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Researchers hone technique to KO pediatric brain tumors
Date:7/14/2008

ug payload of the nanoparticle is not released. The identification and attachment of targeting ligands onto the nanoparticles and the rate and extent of drug release are now what the researchers will concentrate on and seek to improve. Ligands in this application are comprised of peptides and antibodies that bind to specific cell receptors over-expressed in cancer cells.

The cell studies were performed in vitro by Zhiqiang (Jack) Xu, Ph.D., a post-doctoral associate, together with Professor Jeff Leonard, M.D., in the Department of Neurological Surgery and Professor Sheila Stewart, Ph.D., in the Department of Cell Biology and Physiology, each in the School of Medicine at Washington University. Ultimately, in vivo, the nanoparticles are expected to target the tumors through the use of active targeting ligands and also through passive diffusion, as particles are well known to be taken up selectively into tumors by a process called the enhanced permeability and retention effect. The amount of drug released from the nanoparticles "might be enough for the intended therapy, if side effects are limited by selective tumor targeting," Nystrom said.

For these drug-filled nanoparticles to be effective for treating brain tumors, one challenge remainsdecorating the nanoparticles with signatures that direct them to the tumors and away from healthy cells, a process known as tissue specific targeting. Once attached to the tumor, the nanoparticles can release their deadly contents, killing the cancer cells and leaving the healthy cells unharmed.

"Everything depends on getting the nanoparticle to the tissue (tumor) of choice," said Nystrom.

Wooley agrees. "We have been studying these nanoparticles for some time now as a platform technology, achieving high radiolabeling efficiencies and demonstrating variable bio-distributions through a collaboration with the laboratory of Professor Mike Welch, in the Department of Radiology," she said. " Now,
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Contact: Karen L. Wooley
klwooley@wustl.edu
314-935-7136
Washington University in St. Louis
Source:Eurekalert

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