Navigation Links
Researchers get $3 million National Institutes of Health grant for mathematical models of prostate cancer aggressiveness
Date:10/21/2011

TAMPA, Fla. -- Alexander R. A. Anderson, Ph.D., co-director of Integrative Mathematical Oncology (IMO) at Moffitt Cancer Center, and his colleagues, Simon Hayward, Ph.D., at Vanderbilt University and Gustavo Ayala, M.D., at Baylor College of Medicine, have received a five-year, $3 million grant from the National Institutes of Health to create new mathematical models to predict prostate cancer aggressiveness.

"Mathematical models have the potential to be useful prognostic tools, but they have not been optimally developed for the study of cancer progression," said Anderson. "Cancer is a complex disease driven by tumor cells and the tumor microenvironment, which can include stromal cells (connective tissue cells in any organ) and the tumor's vascular bed. The interactions between tumor cells and their microenvironment play a crucial role in both tumor progression and suppression."

Much of their current work on tumor invasion looks at the tumor microenvironment as a "selective force" in the growth and evolution of cancer. Anderson and David Basanta, Ph.D., another key investigator from IMO, believe that mathematical models can predict how the interactions between cellular and microenvironmental components of cancer drive progression. By developing mathematical models that incorporate signaling networks derived from both normal and cancer cells, they aim to help identify aggressive prostate cancer.

Using data collected from microscopy examination of tumor tissues donated from a large cohort of prostate cancer patients with more than a decade of follow-up information, the researchers will construct multi-scale mathematical models to capture both the cell scale signaling and tissue scale morphology. Using these models, parameterized from patient biopsies, they will predict which cancers are aggressive. Secondly, they will test the mathematical predictions in vivo. Finally, they will look for clinical validation of mathematical models as pre
'/>"/>

Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... 2015 The 2015 Deep Market ... professional and in-depth study on the current state ... a focus on the Chinese situation. , The ... including definitions, classifications, applications and industry chain structure. ... the international and Chinese domestic situations including development ...
(Date:3/27/2015)... March 27, 2015 Airy Jeanine is ... the official music video for her debut song “Mama’s ... Combining live-action and abstract styling effects, the thematic video ... on YouTube, Vimeo, and assorted outlets. It will be ... of an expanding full-scale marketing strategy. The video promotion ...
(Date:3/27/2015)... 27, 2015 Smile Brands Inc. ( ... business support services to dental groups in the United ... affiliated Castle Dental office in Hendersonville, TN. ... 37075, this new Castle Dental office provides families with ... latest in comprehensive, quality dental care. Hendersonville marks the ...
(Date:3/27/2015)... “ VXi BlueParott Reveal ” was ... Report, which features the latest and coolest technology products ... special reporter for NewsWatch, conducted the review and shared ... eliminating 90% of ambient noise. , Today, business is ... are important to any professional, voice calls are just ...
(Date:3/27/2015)... March 27, 2015 The Florida Center ... Brain Cancer Cure (ABC2), awarded $350,000 to support brain ... Florida, The Scripps Research Institute and H. Lee Moffitt ... studies with a clear development path and potential to ... the near future. , The awards fund research ...
Breaking Medicine News(10 mins):Health News:Glutathione Industry International and China Market Analysis Report 2015-2020 2Health News:Glutathione Industry International and China Market Analysis Report 2015-2020 3Health News:Airy Jeanine Releases ‘’Mama’s Girl” Official Music Video 2Health News:Castle Dental® Opens Its First Dental Office in Hendersonville, TN 2Health News:Castle Dental® Opens Its First Dental Office in Hendersonville, TN 3Health News:A Device to Tune out Background Noise was Recently Featured on NewsWatch Television 2Health News:The Florida Center for Brain Tumor Research and Accelerate Brain Cancer Cure Award $350,000 to Florida-Based Researchers 2Health News:The Florida Center for Brain Tumor Research and Accelerate Brain Cancer Cure Award $350,000 to Florida-Based Researchers 3
... , , , ... 100 mg showed clear advantages over Crinone* (progesterone gel) for ... (PK) study. Progesterone is necessary to increase endometrial receptivity ... , , ENDOMETRIN(R) rapidly reached ...
... , , CHICAGO, Aug. ... ADLS), today announced positive results from an animal study involving ... to measure Restanza,s therapeutic efficacy in treating inhalation anthrax after ... non-human primate study showed that a 14-day course of Restanza ...
... , FRANKLIN, Mass., Aug. 31 PLC Systems Inc. ... vascular medical device-based technologies, today announced that it will demonstrate its ... European Society of Cardiology, August 29 - September 2, 2009 in ... to attend this event. , , ...
... , OAKLAND, Calif., Aug. 31 Life ... that keep mind, body and emotions rigid. Especially during stressful ... is a challenge. The Breema Bodywork Method helps people find ... regardless of what challenges they may be facing. To help ...
... BEIJING, Aug. 31 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (NYSE Amex:, ... China, announced,today that Sinovac,s H1N1 vaccine has passed the experts ... vaccine is expected to,obtain the production license within this week. ... 2009, State Food and Drug Administration (SFDA),organized and held an ...
... , DEERFIELD, Ill., Aug. 31 Chicago-based Lundbeck ... Achievement by the Illinois Chapter of the Huntington,s Disease Society of ... (HD) community and making a meaningful contribution to the lives of ... past Friday at the fifth annual Celebration of Hope ...
Cached Medicine News:Health News:Recently Published Study Demonstrates Pharmacokinetic Advantages of ENDOMETRIN(R) Over Crinone(R) for Progesterone Supplementation 2Health News:Recently Published Study Demonstrates Pharmacokinetic Advantages of ENDOMETRIN(R) Over Crinone(R) for Progesterone Supplementation 3Health News:Advanced Life Sciences' Restanza Demonstrates Efficacy in Treating Anthrax Infection 2Health News:Advanced Life Sciences' Restanza Demonstrates Efficacy in Treating Anthrax Infection 3Health News:Advanced Life Sciences' Restanza Demonstrates Efficacy in Treating Anthrax Infection 4Health News:Advanced Life Sciences' Restanza Demonstrates Efficacy in Treating Anthrax Infection 5Health News:PLC Medical Systems to Demonstrate RenalGuard(R) at ESC 2009 2Health News:PLC Medical Systems to Demonstrate RenalGuard(R) at ESC 2009 3Health News:PLC Medical Systems to Demonstrate RenalGuard(R) at ESC 2009 4Health News:The Breema Center Presents Its Fall Week-Long Intensive on Giving and Receiving Breema Bodywork 2Health News:Sinovac's H1N1 Vaccine Passes Experts Evaluation Organized by SFDA 2Health News:Sinovac's H1N1 Vaccine Passes Experts Evaluation Organized by SFDA 3Health News:Lundbeck Inc. Recognized With Award of Excellence in Corporate Achievement for Its Commitment to Huntington's Disease Community 2Health News:Lundbeck Inc. Recognized With Award of Excellence in Corporate Achievement for Its Commitment to Huntington's Disease Community 3
(Date:3/26/2015)... , March 26, 2015 Huntington Memorial ... Valley to perform transcatheter aortic valve replacement (TAVR), a ... is a revolutionary new way to replace an aortic ... a heart lung machine. The procedure is ... led by Azhil ( Alex) Durairaj , MD, interventional ...
(Date:3/26/2015)... March 26, 2015  OncoGenex Pharmaceuticals, Inc. (NASDAQ: ... clinical developments and announced fourth quarter and year ... Developments and Anticipated Near-term MilestonesCustirsen , ... to negotiate the termination of their collaboration and ... final termination agreement are ongoing. , Two ...
(Date:3/26/2015)... 26, 2015 According to a ... Volume, Technology (RF, Microwave, Cryoablation, Others), Department (Interventional Radiology, ... Bone Metastasis) - Global Forecasts to 2019", published by ... around $462.0 Million growing at a CAGR of 11.50% ... and 57 figures spread through 195 pages and in-depth ...
Breaking Medicine Technology:Huntington Memorial Hospital Performs Groundbreaking Minimally Invasive Replacement of Heart Valves 2OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 2OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 3OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 4OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 5OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 6OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 7OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 8Tumor Ablation Market Worth $462.0 Million by 2019 2Tumor Ablation Market Worth $462.0 Million by 2019 3Tumor Ablation Market Worth $462.0 Million by 2019 4
... CHAPEL HILL, N.C., May 23 With increased ... generics in the,pharmaceutical market, marketing teams and science ... clinical trial results of new drugs in,development. With ... ones that do have to be spot on ...
... Coalition of Cancer Cooperative Groups sheds light on the ... on Grey,s Anatomy are not just ,do or die., ... episodes and,two-hour season finale of "Grey,s Anatomy" centered on ... doctors, the subject tops the,list of the country,s healthcare ...
Cached Medicine Technology:New Pharma Business Model Increases Pressure on Staff Communicating Trial Data 2The 'Anatomy' of Clinical Trials: 'Grey's' Season Finale Leaves Public in the Dark About the Myths and Realities 2The 'Anatomy' of Clinical Trials: 'Grey's' Season Finale Leaves Public in the Dark About the Myths and Realities 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: