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Researchers granted funding to explore novel lung cancer strategies
Date:5/1/2014

e the drug also appears to inhibit angiogenesis, which is the growth of new blood vessels required to deliver oxygen and nutrients to cancer cells. Cancer researchers have long focused on targeting angiogenesis as a way of stopping tumor development.

Dr. Gerbers planned study will use blood tests, tumor biopsies, and MRI scans before and after itraconazole therapy to determine the drugs effects on angiogenesis and the hedgehog pathway. In addition, researchers will track itraconazole levels in blood and tumor tissue, and determine if the tests can predict which patients are most likely to benefit from itraconazole therapy.

The Department of Defense has begun funding research to fend off expected increases in lung cancer among veterans. Compared to civilians, veterans have twice the incidence of lung cancer and have lower survival rates from the disease, Dr. Gerber said. According to a 2009 Institute of Medicine estimate, just over 20 percent of the U.S. population smokes, while 22 percent of veterans smoke and 32 percent of active-duty military personnel smoke.

Other faculty taking part in the studies include Dr. Kemp Kernstine, Professor and Chief of the Division of Thoracic Surgery in the Department of Cardiovascular and Thoracic Surgery; Dr. Rolf Brekken, Associate Professor of Surgery and principal investigator in the Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research; Dr. Robert Lenkinski, Professor of Radiology and the

Contact: Patrick McGee
patrick.mcgee@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

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