Experts Present Latest Research at Allergy Day 2Experts Present Latest Research at Allergy Day 3Electrodes for Medical Devices Market (Diagnostic Electrodes - ECG, EEG, EMG, ERG and Fetal Scalp Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - Global Industry Analysis, Size, Share, G 2Electrodes for Medical Devices Market (Diagnostic Electrodes - ECG, EEG, EMG, ERG and Fetal Scalp Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - Global Industry Analysis, Size, Share, G 3Electrodes for Medical Devices Market (Diagnostic Electrodes - ECG, EEG, EMG, ERG and Fetal Scalp Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - Global Industry Analysis, Size, Share, G 4
... -- ShangPharma Corporation (NYSE: SHP ) ("ShangPharma" ... research and development outsourcing company, today announced that it ... in its biologics division, which portends strong growth for ... milestones were achieved for two oncology projects that are ...
... WuXi PharmaTech (Cayman) Inc. (NYSE: ... the pharmaceutical, biotechnology, and medical device industries, with operations in ... for the second quarter of 2011. Highlights ... Million for the First Time Second-Quarter 2011 Net ...
Cached Medicine Technology:ShangPharma's Biologics Division Announces Accelerated Achievement of Milestones for Two Multi-Stage Projects 2WuXi PharmaTech Announces Second Quarter 2011 Results 2WuXi PharmaTech Announces Second Quarter 2011 Results 3WuXi PharmaTech Announces Second Quarter 2011 Results 4WuXi PharmaTech Announces Second Quarter 2011 Results 5WuXi PharmaTech Announces Second Quarter 2011 Results 6WuXi PharmaTech Announces Second Quarter 2011 Results 7WuXi PharmaTech Announces Second Quarter 2011 Results 8WuXi PharmaTech Announces Second Quarter 2011 Results 9WuXi PharmaTech Announces Second Quarter 2011 Results 10WuXi PharmaTech Announces Second Quarter 2011 Results 11WuXi PharmaTech Announces Second Quarter 2011 Results 12WuXi PharmaTech Announces Second Quarter 2011 Results 13WuXi PharmaTech Announces Second Quarter 2011 Results 14WuXi PharmaTech Announces Second Quarter 2011 Results 15WuXi PharmaTech Announces Second Quarter 2011 Results 16WuXi PharmaTech Announces Second Quarter 2011 Results 17
Anis tying forcep is extra delicate with smooth jaws, curved. For 9-0 to 11-0 sutures....
Curved shafts and tips with 7 mm tying platform. Serrated handle with polished finish. Overall length 4 inches....
Tying forceps with 6.5 mm tying platform. Round handle with flats provide flexibility of round handle with the stability of a flat handle. Curved shafts. Overall length 3.9 inches....
Straight shafts with 4 mm tying platform. Serrated handle with dull finish. Manufactured in titanium. Overall length 3.3 inches....
Medicine Products: