Navigation Links
Researchers find that eating high levels of fructose impairs memory in rats
Date:7/16/2009

ATLANTA Researchers at Georgia State University have found that diets high in fructose a type of sugar found in most processed foods and beverages impaired the spatial memory of adult rats.

Amy Ross, a graduate student in the lab of Marise Parent, associate professor at Georgia State's Neuroscience Institute and Department of Psychology, fed a group of Sprague-Dawley rats a diet where fructose represented 60 percent of calories ingested during the day.

She placed the rats in a pool of water to test their ability to learn to find a submerged platform, which allowed them to get out of the water. She then returned them to the pool two days later with no platform present to see if the rats could remember to swim to the platform's location.

"What we discovered is that the fructose diet doesn't affect their ability to learn," Parent said. "But they can't seem to remember as well where the platform was when you take it away. They swam more randomly than rats fed a control diet."

Fructose, unlike another sugar, glucose, is processed almost solely by the liver, and produces an excessive amount of triglycerides fat which get into the bloodstream. Triglycerides can interfere with insulin signaling in the brain, which plays a major role in brain cell survival and plasticity, or the ability for the brain to change based on new experiences.

Results were similar in adolescent rats, but it is unclear whether the effects of high fructose consumption are permanent, she said.

Parent's lab works with Timothy Bartness, Regents' Professor of Biology, and John Mielke of the University of Waterloo in Waterloo, Ontario, Canada to examine how diet influences brain function.

Although humans do not eat fructose in levels as high as rats in the experiments, the consumption of foods sweetened with fructose which includes both common table sugar, fruit juice concentrates, as well as the much-maligned high fructose corn syrup has been increasing steadily. High intake of fructose is associated with numerous health problems, including insulin insensitivity, type II diabetes, obesity and cardiovascular disease.

"The bottom line is that we were meant to have an apple a day as our source of fructose," Parent said. "And now, we have fructose in almost everything." Moderation is key, as well as exercise, she said.

Exercise is a next step in ongoing research, and Parent's team will investigate whether exercise might mitigate the memory effects of high fructose intake. Her lab is also researching whether the intake of fish oil can prevent the increase of triglycerides and memory deficits. Results from that research will be presented by her graduate student Emily Bruggeman at the 2009 Society for Neuroscience meeting in Chicago this fall.


'/>"/>

Contact: Jeremy Craig
jcraig@gsu.edu
404-413-1357
Georgia State University
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... A prescription medication bottle, ... the fourth Cradle to Cradle Product Design Challenge , the Cradle to ... series of six circular design challenges scheduled to run through early 2018. The challenges ...
(Date:1/17/2017)... Baltimore, MD (PRWEB) , ... January 17, 2017 , ... ... joined the firm as a Principal in its IT Advisory Services practice . ... in recent months as market demand for strategic IT guidance grows, and the practice ...
(Date:1/17/2017)... ... January 17, 2017 , ... The ... in Tyler, has announced the latest beneficiary of their thriving community involvement program. ... organization dedicated to fulfilling the dreams of terminally ill patients. Donations to this ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... the Montclair State University’s Athletic Training Education program forged a relationship built upon ... Education Program, which is consists of both student members and certified members ...
(Date:1/16/2017)... ... , ... Gym Source, America’s leading retailer of premium residential and commercial fitness ... , “We are elated to be opening this new showroom,” explains Tom Richard, Chief ... clients a seamless and motivating shopping experience.” , Every fitness journey is unique, and ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)...  Edwards Lifesciences Corporation (NYSE: EW ), ... disease and critical care monitoring, plans to announce its ... after the market closes on Wednesday, February 1, 2017, ... ET that day to discuss those results. ... or (201) 689-8037.  For 72 hours following the call, ...
(Date:1/17/2017)... Jan. 17, 2017  OrthoAccel ® Technologies, Inc. ... (JCO) has published "The Effect of Vibration on Molar ... by Dr. S. Jay Bowman , this prospective, ... malocclusions, AcceleDent,s SoftPulse Technology ® speeds up molar ... reducing the number of days to move the upper ...
(Date:1/17/2017)... , Jan. 17, 2017 Following an ... today praised the Food and Drug Administration,s (FDA,s) ... Human Drug Products by Pharmacies and Outsourcing Facilities." ... proposed limitation on pre-packaging -- which would have ... costs to long term care (LTC) pharmacies.  ...
Breaking Medicine Technology: