Navigation Links
Researchers home in on way to predict aggressiveness of oral cancer
Date:6/26/2014

Studying mouth cancer in mice, researchers have found a way to predict the aggressiveness of similar tumors in people, an early step toward a diagnostic test that could guide treatment, according to researchers at Washington University School of Medicine in St. Louis.

"All patients with advanced head and neck cancer get similar treatments," said Ravindra Uppaluri, MD, PhD, associate professor of otolaryngology. "We have patients who do well on standard combinations of surgery, radiation and chemotherapy, and patients who don't do so well. We're interested in finding out why."

Reporting in Clinical Cancer Research, the investigators found a consistent pattern of gene expression associated with tumor spreading in mice. Analyzing genetic data from human oral cancer samples, they also found this gene signature in people with aggressive metastatic tumors.

"We didn't automatically assume this mouse model would be relevant to human oral cancer," said Uppaluri, who performs head and neck surgeries at Barnes-Jewish Hospital. "But it turns out to be highly reflective of the disease in people."

Rather than use genetic methods to induce tumors in the mice, the research team repeatedly applied a known carcinogen, in much the same way humans develop cancer of the mouth.

"Patients often have a history of tobacco and alcohol use, which drive the development of these tumors," Uppaluri said. "We felt that exposing the mice to a carcinogen would be more likely to produce similar kinds of tumors."

The researchers, including first author Michael D. Onken, PhD, research assistant professor of cell biology and physiology, showed that this exposure sometimes produced tumors in the mice that did not spread, but other times resulted in aggressive metastatic tumors, similar to the variety of tumors seen in people. Uppaluri's team then collaborated with Elaine Mardis, PhD, co-director of The Genome Institute at Washington University, to find out whether the mouse and human tumors also were genetically similar. They compared their mouse sequences to human data sets from The Cancer Genome Atlas (TCGA).

"When we sequenced these tumors, we found that a lot of the genetic mutations present in the mouse tumors also were found in human head and neck cancers," Uppaluri said.

Further analysis identified a common signature in the expression of about 120 genes that was associated with the more aggressive tumors, whether in mice or people. The researchers confirmed this signature using data collected from 324 human patients. Subsequently, using oral cancer samples from patients treated at Washington University, they developed a proof of concept test from their signature that identified the aggressive tumors with about 93 percent accuracy.

Working with the Washington University Office of Technology Management, Uppaluri has a patent pending on this technology and recently received funding from the Siteman Cancer Frontier Fund to develop a laboratory test that predicts aggressive disease and would be easily available for any patient diagnosed with head and neck cancer.

"These kinds of tests are available for other types of cancer, most notably breast cancer," he said. "They are transformative genetic tests that can alter the clinical management of patients, tailoring therapies especially for them. It's our goal to develop something like that for head and neck cancer."


'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert  

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers home in on way to predict aggressiveness of oral cancer
(Date:3/22/2017)... ... ... An intensive search of the medical literature has revealed no research yet on ... He says investigating this possibility, is important because Miami-Dade in 2016 led the U.S. ... , His findings appear on Analizir.com. . Dr. Norins, who trained ...
(Date:3/22/2017)... , ... March 22, 2017 , ... Last year, 43 ... a US Department of Agriculture report. While excess dairy can be caused by ... role. Lactose sensitivity is the inability to properly digest lactose, a sugar found in ...
(Date:3/22/2017)... ... 22, 2017 , ... The Vanderbeck Agency, a Long Island firm providing insurance, ... embarking on a combined charity effort with the Great Neck Breast Cancer Coalition to ... the Great Neck Breast Cancer Coalition has worked to support breast cancer patients in ...
(Date:3/22/2017)... ... 2017 , ... The Zabbia Insurance Agency, a Long Island ... owners in the greater Nassau County area, is embarking on a cancer awareness ... minutes, someone in America is diagnosed with blood cancer. Every 9 minutes, someone ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Senior Citizens League (TSCL) is ... default on the federal debt — including the debt held by the Social Security ... said TSCL in a letter to House and Senate budget leaders. “In prior ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... March 22, 2017 Under the impetus ... packaging market size increased year by year at ... to 2021, the market size will maintain the ... to outnumber RMB140 billion in 2021, thanks to ... development of biological agents and supporting policies. ...
(Date:3/22/2017)... March 22, 2017 New Jersey,s ... of patient harm and saved $641 million in healthcare ... in a national quality improvement program. ... for Patients-New Jersey, part of a national initiative from ... selected the New Jersey Hospital Association and its affiliate, ...
(Date:3/22/2017)... Mar 22, 2017 Research and Markets ... Point Inhibitors Market & Clinical Pipeline Insight 2022" drug ... ... & Clinical Pipeline Insight 2022 report gives comprehensive insight on ... of immune check point inhibitors as main streamline drugs in ...
Breaking Medicine Technology: