Navigation Links
Researchers find public sector research responsible for many new drug discoveries
Date:2/9/2011

(Boston) - Researchers from Boston University School's of Medicine (BUSM), Management (SMG) and Law (LAW), along with collaborators from the National Institutes of Health, believe that public-sector research has had a more immediate effect on improving public health than was previously realized. The findings, which appear as a Special Article in the February 10th issue of The New England Journal of Medicine, have economic and policy implications.

Historically, public sector research institutions (PSRI) have not participated in any major way in the downstream, applied phase of drug discovery, in which the actual products are discovered and patented. However, in the mid-1970s, the newly emerging tools of biotechnology allowed PSRIs to create and patent biologic drug candidates and discover and patent small molecule drugs. At that time, all products created in academic institutions were owned by the government, which granted only nonexclusive licenses.

In 1980, Congress passed two pieces of legislation that transformed the ownership, management and transfer of intellectual property that is created by PSRIs. First, the BayhDole Act allowed universities, nonprofit research institutes and teaching hospitals to own the intellectual property resulting from federally funded research and to license it according to terms of their choosing. Second, the StevensonWydler Technology Innovation Act as amended by the Federal Technology Transfer Act of 1986, provided a corresponding authority to federal laboratories. Under this new approach, inventions that arose from PSRIs, in addition to being freely published in the scientific literature, could also be converted into intellectual property and transferred through license agreements to the private sector for commercialization and public use.

In order to quantitate the contribution of public-sector research to the applied-research phase of drug discovery, the researchers identified new drugs and vaccines approved by the Food and Drug Administration (FDA) and classified them according to their therapeutic category and potential therapeutic effect. The researchers found that during the past 30 years, 153 new FDA-approved drugs, vaccines, or new indications for existing drugs were discovered through research carried out in PSRIs. These drugs included 93 small-molecule drugs, 36 biologic agents, 15 vaccines, eight in-vivo diagnostic materials, and one over-the-counter drug. Current and former Boston University researchers were responsible for four of those 153 new drugs, one of which was developed based on research conducted at the University and Boston Medical Center.

"We believe that our study supports the concept that the emergence of biotechnology in the mid-1970s, combined with policy changes implemented in the early 1980s regarding the ownership and management of the intellectual property of PSRIs, allowed these institutions to play an important role in the downstream, applied phase of drug discovery," said lead author Ashley J. Stevens, D.Phil (Oxon), CLP, a lecturer at BUSM as well as Special Assistant to the Vice President for Research, Technology Development and a Senior Research Associate, ITEC, SMG. He is also currently the President of the Association of University Technology Managers.

According to the researchers, the data also suggest that PSRIs tend to discover drugs that have a disproportionately important clinical effect. "Slightly over half of these drugs were for the treatment or prevention of cancer or infectious diseases. Furthermore, drugs discovered by PSRIs received Priority Review by the FDA at twice the rate as for all FDA drug approvals, indicating that PSRI discovered drugs were expected to have a disproportionately high therapeutic impact," added Stevens.

"We hope our research will help inform the amplified conversation taking place around innovation policy in the US and abroad," said co-author Jonathan Jensen, MBA, Director, Business Development, Technology Development at Boston University. "The factors involved in bringing a single one of these drugs to market are complex. With a more comprehensive understanding of the contribution of the public sector to the development of FDA approved drugs, as our work attempts to establish, one can better appreciate and further study the factors involved in the transfer of knowledge from the public to the private sector," he added.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. What makes fructose fattening? OHSU researchers find some answers in the brain
2. Researchers: Elderly patients 4 times more likely to die from treatment complications
3. Researchers identify the genotype of disorders causing cardiac sudden death syndrome
4. Researchers predict nearly 1.3 million cancer deaths in Europe in 2011
5. Researchers develop outline that may help weigh benefits of new imaging technologies
6. Project connects researchers, Latino communities to prevent cancer
7. Researchers get a grip on nervous systems receptors
8. U-M Medical School researchers set new record in NIH funding: $368.7 million
9. UNC researchers developing computer models for pediatric airway problems
10. Rheumatoid arthritis researchers redefine remission
11. Researchers lead search for better drug-addiction treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... The Orthopaedic Research and Education Foundation ... , David G. Lewallen, MD, began his term as president in March, succeeding John ... MD, is OREF’s new president-elect. Richard F. Kyle, MD, will serve as chair, corporate ...
(Date:5/31/2016)... ... May 31, 2016 , ... MinerEye today announced that ... Infrastructure Protection report by Gartner1 Inc. , Each year, Gartner identifies new Cool ... these innovative vendors and their products and services. , According to Gartner, “Gartner's ...
(Date:5/31/2016)... Port Washington, NY (PRWEB) , ... May 31, 2016 , ... ... and other essential nutrients to on the go individuals and dedicated athletes, continues to ... functions. , Loaded with whey, pea and milk protein, branched-chain amino acids (BCAA), ...
(Date:5/30/2016)... ... 30, 2016 , ... Another ER facility operated by First Choice Emergency ... Drive, Plano, TX and is open 24 hours daily. , First Choice Emergency Room ... open house. The Jasper High School band entertained attendees and accepted First Choice Emergency ...
(Date:5/28/2016)... Viejo, California (PRWEB) , ... May 28, 2016 , ... ... need to drag and drop a preset onto their media," said Christina Austin - ... Pixel Film Studios, editors can quickly and easily add stylish color grades to their ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... -- Amarantus BioScience Holdings, Inc. (OTCQX: ... Medicine, Neurology and Orphan Diseases, today announced that President & CEO ... investor conferences: SeeThru Equity MicroCap Conference   ... York City , NY When: Tuesday, May 31 ...   Where: Grand Hyatt Hotel, 109 East 42 nd ...
(Date:5/26/2016)... May 26, 2016 A key ... is the emergence of new treatments. Cardax, a development ... osteoarthritis treatment. The therapy is expected to fulfil large ... UK is conducting studies to develop new treatments for ... the genes involved in osteoarthritis are being investigated, and ...
(Date:5/26/2016)... , May 26, 2016 Since ... matured into an essential life science tool for conducting ... applications. BCC Research reveals in its new report that ... growth phase, one powered by a range of new ...      (Logo: http://photos.prnewswire.com/prnh/20140723/694805 ) , ...
Breaking Medicine Technology: