Navigation Links
Researchers from 5 countries to test hygiene hypothesis with EU funding
Date:5/28/2008

High living standards and the life style connected to them seem to promote the development of autoimmune diseases and allergic symptoms. This has lead to the assumption that the immune system begins to overreact to the organisms own structures or to exogenous non-infectious proteins, i.e. allergens, when it does not have to work hard enough to protect the individual from infections.

The European Union with its Seventh Framework Program has allocated 6 million euros to the University of Helsinki coordinated DIABIMMUNE research project for the years 2008-2013 to establish whether the decrease in the infection load is connected to type 1 diabetes and the emergence of allergies.

The project comprises 12 partners from five countries. The study will include 7 000 children from Finland, Estonia and Russian Karelia in northwestern Russia. In each country the study will follow more than 300 children from birth to their 3rd birthday. In addition, the research will focus on 2 000 children from their third to fifth birthdays.

Earlier we have studied autoimmune phenomena and allergic responses in Finnish and Russian Karelian school children. Now we are to study infants and toddlers in order to yield new information on the maturation of the immune system and the interaction between the immune system and the environment, says Professor Mikael Knip from the University of Helsinki.

Based on earlier studies it is known that the incidence of type 1 diabetes is six times higher and the prevalence of celiac disease five times higher among Finnish children than among Russian Karelian children. The HLA gene variants that predispose people to autoimmune diseases are however approximately equally common in both populations. The studies have also revealed that Russian Karelian school children have helicobacter antibodies as signs of earlier infections 15 times more often, Toxoplasma antibodies five times more often, and hepatitis A antibodies 12 times more often than Finnish children. Karelian children also have considerably more often antibodies against the Coxsackie B4 virus, belonging to the enterovirus group, than Finnish children have.

The differences in the frequency of autoimmune phenomena and allergic responses between Finland and Russian Karelia cannot be due to genetic causes. High living standards and the associated life style appear to promote the development of autoimmune diseases and allergic responses, Knip says.

The DIABIMMUNE project focuses for example on the development of the intestinal bacterial flora after birth and the effect the living environment has on the composition of the bacterial flora. The research also studies the effect infections have on the maturation of the human immune system and the operation of the white blood cells that regulate immune responses. In addition, the researchers study whether the protection conferred by infections against autoimmune and allergic responses is associated with the overall infection load or due to specific microbes. The project also examines the effect of the childs nutrition on the maturation of the immune system, the intestinal bacterial flora and the occurrence of infections.

The diseases we are studying are the most common chronic diseases in children and their impact, both societal and medical, is vast. We are searching for ways to stop these diseases from becoming more frequent and to prevent their development, Knip says.


'/>"/>

Contact: Mikael Knip
mikael.knip@helsinki.fi
358-408-447-671
University of Helsinki
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2017)... ... 2017 , ... Patients with missing teeth now have the ... from Dr. Alejandro Kovacs. Dr. Kovacs is a board-certified periodontist and prosthodontist who ... dental implants in Longview, TX. , During traditional dental implant ...
(Date:7/27/2017)... ... 27, 2017 , ... TransPanel Volume 4 is a collection of animating panel ... exclusive features transitions that contain between 2 and 6 animated panels. Change the direction ... menus. TransPanel Volume 4 makes editing easy in Final Cut Pro X. , TransPanel ...
(Date:7/27/2017)... Clara, CA (PRWEB) , ... July 27, 2017 ... ... announces the addition of a secure cloud-based polysomnography (PSG) distributed scoring solution to ... support accelerated diagnostics and sleep care management. The speed and functionality of scoring ...
(Date:7/27/2017)... ... 2017 , ... SSCI, a division of Albany Molecular Research, ... representing a milestone achievement. , As an industry-leading provider of ... served as expert and fact witnesses to assist our clients to perform infringement ...
(Date:7/27/2017)... ... ... Angeles leg of the US movie premier of the Man in the Camo Jacket will ... Davis Theater inside the Grammy Museum Located in downtown Los Angeles in the LA Live ... musician, Mike Peters (of The Alarm), his rise to fame, battle with cancer and inspiring ...
Breaking Medicine News(10 mins):
(Date:7/24/2017)... July 24, 2017  Diplomat Pharmacy, Inc. (NYSE: ... its second quarter 2017 operating results on Monday, August ... to follow at 5:00 p.m. ET. ... to a live broadcast of the conference call by ... participant code 51641230 approximately 15 minutes prior to the ...
(Date:7/20/2017)... 2017  Prime Therapeutics LLC (Prime) released this statement from ... today,s Institute for Clinical and Economic Review,s (ICER) public ... and value of abuse-deterrent formulations (ADF) of opioids. Prime was ... the meeting. "The ... to the use of abuse-deterrent formulations (ADF) in opioids in ...
(Date:7/14/2017)... VEGAS , July 13, 2017 It should ... United States is in the midst of a ... Control , since 1999, the number of overdose deaths from ... "resulting in over half a million dead from 2001 to ... codeine, oxycodone, and hydrocodone has similarly quadrupled, drawing a compelling ...
Breaking Medicine Technology: