Navigation Links
Researchers form new nerve cells &#8211 directly in the brain
Date:3/26/2013

The field of cell therapy, which aims to form new cells in the body in order to cure disease, has taken another important step in the development towards new treatments. A new report from researchers at Lund University in Sweden shows that it is possible to re-programme other cells to become nerve cells, directly in the brain.

Two years ago, researchers in Lund were the first in the world to re-programme human skin cells, known as fibroblasts, to dopamine-producing nerve cells without taking a detour via the stem cell stage. The research group has now gone a step further and shown that it is possible to re-programme both skin cells and support cells directly to nerve cells, in place in the brain.

"The findings are the first important evidence that it is possible to re-programme other cells to become nerve cells inside the brain", said Malin Parmar, research group leader and Reader in Neurobiology.

The researchers used genes designed to be activated or de-activated using a drug. The genes were inserted into two types of human cells: fibroblasts and glia cells support cells that are naturally present in the brain. Once the researchers had transplanted the cells into the brains of rats, the genes were activated using a drug in the animals' drinking water. The cells then began their transformation into nerve cells.

In a separate experiment on mice, where similar genes were injected into the mice's brains, the research group also succeeded in re-programming the mice's own glia cells to become nerve cells.

"The research findings have the potential to open the way for alternatives to cell transplants in the future, which would remove previous obstacles to research, such as the difficulty of getting the brain to accept foreign cells, and the risk of tumour development", said Malin Parmar.

All in all, the new technique of direct re-programming in the brain could open up new possibilities to more effectively replace dying brain cells in conditions such as Parkinson's disease.

"We are now developing the technique so that it can be used to create new nerve cells that replace the function of damaged cells. Being able to carry out the re-programming in vivo makes it possible to imagine a future in which we form new cells directly in the human brain, without taking a detour via cell cultures and transplants", concluded Malin Parmar.


'/>"/>
Contact: Malin Parmar
Malin.Parmar@med.lu.se
46-462-220-620
Lund University
Source:Eurekalert

Related medicine news :

1. Moffitt Cancer Center researchers design small molecule to disrupt cancer-causing protein
2. UW researchers discover the brain origins of variation in pathological anxiety
3. Researchers decode biology of blood and iron disorders mapping out novel future therapies
4. Researchers developing antiviral drug to combat contagious norovirus
5. WSU researchers to study effect of fatigue on attention
6. Patient Wishes Should Guide End-of-Life Care, Researchers Say
7. Researchers new method may sharpen microscopic images
8. Researchers tackle physician challenge of correctly ordering laboratory tests
9. Moffitt Cancer Center researchers study use of dasatinib for patients with high-risk MDS
10. Brain Circuitry Yields Clue to Autism, Researchers Say
11. NIH-supported researchers identify new class of malaria compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... California ... a web application that helps people assess their risk of developing Alzheimer’s disease. ... will provide users a “Risk Reduction Score™” that summarizes how their lifestyle choices ...
(Date:5/3/2016)... ... May 03, 2016 , ... Horizon ... has been honored as one of the nation’s most accomplished business technology innovators ... Horizon received the recognition for technology achievements that have enabled the delivery of ...
(Date:5/3/2016)... Texas (PRWEB) , ... May 03, 2016 , ... Excessive ... the signs of pet anxiety. "Pet owners often think anxiety only manifests itself ... stress signals in other ways, and there’s things that be done about it,” says ...
(Date:5/3/2016)... ... ... personal injury law firm Monge & Associates is honoring Moms in the time ... for their Mother or any other mother figure. , According to law firm founder, Scott ... on to say, “we are choosing to do this by giving free roses to those ...
(Date:5/3/2016)... ... May 03, 2016 , ... Intrigma, the leading ... Legacy Health is expanding its use of Intrigma’s cloud-based physician scheduling solution, Efficient ... proof of concept. The Portland, Oregon based health system conducted a one-year pilot ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 3, 2016  While you may be familiar with watching a film or ... also known as ultra-high-definition or 8MP in the Medical Industry.  Ampronix  is a renowned authorized ... innovative technology. Photo - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
(Date:5/3/2016)... Pharmacy, Inc. (NYSE: DPLO) announced today that it is celebrating Hepatitis Awareness Month with a ... tell their personal story and encourage those at risk to get tested and begin the ... ... ... Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ...
(Date:5/3/2016)... YORK , May 3, 2016 ... (MRI) Market Size, Share, Development, Growth and Demand Forecast ... Open), by Field Strength (High Field, Very High Field, ... Application (Brain, Head and Neck, Spine, Musculoskeletal, Vascular, Breast, ... the global magnetic resonance imaging (MRI) market was valued ...
Breaking Medicine Technology: