Navigation Links
Researchers get $3 million National Institutes of Health grant for mathematical models of prostate cancer aggressiveness
Date:10/21/2011

TAMPA, Fla. -- Alexander R. A. Anderson, Ph.D., co-director of Integrative Mathematical Oncology (IMO) at Moffitt Cancer Center, and his colleagues, Simon Hayward, Ph.D., at Vanderbilt University and Gustavo Ayala, M.D., at Baylor College of Medicine, have received a five-year, $3 million grant from the National Institutes of Health to create new mathematical models to predict prostate cancer aggressiveness.

"Mathematical models have the potential to be useful prognostic tools, but they have not been optimally developed for the study of cancer progression," said Anderson. "Cancer is a complex disease driven by tumor cells and the tumor microenvironment, which can include stromal cells (connective tissue cells in any organ) and the tumor's vascular bed. The interactions between tumor cells and their microenvironment play a crucial role in both tumor progression and suppression."

Much of their current work on tumor invasion looks at the tumor microenvironment as a "selective force" in the growth and evolution of cancer. Anderson and David Basanta, Ph.D., another key investigator from IMO, believe that mathematical models can predict how the interactions between cellular and microenvironmental components of cancer drive progression. By developing mathematical models that incorporate signaling networks derived from both normal and cancer cells, they aim to help identify aggressive prostate cancer.

Using data collected from microscopy examination of tumor tissues donated from a large cohort of prostate cancer patients with more than a decade of follow-up information, the researchers will construct multi-scale mathematical models to capture both the cell scale signaling and tissue scale morphology. Using these models, parameterized from patient biopsies, they will predict which cancers are aggressive. Secondly, they will test the mathematical predictions in vivo. Finally, they will look for clinical validation of mathematical models as predictors of prostate cancer aggressiveness. This integrated approach could significantly reduce the substantial over-treatment of prostate cancer and dictate which cancer should be treated immediately.

"Our unique combination of resources and team expertise comprises an unparalleled research environment and provides a synergistic approach for gaining an understanding of prostate cancer that goes beyond current science," explained Anderson. "Our models begin and end with human data, assuring that our final products will provide a new and better understanding of human prostate cancer."


'/>"/>
Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... Vighter established its NAEMT Authorized ... providing Prehospital Trauma Life Support (PHTLS) course scholarships to four medics assigned to ... developed in cooperation with the American College of Surgeons to promote critical thinking ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... world countries to hospitals in the United States, it’s a threat that is ... current obstacles facing infection prevention and offers strategies for the healthcare community to ...
(Date:3/24/2017)... Farifax, VA (PRWEB) , ... March 24, 2017 , ... ... its 2017 Quest Awards . The annual awards, now in their 12th year, ... marketing peers selects the winners. , In 2016, the awards were retooled to recognize ...
(Date:3/24/2017)... ... , ... Texas Physical Therapy Specialists (TexPTS) is pleased to announce the ... clinic is the group’s 7th location in San Antonio and 23rd in Texas. ... care from the clinic, which opened March 22, 2017. , The team ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... related services to families and business owners across eastern Michigan, is connecting with ... families struggling with financial difficulties. , The Oxford/Orion FISH Food Pantry works to ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... LONDON , March 23, 2017 ... comprehensive research report created through extensive primary research ... research, the report aims to present the analysis ... basis of Procedure (Replacement and Repair); Replacement Procedure ... (TAVR)), Repair By Technique (Surgical Devices, Balloon Valvuloplasty, ...
(Date:3/23/2017)... 23, 2017  The U.S. Food and Drug Administration ... treatment of adults and pediatric patients 12 years and ... who have not received prior chemotherapy. This is the ... form of skin cancer. "While skin cancer ... a rare form called Merkel cell cancer have not ...
(Date:3/23/2017)... SAN DIEGO and VANCOUVER, British ... Inc. (NASDAQ: SPHS ) (the "Company" or ... for the treatment of urological diseases, today announced that ... which evaluated the drug as a focal treatment for ... on March 26, 2017 at the 32 nd ...
Breaking Medicine Technology: