Navigation Links
Researchers generate immunity against tumor vessel protein
Date:4/25/2014

PHILADELPHIA - Sometimes a full-on assault isn't the best approach when dealing with a powerful enemy. A more effective approach, in the long run, may be to target the support system replenishing the supplies that keep your foe strong and ready for battle. A group of researchers from the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania is pursuing this strategy by employing a novel DNA vaccine to kill cancer, not by attacking tumor cells, but targeting the blood vessels that keep them alive. The vaccine also indirectly creates an immune response to the tumor itself, amplifying the attack by a phenomenon called epitope spreading. The results of the study were published this month in the Journal of Clinical Investigation.

Previous studies have targeted tumor angiogenesis (the formation of new blood vessels that feed the tumor cells). However, this approach can also interfere with normal processes involved in wound healing and development. Penn researchers avoided this pitfall by designing a DNA vaccine that specifically targets TEM1 (tumor endothelial marker 1), a protein that is overexpressed in tumors and poorly expressed in normal tissues.

"We demonstrated that by targeting TEM1, our vaccine can decrease tumor vascularization, increase hypoxia of the tumor and reduce tumor growth," says Andrea Facciabene, PhD, research assistant professor of Obstetrics and Gynecology and a faculty member in the Ovarian Cancer Research Center at Penn Medicine. "Our results confirm that we were directly targeting the tumor vasculature and also indirectly killing tumor cells through epitope spreading."

The Penn team injected mice with a DNA fusion vaccine called TEM1-TT, created by fusing TEM1 complementary DNA with a fragment of the tetanus toxoid (TT). In mouse models of three cancer types (breast, colon, and cervical), tumor formation was delayed or prevented in mice vaccinated with the TEM1-TT DNA
'/>"/>

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-776-6063
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers at LSTM part of the international team to sequence the tsetse genome
2. Oxygen diminishes the hearts ability to regenerate, researchers discover
3. Finnish team of researchers finds a mutation in a tumor of the jaw
4. Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches
5. Life stressors trigger neurological disorders, researchers find
6. Penn researchers find link between sleep and immune function in fruit flies
7. Penn Medicine researchers uncover hints of a novel mechanism behind general anesthetic action
8. CU researchers discover target for treating dengue fever
9. BUSM researchers find anti-seizure drug may reduce alcohol consumption
10. Researchers identify children with emotional behavior difficulties
11. Researchers identify similarities between HIV/AIDS and opioid addiction epidemics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Angeles, CA (PRWEB) November 21, 2014 ... reference for the dental practice. It includes everything needed ... . , Procedure Coding with CDT , CDT 2015 ... provided from January 1, 2014 - December 31, 2014. ... report procedures and services on dental claims. There are ...
(Date:11/21/2014)... Even with years of experience under his belt, ... for growth, participating in two recent events for his State ... a networking event with the leaders of State Farm and ... latest and greatest in insurance news and products for his ... team (Stacy, Anthony, Reina and Jacob) as exhibitors at the ...
(Date:11/21/2014)... (PRWEB) November 21, 2014 CARE Surrogacy ... its intended parents — and at the same time enhancing ... sense of optimism for future parents across the globe, the ... , Prospective parents today are zoning in on the skyrocketing ... the encumbering costs, are individuals over-stressing clinical success rates ...
(Date:11/21/2014)... 21, 2014 According to a National ... June 11th, 2014, the inflating system found in certain ... airbag inflates. The force of inflation may cause the ... metal shards may pierce the airbag’s fabric and potentially ... , According to a Bloomberg Business Week article ...
(Date:11/21/2014)... 2014 Nature’s Sleep is excited to announce the ... contest calls for the creation of any type of art — ... encompasses sleep, a bed or a mattress. , “We had ... Vice President of Marketing for Nature’s Sleep, “that we decided to ... than 10,000 creative entries from some very talented artists all the ...
Breaking Medicine News(10 mins):Health News:PMIC Announces CDT PLUS! 2015, the Ultimate Coding Reference for Dentists and Oral Surgeons 2Health News:Kirk Martin Insurance Agency Goes Local and National with State Farm 2Health News:CARE Surrogacy Center Reports on its Multiple Measures of Success 2Health News:CARE Surrogacy Center Reports on its Multiple Measures of Success 3Health News:Takata Airbag Recall Class Action Lawsuit Resource Released by Florida Injury Attorney 2Health News:Takata Airbag Recall Class Action Lawsuit Resource Released by Florida Injury Attorney 3Health News:Nature’s Sleep Kicks Off their 2nd Art Of Sleep Contest 2
... The chances of suffering a stroke are linked to the ... system, a new study from Karolinska Institutet shows. The researchers ... mobilise the body,s own defence against arteriosclerosis and stroke. ... Frostegrd, has previously demonstrated that high levels of a certain ...
... taking action, study finds , FRIDAY, Feb. 12 ... opening in Canada Friday seem more on the ball ... activity enables elite athletes to see and react to ... new study finds. , Researchers analyzed the reaction time ...
... successfully inserted to reopen clogged coronary artery , THURSDAY, ... was said to be "in good spirits" Thursday evening ... two stents inserted into a clogged heart artery. , ... 2004, had been complaining of chest pains. , "Today ...
... , ... in Twin Cities , ... February 12, 2010 -- Ecumen an innovative non-profit senior housing, services and ... on its second senior housing community in Apple Valley and will manage The Seasons at ...
... ... to an underage passenger hurt in a vehicle crash after he left a party. ... Providence, RI (PRWEB) February 12, ... the liability homeowners face when they allow underage drinking in their homes., , ,Details of ...
... , ... Qigong has been called the secret of youth and longevity, and in his latest book, ... Eastern movements can slow the ageing process down and promote youthful skin from the inside ... (PRWEB) February 12, ...
Cached Medicine News:Health News:Ex-President Clinton Said To Be Fine After Heart Procedure 2Health News:Ex-President Clinton Said To Be Fine After Heart Procedure 3Health News:Ecumen Building Senior Housing in Apple Valley, Minnesota and Will Manage New Maplewood, Minnesota Property 2Health News:Ecumen Building Senior Housing in Apple Valley, Minnesota and Will Manage New Maplewood, Minnesota Property 3Health News:Rhode Island Settlement Reflects Homeowner Liability for Serving Alcohol to Those Under 21, Says Providence Lawyer Mark Gemma 2Health News:New Book Reveals How Qigong Could Be The Eastern Answer To Botox 2
(Date:11/21/2014)... Calif. , Nov. 21, 2014 In ... and Performance Scrubs carried out a new product development ... industry,s very first "limited edition" lab coat , ... female professors of surgery in the world. The new ... its unisex predecessors, with a sleek envelope collar, vertical ...
(Date:11/21/2014)... Nov. 21, 2014  Heated dialogue in recent months ... from cancer treatments to Gilead,s new hepatitis C drug ... the world questioning what it means to put a ... And while drug pricing is one of ... from both a general business and ethical standpoint – ...
(Date:11/21/2014)... 2014 Clementia Pharmaceuticals, ... dass die Europäische Arzneimittel-Agentur (European Medicines ... Orphan-Medizinprodukt an Palovarotene vergeben hat, den ... von Fibrodysplasia ossificans progressiva (FOP). FOP ... Krankheit, die von schmerzhaften, wiederkehrenden Episoden ...
Breaking Medicine Technology:Medelita Introduces Medical Industry's First Limited Edition Women's Designer Lab Coat 2"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 2"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 3"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 4"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 5Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 2Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 3
... designed with the safety and comfort of the ... (also called SF-6) leaded glass, the industry standard ... as set for optical clarity, visible light transmission, ... is protecting your eyes, it also helps you ...
Panoramic styling that contours closely to the face and brow. Saddle bridge fits average to fuller noses. Adjustable temple hinge adjusts up or down, longer or shorter. Soft cushion behind ear for co...
Qualcraft™ Radiation Protection Eyewear, Metal, Bifocal. Provides maximum comfort and eye protection! Plano (nonprescription). Black with bronze temple bar....
QualCraft™ Radiation-Reducing Eyewear is 50% lighter than other protective eyewear. Manufactured for the ultimate combination of comfort, function, and protection....
Medicine Products: