Navigation Links
Researchers find that aspirin reduces the risk of cancer recurrence in prostate cancer patients
Date:5/2/2011

PALM BEACH, FL (May 1, 2011)Some studies have shown that blood-thinning medications, such as aspirin, can reduce biochemical failurecancer recurrence that is detected by a rising prostate-specific antigen (PSA) levelthe risk of metastasis and even death in localized prostate cancer. These studies, although very telling, have all emphasized the need for more data. Now, with researchers at Fox Chase Cancer Center having concluded the largest study on this topic, and there is substantial data suggesting that aspirin improves outcomes in prostate cancer patients who have received radiotherapy.

A team led by Mark Buyyounouski, M.D., M.S., a radiation oncologist at Fox Chase, examined a database of over 2000 prostate cancer patients who underwent radiotherapy at Fox Chase between 1989 and 2006 and found that aspirin use lowers the risk of cancer recurrence. The scientists will present their findings on Sunday, May 1 at the 93rd Annual Meeting of the American Radium Society.

The team found that the 761 men who took aspirin at or after the time of radiotherapy were less likely to experience biochemical failureas indicated by the levels of PSAthan were the 1380 men who didn't take the drug.

After 10-years from completion of treatment, 31% of the men who took aspirin developed recurrence compared with 39% of non-aspirin users (p=0.0005). There was also a 2% improvement in 10-year prostate cancer related survival associated with aspirin use with a trend toward statistical significance (p=0.07). "We know that prostate cancer has a long natural history and 15 years or more may be necessary to detect significant difference in survival," Dr. Buyyounouski explains. "Longer follow-up is needed, but these results warrant further study."

The readily available drug could be a promising supplement to radiotherapy in prostate cancer patients, and its beneficial effects may generalize to other types of cancer, Buyyounouski says. Still, he cautions that "it's a little premature to say that men need to start taking aspirin if they have a history of prostate cancer."

The optimal dose, timing, and duration of aspirin therapy, as well as potential side effects are not well understood, Buyyounouski explains. It's not clear how exactly the aspirin is helping and more research is needed to investigate this. "Its possible aspirin therapy is making the radiation more effective or preventing the cancer from spreading".

"Hopefully, these clinical results will provide feedback to laboratory researchers to try to explain the underlying mechanism so that we can better study the clinical effects in targeted populations," Buyyounouski says.


'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Related medicine news :

1. Researchers discover mechanism that could convert certain cells into insulin-making cells
2. Unintentional child injuries, deaths can be prevented, public health researchers say
3. Researchers Describe Gene Activity in Living Cells
4. Researchers observe disruptions of daily rhythms in Alzheimers patients brains
5. Researchers identify novel pathophysiologic mechanism responsible for autoimmunity
6. Researchers report widespread use of medications among pregnant women
7. Couch-Potato Kids: It Shows in Their Eyes, Researchers Say
8. Antidepressants may not improve all symptoms of depression, UT Southwestern researchers find
9. Women Taking Calcium Supplements May Risk Heart Health, Researchers Say
10. Limiting carbs, not calories, reduces liver fat faster, UT Southwestern researchers find
11. Mutated gene found in dog disease the same in humans, MU researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 19, 2017 , ... DMG Productions, producers of the ... in an upcoming episode, slated to air fourth quarter 2017. Check your local ... Group; a company committed to supporting dentistry using the most technologically advanced restorative ...
(Date:8/19/2017)... ... August 18, 2017 , ... President ... of 2017, legislation that provides for greater public access to over-the-counter (OTC) hearing ... to access OTC hearing aids without being seen by a certified and licensed ...
(Date:8/19/2017)... ... 2017 , ... Praeclarus Press has launched a new ... the diversity of the breastfeeding mothers, using bright colors and contemporary themes. These ... are also available on tote bags, notepads, smartphone cases, clocks, and travel mugs. ...
(Date:8/19/2017)... Fla. (PRWEB) , ... August 19, 2017 , ... ... Taufiq Ahmed, M.D., has joined its Orlando location as an interventional pain management ... anesthesiology, a focus on the treatment of migraine headaches, and significant experience in ...
(Date:8/18/2017)... , ... August 18, 2017 , ... More than 20,000 ... Republic of Congo (DRC) thanks to an ambitious venture that conjoined the passions of ... the generous support of the Liberty community. These shoes will save lives from the ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... ROCKVILLE, Md. , Aug. 4, 2017 ... during or shortly after a physician/patient consult has long ... industry, and was a notable focus of the largest ...  This is according to healthcare market research firm Kalorama ... of care testing (POCT) offerings or related supplies and ...
(Date:8/2/2017)... 2, 2017  Life Flight Network and PeaceHealth Oregon Network ... patient care and operational efficiency for patients at hospitals in ... Cottage Grove , and Florence, ... and Life Flight Network work collaboratively to move patients who ... when a time sensitive emergency exists. ...
(Date:7/31/2017)... 7D Surgical, developer of ground breaking surgical navigation ... Surgical System to support its strategic sales plan in ... and Virginia.  7D Surgical has entered into an exclusive sales ... medical facilities within those markets. ... Spartan Medical Purchases ...
Breaking Medicine Technology: