Navigation Links
Researchers form new nerve cells &#8211 directly in the brain
Date:3/26/2013

The field of cell therapy, which aims to form new cells in the body in order to cure disease, has taken another important step in the development towards new treatments. A new report from researchers at Lund University in Sweden shows that it is possible to re-programme other cells to become nerve cells, directly in the brain.

Two years ago, researchers in Lund were the first in the world to re-programme human skin cells, known as fibroblasts, to dopamine-producing nerve cells without taking a detour via the stem cell stage. The research group has now gone a step further and shown that it is possible to re-programme both skin cells and support cells directly to nerve cells, in place in the brain.

"The findings are the first important evidence that it is possible to re-programme other cells to become nerve cells inside the brain", said Malin Parmar, research group leader and Reader in Neurobiology.

The researchers used genes designed to be activated or de-activated using a drug. The genes were inserted into two types of human cells: fibroblasts and glia cells support cells that are naturally present in the brain. Once the researchers had transplanted the cells into the brains of rats, the genes were activated using a drug in the animals' drinking water. The cells then began their transformation into nerve cells.

In a separate experiment on mice, where similar genes were injected into the mice's brains, the research group also succeeded in re-programming the mice's own glia cells to become nerve cells.

"The research findings have the potential to open the way for alternatives to cell transplants in the future, which would remove previous obstacles to research, such as the difficulty of getting the brain to accept foreign cells, and the risk of tumour development", said Malin Parmar.

All in all, the new technique of direct re-programming in the brain could open up new possibilities to more effectively replace dying brain cells in conditions such as Parkinson's disease.

"We are now developing the technique so that it can be used to create new nerve cells that replace the function of damaged cells. Being able to carry out the re-programming in vivo makes it possible to imagine a future in which we form new cells directly in the human brain, without taking a detour via cell cultures and transplants", concluded Malin Parmar.


'/>"/>
Contact: Malin Parmar
Malin.Parmar@med.lu.se
46-462-220-620
Lund University
Source:Eurekalert

Related medicine news :

1. Moffitt Cancer Center researchers design small molecule to disrupt cancer-causing protein
2. UW researchers discover the brain origins of variation in pathological anxiety
3. Researchers decode biology of blood and iron disorders mapping out novel future therapies
4. Researchers developing antiviral drug to combat contagious norovirus
5. WSU researchers to study effect of fatigue on attention
6. Patient Wishes Should Guide End-of-Life Care, Researchers Say
7. Researchers new method may sharpen microscopic images
8. Researchers tackle physician challenge of correctly ordering laboratory tests
9. Moffitt Cancer Center researchers study use of dasatinib for patients with high-risk MDS
10. Brain Circuitry Yields Clue to Autism, Researchers Say
11. NIH-supported researchers identify new class of malaria compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... New York, NY (PRWEB) , ... October 13, 2017 , ... ... most influential people in business to advocate for action towards gender equality at their ... 18,000 views from around the globe, and reached a social audience of over 3 ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
(Date:10/12/2017)... Malvern, PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best ... New York City on October 11, 2017. , The annual award competition recognizes editorial ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... FLINT, Mich. , Oct. 2, 2017 ... acquired 8th Day Software and Consulting, LLC , ... 8th Day Software, based in Tennessee ... Management LLC. 8th Day expands EnvoyHealth,s service offerings for ... product development. "In ...
(Date:10/2/2017)... PHILADELPHIA , Oct. 2, 2017 Halo Labs announces ... particle analysis system called the HORIZON at MIBio 2017 in ... analyzes subvisible and visible particulate matter in biopharmaceutical samples with unprecedented ... use of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... 28, 2017 Cohen Veterans Bioscience and Early ... of wearable and home sensors for real-time monitoring of ... Foundation, a nonprofit organization focused on disruptive health solutions ... affordable analytical system to record and integrate behavioral, cognitive, ... ...
Breaking Medicine Technology: