Navigation Links
Researchers find that inhibiting microRNAs may help prevent degenerative eye disorders
Date:6/6/2011

DALLAS June 7, 2011 Blocking two tiny molecules of RNA a chemical cousin of DNA appears to suppress the abnormal growth of blood vessels that occurs in degenerative eye disorders, UT Southwestern Medical Center researchers have found.

Their findings, available in the Proceedings of the National Academy of Sciences, suggest a potential strategy to treat age-related macular degeneration (AMD), a vascular eye disorder that affects nearly 2 million Americans and is a leading cause of blindness among older people.

"MicroRNAs can affect multiple pathways involved in age-related macular degeneration," said Dr. Shusheng Wang, assistant professor of ophthalmology and pharmacology and co-senior author of the study. "Therapeutic manipulation of microRNAs 23 and 27 may give us a way to treat choroidal neovascularization in patients with degenerative retinal diseases."

In the study, researchers found that silencing the microRNA cluster members miR-23 and miR-27 hindered the excessive formation of blood vessels in the back of the eye, known as choroidal neovascularization. When these blood vessels hemorrhage and leak, it creates a sudden deterioration of central vision.

MicroRNAs are tiny pieces of genetic material that can target multiple components of signaling pathways. By interacting with other protein-making molecules in cells, they help fine-tune the expression of networks of genes and control cell function.

But microRNAs also can contribute to the excessive blood vessel formation that is responsible for vascular disorders, the current UT Southwestern study shows. That's because they stimulate the growth of new blood vessels from pre-existing vessels, a process called angiogenesis, which is an important natural process in the body used for healing and reproduction.

The body usually controls angiogenesis through a precise balance of growth and inhibitory factors in healthy tissues, Dr. Wang said. When t
'/>"/>

Contact: Robin Russell
robin.russell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Two sisters in high school have developed ways to ... Krishen use electronic stethoscopes, which electronically amplify body sounds, ... or heartbeats. Ilina, a senior at Port Huron ... way to detect early lung damage in people exposed ... recorded one breath cycle each from 16 smokers, 25 ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... part of conventional in vitro fertilization (IVF) -- the incubation ... place in a device inside the vagina, new research suggests. ... the device, called an INVOcell, might sharply cut costs for ... the technology more accessible to those who don,t live near ...
(Date:10/22/2014)... HealthDay Reporter , MONDAY, Oct. 20, ... tightened guidelines for health workers treating Ebola patients, now requiring ... a respirator at all times. The U.S. Centers for ... after two Dallas nurses contracted Ebola while caring for the ... Thomas Eric Duncan. Nina Pham is currently being treated for ...
(Date:10/20/2014)... Dallas, Texas (PRWEB) October 20, 2014 ... is the must-have source of thousands of facts, figures ... 72 countries and 68 medical sector forecast categories the ... you with global, regional and national views on the ... future outlook. , The report gives you data for ...
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute is offering ... a damaged mitral valve as the heart continues to ... Abbott Vascular , is designed to treat degenerative ... which the heart’s mitral valve leaflets fail to close ... left ventricle into the left atrium. The heart must ...
Breaking Medicine News(10 mins):Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 4Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3
... Kidney Disease (CKD) are more likely to have mothers ... to a study presented at the American Society of ... W. Hsu, MD (University of Washington, Seattle) and colleagues. ... with childhood CKDdiagnosed at age 21 or youngerin Washington ...
... HealthDay Reporter , FRIDAY, Nov. 19 (HealthDay News) -- Computer ... they,ll look after a "nose job," and the majority value ... The "morphing" software, used by plastic surgeons since the 1990s, ... study said. "Having an image of an individual in ...
... Holohan HealthDay Reporter , FRIDAY, Nov. 19 (HealthDay ... can relax and have a drink a two, but they ... Dutch studies show. The researchers found that fears about ... concerns about weight are not. Both studies, conducted by ...
... (HealthDay News) -- Homeless youth who were sexually abused as ... they believe sex is a way to get people to ... information from 179 homeless youth, aged 16 to 21, from ... 42 percent of them reported they were sexually abused as ...
... HealthDay Reporter , FRIDAY, Nov. 19 (HealthDay News) ... helmets in the United States, more serious head injuries ... costs, two new companion studies show. In 2006, ... in motorcycle crashes involving 12- to 20-year-olds resulted in ...
... Columbia University Medical Center will present the 2010 ... made important advances in understanding the molecular basis for ... young investigator at Columbia will also be recognized for ... metabolism in diabetes. The 2010 ...
Cached Medicine News:Health News:How mom's health may increase risk of kidney disease 2Health News:Computer Imaging Adds to 'Nose Job' Satisfaction: Study 2Health News:Computer Imaging Adds to 'Nose Job' Satisfaction: Study 3Health News:Moderate Drinking Could Lower Death Risk for Kidney Transplant Patients 2Health News:Moderate Drinking Could Lower Death Risk for Kidney Transplant Patients 3Health News:Moderate Drinking Could Lower Death Risk for Kidney Transplant Patients 4Health News:Past Abuse Puts Homeless Youth at Risk for Early Sex: Study 2Health News:Young Motorcycle Riders Suffering More Brain Injuries 2Health News:Young Motorcycle Riders Suffering More Brain Injuries 3Health News:Harvard expert on inflammation's role in obesity receives Columbia's 2010 Naomi Berrie Award 2Health News:Harvard expert on inflammation's role in obesity receives Columbia's 2010 Naomi Berrie Award 3Health News:Harvard expert on inflammation's role in obesity receives Columbia's 2010 Naomi Berrie Award 4
(Date:10/22/2014)... 2014 Moms are ready to live the ... and their kids, according to the results of the ... Go Mobile for Moms, the latest installment in BabyCenter,s ... 1 pregnancy and parenting web and mobile destination worldwide, ... moms surveyed say they can,t think of a reason ...
(Date:10/22/2014)... October 22, 2014 A new ... Market (Product type, Form, End user, Application and Geography) ... Analysis, Research, Report, Opportunities, Segmentation and Forecast, 2013 - ... market. Based on key trends tracked, it is anticipated ... $7.9 billion by 2020, registering a CAGR of 6.2% ...
(Date:10/22/2014)... JERUSALEM , October 22, 2014 ... http://www.oramed.com ), a clinical-stage pharmaceutical company focused ... today reported positive top-line clinical results from its ... proprietary oral insulin capsules, to treat type 1 ... United States under a U.S. Food ...
Breaking Medicine Technology:BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 4
... Dengue virus belongs to the Flavavirus group ... throughout the tropics.,Symptoms of Dengue fever are ... in the back and limbs, lymphadenopathy,maculopapular rash ... professional use as an aid in the ...
... The Dengue virus belongs to the Flavavirus ... commonly throughout the tropics.,Symptoms of Dengue fever ... pain in the back and limbs, lymphadenopathy,maculopapular ... for professional use as an aid in ...
The IntraStent DoubleStrut Biliary Stent represents a completely new direction in stent design. The combination of parallel struts and unique cell geometry provide unparalleled performance....
For the rapid determination of human chorionic gonadotropin (hCG) in urine. The test strip is used to obtain a visual qualitative result....
Medicine Products: