Navigation Links
Researchers find roadmap to next-generation cancer therapies
Date:5/25/2008

Pinpointing new targets for cancer treatments is as difficult as finding a needle in a haystack, yet a University of Rochester team has discovered an entire novel class of genes they believe will lead to a greater understanding of cancer cell function and the next generation of effective and less harmful therapies for patients.

In a paper in the journal Nature, available online May 25, the researchers describe how multiple cancer genes cooperate to cause malignant cell transformation. Further, they describe the discovery of approximately 100 genes that work downstream of known cancer-causing mutations, providing a host of new opportunities for intervention.

We believe that we have found a cornerstone for development of new treatments that ultimately will allow selection of drugs and drug combinations from a pool of compounds directed against these new genes, said lead author Hartmut Land, Ph.D., professor and chair of the Department of Biomedical Genetics at the University of Rochester Medical Center and scientific director of the James P. Wilmot Cancer Center at the URMC.

However, much more work needs to be done to explore how our findings may lead to successful targeting of various cancer types and cancer stem cells, he said.

Targeted cancer therapy such as the drug Gleevec that works for patients with certain types of leukemia and gastrointestinal tumors is based on a keen understanding of the architecture of cancer. Much has been learned in the past several years, but what has been lacking is a clear roadmap leading to dozens of new molecular targets.

Twenty-five years ago Land was among the first scientists to discover that malignant cell transformation required multiple mutations in distinct cancer genes. Ever since, he has been studying the cooperative nature of this process and the inner workings of cancer cell function.

His research group began testing, at the genomic scale, a prediction that gen
'/>"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Monitoring blood flow helps improve prostate biopsies, Jefferson researchers report
2. 2008 LOreal USA Fellowships For Women in Science Awarded to Five Groundbreaking Researchers
3. Researchers explore the emerging role of infection in Alzheimers disease
4. 2 LA BioMed researchers named Heroes of Emergency Medicine
5. Virtual biopsy can tell whether colon polyp is benign without removal, Mayo researchers say
6. Researchers close in on new melanoma gene
7. Traditional herbal medicine kills pancreatic cancer cells, Jefferson researchers report
8. Researchers develop first transgenic monkey model of Huntingtons disease
9. Researchers expand natural killer cells in cord blood to fight leukemia
10. Medical College of Wisconsin researchers identify proteins that help develop mammalian hearts
11. Mastectomies on the rise and MRI use may explain part of the trend, say Mayo researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... 28, 2015 , ... Saint Petersburg, FL —Pocket Protein™, a ... carbs, sugar, gluten, lactose or caffeine in a convenient 2 oz. pouch that ... Editor’s Choice Awards. , Five consumer packaged goods (CPG) products were selected by ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... specialist, Dr. James Strawbridge, gives a new approach on solutions in his new ... with the employer and employees getting together for meaningful group meetings. "This would ...
(Date:8/28/2015)... , ... August 28, 2015 , ... ... three-year accreditation for its adolescent residential, counseling, day treatment and intensive family based ... meets international standards for quality and its pursuit of excellence. As a nonprofit ...
(Date:8/28/2015)... NY (PRWEB) , ... August 28, 2015 , ... The ... Kybella™. It is the first and only nonsurgical product approved by the Food ... Dr. Vito Quatela and Dr. William Koenig are among the ...
(Date:8/28/2015)... ... 2015 , ... SharkNinja, an innovative leader in the housewares ... Sofia Vergara, and unveil the Ninja® brand’s new coffee machine, the Ninja ... variety of sizes and styles while achieving the perfect brew richness level every ...
Breaking Medicine News(10 mins):Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 3Health News:West Ridge Academy Awarded CARF Three-Year Accrediation 2Health News:Non-surgical Treatment to Get Rid of The "Double Chin," Kybella™, Now Available at the Quatela Center for Plastic Surgery 2Health News:Non-surgical Treatment to Get Rid of The "Double Chin," Kybella™, Now Available at the Quatela Center for Plastic Surgery 3Health News:Sofia Vergara Partners With SharkNinja® To Launch The Ninja Coffee Bar™ 2Health News:Sofia Vergara Partners With SharkNinja® To Launch The Ninja Coffee Bar™ 3
... EAST LANSING, Mich., Oct. 25 The Board of,Directors ... ),has declared a cash dividend of 10 cents per ... at the close of business on December 13,2007. At ... Corporate Description American Physicians Capital, Inc. is ...
... Calif., Oct. 25 Thoratec,Corporation (Nasdaq: THOR ), ... announced that it will report its operating,results for the ... The company will hold a conference call to ... interested parties at 8:30,a.m., Pacific Daylight Time (11:30 a.m., ...
... tensor imaging can identify structural changes in the white ... even in patients with mild traumatic brain injury. ... of the journal Brain. , "We studied patients ... to severe -- and found that abnormalities in white ...
... Vessel Road Mapping and Magnetic Guidewire Navigation ... Capabilities Demonstrated in Multiple Cases, ST. ... the details of successful, live percutaneous coronary,and peripheral cases ... the Main Arena at the Transcatheter Cardiovascular,Therapeutics (TCT) symposium, ...
... USO has,partnered with CarePages.com to provide wounded troops an ... friends while recovering,in the hospital and at home. Called ... sharing health updates, photos and supportive,messages via a private ... care and support, and allows them to share updates ...
... drugs of tomorrow and how will they be ... Molecular Targets and Cancer Therapeutics, researchers will present ... regarding emerging cancer therapeutics. , New ... cancer tumors, provide tantalizing targets for engineered antibodies ...
Cached Medicine News:Health News:Thoratec Schedules Third Quarter Conference Call, Webcast 2Health News:Imaging shows structural changes in mild traumatic brain injury 2Health News:Imaging shows structural changes in mild traumatic brain injury 3Health News:Stereotaxis Highlights Live Coronary and Peripheral Vascular Cases Performed at TCT With Stereotaxis Magnetic Navigation System 2Health News:Stereotaxis Highlights Live Coronary and Peripheral Vascular Cases Performed at TCT With Stereotaxis Magnetic Navigation System 3Health News:Stereotaxis Highlights Live Coronary and Peripheral Vascular Cases Performed at TCT With Stereotaxis Magnetic Navigation System 4Health News:The USO and CarePages.com Help Wounded Troops Stay Connected to Their Families 2Health News:The USO and CarePages.com Help Wounded Troops Stay Connected to Their Families 3Health News:Targets on the horizon: Emerging therapies and novel targets 2Health News:Targets on the horizon: Emerging therapies and novel targets 3Health News:Targets on the horizon: Emerging therapies and novel targets 4Health News:Targets on the horizon: Emerging therapies and novel targets 5Health News:Targets on the horizon: Emerging therapies and novel targets 6Health News:Targets on the horizon: Emerging therapies and novel targets 7
(Date:8/27/2015)... , Aug. 27, 2015  A mere one ... Booz Allen Hamilton . A new white ... development inefficiencies are impeding and disrupting manufacturers, success. ... Waste and Improve Value In Product Development Processes ... inaccessible data and how it affects the product development ...
(Date:8/27/2015)... , Aug. 27, 2015 NorthStar Anesthesia ... today that it has been selected by Mercy, based in ... services for four of their hospitals:  Mercy St. Vincent  Medical ... Toledo , Mercy St. Charles  Hospital in ... Tiffin . "As we ...
(Date:8/27/2015)... -- According to a new market research ... by Deployment Mode (Web based, On-Premise, Cloud-Based), by End ... by Component - Global Trends & Forecast to 2019", ... $501.1 Million 2014, and is projected to reach $722.7 ... 2014 to 2019. Browse 60 T ...
Breaking Medicine Technology:New White Paper Reveals How Manufacturers Can Improve Product Development Processes 2Four Mercy Hospitals in Northwest Ohio Select NorthStar Anesthesia 2Radiology Information Systems Market Worth $722.7 Million by 2019 2Radiology Information Systems Market Worth $722.7 Million by 2019 3Radiology Information Systems Market Worth $722.7 Million by 2019 4
... March 24, 2011 A new program from American ... consumers regarding the price of advanced diagnostic imaging exams ... are performed, offering significant cost savings and increased satisfaction. ... care spending, there is a growing need for information ...
... PARSIPPANY, N.J., March 24, 2011 PDI, Inc. (Nasdaq: ... NASDAQ Stock Market Closing Bell on Tuesday, March 29, 2011, at ... PDI CEO Nancy Lurker will ring the Closing Bell together with ... "Ringing the NASDAQ bell is a particularly meaningful event for PDI ...
Cached Medicine Technology:American Imaging Management Promotes Affordability and Choice to Health Care Consumers 2American Imaging Management Promotes Affordability and Choice to Health Care Consumers 3American Imaging Management Promotes Affordability and Choice to Health Care Consumers 4
... camera incorporates a Progressive Scan 1/3" CCD with ... x 768 (V) XGA. Whats more the XCD-X710CR ... called a "Bayer filter") and outputs the "raw ... to be converted to a color image on ...
... Sonys XCD-X710 digital camera incorporates a Progressive ... offers excellent sensitivity (1024 x 768 XGA ... high-resolution, digital B/W images and features an ... exposure range from 1/100,000 to 17.5 second, ...
... The PL-A661 is a monochrome " 1.3 ... microscopy applications. Desgined to simplify real-time ... the PL-A661 provides uncompromising video and digital ... package. The PL-A661 is ideal for industrial ...
... FireWire, high dynamics. Exceptional performance in the ... for your applications: The possibility to respond ... and laboratory work, meeting new challenges with ... been combined with so much flexibility in ...
Medicine Products: