Navigation Links
Researchers gain better understanding of mechanism behind tau spreading in the brain
Date:5/1/2012

Researchers at Mount Sinai School of Medicine have gained insight into the mechanism by which a pathological brain protein called tau contributes to the progression of Alzheimer's disease (AD) and other neurodegenerative disorders. This finding, published in the most recent issue of the Journal of Biological Chemistry, may provide the basis for future investigations on how to prevent tau from damaging brain circuits involved in cognitive function.

Previous studies have shown that the abnormal folding, or misfolding, and buildup of tau are key neuropathological features of many neurodegenerative disorders, including AD. Some research has demonstrated that AD-type tau neuropathology spreads in the brain, seemingly moving from one brain cell to another.

A research group led by Giulio Maria Pasinetti, MD, PhD, Saunders Family Chair in Neurology at Mount Sinai School of Medicine, explored whether misfolded tau released by neurons from the human brain also known as paired helical filaments (PHFs) could actually be taken up by surrounding cells and promote the spread of tau neuropathology. The evidence was gathered by treating human neuronal cell lines with human Alzheimer's disease-derived PHFs. The researchers found that not only did the cells in fact internalize the human PHFs, the abnormal tau then propagated its abnormal state to the native, normal tau protein in the cells.

"While these findings are potentially important for possibly opening new therapeutic avenues in Alzheimer's disease, they also shed light on a new therapeutic target for a wide variety of disorders sharing pathological features with Alzheimer's disease, for which there are currently no cures," said Dr. Pasinetti. "Such diseases include Progressive Supranuclear Palsy, frontotemporal dementia, and other devastating neurodegenerative disorders in which misfolded tau forms aggregates in the brain."

Next the researchers treated the same cell lines with a grape-seed extract enriched in polyphenols, which are natural compounds found in grapes, fruits, and vegetables, based on 2011 research showing the efficacy of this extract in preventing the progression of AD in mice. Dr. Pasinetti's group found that a subfraction of this natural grape-seed extract enriched in polyphenols was able to prevent the cell-to-cell spread of tau pathology in the same human neuronal cell lines.

"Pathology in neurodegenerative disorders is thought to be initiated decades before disease onset," said Dr. Pasinetti. "While further research is needed in humans, we hypothesize that this grape-derived compound may be a promising therapy for not only treating but preventing neurodegenerative disorders involving tau neuropathology."

Dr. Pasinetti and Jun Wang, PhD, Assistant Professor of Neurology at Mount Sinai, are named inventors of a pending application filed by Mount Sinai School of Medicine titled "Methods Preventing Neurodegenerative Disease" related to the use of grape-seed extracts for the treatment of neurodegenerative diseases and may benefit financially from this patent.


'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
2. Researchers determine vitamin D blood level for reducing major medical risks in older adults
3. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
4. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
5. Moffitt Cancer Center researchers working at frontiers of melanoma research
6. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
7. UCLA researchers combat global disease with a cell phone, Google Maps and a lot of ingenuity
8. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
9. Moffitt researchers find cancer therapies affect cognitive functioning among breast cancer survivors
10. Gene Behind Psoriasis Identified, Researchers Say
11. McMaster researchers find potential for new uses of old drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2020)... , ... May 15, 2020 , ... For patients who have gone to see ... that the office has always had in place. After being allowed to re-open during the ... that patients and staff are as safe and comfortable as possible while going through their ...
(Date:5/16/2020)... (PRWEB) , ... May 16, 2020 , ... Dr. ... relatively early, this will prevent permanent arthritis from developing. This can keep the foot ... Biernacki further states “It is estimated that the people who develop flat feet and ...
(Date:5/15/2020)... ... May 15, 2020 , ... Cisive, a ... the company and its healthcare-focused background screening division, PreCheck, were both named by ... Companies 2020. A distinguished panel comprising of CEOs, CIOs, CHROs, and analysts, along ...
(Date:5/15/2020)... ... May 15, 2020 , ... ... the final beam atop the hospital’s new six-story, 300,000 square foot patient and ... B. Downs Boulevard. The topping off celebrates the structural completion of the $256 ...
(Date:5/14/2020)... ... 14, 2020 , ... SGF , a premier fertility and IVF center and home to ... in the Tampa Bay region. , “While this pandemic has tested us, we are resilient ... patients have risen to the occasion. Through the work of many, I am happy that ...
Breaking Medicine News(10 mins):
(Date:5/21/2020)... ... May 21, 2020 , ... Rapid Application Group (RAG), ... deliver thousands of critical Personal Protection Equipment (PPE) devices to local first responders ... work, the three companies teamed together to start production of face shields and ...
(Date:5/21/2020)... ... May 21, 2020 , ... The COVID-19 outbreak has changed ... this year, leadership at SPIRE Institute & Academy (IA) have closely followed the recommendations ... Mike DeWine’s office to prevent the spread of coronavirus, and keep students, campers, parents, ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... resource, donated its second COVID-19 drive-through testing shelter in Camden County, New Jersey. ... County Freeholders and Connor Strong & Buckelew and is located at 3100 Federal ...
Breaking Medicine Technology: