Navigation Links
Researchers get $3 million National Institutes of Health grant for mathematical models of prostate cancer aggressiveness
Date:10/21/2011

TAMPA, Fla. -- Alexander R. A. Anderson, Ph.D., co-director of Integrative Mathematical Oncology (IMO) at Moffitt Cancer Center, and his colleagues, Simon Hayward, Ph.D., at Vanderbilt University and Gustavo Ayala, M.D., at Baylor College of Medicine, have received a five-year, $3 million grant from the National Institutes of Health to create new mathematical models to predict prostate cancer aggressiveness.

"Mathematical models have the potential to be useful prognostic tools, but they have not been optimally developed for the study of cancer progression," said Anderson. "Cancer is a complex disease driven by tumor cells and the tumor microenvironment, which can include stromal cells (connective tissue cells in any organ) and the tumor's vascular bed. The interactions between tumor cells and their microenvironment play a crucial role in both tumor progression and suppression."

Much of their current work on tumor invasion looks at the tumor microenvironment as a "selective force" in the growth and evolution of cancer. Anderson and David Basanta, Ph.D., another key investigator from IMO, believe that mathematical models can predict how the interactions between cellular and microenvironmental components of cancer drive progression. By developing mathematical models that incorporate signaling networks derived from both normal and cancer cells, they aim to help identify aggressive prostate cancer.

Using data collected from microscopy examination of tumor tissues donated from a large cohort of prostate cancer patients with more than a decade of follow-up information, the researchers will construct multi-scale mathematical models to capture both the cell scale signaling and tissue scale morphology. Using these models, parameterized from patient biopsies, they will predict which cancers are aggressive. Secondly, they will test the mathematical predictions in vivo. Finally, they will look for clinical validation of mathematical models as predictors of prostate cancer aggressiveness. This integrated approach could significantly reduce the substantial over-treatment of prostate cancer and dictate which cancer should be treated immediately.

"Our unique combination of resources and team expertise comprises an unparalleled research environment and provides a synergistic approach for gaining an understanding of prostate cancer that goes beyond current science," explained Anderson. "Our models begin and end with human data, assuring that our final products will provide a new and better understanding of human prostate cancer."


'/>"/>
Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... Georgia State University ... specialty academic programs. , Answering to the increasing demand for curricular specializations, the ... law, and environmental and land use law. ,  , “The demand for lawyers ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Woodlands at John Knox ... new model of care for living and healing, celebrated its grand opening, today. The ... a Real Home provided by Empowered Staff. , “This is an incredibly fulfilling time ...
(Date:5/26/2016)... ... May 26, 2016 , ... MadgeTech will be showcasing its line of ... Warner, New Hampshire at the MadgeTech headquarters. With products sold in more than 100 ... government agencies, including NASA. , In 2012, NASA strategically set up 17 RHTemp101A ...
(Date:5/26/2016)... ... ... An April Gallup survey found rising health care costs to be the top ... Living (SHSL) may not share those same worries thanks to a new bundled ... while holding the line on increasing their contributions, including premiums, deductibles and the portions ...
(Date:5/26/2016)... ... May 26, 2016 , ... Leadership ... solutions, today announced the organization has earned its ISO 13485 certification, indicating the ... compliant with all rules and policies associated with ISO quality standard 13485. ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 ... the Dario™ Diabetes Management Tool, today announced that the Company,s ... the Marcum MicroCap Conference being held June 1-2 in ... Invitational, being held June 7-9 in Los Angeles, ... will discuss recent corporate and operational milestones, including the U.S. ...
(Date:5/27/2016)... Amarantus BioScience Holdings, Inc. (OTCQX: AMBS), ... Neurology and Orphan Diseases, today announced that President & CEO ... conferences: SeeThru Equity MicroCap Conference   ... City , NY When: Tuesday, May 31 st ... Where: Grand Hyatt Hotel, 109 East 42 nd ...
(Date:5/26/2016)... TARE (Transarterial Radio-embolization) Using ... and Overall Decreased Use of Hospital Resource ... specialist healthcare company, has today announced the publication ... of ISPOR (International Society for Pharmacoeconomics and Outcomes ... using yttrium-90 glass microspheres is associated with cost ...
Breaking Medicine Technology: