Navigation Links
Researchers from Boston University receive grant to develop improved virus detection system

(Boston) A team of researchers from Boston University's School of Medicine (BUSM) and College of Engineering (COE) have been awarded a five-year, $4.8 million National Institutes of Health (NIH) grant to develop a low-cost, multiplexed virus detection platform. Based on technologies developed with seed funding from Boston University's Photonics Center, the resulting diagnostic platform should be capable of rapidly detecting - at the point of care- viral pathogens such as Ebola, Lassa Fever and Marburg.

The actual testing of the virus detections platform with "hot" virus will take place at the University of Texas Medical Branch.

Led by principal investigator John Connor, PhD, an assistant professor of microbiology at BUSM, the research team also includes Selim nl, PhD, Hatice Altug, PhD, Catherine Klapperich, PhD and Mario Cabodi, PhD, all from the COE. Together their research groups will work to apply cutting-edge developments in engineering and physics to the task of finding and identifying infectious agents

"We brought together this interdisciplinary team in order to develop a breakthrough detector system that will allow a simple test for the presence of multiple viruses," said Connor. "To do that, we are working to negate the need for enzymes or fluorescent labels and are building nanoscale platforms that can look for multiple viruses at the same time," he added.

The team is working on two different detection technologies. For both technologies, the complete system will consist of a small "detector" chip containing integrated microfluidics. The microfluidics will allow samples to be drawn over the active sensing chip that will capture viruses.

The chip will then be analyzed in a "reader" that is capable of rapidly reading the detector chips and providing diagnostic information. The system should be able to simultaneously assess multiple possible infectious agents. The chips are smaller than a quarter, and the readers are expected to be the size of a breadbox, making them easily portable.

Early tests of the system will be carried out in Connor's laboratory which will use pseudo-viruses that will help with the development of the detection platforms. He will be utilizing a veterinary virus that will establish the sensitivity, reproducibility and the flexibility of the detection platforms. Following the initial development and validation of the detectors, the researchers will partner with Becton Dickinson (BD), a leading global medical technology company, to transform one of the virus diagnostic platforms into a working prototype. They will send the prototype for testing to the lab of Thomas Geisbert, PhD, from the University of Texas Medical Branch.

According to the researchers, the current limitations of conventional virus detection methods include expensive equipment, relatively long process times and require extensive training. "Under the new NIH grant, our goal is to produce a highly-sensitive, user-friendly, commercially-viable virus detection system that can be deployed at the point of care and detect viruses in about 30 minutes," explained nl.


Contact: Gina DiGravio
Boston University Medical Center

Related medicine news :

1. Researchers review studies on CCSVI-MS link
2. Researchers call for more awareness of male breast cancer as cases rise
3. Researchers transform iPhone into high-quality medical imaging device
4. Fox Chase researchers identifiy more accurate treatment delivery for robotic radiosurgery system
5. Georgia Tech researchers receive 3 NSF Emerging Frontiers awards
6. Childrens National researchers make breakthrough in understanding white matter development
7. UH researchers explain hormonal role in glucose and fat metabolism
8. Researchers identify enzyme that regulates degradation of damaged proteins
9. UTHealth researchers train promotoras to combine mobile technology, cancer prevention messages
10. Researchers uncover gene associated with blood cancers
11. Boston researchers share in $10 million grant to study HIV and alcohol
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... ThirdLove, the fast-growing bra company ... early, offering 40% off select bras and underwear styles, now through Saturday, November ... fit technology and the latest fashion, quickly becoming the next generation of luxury ...
(Date:11/24/2015)... , ... November 24, 2015 , ... ... leaders when it comes to several aspects of orthopedic care. They have received ... orthopedic surgeries and general orthopedic care. , Becker's Hospital Review selected hospitals ...
(Date:11/24/2015)... Berkeley, California (PRWEB) , ... November 24, 2015 ... ... Brillouin Energy's LENR HHT Bolier Reactor System. Brillouin is the developer of renewable ... on controlled low energy nuclear reactions (“LENR”), announced today that its WET™ and ...
(Date:11/24/2015)... VA (PRWEB) , ... November 24, 2015 , ... ... people across the United States to support their local poison centers through donations ... designated as #GivingTuesday: calls it “a day that inspires people to collaborate ...
(Date:11/24/2015)... ... November 24, 2015 , ... Aided by seed funding from the Ron ... designed to yield insights into how to detect and treat pancreatic cancer (PC). ... from small, non-coding RNA molecules (ncRNA), genetic material that is present in the blood ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... CHICAGO , Nov. 24, 2015  Figure 1, ... view and share medical cases, has launched a new ... of the web version allows radiologists, who work primarily ... workstation. To further engage with its radiologist user base, ... Society of North America (RSNA) ...
(Date:11/24/2015)... , Nov. 24, 2015 Teledyne DALSA , ... image sensing technology, will introduce its CMOS X-Ray detector ... , November 29 to December 3, at McCormick Place in ... detectors for diagnostic and interventional imaging will be on display ... family of advanced CMOS X-Ray detectors is the industry ...
(Date:11/24/2015)... Nov. 24, 2015  NuShield, Inc., an industry leader in LCD screen protection and glare-elimination technology, ... technology as part of their patient monitoring or electronic documentation system. ... ... ... A study in 2013 ...
Breaking Medicine Technology: