Navigation Links
Researchers generate immunity against tumor vessel protein
Date:4/25/2014

PHILADELPHIA - Sometimes a full-on assault isn't the best approach when dealing with a powerful enemy. A more effective approach, in the long run, may be to target the support system replenishing the supplies that keep your foe strong and ready for battle. A group of researchers from the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania is pursuing this strategy by employing a novel DNA vaccine to kill cancer, not by attacking tumor cells, but targeting the blood vessels that keep them alive. The vaccine also indirectly creates an immune response to the tumor itself, amplifying the attack by a phenomenon called epitope spreading. The results of the study were published this month in the Journal of Clinical Investigation.

Previous studies have targeted tumor angiogenesis (the formation of new blood vessels that feed the tumor cells). However, this approach can also interfere with normal processes involved in wound healing and development. Penn researchers avoided this pitfall by designing a DNA vaccine that specifically targets TEM1 (tumor endothelial marker 1), a protein that is overexpressed in tumors and poorly expressed in normal tissues.

"We demonstrated that by targeting TEM1, our vaccine can decrease tumor vascularization, increase hypoxia of the tumor and reduce tumor growth," says Andrea Facciabene, PhD, research assistant professor of Obstetrics and Gynecology and a faculty member in the Ovarian Cancer Research Center at Penn Medicine. "Our results confirm that we were directly targeting the tumor vasculature and also indirectly killing tumor cells through epitope spreading."

The Penn team injected mice with a DNA fusion vaccine called TEM1-TT, created by fusing TEM1 complementary DNA with a fragment of the tetanus toxoid (TT). In mouse models of three cancer types (breast, colon, and cervical), tumor formation was delayed or prevented in mice vaccinated with the TEM1-TT DNA
'/>"/>

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-776-6063
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers at LSTM part of the international team to sequence the tsetse genome
2. Oxygen diminishes the hearts ability to regenerate, researchers discover
3. Finnish team of researchers finds a mutation in a tumor of the jaw
4. Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches
5. Life stressors trigger neurological disorders, researchers find
6. Penn researchers find link between sleep and immune function in fruit flies
7. Penn Medicine researchers uncover hints of a novel mechanism behind general anesthetic action
8. CU researchers discover target for treating dengue fever
9. BUSM researchers find anti-seizure drug may reduce alcohol consumption
10. Researchers identify children with emotional behavior difficulties
11. Researchers identify similarities between HIV/AIDS and opioid addiction epidemics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... The Fresh Diet, America’s premier gourmet meal ... Vegetarian meal plan. Originating from The Fresh Diet’s commitment ... is designed to satisfy customers seeking a convenient, worry-free ... Responding to the growing demand by customers for non-meat ... (Forbes) with 14% of Americans identifying vegetarian meals as ...
(Date:8/29/2014)... 29, 2014 (HealthDay News) -- The main strain ... Middle East and North Africa originated in sub-Saharan ... so-called community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) ... not recently been hospitalized. These infections typically affect ... contact or through touching contaminated objects such as ...
(Date:8/29/2014)... Parker Waichman LLP, a national law ... rights of victims who have been injured by medications ... new regulations for all hydrocodone combination products. According to ... dated August 21, 2014, the DEA will be regulating ... law. , The long-awaited announcement comes after a ...
(Date:8/29/2014)... 2014 TayganPoint Consulting Group, a leading ... second time, Inc. Magazine has named the company one ... Based on solid revenue growth of over 166% over ... on the list. TayganPoint’s repeat success in this ... past few years, is a demonstration of its strong ...
(Date:8/29/2014)... 2014 Gwyneth Paltrow, Beyonce and Angelina Jolie ... have inspired dieters all over the United States, to find ... to help them quickly shed excess fat. And, recent inspiration ... that substitutes all gluten products, eggs and meats for ingredients ... associated with following this type of diet, one must be ...
Breaking Medicine News(10 mins):Health News:The Fresh Diet America's #1 At-Home Meal Delivery Company, Debuts Fresh Vegetarian Meal Plan Offering All-Natural Ingredients 2Health News:The Fresh Diet America's #1 At-Home Meal Delivery Company, Debuts Fresh Vegetarian Meal Plan Offering All-Natural Ingredients 3Health News: European MRSA Originated in Sub-Saharan Africa, Study Finds 2Health News:The Drug Enforcement Agency (DEA) Just Announced Plans to Regulate All Hydrocodone Combination Drugs as Schedule II Drugs, Parker Waichman LLP Comments 2Health News:The Drug Enforcement Agency (DEA) Just Announced Plans to Regulate All Hydrocodone Combination Drugs as Schedule II Drugs, Parker Waichman LLP Comments 3Health News:Diet Doc Announces Diet Plans that Deliver Fast Weight Loss Results at a Fraction of the Cost of Celebrity Diets 2Health News:Diet Doc Announces Diet Plans that Deliver Fast Weight Loss Results at a Fraction of the Cost of Celebrity Diets 3
... Migraine is a neurovascular disease that affects about ... and beverages (chocolate, wine, citrus, etc) considered as ... and phenolic compounds. Avoiding those triggers may ... patients. However, only a small percentage ...
... reduce the use of mechanical ventilation with premature infants ... can profoundly affect those children,s outcomes while reducing the ... at Children,s Hospital Boston. The team, led ... Medicine at Children,s Hospital Boston and the Neonatal Intensive ...
... The American Association for Cancer Research is pleased to ... their families and caregivers won first place in ... of Colon and Rectal Surgeons. Separately, it received three ... the Society of Professional Journalists. "We are ...
... Daytime sleepiness may affect inhibitory control in the ... research abstract that will be presented Monday, June ... 25th Anniversary Meeting of the Associated Professional Sleep ... daytime sleepiness was associated with decreased activation in ...
... insomnia may be able to find relief by wearing a ... abstract that will be presented Monday, June 13, in Minneapolis, ... Associated Professional Sleep Societies LLC (APSS). According to the ... occurs while falling asleep and is associated with restorative sleep. ...
... Multiple Sclerosis sufferers emotional support through group therapy sessions ... NHS almost 500 per patient, a study at The ... planning a larger multi-centre study into the issue to ... MS services currently provided by the NHS. The ...
Cached Medicine News:Health News:The association of alcohol drinking with migraine headache 2Health News:Guidelines for ventilator use help premature infants breathe easier 2Health News:AACR's CR magazine honored with 4 prestigious journalism awards 2Health News:Sleepiness may impair the brain's inhibitory control when viewing high-calorie foods 2Health News:Cooling the brain during sleep may be a natural and effective treatment for insomnia 2Health News:Cooling the brain during sleep may be a natural and effective treatment for insomnia 3Health News:Group therapy helps MS sufferers cope with depression, study finds 2Health News:Group therapy helps MS sufferers cope with depression, study finds 3
(Date:8/28/2014)... PORTLAND, Oregon , August 28, 2014 /PRNewswire/ ... Market Research titled, "DNA diagnostics Market (products, applications, ... Analysis, Trends, Opportunities, Growth and Forecast, 2013 - ... would reach $19 billion by 2020 registering a ... potential to provide accurate diagnosis and cost effectiveness ...
(Date:8/28/2014)...  In recognition of the increased risks that ... flu, pneumonia, shingles and other illnesses, CVS/pharmacy ® ... to be Senior Vaccination Month. Because people,s immune ... that adults ages 65 years and older stay ... and MinuteClinic nurse practitioners and physician assistants will ...
(Date:8/28/2014)... Aug. 28, 2014 Reportlinker.com ... report is available in its catalogue: ... Asia-Pacific Markets to 2020 - Novel ... in Newly Diagnosed and Recurrent GBM ... Glioblastoma Multiforme Therapeutics ...
Breaking Medicine Technology:DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 2DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 3September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 2September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 3September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 4Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 2Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 3Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 4Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 5Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 6Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 7Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 8Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 9
... Ph.D., will join the executive committee of Eli Lilly and ... Walsh will continue in her current role as Lilly,s ... Ph.D., chairman, president, and CEO, and working to ensure Lilly ... Walsh is a recognized thought leader in the ...
... June 30, 2011 Xlumena, Inc., a ... and endoscopic surgeon, announced today that it has received ... The NAVIX is a multi-function system that enables exchange-free ... endoscopic pancreatic pseudocyst drainage.  The NAVIX will join the ...
Cached Medicine Technology:Lilly Quality Leader Walsh Appointed to Company's Executive Committee 2Xlumena Receives CE Mark for NAVIX™, Second Product to Enter European Market 2
... is the least expensive of the series. It has ... central area of the cornea. The model comes with ... a picture of a patients corneal endothelium, you simply ... on the chin rest. The left side of the ...
... The JSZ Orthokeratology (oprifocon ... gas permeable contact lenses used ... temporarily corrects nearsightedness (myopia). The ... and removes them in the ...
... contact lenses used for corneal refractive therapy, ... The patient wears the lenses overnight while ... the day, nearsightedness is corrected or greatly ... contact lenses apply slight pressure to the ...
... Looking for a way to help your ... cardiovascular disease? Based on the outcomes ... Counterpulsation (ECP) has improved the quality of ... perform normal activities of daily living. , ...
Medicine Products: