Navigation Links
Researchers find roadmap to next-generation cancer therapies
Date:5/25/2008

Pinpointing new targets for cancer treatments is as difficult as finding a needle in a haystack, yet a University of Rochester team has discovered an entire novel class of genes they believe will lead to a greater understanding of cancer cell function and the next generation of effective and less harmful therapies for patients.

In a paper in the journal Nature, available online May 25, the researchers describe how multiple cancer genes cooperate to cause malignant cell transformation. Further, they describe the discovery of approximately 100 genes that work downstream of known cancer-causing mutations, providing a host of new opportunities for intervention.

We believe that we have found a cornerstone for development of new treatments that ultimately will allow selection of drugs and drug combinations from a pool of compounds directed against these new genes, said lead author Hartmut Land, Ph.D., professor and chair of the Department of Biomedical Genetics at the University of Rochester Medical Center and scientific director of the James P. Wilmot Cancer Center at the URMC.

However, much more work needs to be done to explore how our findings may lead to successful targeting of various cancer types and cancer stem cells, he said.

Targeted cancer therapy such as the drug Gleevec that works for patients with certain types of leukemia and gastrointestinal tumors is based on a keen understanding of the architecture of cancer. Much has been learned in the past several years, but what has been lacking is a clear roadmap leading to dozens of new molecular targets.

Twenty-five years ago Land was among the first scientists to discover that malignant cell transformation required multiple mutations in distinct cancer genes. Ever since, he has been studying the cooperative nature of this process and the inner workings of cancer cell function.

His research group began testing, at the genomic scale, a prediction that gen
'/>"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Monitoring blood flow helps improve prostate biopsies, Jefferson researchers report
2. 2008 LOreal USA Fellowships For Women in Science Awarded to Five Groundbreaking Researchers
3. Researchers explore the emerging role of infection in Alzheimers disease
4. 2 LA BioMed researchers named Heroes of Emergency Medicine
5. Virtual biopsy can tell whether colon polyp is benign without removal, Mayo researchers say
6. Researchers close in on new melanoma gene
7. Traditional herbal medicine kills pancreatic cancer cells, Jefferson researchers report
8. Researchers develop first transgenic monkey model of Huntingtons disease
9. Researchers expand natural killer cells in cord blood to fight leukemia
10. Medical College of Wisconsin researchers identify proteins that help develop mammalian hearts
11. Mastectomies on the rise and MRI use may explain part of the trend, say Mayo researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Key West Health & Beauty’s ( http://www.keywesthealthandbeauty.com ... anticipated study results of the 12 best and worst ... accompanying infographic on their website. It appears that the ... impact on the skin and contribute to many unwanted ... asked how they determined the results, founder and skin ...
(Date:8/22/2014)... Medical Oncology (ESMO), the leading pan-European organisation representing ... three outstanding individuals receiving the Society,s esteemed annual ... Bokemeyer, Heikki Joensuu and Peter Boyle on the ... Madrid, Spain. , Carsten Bokemeyer will receive the ... transition of cancer discovery into real benefit at ...
(Date:8/22/2014)... in Sweden provides insight on how the brain processes ... different sources and sides of the body, in order ... are presented in the journal Neuron , show ... various types of sensory information, with specialised functional roles ... the main input structure in the basal ganglia, and ...
(Date:8/22/2014)... Oncology (ESMO), the leading pan-European organisation representing medical ... outstanding individuals receiving the Society,s esteemed annual awards. ... Heikki Joensuu and Peter Boyle on the occasion ... Spain. , Carsten Bokemeyer will receive the ESMO ... of cancer discovery into real benefit at patient ...
(Date:8/22/2014)... air in American cities is getting safer to breathe, ... progress has been made in reducing levels of harmful ... said in a news release. Since 1990, there ... from human sources such as coal-fired plants, a 66 ... in lead, which harms brain development in children. ...
Breaking Medicine News(10 mins):Health News:Key West Health & Beauty Announces The 12 Best & Worst U.S. Cities For Skin Study 2Health News:ESMO honors outstanding oncology professionals 2Health News:ESMO honors outstanding oncology professionals 3Health News:The striatum acts as hub for multisensory integration 2Health News:ESMO honours outstanding oncology professionals 2Health News:ESMO honours outstanding oncology professionals 3Health News:Air in U.S. Cities Getting Cleaner, EPA Says 2
... food cravings and keeping them in check may be ... first six-month phase of the study provides new insights ... their role in weight control. ,Cravings are ... Susan Roberts, PhD, director of the USDA HNRCAs Energy ...
... typically graduate students hired to help undergrads with their ... expert Bernardo J. Carducci said social assistants, people ... and social skills, should become staples, as well. ... Research Institute at IU Southeast, are no different than ...
... industrial body recognizing the downward trend of access to quality ... reverse the situation- more money and a significant private-public partnership. ... Chambers of Commerce and Industry (FICCI), India needs to spend ... of achieving 'Health for all' is to be attained by ...
... is considered a healthy role model the world over, but ... land of the rising sun. ,Japan's health ministry estimates ... age of 40 is obese and experts have identified a ... ,"The everyday habits among the Japanese have become ...
... what boys lose in the process of circumcision turns ... penis. ,The long-term-health impact of neo-natal ... circumcision on sexual function in the adult male have ... recent study, by M. Sorrels and colleagues from the ...
... but they plan to add to their family in a big way ... Stewart inquired as to just how many kids Angelina wanted in all, ... as many as 14 little ones. ,"Hmm, it fluctuates between ... tewart then praised her by saying, "Wow, I'll tell you this: I ...
Cached Medicine News:Health News:Weight Management Achieved by Controlling and Not Suppressing Food Cravings 2Health News:Binge Drinking on College Campuses is a Matter of Fear, Not Freedom 2Health News:Binge Drinking on College Campuses is a Matter of Fear, Not Freedom 3Health News:FICCI Proposes Models To Solve Indias Healthcare Crisis 2Health News:Japanese are Weighed Down by Deviating from Their Traditional Diet 2
(Date:8/22/2014)... Aug. 22, 2014   Zacks Equity Research highlights Epizyme ... the Day and Panera (Nasdaq: PNRA - Free Report ) ... provides analysis on Amicus Therapeutics (Nasdaq: FOLD - Free Report ... (Nasdaq: SHPG - Free Report ). Here is ... of the Day : The biotech bull market ...
(Date:8/22/2014)... Research and Markets has announced the addition ... Report 2014" report to their offering. ... 2014 is a professional and in-depth study on the ... a focus on the Chinese situation. The report ... classifications, applications and industry chain structure. The particulate respirators ...
(Date:8/22/2014)... , Cali ., Aug. 22, 2014 ... Papillomavirus Conference shows that a therapy being developed by Hera ... two that cause 70 percent of all cervical cancer. ... blocked the replication of HPV-16, HPV-18 and HPV-11 cells, according ... Broker , Ph.D., who presented the findings at the ...
Breaking Medicine Technology:Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 3Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 4Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 5Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 6Global and Chinese Particulate Respirators Industry Report 2014 2Study shows Hera Therapeutics experimental compound shuts down human papillomavirus that causes most cervical cancer 2
... DIEGO, Jan. 31, 2011 Volcano Corporation (Nasdaq: ... of Massachusetts has issued a decision that ruled in ... Inc., and against LightLab Imaging, Inc., on all of ... 11-page decision also rejected LightLab,s request for injunctive relief. ...
... its continuing partnerships with Brazilian public health authorities and ... Mr. Nelson dos Santos as interim vice president of ... nonprofit organization whose mission is to improve the health ... programs that help ensure the quality, safety and benefit ...
Cached Medicine Technology:Massachusetts Court Rules in Favor of Volcano and Against St. Jude Medical Subsidiary in Trade Secrets Case 2New Interim Leadership for USP-Brazil 2
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 8.0 mm and length 7.5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 7.0 mm and length 7.7 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 8.0 mm and length 5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 13.0 mm and length 12 mm....
Medicine Products: