Navigation Links
Researchers from 5 countries to test hygiene hypothesis with EU funding
Date:5/28/2008

High living standards and the life style connected to them seem to promote the development of autoimmune diseases and allergic symptoms. This has lead to the assumption that the immune system begins to overreact to the organisms own structures or to exogenous non-infectious proteins, i.e. allergens, when it does not have to work hard enough to protect the individual from infections.

The European Union with its Seventh Framework Program has allocated 6 million euros to the University of Helsinki coordinated DIABIMMUNE research project for the years 2008-2013 to establish whether the decrease in the infection load is connected to type 1 diabetes and the emergence of allergies.

The project comprises 12 partners from five countries. The study will include 7 000 children from Finland, Estonia and Russian Karelia in northwestern Russia. In each country the study will follow more than 300 children from birth to their 3rd birthday. In addition, the research will focus on 2 000 children from their third to fifth birthdays.

Earlier we have studied autoimmune phenomena and allergic responses in Finnish and Russian Karelian school children. Now we are to study infants and toddlers in order to yield new information on the maturation of the immune system and the interaction between the immune system and the environment, says Professor Mikael Knip from the University of Helsinki.

Based on earlier studies it is known that the incidence of type 1 diabetes is six times higher and the prevalence of celiac disease five times higher among Finnish children than among Russian Karelian children. The HLA gene variants that predispose people to autoimmune diseases are however approximately equally common in both populations. The studies have also revealed that Russian Karelian school children have helicobacter antibodies as signs of earlier infections 15 times more often, Toxoplasma antibodies five times more often, and hepatitis A antibodies 12 times more often than Finnish children. Karelian children also have considerably more often antibodies against the Coxsackie B4 virus, belonging to the enterovirus group, than Finnish children have.

The differences in the frequency of autoimmune phenomena and allergic responses between Finland and Russian Karelia cannot be due to genetic causes. High living standards and the associated life style appear to promote the development of autoimmune diseases and allergic responses, Knip says.

The DIABIMMUNE project focuses for example on the development of the intestinal bacterial flora after birth and the effect the living environment has on the composition of the bacterial flora. The research also studies the effect infections have on the maturation of the human immune system and the operation of the white blood cells that regulate immune responses. In addition, the researchers study whether the protection conferred by infections against autoimmune and allergic responses is associated with the overall infection load or due to specific microbes. The project also examines the effect of the childs nutrition on the maturation of the immune system, the intestinal bacterial flora and the occurrence of infections.

The diseases we are studying are the most common chronic diseases in children and their impact, both societal and medical, is vast. We are searching for ways to stop these diseases from becoming more frequent and to prevent their development, Knip says.


'/>"/>

Contact: Mikael Knip
mikael.knip@helsinki.fi
358-408-447-671
University of Helsinki
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... 2017 , ... The American College of Medical Informatics (ACMI) will present the ... Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... a pioneer in the field of medical informatics, this prestigious award is presented to ...
(Date:10/12/2017)... ... 12, 2017 , ... Dr. Parsa Mohebi, the Los Angeles ... to the newly revamped Cosmetic Town journal section, featuring articles written ... known as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I ...
(Date:10/12/2017)... ... , ... On Saturday, October 21, the Health & Wellness Center at Florida ... money for the American Heart Association Heart Walk. Teams of up to 10 people ... keep their treadmills moving for 5 hours. Treadmills will start at 7:00 p.m. on ...
(Date:10/12/2017)... BALTIMORE (PRWEB) , ... October 12, 2017 , ... ... average of $3,296 in property taxes a year. In some states—like New York, ... higher. , By contrast, many overseas retirement havens have extremely low property-tax rates, ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... presents its enhanced Pepper Flow promotional review platform at the Promotional Review ... increased insight-driven capabilities help marketers streamline the medical, legal, and regulatory review ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 West Pharmaceutical ... innovative solutions for injectable drug administration, today announced that ... market opens on Thursday, October 26, 2017, and will ... and business expectations at 9:00 a.m. Eastern Time. To ... 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... , Oct. 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") ... Surgical facility in Las Piedras, Puerto Rico ... and blades. ... the facility sustained minor structural damage, temporary loss of ... Repairs have been completed, manufacturing operations have resumed, and ...
(Date:10/5/2017)... 5, 2017  In response to the nationwide ... Maxillofacial Surgeons (AAOMS) released prescribing recommendations that urge ... used as a first-line therapy to manage a ... Recognizing the value and importance ... "Opioid Prescribing: Acute and Postoperative Pain Management" stresses ...
Breaking Medicine Technology: